Highly sensitive detection and mechanism study of tetracycline in water by CuFeO/NiCo-LDH heterojunction electrochemical sensor.

A CuFeO/NiCo-LDH heterojunction electrochemical sensor (LDH: layered double hydroxide) was developed for the sensitive detection of tetracycline (TC). The sensor was constructed by integrating ZIF-67-derived nanocage NiCo-LDH on nickel foam with CuFeO, forming a p-n heterojunction that enhanced electron transfer and TC adsorption. The sensor exhibited bilinear detection ranges (0.

Resistance to Silicosis Progression in Mice with Ch25h Downregulation: The Involvement of NLRP3 Inflammasome.

Silicosis is a fatal occupational lung disease characterized by persistent inflammation and irreversible fibrosis. However, the pathogenesis of silicosis is currently unclear. In this study, a mouse model of silicosis was established by intranasal instillation of silica, and transcriptomic alterations in lung tissues were assessed by mRNA-sequencing.

Biofortification of tomatoes with beta-carotene through targeted gene editing.

Vitamin A deficiency is one of the most severe micronutrient-related health issues worldwide. Tomatoes, a widely cultivated crop for their adaptability, nutritional value, and lycopene content (a beta-carotene precursor), are ideal candidates for biofortification. In this study, CRISPR-mediated knockout mutants (cr-SlLCYe and cr-SlBCH) were generated to enhance the precursor supply to the β-carotene biosynthetic pathway and reduce its degradation.

Diatom-inspired hierarchical carbon catalysts advance sustainable water decontamination via electron transfer-driven peroxide activation.

Catalysts for heterogeneous advanced oxidation processes (AOPs) in water remediation face environmental sustainability challenges, due to the intensive production of catalysts and limited stability of catalysts while maintaining high efficiency. Herein, we design a biomimetic carbon catalyst (BCC) inspired by the diatom frustule valve structure, achieving high environmental sustainability while maintaining superior water decontamination performance by a non-radical direct electron transfer (DET) pathway through activating peracetic acid (PAA). Utilizing a hydrogen-bonding strategy, BCC features pillared layered hierarchical pores with an ultrahigh specific surface area of 2710.

Effects of etomidate versus propofol for total intravenous anaesthesia on postoperative quality of recovery in patients undergoing day-case laparoscopic cholecystectomy: protocol for a multicentre, randomised controlled non-inferiority trial.

Background: The choice of anaesthetic agents may influence specific aspects of postoperative recovery, such as haemodynamic stability, recovery times and the incidence of adverse events, in patients undergoing day-case laparoscopic cholecystectomy. Propofol is widely used in total intravenous anaesthesia (TIVA) for its favourable recovery profile, while etomidate, valued for its haemodynamic stability, is less commonly used due to concerns about adrenal suppression. This study aims to compare etomidate-based and propofol-based TIVA on postoperative quality of recovery in patients undergoing day-case laparoscopic cholecystectomy, hypothesising that etomidate is non-inferior to propofol.

Promising application of microalgal-bacterial granular sludge for 17α-ethinylestradiol removal: Effective transformation and detoxification.

Microalgal-bacterial granular sludge (MBGS) efficiently removes conventional contaminants, but its potential for estrogen transformation and detoxification remains unclear, which is a concerning topic for biological wastewater treatment of endocrine-disrupting contaminants. This study comprehensively investigated the fate, transformation, and detoxification of 17α-ethinylestradiol (EE2) in MBGS. Results demonstrated that MBGS showed superior performance to standalone Chlorella vulgaris and aerobic granular sludge, achieving 80.

Recaticimab in adult heterozygous familial hypercholesterolemia (REMAIN-3): A multicentre, randomised, double-blind, placebo-controlled phase 3 study.

Aims: Heterozygous familial hypercholesterolemia (HeFH) is a genetic disorder, characterised by high plasma concentrations of low-density lipoprotein cholesterol (LDL-C) from birth. This study aimed to assess the efficacy and safety of recaticimab, a new humanised anti-PCSK9 antibody capable of reducing LDL-C levels in patients with poorly controlled HeFH.

Methods And Results: REMAIN-3 was a multicentre, randomised, double-blind, placebo-controlled phase 3 study done at 25 sites in China.

Finerenone in type 1 diabetes and chronic kidney disease: short-term efficacy and safety insights.

Purpose: To evaluate the short-term efficacy and safety of finerenone in patients with type 1 diabetes (T1D) and chronic kidney disease (CKD).

