Stable and highly sensitive self-powered X-ray detection high-density CsPbBr-type Dion-Jacobson trilayer hybrid perovskites.

Dion-Jacobson (DJ)-type organic-inorganic hybrid perovskites have emerged as promising candidates for X-ray detection owing to their exceptional stability and remarkable X-ray absorption ability. Nevertheless, achieving enhanced detection sensitivity continues to pose a significant challenge in this research domain. Herein, we have successfully synthesized and grown a DJ-type (4-AMP)CsPbBr (1, 4-AMP = 4-ammoniomethylpiperidinium) hybrid perovskite single crystal with a high density of 3.

Carbon-Caged-Yttria Catalysts for Stable Electrosynthesis of HO in Concentrated Acid.

The electrosynthesis of hydrogen peroxide (HO), with renewable electricity, air, and water as inputs, offers a sustainable alternative to the conventional anthraquinone process. Performing HO electrosynthesis in concentrated acid offers advantages in functionality and energy efficiency over alkaline media yet is currently limited by short longevity. Here, we first investigate the origins of performance loss of oxidized carbon, a proven catalyst for HO electrosynthesis, and observe its gradual reduction to pristine carbon during acidic electrolysis.

Optimization of emergency logistics for urban flooding with consideration of rainfall effects.

Urban flooding frequently causes significant damage to infrastructure and facilities, leading to critical supply shortages in affected regions. Ensuring rapid and efficient distribution of relief supplies remains a key challenge during disaster response operations. This study proposes a two-stage optimization framework for emergency logistics.

ESCO2 drives breast cancer proliferation and metastasis through PI3K/AKT/mTOR phosphorylation: A potential therapeutic target.

Breast cancer remains a major global health threat to women, underscoring the urgent need for novel therapeutic targets. While ESCO2, an essential cell cycle regulator, has been implicated in cancer progression, its precise role and molecular mechanisms in breast cancer remain poorly understood. In this study, we first demonstrated significant upregulation of ESCO2 in breast cancer through analysis of TCGA and GEO datasets, which was further validated in clinical specimens and cell lines, with its expression correlating with advanced T-stage, aggressive molecular subtypes and poor prognosis.

ESCO2 inhibition induces cell cycle arrest and apoptosis in breast cancer via the P53-CDK1 axis and the BAX/Bcl2/caspase signaling cascade.

Background: Breast cancer is a major threat to women's health, and dysregulation of the cell cycle is a critical driver of its progression. ESCO2, a potential key regulator of the cell cycle, is implicated in cancer development; however, its specific role and mechanisms in breast cancer remain poorly understood.

Methods: We analyzed differentially expressed genes between breast cancer and normal breast samples from GEO datasets to identify potential key regulators of the cell cycle pathway.

Humic Acid and Cellulose Nanocrystal-Based Antifreeze Nanocomposite Hydrogel Flexible Sensor.

Humic acid (HA), a natural organic compound rich in carboxyl, phenolic hydroxyl, and quinone groups, was incorporated into hydrogels to enhance mechanical strength, antifreeze performance, UV resistance, and adhesion. Cellulose nanocrystals (CNCs), extracted using phytic acid (PA), were co-introduced with HA into a polyvinyl alcohol (PVA)/β-glycerophosphate (β-GP) network. The abundant functional groups in HA provided additional cross-linking sites, forming a robust three-dimensional structure.

Dynamic changes of vaginal microbiota in healthy Chinese women from pre-pregnancy to the postpartum period.

Objective: To carry out longitudinal observation of the changes in vaginal microbiota from pre-pregnancy to the postpartum period.

Methods: The present study enrolled 80 healthy Chinese women of childbearing age, following them up from pre-pregnancy to the postpartum period. Vaginal secretions were obtained from each of the women to determine bacterial density, bacterial diversity, dominant bacteria, vaginal pH, and Nugent score, by conducting direct microscopy, microscopic examination of Gram-stained samples, and pH test.

