[Clinical research of Zhuangdan Yanshi Decoction combined with dapoxetine hydrochloride in the treatment of premature ejaculation with cholestasis and phlegm disturbance syndrome].

Objective: To investigate the clinical efficacy of Zhuangdan Yanshi Decoction combined with dapoxetine hydrochloride in the treatment of premature ejaculation with cholestasis and phlegm disturbance.

Methods: A total of 120 patients diagnosed with premature ejaculation and treated in the Andrology Outpatient Department of Shaanxi Provincial Hospital of Traditional Chinese Medicine from March to December in 2022 were selected and randomly divided into treatment group and control group, with 60 cases in each group. The incubation period of intravaginal ejaculation (IELT), the Diagnostic Scale of Premature Ejaculation (PEDT), the Premature Ejaculation Assessment Scale (PEP), the 5-item Sexual Function Evaluation of Chinese Premature Ejaculation Patients (CIPE-5) and the improvement of traditional Chinese medicine symptom scores were compared before and after the treatment.

A novel RHD*01N allele harboring a c.634+1G>A splice site variant results in the RhD-negative phenotype in a Chinese blood donor.

Background: The D-negative phenotype demonstrates significant ethnic diversity in its molecular background. This study reports the identification of a novel RHD*01 N allele resulting from a splicing site variation observed in a Chinese blood donor.

Study Design And Methods: The D blood group phenotype was determined using serological techniques, including the saline method, and the indirect antiglobulin test (IAT) performed by both tube and microcolumn gel methods.

Case Report: Diagnosis of splenic marginal zone lymphoma by ultrasound and contrast- enhanced ultrasound.

Early diagnosis of splenic marginal zone lymphoma (SMZL) is difficult because of its insidious symptoms and slow progression. Combining conventional ultrasound with contrast-enhanced ultrasound can enable to differentiate between benign and malignant splenic lesions, which could guide further clinical examination and eventually improve the diagnostic rate of SMZL.

First-line benmelstobart plus anlotinib versus sunitinib in advanced renal cell carcinoma (ETER100): a multicentre, randomised, open-label, phase 3 trial.

Background: The underexplored potential of PD-L1 blockade in advanced renal cell carcinoma highlights an urgent need for novel agents. This trial aimed to compare benmelstobart (a novel PD-L1 inhibitor) plus anlotinib with sunitinib as first-line treatment for advanced renal cell carcinoma.

Methods: ETER100 was a multicentre, randomised, open-label, phase 3 trial conducted at 37 medical sites in China.

Effect of short-term exposure to fine particulate matter components on respiratory mortality - evidence from a study of inland cities in China.

There is a lack of research on the association between fine particulate matter (PM) fractions and respiratory disease mortality. Therefore, this study aims to investigate how short-term exposure to fine particulate matter components affects the mortality risk of patients with respiratory diseases.We collected data on the number of respiratory deaths and fine particulate matter components, including sulfate (SO), nitrate (NO), ammonium (NH), organic matters (OM), and black carbon (BC), in Hefei, Anhui Province, between 2017 and 2020.

Association between air pollution and risk of non-alcoholic fatty liver disease: an updated meta-analysis.

Objective: Air pollution is a major environmental risk to human health, with increasing evidence linking it to non-alcoholic fatty liver disease (NAFLD). However, findings remain inconsistent. This meta-analysis aimed to assess the relationship between air pollutants and the risk of NAFLD.

Pay more attention to the robustness of LLMs on adversarial prompt for instruction data mining.

Instruction tuning has emerged as a paramount method for tailoring the behaviors of LLMs. Recent studies have unveiled the potential for LLMs to achieve high performance through fine-tuning with a limited quantity of high-quality instruction data. Instruction-Following Difficulty is one of the most representative approaches in instruction data mining, which involves selecting samples where LLMs fail to generate response that align with the provided instructions as the high-quality instruction data.

[Clinical efficacy of demineralized dentin matrix particles in immediate implantation for bone defects in posterior region: a 1 to 5-year follow-up study].

Objectives: This study aims to evaluate the short- to medium-term clinical efficacy of demineralized dentin matrix (DDM) particles applied during the immediate implantation of alveolar bone defects in the posterior region.

Methods: A total of 76 patients with 110 simple taper retentive implants were included in the conducted study and divided into Groups A and B in accordance with the bone grafting materials. Cone beam computed tomography and panoramic radiographs were taken immediately after implant surgery, immediate crown repair, and final follow-up time.

Robotic retrohepatic inferior vena cava thrombectomy using the caudate lobectomy technique: indications and initial outcomes.

