A retrospective study on Mohs micrographic surgery combined with adjuvant radiotherapy in the treatment of extramammary Paget's disease: analysis of 87 patients.

Purpose: This retrospective study assessed the effectiveness of Mohs micrographic surgery (MMS) combined with adjuvant radiotherapy for the treatment of extramammary Paget's disease (EMPD).

Methods: This retrospective study included 87 patients with pathologically confirmed EMPD and complete follow-up data who were treated at the Radiation Therapy Department of Peking University First Hospital between January 2012 and December 2021. The surgical approach for the primary lesion involved MMS, followed by postoperative radiotherapy with doses ranging from 50 to 60 Gy administered over 25-30 fractions.

Ultrastrong circularly polarized electroluminescence achieved by chiral co-assembly of a liquid crystal-functionalized carbazole derivative.

Circularly polarized organic light-emitting diodes (CP-OLEDs) exhibiting circularly polarized electroluminescence (CP-EL) properties hold significant promise for future display technologies. However, enhancing the electroluminescence dissymmetry factor ( ) remains a substantial challenge. Herein, ultrastrong CP-EL emissions are achieved using a liquid crystal (LC)-functionalization strategy under the regulation of chiral co-assembly.

Adaptive divergence of three Aphis gossypii haplotypes on leguminous hosts.

Background: As a polyphagous agricultural pest of global significance, Aphis gossypii exhibits substantial population differentiation and inflicts damage across a broad host range, including economically important leguminous crops. This study aimed to clarify the adaptation of three A. gossypii haplotypes (Hap1, Hap3, Hap4) to four legume hosts: cowpea (Vigna unguiculata) varieties Zhongshouluchangfeng (ZLC) and Zhongshoucuichangfeng (ZCC), hyacinth bean (Lablab purpureus) and winged bean (Psophocarpus tetragonolobus).

CerebrAlcare Pills on CereBral Small VesseL DiseasE (CABLE) trial: rationale and design.

Rationale: Cerebral small vessel disease (CSVD) is responsible for 25% of ischaemic strokes and 45% of dementia cases. Currently, therapies targeting individual mechanisms have not shown significant efficacy. As CSVD involves multiple pathophysiological mechanisms, Cerebralcare pills, a traditional Chinese medicine with multiple pharmacological mechanisms, may be effective in treating cognitive dysfunction in CSVD.

Super-enhancers in immune system regulation: mechanisms, pathological reprogramming, and therapeutic opportunities.

Super-enhancers (SEs) are dynamic chromatin structures that function as epigenetic hubs, orchestrating cell-type-specific transcriptional programs crucial for immune cell differentiation, functional specialization, and adaptive responses. These enhancer clusters integrate transcription factor (TF) networks, chromatin-modifying signals, and three-dimensional genome organization to govern lineage commitment, effector function acquisition, and metabolic reprogramming while enabling plasticity in response to environmental cues. SEs exhibit spatiotemporal regulatory properties, such as chromatin looping, phase-separated condensate formation, and stimulus-driven enhancer-promoter rewiring, all of which stabilize transcriptional outputs vital for immune homeostasis.

Programmable Circularly Polarized Electroluminescence Through Stereocontrol of Chiral Liquid-Crystalline Co-Assemblies.

Circularly polarized organic light-emitting diodes (CP-OLEDs) are essential to prospective 3D displays and advanced polarized lighting systems. The rational design of programmable circularly polarized electroluminescence (CP-EL) materials with a large electroluminescence dissymmetry factor (g) remains a great challenge and is still in its preliminary exploration phase. In this work, two aggregation induced emission active (AIE-active) chiral inducers with different dihedral angles of binaphthalene (S-/R-1 and S-/R-2) and achiral acrylate-based liquid crystalline polymer (LCP) (PyP) were chosed to construct chiral co-assemblies through an intermolecular chirality induction mechanism.

Stable and highly sensitive self-powered X-ray detection high-density CsPbBr-type Dion-Jacobson trilayer hybrid perovskites.

Dion-Jacobson (DJ)-type organic-inorganic hybrid perovskites have emerged as promising candidates for X-ray detection owing to their exceptional stability and remarkable X-ray absorption ability. Nevertheless, achieving enhanced detection sensitivity continues to pose a significant challenge in this research domain. Herein, we have successfully synthesized and grown a DJ-type (4-AMP)CsPbBr (1, 4-AMP = 4-ammoniomethylpiperidinium) hybrid perovskite single crystal with a high density of 3.