Survival Impact of Postoperative Primary Area Radiotherapy on De Novo Metastatic Breast Cancer: A Retrospective Study.

IntroductionThe role of radiotherapy (RT) in de novo metastatic breast cancer (dnMBC) patients undergoing surgery remains controversial due to limited evidence. This study aimed to evaluate the impact of postoperative radiotherapy on survival outcomes in this population.Materials and methodsWe retrospectively analyzed 102 dnMBC patients who underwent surgery at a provincial cancer hospital.

Effects of Chinese Medicine on modulating interleukin-17-regulated macrophages in coronary heart disease.

Coronary atherosclerotic heart disease (CHD) is one of the leading causes of death from cardiovascular disease worldwide and has significant inflammatory features. Macrophages play an important role in atherosclerotic plaque formation and inflammation. IL-17, as a pro-inflammatory cytokine, further exacerbates the development of CHD by interacting with macrophages.

D-orbital Reconstruction Achieves Low Charge Overpotential in Li-oxygen Batteries.

Charge overpotential for oxygen evolution reaction is a crucial parameter for the energy conversion efficiency of lithium-oxygen (Li-O) batteries. So far, the realization of low charge overpotential via catalyst design is a grand challenge in this field, which usually exceeds 0.25 V.

Surface modification of cellulose by sequential metal-free photoinduced atom transfer radical polymerization and its application for aqueous Hg(II) removal.

Cellulose-based polymer brush-on-brush composite adsorbent is prepared under simple and mild conditions via a four-step two sequential organophotocatalyzed atom transfer radical polymerization for the efficient removal of Hg(II) from aqueous media. The defined structure of the cellulose-based composites was supported by the characterization results. Influences of solution pH, temperature and adsorbent dosage on the adsorption behavior of the adsorbent were determined by batch experiments.

A three-phase contact-breakage model for brittle spherical particles with conical nucleus formation.

A novel contact-breakage (CB) model is proposed to characterize the complete breakage process of brittle spherical particles, with particular emphasis on the critical role of conical nucleus formation. Unlike conventional elastic models, the CB model incorporates three distinct mechanical phases: local compaction, elastic deformation, and integral crushing. The model introduces a crushing modulus to quantify the relationship between compacted volume and contact force during local compaction, while adapting a strength criterion for brittle materials to determine integral crushing.

Dynamic ctDNA tracking stratifies relapse risk for triple negative breast cancer patients receiving neoadjuvant chemotherapy.

Early Triple negative breast cancer (eTNBC) is the subtype with the worst outcome. Circulating tumor DNA (ctDNA) is shown to predict the prognosis of breast cancer, but its utility in eTNBC remains unclear. 130 stage II-III female eTNBC patients receiving neoadjuvant chemotherapy (NAC) have been enrolled prospectively and subjected to ctDNA analysis.

Fluorinated poly(aryl ether)/polypropylene composite patch for prevention of abdominal adhesions after hernia repairs.

Hernia typically does not heal spontaneously. Large-pore patches, most notably polypropylene patches (PP patches), are the gold standard in hernia repair surgery. However, a single patch is insufficient for both anti-adhesion and tissue fusion, leading to complications such as organ adhesions.

Stable self-powered X-ray detection with a low detection limit using a green halide hybrid perovskite ferroelectric crystal.

Lead halide hybrid perovskite ferroelectrics show great potential in the field of self-powered X-ray detection due to their excellent X-ray absorption, high carrier mobility, large carrier lifetime, and interesting ferroelectricity. Nonetheless, the toxicity of lead raises concerns regarding safety for humans and the environment, which limits their practical applicability. Herein, we successfully realized stable self-powered X-ray detection with a low detection limit using a lead-free halide hybrid perovskite ferroelectric crystal, [Hmdap]BiBr (1, Hmdap = -methyl-1,3-diaminopropanium), driven by the switchable spontaneous polarization ( ).

