Efficacy and safety of tazemetostat, an EZH2 inhibitor, in Chinese patients with relapsed/refractory follicular lymphoma: a multicentre, single-arm, phase 2 study.

Background: Tazemetostat, the first enhancer of zeste homolog 2 (EZH2) inhibitor approved by the U.S. Food and Drug Administration, has shown efficacy in a global population with relapsed or refractory (R/R) follicular lymphoma (FL).

Ontogenetic niche segregation and its implications for mercury levels in Japanese anchovy from the high seas of the northwestern Pacific Ocean as revealed by fatty acid analysis.

Japanese anchovy (Engraulis japonicus) is a small pelagic fish that is frequently targeted by commercial fisheries. Japanese anchovy plays a crucial role as a vital link between primary and higher-order consumers. The elemental mercury in Japanese anchovy muscles easily bioaccumulates and is transmitted to top predators.

Nanomaterial-Enhanced Phytoremediation of (L.) Urban in Cd-Contaminated Soils.

This study investigates the effectiveness of titanium dioxide nanoparticles (TiO NPs) on the uptake, accumulation, translocation, and phytoremediation efficiency of Cd by-(L.) Urban (). TiO NPs at a concentration of 100 mg/kg were applied to soils contaminated with Cd at varying levels (10, 100 mg/kg).

Multiple drug resistance caused by germline mutation of exon 27 of BRCA2 gene in triple-negative breast cancer: a case report and literature review.

BRCA genes, including BRCA1 and BRCA2, are tumor suppressor genes that play a crucial role in the HRR pathway for double-strand DNA breaks. Mutations in these genes lead to the loss of function of their respective proteins, resulting in HRD and the development of hereditary breast cancer. The BRCA2 gene is located on chromosome 13 at the 13q12.

Clinical application of 90-gene expression test in a patient with occult breast cancer: a case report and literature review.

Occult breast cancer is an exceptionally rare disease characterized by ambiguous diagnostic criteria. Currently employed diagnostic methods include breast MRI, PET-CT, and immunohistochemistry; however, challenges in achieving accurate diagnoses persist in certain cases. The utilization of the 90-gene test has been implemented to identify the origin of unknown tumors, demonstrating an overall accuracy rate of 94.

Improving the Soluble Expression of Sweet Protein Thaumatin II through Directed Evolution in .

Thaumatin is a natural sweet protein valued for its intense sweetness, long-lasting effect, low-calorie content, and safety. However, limited solubility and low yields hinder microbial fermentation. To overcome these challenges, we engineered to express thaumatin II and implemented three strategies to improve its solubility.

Occurrence of vanA/vanM-positive vancomycin-resistant Enterococcus faecium in hospital wastewater associated with clinical infections in Guangzhou, China: A genomic epidemiological study.

Background: The emerging ST80 vancomycin-resistant Enterococcus faecium (VREfm) lineage, linked to the increases of clinical infections in China and Japan, raises concerns about environmental transmission. Hospital wastewater systems are recognized reservoirs for antimicrobial-resistant bacteria, but their role in disseminating ST80 VREfm remains unclear. This study investigates VREfm prevalence in hospital wastewater and genomic links between patients and hospital wastewater.

Identification of the MYC gene family in Camellia oleifera and the role of CoMYC2-like genes in growth and stress responses.

The myelocytomatosis (MYC) transcription factors are crucial regulators of plant growth, development, and stress responses. In this study, we identified and characterized the CoMYC gene from Camellia oleifera Abel. and investigated its functional roles through heterologous expression in Arabidopsis thaliana.

Composite B‑cell lymphoma and extranodal natural killer/T‑cell lymphoma presenting with distinct clone evolution and tumor microenvironment: A report of two cases.

Composite lymphoma containing both B-cell lymphoma and extranodal natural killer/T-cell lymphoma (ENKTL) is extremely rare. Clonal evolution and tumor microenvironment (TME) features have not been reported previously. The present study reports one case of the heterochronous occurrence of follicular lymphoma (FL) and ENKTL and one case of the simultaneous occurrence of diffuse large B-cell lymphoma (DLBCL) and ENKTL.

A multicenter, open-label, single-arm, phase Ib clinical trial of HH2853 treatment in patients with relapsed and/or refractory peripheral T-cell lymphoma.