Methods: A retrospective cohort study was conducted on a relatively small sample of 23 patients diagnosed with T1D and CKD between January 2023 and August 2024. All patients received renin-angiotensin system inhibitors (RASi), with 12 patients additionally treated with finerenone.

Piezo knockdown reduces 5‑hydroxytryptamine release from enterochromaffin cells and exacerbates intestinal dyskinesia in mice with functional constipation.

Enterochromaffin (EC) cell dysfunction decreases 5‑hydroxytryptamine (5‑HT) secretion, contributing to functional constipation (FC). However, the underlying mechanisms remain unclear. Piezo ion channels mediate 5‑HT release from EC cells.

GSH-responsive magnetic imaging for monitoring of tumor chemodynamic therapy.

Chemodynamic therapy (CDT) is a promising treatment modality that utilizes highly toxic hydroxyl radicals (˙OH) to kill tumor cells . However, real-time monitoring of drug distribution and therapeutic response remains a challenge, hindering the optimization of personalized treatment regimens. Here, we developed a glutathione (GSH)-responsive nanoreactor (FA-Mn NR), with integrated magnetic resonance imaging (MRI) functionality for self-enhanced CDT.

Iminoboronate chemistry enables multifunctional and reprocessable polyphenol-derived vitrimers.

Polyphenol-derived vitrimers offer compelling prospects for sustainable materials owing to their intrinsic recyclability, reprocessability and biodegradability. However, practical development remains constrained by structure degradation under harsh reprocessing conditions and the need for sophisticated modifications of the bio-sourced precursors. Herein, we reported a strategy that integrates commercially available polyphenols and low-molecular-weight PDMS through adaptable iminoboronate chemistry, obviating the need for structural modifications.

Identifying subtypes of longitudinal motor symptom severity trajectories in early Parkinson's disease patients.

Background: Motor symptoms of Parkinson's disease (PD) patients affect their ability of daily activities. Identifying distinct trajectories of motor symptom progression in PD patients can facilitate long-term management.

Methods: A total of 155 PD patients were acquired from the Parkinson's Disease Progression Marker Initiative (PPMI).

Nonlinear Associations of Depression and Stigma With Subclinical Hikikomori in Cancer Survivors.

Background: Cancer survivors often experience depression and stigma associated with chronic diseases, which may increase the risk of subclinical hikikomori.

Aims: This study examined the prevalence of subclinical hikikomori and its nonlinear associations with depression and stigma among cancer patients.

Methods: A cross-sectional survey was conducted among 1951 cancer survivors.

Ultra-trace analysis of polycyclic aromatic hydrocarbons in heated tobacco products based on large volume thermal injection-column internal evaporation concentration.

Polycyclic aromatic hydrocarbons (PAHs), carcinogenic persistent organic compounds, require ultrasensitive detection for health risk assessment of tobacco products. While traditional cigarette smoke contains FDA-monitored PAHs (e.g.

The compound risk of decabromodiphenyl ethane and cadmium to soil nutrient cycling in agroecosystems: Linking the enzyme, microbial community, gene networks to plant stress.

Soil serves as the habitat for numerous organisms and is increasingly threatened from co-pollution of novel brominated flame retardant (NBFRs) and heavy metals (HMs). Focusing on Deca-bromodiphenyl ethane (DBDPE) and cadmium (Cd) as the targets, we constructed a soil-lettuce-earthworm microcosm to explore co-pollution effects in rhizosphere soils. Results showed that DBDPE increased bioavailable Cd fraction to amplified its ecological risks.

Food traceability analysis and quality marker monitoring in Ophiocordyceps sinensis with multimodal ensemble learning.

Ophiocordyceps sinensis (OS) faces serious risks of food fraud, including quality misrepresentation, adulteration and illegal additives. To preserve the economic interests of consumers and the transparent management of food trade, so this study proposed a rapid and non-destructive detection tool to identify traceability of the growth environment and predict quality markers of OS. Colors, textures and spectra were utilized to build unimodal models, respectively.

STAD-CoAtt: Integration of Evolving Gene Graphs in the Assessment of Neuropathological Stages Using Spatiotemporal Representations of Brain Transcriptomics Data.

