Disrupting mitochondrial dynamics attenuates ferroptosis and chemotoxicity via upregulating NRF2-mediated FSP1 expression.

Ferroptosis is a regulated necrosis driven by iron-dependent lipid peroxidation. Mitochondria play vital roles in ferroptosis. Mitochondrial dynamics is critical for the health of mitochondria and cells.

SMARCB1 (INI1)-deficient sinonasal carcinoma with yolk sac differentiation, a case of long-term clinical remission after multiple rounds of radiotherapy-a case report and literature review.

Rationale: SMARCB1 (INI1) deficient sinonasal carcinoma is a subtype of Switch/Sucrose nonfermentable (SWI/SNF) complex deficient sinonasal carcinoma, which is distinct from sinonasal undifferentiated carcinoma (SNUC) in 5th edition of the WHO classification of head and neck tumors. It commonly shows basaloid, eosinophilic, oncocytoid or rhabdoid morphology. However, it can exhibit yolk sac like differentiation in very rare cases, with associated SALL4, GPC-3 and CDX2 and AFP expression, which can lead to the misdiagnosis of primary nasopharyngeal yolk sac tumor (YST).

Polysaccharides Alleviate Aflatoxin B1-Induced Liver Damage and Immune Disorders by Inhibiting the ROS-Mediated Mitochondrial Apoptosis Pathway.

polysaccharide (DSPS) is the main natural compound extracted from the traditional Chinese herb . Although DSPS is well-known for its antioxidant and anti-inflammatory properties, its impact on aflatoxin B1 (AFB1)-induced damage has not been explored. This study aims to investigate the potential protective mechanisms of DSPS against AFB1-induced liver damage and immune disorders.

Combining Observations and Models: A Review of the CARDAMOM Framework for Data-Constrained Terrestrial Ecosystem Modeling.

The rapid increase in the volume and variety of terrestrial biosphere observations (i.e., remote sensing data and in situ measurements) offers a unique opportunity to derive ecological insights, refine process-based models, and improve forecasting for decision support.

Unveiling the potential of in digestive diseases: a comprehensive review.

Background: () is a lactic acid-producing probiotic, possessing the potential to modulate intestinal microbiota balance, which can enhance immune function, and reduce the risk of intestinal infections. In recent years, increasing studies have demonstrated the positive impact of this strain and its metabolites on the health of multiple systems, including the stomach, intestine, liver, and brain.

Objective: This article aims to systematically review the mechanisms of action and clinical application progress of in the prevention and treatment of digestive system-related diseases.

LCCPs exposure induces pulmonary inflammatory injury via AIM2 mediated pulmonary macrophage PANoptosis and M1 polarization.

In recent years, with the wide application of long-chain chlorinated paraffins (LCCPs), long-chain chlorinated paraffins have been detected all over the world. High concentrations of LCCPs are being detected in the air of human living environments. As the main gas exchange organ of the human body, the lungs are responsible for transporting oxygen throughout the body, but there are no studies on the toxicological effects of LCCPs on the lungs.

Voriconazole-induced liver injury: incidence patterns and risk factors in a retrospective cohort.

Voriconazole, a first-line therapy for invasive aspergillosis, carries hepatotoxicity risks lacking comprehensive epidemiological characterization. Current evidence is limited by heterogeneity in diagnostic criteria (e.g.

Efficacy and safety of combined Baduanjin-auricular acupressure treatment for the postoperative rehabilitation of patients with non-small cell lung cancer: protocol for a randomized controlled trial.

Background: Active participation in postoperative pulmonary rehabilitation training is an indispensable part of the rehabilitation process for patients with lung cancer and is critical to improving the quality of life (QOL). Baduanjin or auricular acupuncture can significantly improve exercise tolerance, fatigue, and QOL in patients with lung cancer. Baduanjin promotes physical function and psychological well-being through gentle movement and breathing control, while auricular acupressure may further alleviate symptoms by modulating neuroendocrine pathways.

LCCPs causes cartilage damage and exacerbates osteoarthritis by inducing necroptosis of chondrocytes.

LCCPs, which emerged as alternatives to restricted short- and medium-chain CPs, raised concerns due to their bioaccumulation, biotoxicity, and environmental persistence. Despite their widespread detection in various environmental media, the toxicological effects of LCCPs, particularly on skeletal health, remain poorly understood. We used two chondrocyte models and an in vivo mouse model to investigate the effects of LCCPs on chondrocytes and cartilage tissue.