Background: Peripheral T-cell lymphoma (PTCL) is an aggressive malignancy with limited treatment options and poor prognosis, particularly for relapsed or refractory (r/r) patients. HH2853, a novel dual inhibitor of EZH1/2, has previously demonstrated clinical benefits in solid tumors. Here, we report safety and efficacy data from a phase Ib trial of HH2853 in r/r PTCL.

CD5 and p53 immunohistochemistry: valuable prediction method in molecular typing of CD5-positive diffuse large B-cell lymphoma.

Background: CD5 positive diffuse large B-cell lymphoma (DLBCL) has unique clinical and pathological characteristics.

Methods: We analyzed 25 cases of CD5-positive DLBCL, focusing on their clinical, morphological, immunohistochemical and genetic features.

Results: Among the 13 females and 12 males, 14 were over 60 years (14/25, 56%).

Shape-Selective Molecular Separations Enabled by Rigid and Interconnected Confinements Engineered in Conjugated Microporous Polymer Membranes.

Separating molecules with similar sizes but different shapes is essential yet challenging. Here, conjugated microporous polymer (CMP) membranes with narrowly distributed network pores are prepared by diffusion-modulated electropolymerization. This approach precisely controls the monomer diffusion and coupling processes, regulating the crosslinking degree to prevent broad aggregate pores and microporous defects.

Correlations of serum uric acid, fibrinogen and homocysteine levels with carotid atherosclerosis in hypertensive patients.

Objective: Uric acid (UA), fibrinogen (FIB), and homocysteine (Hcy) are the main contributors to cardiovascular and cerebrovascular diseases, and are related to hypertension. Hypertension plays a role in atherosclerosis (CAS). We hence explored the correlations of UA, FIB, and Hcy levels with CAS in hypertensive patients.

Computational mining and redesign of superoxide dismutase with activity-thermostability improvement.

Superoxide dismutase (SOD) is a redox metalloenzyme that serves as a critical defense against oxidative damage caused by reactive oxygen species, with applications across food, cosmetic, and pharmaceutical industries. However, the limited catalytic activity and poor thermostability restrict its effectiveness in industrial processes. Herein, we report a SOD from Deinococcus wulumuqiensis R12 (SOD(R12)) that demonstrates remarkable catalytic activity of 1356.

A flexible multifunctional sensor based on in situ reduction of Ag nanoparticles by yam polysaccharides.

Developing flexible multifunctional sensors that combine humidity, temperature, and strain sensing properties is a challenge. In this paper, PVA/YPs/HPO/AgNPs (PYHA) flexible composite films loaded with Ag nanoparticles (AgNPs) were synthesized through in situ reduction and solution casting using polyvinyl alcohol (PVA), yam polysaccharide (YPs), phosphoric acid (HPO), and silver nitrate (AgNO) as raw materials, which exhibited sensitivity to humidity, temperature, and strain. The prepared PYHA humidity sensor was capable of generating stable electrical signals through adsorption and desorption over the relative humidity (RH) range of 35-95 %.

Pirtobrutinib in Chinese patients with relapsed or refractory B-cell malignancies: A single-arm, open-label, phase 2, multicenter trial.

Pirtobrutinib, a highly selective, noncovalent (reversible) Bruton tyrosine kinase inhibitor (BTKi), demonstrated clinically meaningful antitumor responses in covalent BTKi pretreated mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) in the global phase 1/2 BRUIN study. In this multi-center, open-label, phase 2 trial, we investigated the efficacy and safety of pirtobrutinib in Chinese patients with BTKi pretreated relapsed/refractory (R/R) MCL, CLL/SLL, or other B-cell malignancies. All patients received pirtobrutinib once daily in continuous 28-day cycles.

Polatuzumab vedotin plus bendamustine and rituximab in relapsed/refractory diffuse large B-cell lymphoma: A phase III bridging study in Chinese patients.

Background: Patients with transplant-ineligible relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) have limited treatment options and poor outcomes.

Methods: This phase III study (NCT04236141) evaluated the efficacy and safety of polatuzumab vedotin plus bendamustine and rituximab (Pola+BR) versus BR in Chinese patients with transplant-ineligible R/R DLBCL to support regulatory submission in China. Patients were randomized 2:1 to receive Pola+BR or placebo+BR.

