Correction: Leisure constraints and the negotiation of structural relationships: a case study of scuba diving enthusiasts.

[This corrects the article DOI: 10.3389/fspor.2025.

An LCN2-Dependent Positive-Feedback Loop Between Gastric Cancer Cells and Tumor-Associated-Macrophages Mediates Lymphangiogenesis and Lymphatic Metastasis.

Lymph node (LN) metastasis is a major determinant of poor prognosis in patients with gastric cancer (GC). Tumor-associated macrophages (TAMs) play a crucial role in promoting tumor metastasis and progression; however, the underlying mechanisms through which TAMs induce LN metastasis in GC remain poorly understood. This study demonstrates that low lipocalin-2 (LCN2) expression is associated with increased LN metastasis and shorter survival in GC.

Spatial and electronic features driving SGLT1/2 selectivity: a combined molecular dynamics and quantum mechanics study.

The rising global prevalence of diabetes underscores the need for highly selective sodium-glucose cotransporter (SGLT) inhibitors, which are essential for glucose regulation. While human Na-D-glucose cotransporter (hSGLT) inhibitors offer therapeutic potential, the high sequence similarity between SGLT1 and SGLT2 complicates selective inhibitor design. To elucidate the selective inhibition mechanisms of SGLT1/2, molecular dynamics (MD) simulations and quantum calculations were combined to explore SGLT1/2 inhibition mechanisms.

Unveiling the potential of in digestive diseases: a comprehensive review.

Background: () is a lactic acid-producing probiotic, possessing the potential to modulate intestinal microbiota balance, which can enhance immune function, and reduce the risk of intestinal infections. In recent years, increasing studies have demonstrated the positive impact of this strain and its metabolites on the health of multiple systems, including the stomach, intestine, liver, and brain.

Objective: This article aims to systematically review the mechanisms of action and clinical application progress of in the prevention and treatment of digestive system-related diseases.

Coupled transport and electrochemical characteristics in redox flow batteries.

With widespread public attention to long-duration energy storage technologies, redox flow batteries are attracting increasing interests of researchers due to their intrinsic safety and good design flexibility. Currently, high capital costs are constraining the widespread commercialization of this system, which calls for the further enhancement of the output performance in its power units. The power output in a redox flow battery is greatly influenced by macro-to-micro mass transport and electrochemical reactions, which are coupled with each other and together determine the performance of the battery.

AI-Based Ultrasound Nomogram for Differentiating Invasive from Non-Invasive Breast Cancer Masses.

This study aimed to develop a predictive nomogram integrating AI-based BI-RADS lexicons and lesion-to-nipple distance (LND) ultrasound features to differentiate mass-type ductal carcinoma in situ (DCIS) from invasive ductal carcinoma (IDC) visible on ultrasound. The final study cohort consisted of 170 women with 175 pathologically confirmed malignant breast lesions, including 26 cases of DCIS and 149 cases of IDC. LND and AI-based features from the S-Detect system (BI-RADS lexicons) were analyzed.

Augmented secretary bird optimization algorithm for wireless sensor network deployment and engineering problem.

This study develops an enhanced Secretary Bird Optimization Algorithm (ASBOA) based on the original Secretary Bird Optimization Algorithm (SBOA), aiming to further improve the solution accuracy and convergence speed for wireless sensor network (WSN) deployment and engineering optimization problems. Firstly, a differential collaborative search mechanism is introduced in the exploration phase to reduce the risk of the algorithm falling into local optima. Additionally, an optimal boundary control mechanism is employed to prevent ineffective exploration and enhance convergence speed.

Genome editing of phylogenetically distinct bacteria using portable retron-mediated recombineering.

Advanced genome editing technologies have enabled rapid and flexible rewriting of the genome, benefiting fundamental biology and biomanufacturing. Unfortunately, some of the most useful technologies to advance genome editing in have not yet been ported into other bacterial species. For instance, the addition of bacterial retrons to the genome editing toolbox has increased the efficiency of recombineering in by enabling sustained, abundant production of ssDNA recombineering donors by reverse transcription that install flexible, precise edits in the prokaryotic chromosome.

Leisure constraints and the negotiation of structural relationships: a case study of scuba diving enthusiasts.