For neurological disorders, single-nucleus RNA sequencing(snRNA-seq) data from human brain samples have revealed valuable insights about regulatory mechanisms that are associated with disease progression. During data mining of RNA-seq data that are associated with Alzheimer's disease(AD) and dementia, conventional deep learning methods generally focus on changes in gene transcript levels, while ignoring graph features of dementia-specific gene networks to a certain degree. It is noted that graph features underlying transcriptomics data have the potential to enhance model performance by analyzing structural information of AD-specific regulatory networks namely AD-GRN.

Correction: COMET (Composite Outcomes of Mesh vs suture Techniques for prolapse repair)- Protocol for a single blind randomized controlled multicenter trial testing surgical innovation in female pelvic surgery.

[This corrects the article DOI: 10.1371/journal.pone.

Endoscopic Anti-reflux Mucosal Interventions for Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis of Efficacy, Safety, and Comparative Outcomes.

Background: This meta-analysis evaluates efficacy and safety of anti-reflux mucosal interventions (ARMIs) for gastroesophageal reflux disease (GERD), and comparative effectiveness against traditional interventions.

Methods: A systematic search identified 37 studies (11 comparative and 26 single-arm studies) evaluating ARMIs. Outcomes included GERD symptom scores (GERD-Q, GERD-HRQL), DeMeester score, acid exposure time (AET), complete cessation of proton-pump inhibitor (PPI) therapy, and adverse events (AEs).

Disrupting mitochondrial dynamics attenuates ferroptosis and chemotoxicity via upregulating NRF2-mediated FSP1 expression.

Ferroptosis is a regulated necrosis driven by iron-dependent lipid peroxidation. Mitochondria play vital roles in ferroptosis. Mitochondrial dynamics is critical for the health of mitochondria and cells.

High Warming Restricts the Growth and Movement of a Larval Chinese Critically Endangered Relict Newt.

Amphibians are the most threatened vertebrates, yet their resilience in relation to growth and locomotor performance with rising temperatures remains poorly understood. Here, we chose a critically endangered amphibian-the Chinhai spiny newt ()-as the study species and set four water temperature gradients (20 °C, 24 °C, 28 °C, and 32 °C) to simulate climate changes. The thermal performance to climate warming was quantified by measuring morphometric parameters, basal metabolic rate (oxygen consumption rate), and the locomotor performance of Chinhai spiny newt larvae.

Integrating genomic and transcriptome features for characterization and prognostic prediction of angioimmunoblastic T-cell lymphoma.

In this study, we conducted integrated molecular analyses of the transcriptome and tumor genome in 24 newly diagnosed patients with angioimmunoblastic T-cell lymphoma (AITL). Gene expression profiling revealed significant enrichment of B cell receptor signaling and innate immune-related pathways in the response group. CIBERSORT-based deconvolution analysis showed that the proportions of tumor-infiltrating B cells and M1 macrophages were significantly higher in the response group compared to the non-response group (B cells: 17.

Self-Medicating Molten-Salt Synthesis of Bulk-Stabilized High-Energy Cathodes for Li-Ion Batteries.

High-energy lithium-ion batteries necessitate stable Ni-rich layered cathodes, yet critical challenges such as lattice distortion and surface structure collapse remain unresolved. While conventional high-valence doping greatly alleviates surface degradations, it is ineffective in stabilizing bulk lattice due to dopant segregation. Here, we propose a slightly Li-rich (SLR) lattice design by partially substituting transition-metal (TM) ions with Li ions in TM layers, reducing electrostatic repulsion against high-valence dopants.

Room-Temperature Ferroelectricity in Ultra-Thin p-Type BiCuSeO Films.

Atomically thin 2D layered ferroelectric semiconductors, where polarization switching transpires within the channel material itself, are pivotal to advancing the next generation of high-performance electronics. Nevertheless, the challenge remains in either the controllable synthesis of films or the manipulation of associated ferroelectricity. Here, 2D p-type BiCuSeO (BCSO) films with a thickness down to ≈3 nm are successfully synthesized using molecular beam epitaxy.

Programmable Chemoenzymatic Assembly of a Bisected and Core-Fucosylated N-Glycan Library Reveals Glycan-Binding Protein Specificity and Branch Preference.

Bisected and core-fucosylated N-glycans represent a distinct class of complex biomolecules that are implicated in diverse biological and pathological processes. The structural complexity and synthetic challenges of these glycans hinder comprehensive understanding of their biological functions due to limited access to well-defined samples. Despite advances in the complex N-glycan synthesis, the efficient preparation of bisected and core-fucosylated asymmetric N-glycans with various branches and terminal epitopes remains an unmet challenge.