Signal Detection Based on Separable CNN for OTFS Communication Systems.

This paper proposes a low-complexity signal detection method for orthogonal time frequency space (OTFS) communication systems, based on a separable convolutional neural network (SeCNN), termed SeCNN-OTFS. A novel SeparableBlock architecture is introduced, which integrates residual connections and a channel attention mechanism to enhance feature discrimination and training stability under high Doppler conditions. By decomposing standard convolutions into depthwise and pointwise operations, the model achieves a substantial reduction in computational complexity.

The Novel Disease Caused by in China: Implications for Host Growth, Photosynthesis, and Nutritional Quality.

, an important forage legume on China's Qinghai-Tibetan Plateau, exhibited dark-brown sunken lesions on their stems at the Qingyang Experimental Station of Lanzhou University. The fungus isolated from the diseased tissues was identified as via a multi-locus phylogeny (ITS-----). The pathogenicity was confirmed by Koch's postulates.

Electrochemical Intercalation Reaction of Sodium into the Layered Transition Metal Dichalcogenide ZrS─Influence of the Electrolyte Solvent.

While TiS has been extensively studied for its ability to intercalate alkali metals like Li or Na, the higher homologue ZrS was studied only sparsely. Furthermore, an influence of different coordinating and noncoordinating electrolyte solvents on cyclability as well as the structural changes of the host structures had been observed for different active materials. In this study, we therefore investigated the intercalation mechanism of Na ions into layered 1T-ZrS using electrolytes with solvents of different coordination strengths toward Na, namely sodium trifluoromethanesulfonimide in ethylene carbonate and diethyl carbonate (1:1, EC/DEC) and sodium triflate in bis(2-methoxyethyl) ether (diglyme).

Geographical association of heavy metal exposure and semen quality: A national multi-center study.

Background: Assessing the adverse effects of geographical heavy metal mixture exposure on human semen quality is challenging. Our study aims to quantify the impact of these heavy metals on semen quality under both individual and combined exposures.

Methods: We recruited 32,072 reproductive-age men from ten human sperm banks across 31 provinces in China during the period from 2019 to 2022.

The influence of mixed solvents on the morphology of ε-CL-20 crystal.

Context: CL-20 (especially the ε-crystal form) is a high-energy density explosive, but the preparation of centimeter-sized ε-CL-20 crystals is complex, which limits the study of its properties and mechanisms. Since crystal morphology can significantly affect the performance and sensitivity of energetic materials, this study combines MD simulation and experimental techniques to study and examine the differences in ε-CL-20 crystal habit as well as the interplay between the principal growing crystal planes of ε-CL-20 and the mixed solvent molecules. The findings reveal that according to the AE model, ε-CL-20 consists of (0 1 1), (1 1 0), (1 0 -1), (1 1 -1), (0 0 2), (0 2 1), and (1 0 1) seven independent surfaces under vacuum, and the (0 1 1) surface is the most important growth surface.

Childhood trauma and psychopathy in emerging adults: the mediating role of family cohesion.

Objectives: To identify the mediating role of family cohesion in the relationship between childhood trauma and psychopathy in Chinese emerging adults.

Methods: The cross-sectional study was conducted from November 2022 to February 2023 in China, and comprised individuals aged 18-25 years who had experienced childhood maltreatment, like abuse and neglect. Data was collected online through screening for experiences of childhood trauma, psychopathy and family cohesion.

Erianin Suppresses Pancreatic Cancer Progression by Inducing Cell Cycle Arrest and Ferroptosis.

Background: Pancreatic cancer is a highly aggressive malignancy with limited therapeutic options and poor prognosis. Erianin, a natural product, has shown anti-cancer properties in various malignancies, but its effects on pancreatic cancer and the underlying mechanisms remain poorly understood.

Aim: This study aimed to evaluate the anti-tumor effects of erianin on pancreatic cancer cells and to explore the regulatory mechanisms involved.

Diagnostic utility of combined coagulation and inflammatory biomarkers in sepsis stratification: A retrospective study.

Objective: The aim of this study is to evaluate the diagnostic utility of coagulation parameters-prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-Dimer (D-D), prothrombin time activity (PTA), and international normalized ratio (INR) -in combination with inflammatory markers, including procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 (IL-6), systemic inflammation index (SII), and lymphocyte-C-reactive protein ratio (LCR), for stratifying sepsis severity.