Background And Aims: College students' social media addiction is linked to psychological anxiety. This study explores the relationship mechanisms, particularly the mediating roles of self-efficacy and coping styles.

Methods: Data were collected from 615 college students using questionnaires.

Proteogenomic characterization reveals that lipid droplet formation promotes esophageal squamous cell cancer progression.

Esophageal cancer is one of the most common cancers and a leading cause of cancer-related mortality in the world. Here, we have performed comprehensive characterization of genetic, transcriptomic, proteomic, and phosphoproteomic features in 293 patients with esophageal squamous cell carcinoma (ESCC). Chromosome 12q13.

Interpretable inverse iteration mean shift networks for clustering tasks.

Neural networks have become the standard approach for tasks such as computer vision, machine translation and pattern recognition. While they exhibit significant feature representation capabilities, they often lack interpretability. This suggests that it might be beneficial to explore interpretable machine learning approaches in order to inform the neural network architectures.

Assessment of suitable habitat of Semen Armeniacae Amarum. in China under different climatic conditions by Internal Transcribed Spacer 2 and Maxent model.

Semen Armeniacae Amarum is a Chinese medicine. The Chinese Pharmacopoeia stipulates that the dried ripe seeds of these four plants (Prunus armeniaca L. var.

Profiling of lincRNAs and differential regulatory mechanisms in response to nanoplastic toxicity at environmentally relevant concentrations in Caenorhabditis elegans.

Polystyrene nanoplastics (PS-NPs) at environmentally relevant concentrations have been shown to be toxic to living organisms, but the role of long noncoding RNAs (lncRNAs) in their toxicity regulation is not yet clear. Using Caenorhabditis elegans (C. elegans) as a model organism, we investigate the mechanisms and roles of lncRNAs in PS-NPs toxicity at environmentally relevant concentrations.

Fecal microbiota transplantation: application scenarios, efficacy prediction, and factors impacting donor-recipient interplay.

Fecal microbiota transplantation (FMT) represents a therapeutic approach that directly regulates the gut microbiota of recipients, normalizes its composition and reaping therapeutic rewards. Currently, in addition to its general application in treating () infection (CDI), FMT treatment has also been extended to the fields of other gastrointestinal diseases, infections, gut-liver or gut-brain axis disorders, metabolic diseases and cancer, etc. Prior to FMT, rigorous donor screening is essential to reduce the occurrence of adverse events.

ameliorates indomethacin-induced enteropathy by promoting MUC2 secretion via suppressing the Notch pathway.

Nonsteroidal anti-inflammatory drug (NSAID) enteropathy is a serious clinical complication with no effective treatments available. Modulating the intestinal microbiota through dietary and nutritional targets is a promising strategy for preventing NSAID enteropathy. This study aimed to investigate the protective effect and underlying mechanisms of the probiotic (CB) on indomethacin (IND)-induced enteropathy.

CONSTRUCTION OF CONFIDENCE REGIONS FOR UNCERTAIN SPATIAL DISPLACEMENTS WITH DUAL RODRIGUES PARAMETERS.

This paper follows our recent work on the computation of kinematic confidence regions from a given set of uncertain spatial displacements with specified confidence levels. Dual quaternion algebra is used to compute the mean displacement as well as relative displacements from the mean. In constructing a 6D confidence ellipsoid, however, we use dual Rodrigue parameters resulting from dual quaternions.

Comparative Study of AI Modes in Ultrasound Diagnosis of Breast Lesions.

This study evaluated the diagnostic performance of the S-Detect ultrasound system's three selectable AI modes-high-sensitivity (HSe), high-accuracy (HAc), and high-specificity (HSp)-for breast lesion diagnosis, comparing their performance in a clinical setting. This retrospective analysis evaluated 260 breast lesions from ultrasound images of 232 women (mean age: 50.2 years) using the S-Detect system.

N-methylguanosine tRNA modification promotes gastric cancer progression by activating SDHAF4-dependent mitochondrial oxidative phosphorylation.