Cavities-Induced Compressive Strain in Unique Nanotubes Boosts the C1 Pathway of Ethanol Oxidation Electrocatalysis.

Engineering structural defects is beneficial for electrocatalytic performances. Herein, a class of acid-etched PtNiRh nanotubes with abundant structural defects around cavities were constructed. Modulated electronic and coordination structures closely associated with structural defects boost the ethanol oxidation reaction (EOR) activity and selectivity.

BSA/PEI/GOD modified cellulose nanocrystals for construction of hydrogel-based flexible glucose sensors for sweat detection.

With the miniaturization, integration and intelligence of sweat electrochemical sensor technology, hydrogel flexible sensors have demonstrated immense potential in the field of real-time and non-invasive personal health monitoring. However, it remains a challenge to integrate excellent mechanical properties, self-healing properties, and electrochemical sensing capabilities into the preparation of hydrogel-based flexible sensors. The utilization of CBPG (cellulose nanocrystals (CNCs)@bovine serum albumin (BSA)@polyethyleneimine (PEI) glucose oxidase (GOD) nanomaterial) as both an enhancing phase and sensor probe within a hydrogel matrix, with poly(vinyl alcohol) (PVA) serving as the primary network constituent, has been proposed as a non-invasive technique for monitoring trace glucose levels in sweat.

Optimization of a two-stage emergency logistics system considering public psychological risk perception under earthquake disaster.

To enhance the level of emergency supplies deployment during earthquake disaster, this study focuses on emergency logistics in China. An integrated two-stage optimization framework is adopted to incorporate demand and time satisfaction indicators into the supply allocation and route optimization models, respectively. Firstly, historical data and seismic monitoring information are used to estimate the number of people affected and to forecast the need for emergency supplies; Secondly, the concept of psychological risk perception and the degree of urgency of requirements are introduced.

Antifreeze proteins and surface-modified cellulose nanocrystals for designing anti-freezing conductive hydrogel sensors.

Antifreeze proteins (AFPs) are a type of protein capable of inhibiting ice crystal growth, lowering the freezing point, and protecting organisms from cold-induced damage. In this study, cellulose nanocrystals (CNCs) are chemically modified to enhance the hydrogel's performance. The synergistic effect with AFPs further regulates its mechanical properties, antifreeze performance, and high sensing sensitivity.

Design of self-healing nanocomposite hydrogels and the application to the detection of human exercise and ascorbic acid in sweat.

Hydrogel sensors have broad application prospects in human motion monitoring and sweat composition detection. However, hydrogel-based sensors are faced with challenges such as low accuracy and poor mechanical properties of analytes detection. Based on mussel-inspired chemistry, we synthesized mesoporous silica@polydopamine-Au (MPS@PDA-Au) nanomaterials and designed a self-healing nanocomposite hydrogel to monitor human movement and ascorbic acid detection in sweat.

Multi-Axial Self-Driven X-Ray Detection by a Two-Dimensional Biaxial Hybrid Organic-Inorganic Perovskite Ferroelectric.

Metal halide perovskite ferroelectrics combining spontaneous polarization and excellent semiconducting properties is an ideal platform for enabling self-driven X-ray detection. However, achievements to date have been only based on uniaxiality, which increases the complexity of device fabrication. Multi-axial ferroelectric materials have multiple equivalent polarization directions, making them potentially amenable to multi-axial self-driven X-ray detection, but the report on these types of materials is still a huge blank.

Phytic Acid-Functional Cellulose Nanocrystals and Their Application in Self-Healing Nanocomposite Hydrogels.

Cellulose nanocrystals (CNCs) have garnered significant attention as a modifiable substrate because of their exceptional performances, including remarkable degradability, high tensile strength, high elastic modulus, and biocompatibility. In this article, the successful adsorption of phytic acid (PA) onto the surface of cellulose nanocrystals @polydopamine (CNC@PDA) was achieved. Taking inspiration from mussels, a dopamine self-polymerization reaction was employed to coat the surface of CNCs with PDA.