Catechin suppresses HNSC via STXBP1 dependent inhibition of macrophage infiltration and CD47 mediated immune evasion.

The treatment of head and neck squamous cell carcinoma (HNSC) faces significant challenges, primarily due to the lack of reliable biomarkers and effective therapeutic drugs. This study reveals the crucial mechanistic role of STXBP1 in the HNSC tumor microenvironment: STXBP1 promotes tumor immune escape through dual pathways, not only enhancing the infiltration of M2-type macrophages but also activating the 'don't eat me' signaling pathway through upregulation of CD47. Clinical data analysis demonstrates that STXBP1 expression levels significantly correlate with HNSC patient prognosis, suggesting its potential as a diagnostic marker and prognostic indicator.

Research on the correlation between gut microbiota and brain cognitive function under chronic hypoxia at high altitude.

Background: Long-term exposure to high-altitude hypoxia can lead to cognitive impairment, yet the role of the gut microbiota in this process remains unclear. This study investigated the contribution of gut microbiota to cognitive dysfunction induced by chronic hypoxia.

Methods: C57BL/6 J mice were assigned to four groups: control group (NC), control pseudo-germ-free group (CA), hypoxic group (HC), and hypoxic pseudo-germ-free group (HA).

A subset of evolutionarily conserved centriolar satellite core components is crucial for sperm flagellum biogenesis.

: Centriolar satellites are non-membranous cytoplasmic granules that cluster around centrosomes, with pericentriolar material 1 (PCM1) serving as the molecular marker for these structures. Although significant progress has been made in understanding their composition, cellular, and organismal functions over the past decades, the tissue-specific roles of centriolar satellite proteins in sperm flagellum biogenesis and male fertility are still not well understood. : We utilize publicly available data and conduct phylogenetic analysis to explore the tissue distribution and conservation of centriole satellite components across flagellated species.

Research progress of polysaccharide drug delivery systems in the treatment of intestinal diseases: A review.

Intestinal diseases (IDs), as a type of complex immune-related diseases, have long faced challenges such as low drug delivery efficiency, insufficient targeting, and significant systemic toxic and side effects in their treatment strategies. Although oral administration is widely adopted due to its noninvasiveness and high patient compliance, the heterogeneity of the gastrointestinal environment severely limits the precise release and effective accumulation of drugs in the colon. Therefore, developing a new type of drug carrier system that can overcome physiological barriers and achieve colonic targeted delivery has become one of the core research directions in the field of ID therapy.

Impact of postoperative depression and immune-inflammatory biomarkers on the prognosis of patients with esophageal cancer receiving minimally invasive esophagectomy: a retrospective cohort study based on a Chinese population.

Background: Patients with esophageal cancer (EC) frequently experience depression following neoadjuvant therapy and surgery, a condition that may trigger systemic inflammation, suppress antitumor immunity, and alter immune-inflammatory pathways in the tumor microenvironment (TME), potentially contributing to residual tumor progression and theoretically worsening patient prognosis. This study aimed to investigate the interrelationship between depression and prognosis in patients with EC, with a focus on immune-inflammatory biomarkers.

Methods: This single-center retrospective trial was conducted at the National Cancer Center/Cancer Hospital of the Chinese Academy of Medical Sciences.

Translation and psychometric evaluation of the Chinese version of The Prediction-Related Experiences Questionnaire (PRE-Q-C).

Objective: Prediction is a fundamental cognitive process that facilitates adaptive interactions with the environment. The Prediction-Related Experiences Questionnaire (PRE-Q), a 19-item measure, assesses individuals' everyday predictive abilities. This study aimed to develop and validate a Chinese version (PRE-Q-C) by translating and adapting the original scale and examining its psychometric properties in a large Chinese sample.

Functional screening of somatic mutant events in extranodal natural killer/T-cell lymphoma with adrenal involvement.

Background: Extranodal natural killer/T-cell lymphoma (ENKTL) involving the adrenal glands is extremely rare, and only a few cases have been reported. However, the genetic alterations, clinicopathological features and prognosis of these patients have not yet been fully elucidated.

Methods: Profiling of tumor mutations in ENKTL patients with adrenal involvement was conducted by whole-genome sequencing, and the predisposing genes and driver mutation gene variants were verified through Sanger sequencing.

Tumor microenvironment and immune-related myositis: addressing muscle wasting in cancer immunotherapy.