Pharmacokinetics, efficacy, and safety of subcutaneous versus intravenous rituximab in previously untreated Chinese patients with CD20+ diffuse large B-cell lymphoma: a phase II randomized controlled trial.

Subcutaneous (SC) rituximab has demonstrated advantages over intravenous (IV) administration; however, insufficient data exist on its use with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in Chinese patients with diffuse large B-cell lymphoma (DLBCL). This multicenter, phase II, randomized, controlled study was conducted across China between February 2021 and October 2022. Fifty adult patients with previously untreated CD20-positive DLBCL were randomized to receive one cycle of IV rituximab and seven cycles of SC rituximab (R-CHOP;  = 26), or eight cycles of IV rituximab (R-CHOP;  = 24), combined with six or eight cycles of CHOP.

A machine learning-based model to predict POD24 in follicular lymphoma: a study by the Chinese workshop on follicular lymphoma.

Background: Disease progression within 24 months (POD24) significantly impacts overall survival (OS) in patients with follicular lymphoma (FL). This study aimed to develop a robust predictive model, FLIPI-C, using a machine learning approach to identify FL patients at high risk of POD24.

Methods: A cohort of 1,938 FL patients (FL1-3a) from seventeen centers nationwide in China was randomly divided into training and internal validation sets (2:1 ratio).

CD146⁺ Endothelial Cells Facilitate Renal Interstitial Fibrosis Through Endothelial-to-Mesenchymal Transition.

BACKGROUND Endothelial cells play a crucial role in the pathogenesis of renal interstitial fibrosis (RIF), with CD146 being upregulated on injured endothelial cells. However, the precise contribution of CD146⁺ endothelial cells to RIF remains unclear. This study aimed to observe and detect the relationship between CD146 expression and endothelial cells and to explore the role and possible mechanism of CD146 promoting endothelial-mesenchymal transition in RIF.

Preparation and evaluation of novel Agriophyllum squarrosum starch nanoparticles for encapsulation of lycopene with enhanced retention rate and bioactivity during simulated in-vitro digestion.

In this study, we developed novel Agriophyllum squarrosum starch nanoparticles (ASSNPs) for the encapsulation of lycopene (LYC), aiming to enhance its stability and bioactivity under adverse environmental and digestive conditions. The small-granule starch extracted from A. squarrosum seeds was processed using ionic liquids (ILs) as an effective "green" solvent, followed by a systematic treatment involving ultrasonication and pullulanase to prepare the ASSNPs.

The ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol is associated with diabetic kidney disease: A cross-sectional study.

Non-High-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol Ratio (NHHR) is a significant indicator of atherosclerosis. However, its association with diabetic kidney disease (DKD) remains unclear. This study aims to explore the relationship between NHHR and the prevalence of DKD among the U.

Causal correlations between inflammatory proteins and heart failure: A two-sample Mendelian randomization analysis.

Aims: Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation-related proteins and HF risk remains unclear. This study aims to investigate the genetically supported causality between inflammatory proteins and HF using a two-sample Mendelian randomization (MR) analysis.

Identification of oxidative stress-related hub genes for predicting prognosis in diffuse large B-cell lymphoma.

Background: Oxidative stress is a cellular characteristic that might induce the proliferation and differentiation of tumor cells and promote tumor progression in diffuse large B-cell lymphoma (DLBCL).

Methods: The DLBCL gene sequencing dataset, tumor mutation burden data, copy number variation data of Somatic cell mutation data in TCGA were downloaded for data training analysis, along with four DLBCL datasets in GEO for validation analysis. The known oxidative stress related genes (OSRGs) were collected from websites.

Neutrophil percentage-to-albumin ratio is associated with cognitive function in adults aged over 60 years: An analysis of data from the NHANES 2011-2014.

Background: The aging global population is increasing the attention to cognitive decline in older individuals.

Objective: This study sought to examine the potential link between the neutrophil percentage-to-albumin ratio (NPAR) and cognitive function.

Methods: We analyzed data from the National Health and Nutrition Examination Survey 2011-2014 using multivariate logistic regression and smooth curve fitting, to investigate the correlation between NPAR and cognitive performance.