N-methylguanosine (mG) tRNA modification is closely implicated in tumor occurrence and development. However, the precise function and molecular mechanisms of mG tRNA modification in gastric cancer (GC) remain unclear. In this study, we evaluated the expression and function of methyltransferase-like 1 (METTL1) and WD repeat domain 4 (WDR4) in GC and elucidated the mechanisms underlying the role of METTL1/WDR4-mediated mG tRNA modifications in promoting GC progression.

The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights.

The gut microbiota plays a pivotal role in human metabolic health by influencing immune responses, digestion, and metabolic homeostasis. Recent research highlights the intricate interactions between gut microbiota and RNA, especially non-coding RNAs, in regulating metabolic processes. Dysbiosis of the gut microbiota has been linked to metabolic disorders such as type 2 diabetes, obesity, metabolic-associated fatty liver disease (MAFLD) and metabolic heart disease.

Enhanced ZBTB10 expression induced by betulinic acid inhibits gastric cancer progression by inactivating the ARRDC3/ITGB4/PI3K/AKT pathway.

Background: Gastric cancer (GC) ranks as the fourth leading cause of cancer-related deaths worldwide, with most patients diagnosed at advanced stages due to the absence of reliable early detection biomarkers.

Methods: RNA-sequencing was conducted to identify the differentially expressed genes between GC tissues and adjacent normal tissues. CCK8, EdU, colony formation, transwell, flow cytometry and xenograft assays were adopted to explore the biological function of ZBTB10 and betulinic acid (BA) in GC progression.

Enhancing selectivity of β-O-4 bond cleavage for lignin depolymerization a sacrificial anode.

Herein, we report a novel electrochemical hydrogenolysis method for β-O-4 bond cleavage by using carbon foam as the cathode and waste aluminum as the anode. The reaction takes place at the cathode, producing ketones and phenolic compounds. Employing waste aluminum as the anode could avoid anodic excessive oxidation of phenols.

Association Between Resting Heart Rate and the Risk of Incident Hypertension Among Older Chinese Adults: A Prospective Cohort Study.

Examining the role of resting heart rate (RHR) in hypertension risk could improve our understanding of its pathogenesis. However, most relevant studies have been conducted in developed countries such as the United States and Brazil, with no evidence for the older Chinese population. Therefore, this study aimed to investigate the association between RHR and the risk of developing hypertension in an older Chinese population.

Superior flame retardancy, thermal insulation, and mechanical properties of konjac glucomannan/sodium alginate biomass aerogel modified by supramolecular assembled phytic acid-melamine nanosheet.

The development of biomass-based eco-friendly aerogel with superior flame retardancy, thermal insulation, and mechanical properties at the same time has long been a tough challenge. In this study, the polysaccharide-based aerogels composed of konjac glucomannan, sodium alginate, and supramolecular assembled melamine phytate (MPA) nanosheets were successfully fabricated through the freeze-drying method. Owing to the excellent charcoal-forming and non-combustible gas-releasing effect of MPA nanosheets, the thermal stability and flame retardancy properties of the aerogels were both significantly enhanced, with the highest limiting oxygen index value reaching 42.

High-efficiency expression of alginate lyase in Pichia pastoris facilitated by Vitreoscilla hemoglobin.

Vitreoscilla hemoglobin (VHb) can enhance the ability of recombinant strains to express heterologous proteins under low-oxygen conditions. However, its mechanism of action in the Pichia pastoris expression system remains unclear. In this study, three VHb construction strategies were designed to elucidate the mechanisms by which VHb promotes heterologous protein expression in P.

Microenvironment modulation of biocatalyst derived from natural cellulose of wheat straw for enhancing p-nitrophenol degradation via boosting peroxymonosulfate activation.

Defect-rich nitrogen-doped biocatalyst (B-NC) was synthesized from natural cellulose of wheat straw using straightforward mechanical method and one-step pyrolysis approach. In contrast to the nitrogen-doped biocatalyst (NC), by leveraging the synergistic effects of nitrogen dopants and surface defects, the microenvironment-modulated B-NC exhibited the enhanced mass transfer efficiency and a significant improvement in reactivity for p-nitrophenol degradation (111 %-196 %). The catalyst's exceptional performance primarily arose from graphitic N, pyridinic N and CO active sites, which mainly derived from the cellulose structure of wheat straw and nitrogen dopants.