Cancer immunotherapy, which leverages the immune system to target neoplastic cells, has undergone significant transformation in recent. However, immunotherapy may have negative effects on skeletal muscle function, causing muscle wasting and functional decline in cancer patients. In this study, we review the mechanisms by which immunotherapy influences skeletal muscle, focusing on immune-related myositis, inflammation, and metabolic alterations within the tumor microenvironment (TME).

The aroma evolution in lotus (Nelumbo nucifera Gaertn.) seed juice: A comprehensive analysis of processing and low-temperature storage effects.

Lotus seed juice has significant potential in the plant-based beverage market owing to its distinctive flavor. However, its sensory quality is significantly influenced by processing and storage conditions. This study examined the effects and underlying mechanisms of fresh squeezing, sterilization, and refrigeration at 4 °C (for 1-6 months) on the aroma profile of lotus seed juice using an electronic nose, gas chromatography-ion mobility spectrometry (GC-IMS), and non-targeted metabolomics.

Intelligent Testing Method for Multi-Point Vibration Acquisition of Pile Foundation Based on Machine Learning.

To address the limitations of the conventional low-strain reflected wave method for pile foundation testing, this study proposes an intelligent multi-point vibration acquisition testing model based on machine learning to evaluate the integrity of in-service, high-cap pile foundations. The model's performance was assessed using statistical error metrics, including the correlation coefficient R, mean absolute error (MAE), and variance accounted for (VAF), with comparative evaluations conducted across different model frameworks. Results show that both the convolutional neural network (CNN) and the long short-term memory neural network (LSTM) consistently achieved high accuracy in identifying the location of the first reflection point in the pile shaft, with R values greater than 0.

Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology.

The intricate interaction between skeletal muscle biomechanics, the tumor microenvironment, and immunotherapy constitutes a pivotal research focus oncology. This work provides a comprehensive review of methodologies for evaluating skeletal muscle biomechanics, including handheld dynamometry, advanced imaging techniques, electrical impedance myography, elastography, and single-fiber experiments to assess muscle quality and performance. Furthermore, it elucidates the mechanisms, applications, and limitations of various immunotherapy modalities, including immune checkpoint inhibitors, adoptive cell therapy, cancer vaccines, and combined chemoimmunotherapy, while examining their effects on skeletal muscle function and systemic immune responses.

Membrane-associated ring-CH-type finger 2 protects against metabolic dysfunction-associated fatty liver disease by targeting fatty acid synthase.

Objective: Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as an important public health concern that poses a significant threat to human health and imposes a substantial economic burden. Research has demonstrated that ubiquitin ligase-mediated substrate protein ubiquitination is a pivotal factor influencing liver lipid homeostasis and metabolic abnormalities in MAFLD. Nevertheless, the specific enzyme molecules implicated in this regulatory process remain to be elucidated.

ameliorates indomethacin-induced enteropathy by promoting MUC2 secretion via suppressing the Notch pathway.

Nonsteroidal anti-inflammatory drug (NSAID) enteropathy is a serious clinical complication with no effective treatments available. Modulating the intestinal microbiota through dietary and nutritional targets is a promising strategy for preventing NSAID enteropathy. This study aimed to investigate the protective effect and underlying mechanisms of the probiotic (CB) on indomethacin (IND)-induced enteropathy.

Impact of hypoxia on the hippocampus: A review.

Oxygen is the most abundant chemical substance and is a basic material for human activities. A decline in oxygen concentration affects many physiological processes in the body, leading to pathological changes and even the occurrence of diseases. Therefore, an increasing number of studies have focused on the pathological state of hypoxia.

Insight into the binding mode of different lotus seed natural starch-phenolic acids complexes.

This study investigated the influence of natural lotus seed starch on the adsorption of seven endogenous phenolic acids present in lotus seeds. The research delineated the interaction mechanisms and subsequently analyzed the alterations in starch characteristics following adsorption. A comprehensive suite of analytical techniques, including adsorption isotherms, C NMR, DSC, LF-NMR, rheology, particle size, and potential analyses was employed.

Clinical characteristics, surgical approaches, and prognosis of follicular and papillary thyroid cancer in children and adolescents: a retrospective cohort study.

Purpose: Follicular and papillary thyroid cancers are prevalent endocrine tumors in children and adolescents. This study seeks to highlight distinctions between papillary thyroid cancer  (PTC) and follicular thyroid cancer  (FTC) to inform subtype-specific guidelines.

Patients And Methods: Utilizing data from the SEER database, this study contrasts the clinical features, survival rates, causes of death, TNM staging, and surgical interventions for pediatric and adolescent patients diagnosed with PTC and FTC from 2000 to 2020.