Methods: This retrospective study included 123 patients diagnosed with sepsis and confirmed by positive blood cultures between October 2020 and October 2024. A control group comprising 50 healthy individuals undergoing routine physical examinations was also included.

Identification of microRNAs from juvenile greater amberjack (Seriola dumerili) in response to marine heatwaves.

Marine heatwaves (MHWs) have become more frequent in recent years, and this has had a major effect on fisheries and marine ecosystems. MicroRNAs (miRNAs) are essential regulators of the thermal stress response. Here, we identified the miRNAs involved in the response to MHWs in Seriola dumerili.

A disproportionality analysis of FDA adverse event reporting system (FAERS) events for methimazole and propylthiouracil.

Background: Methimazole and propylthiouracil are the most common antithyroid drugs. We assessed the safety signals associated with methimazole and propylthiouracil by data mining the FDA pharmacovigilance database.

Methods: Data were retrieved from the FAERS database from the 1st quarter of 2004 through the 4th quarter of 2023.

Study on the influence and control of different processing methods on the quality characteristics of brown rice cake.

Background: To enhance the taste and flavor quality of brown rice cake, various processing methods are employed, including internal enzyme germination modification, extrusion, stabilization of rice bran, exogenous enzyme hydrolysis, and backfilling. This study aimed to compare the texture, volatile flavor substances, taste changes, and internal texture structure of brown rice cakes subjected to different modification treatments, thereby clarifying the impact of these treatments on the overall quality of the brown rice cake.

Results: Following extrusion and enzymatic hydrolysis, the characteristic viscosity and disintegration value of brown rice flour decreased, while the recovery value and gelatinization temperature increased significantly.

Development and characterization of the genotype F attenuated mumps candidate strains.

Background: Mumps is an acute infectious disease caused by the mumps virus (MuV), primarily affecting the parotid glands, though it can also lead to systemic infections, including the nervous system. In China, the predominant circulating MuV genotype is F, while the vaccine strain (S79 or WM84) belongs to genotype A, raising concerns about immunization effectiveness.

Methods: A genotype F MuV strain was isolated from throat swabs of six suspected mumps patients.

L-shaped association of the non-high-density lipoprotein to high-density lipoprotein ratio with low bone mass disorders.

Osteoporosis and osteopenia, collectively referred to as Low Bone Mass Disorders (LBMD), are characterized by decreased bone density and increased fracture risk. Studies have identified a potential link between cardiovascular disease and LBMD, and the role of lipid metabolism in this has attracted widespread attention. We analyzed participant information collected from multiple NHANES cycles using weighted multivariable logistic regression, subgroup analysis, restricted cubic splines (RCS) curve analysis, and causal mediation analysis.

Influence of pH and electric field on HgCl adsorption in clay-water systems and its environmental implications.

Mercury and its compounds, particularly mercury chloride (HgCl), are highly toxic and persistent environmental pollutants. Understanding the adsorption behavior of HgCl in clay-water systems is essential for developing effective mercury remediation strategies. This study investigates the effects of pH and background cations on the adsorption kinetics, adsorption energy, and dipole moment of HgCl in montmorillonite clay systems.

Effect of ammonium chloride on the salt-induced cohesive behavior of egg yolk liquid and its plasma with granules.

This study was conducted to investigate the effect of partial substitution of NaCl by NH₄Cl on the gelatinization process of salted egg yolks. In this study, the differences of NH₄Cl substitution on the gelatinization process of egg yolk liquid, plasma, and granular were systematically analyzed by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and chemical analysis. The results showed that ammonium chloride could significantly increase the oil yield of plasma gel, promote the construction of gel network structure and protein aggregation in the gelation process of egg yolk components, shorten the gelation time to a certain extent, and precipitate protein particles on the surface of the gel during the process.

Agricultural propiconazole residues promote triazole cross-resistance in through and efflux pump overexpression.

Fluconazole remains a cornerstone for consolidation therapy in cryptococcal meningitis. However, resistance poses a significant risk of treatment failure in sub-Saharan Africa, where fluconazole monotherapy is common. Beyond clinical use, triazole fungicides are suspected drivers of resistance pathways.

Mechanism of USP11 regulated SIRT3/ROS in drug resistance of acute myeloid leukemia.

Acute myeloid leukemia (AML) represents a highly heterogeneous group of hematological malignancies. This study aims to elucidate the protective role of USP11 in mediating drug resistance in AML. We observed elevated USP11 mRNA expression levels in AML patients.