Background: Liver mobilization is essential for exposing the retrohepatic inferior vena cava (IVC) during level II-III robot-assisted IVC thrombectomy (RA-IVCT), but complex cases present significant challenges with a high risk of severe complications. This study aimed to evaluate the safety and feasibility of caudate lobectomy in facilitating retrohepatic IVC exposure in these complex cases.

Methods: Sixteen patients with complex level II-III IVC tumor thrombus (IVC-TT) underwent RA-IVCT with caudate lobectomy in our institution from January 2021 to November 2023.

Integrating experiential learning theory with innovation and entrepreneurship education: a qualitative study on Chinese medical students.

Background: Traditional medical education models emphasizing didactic knowledge transmission inadequately prepare healthcare professionals for complex challenges in modern medicine. Innovation and Entrepreneurship Education (IEE) offers opportunities for fostering innovative thinking, yet limited research systematically examines how medical students experience entrepreneurial learning processes. Accordingly, this study applies Experiential Learning Theory (ELT) to examine how medical students engage with IEE and develop entrepreneurial competencies within healthcare contexts.

MALAT1 elevates the secretion of Th2 cytokines via miR-422a/NUP155 axis in allergic rhinitis mice.

MALAT1 is one of the most well-studied lncRNAs in various diseases. This work attempted to investigate whether long non-coding RNA MALAT1 participate in the development of allergic rhinitis (AR). In this work, nasal mucosal tissues were obtained from AR patients.

Data-Driven Additive Discovery with HOMO-Descriptor Enables Durable Aqueous Zinc Batteries via Interfacial Kinetics Engineering.

Dendritic growth and parasitic reactions severely hinder aqueous Zn-ion batteries due to interfacial instability and uncontrolled charge transfer. Here, a machine learning-accelerated strategy for rational additive screening, establishing a predictive framework that links the highest occupied molecular orbital (HOMO) energy level to the adsorption and reduction behavior of Zn, is reported. An interpretable machine learning model (Adaptive Boosting), trained on a curated molecular dataset, achieves high accuracy (Mean Squared Error = 0.

Multi-Omics Reveals Aberrant Phenotypes of Respiratory Microbiome and Phospholipidomics Associated with Asthma-Related Inflammation.

Respiratory microbiota and lipids are closely associated with airway inflammation. This study aimed to analyze the correlations among the respiratory microbiome, the airway glycerophospholipid-sphingolipid profiles, and airway inflammation in patients with asthma. We conducted a cross-sectional study involving 61 patients with asthma and 17 healthy controls.

Host-Dependent Variation in Fitness and Microbiota Composition Across Strawberry Cultivars.

, commonly known as the two-spotted spider mite, is a highly adaptable and polyphagous arthropod in the family Tetranychidae, capable of feeding on over 1200 plant species, including strawberries ( Duch.). The fitness and microbiota of herbivorous arthropods can vary significantly across different plant species and cultivars.

Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling.

Background: Melanoma, a highly aggressive and immunogenic skin cancer, often develops resistance to immunotherapy due to the immunosuppressive tumor microenvironment (TME). Although PD-1/PD-L1 inhibitors have significantly improved treatment outcomes, 30%-40% of patients exhibit no response or develop resistance. Mechanisms such as T-cell exhaustion within the TME limit therapeutic efficacy, necessitating the exploration of novel strategies to enhance immune responses.

Energy-band engineering and deep-ultraviolet photodetection of GaOalloys: a concise review.

Gallium oxide (GaO)-based solar-blind ultraviolet photodetectors gained much attention for their promising prospects in new-generation solid-state optoelectronics and electronics. Catering for the demands of broadband photodetection, tunable energy-band, adjusted carrier concentration and effective carrier transition, alloying engineering through doping is gradually launched as one of the research emphases. This review is proposed to understand the photodetection performances in view of energy-band engineering.

Automated assessment of upper limb spasticity in stroke patients with fusion of multichannel surface electromyography features.

Objective: The objective of this study was to investigate a more accurate and efficient technique for assessing spasticity in stroke patients via surface electromyography (sEMG).

Methods: 45 hemiplegic individuals were recruited and spasticity was assessed via the modified Ashworth scale (MAS). Multichannel sEMG data were collected from 3 muscles: the long head of the biceps brachii (LB), the short head of the biceps brachii (SB), and the brachioradialis (BR).

N2 neutrophils induce cell stemness reprogramming to promote gastric cancer progression via exosomal miRNAs.

Exosomes mediate cellular communications and have a profound impact on cancer progression. N2 neutrophils, which are polarized by factors from cancers, extensively infiltrate into tumor tissues and promote cancer progression via distinct mechanisms. However, the role and underlying mechanism of exosomes derived from N2 neutrophils (N2-EXO) in cancer remain to be investigated.

Resveratrol: Great potential for alleviating di-2-ethylhexyl phthalate (DEHP)-induced testicular ferroptosis via the SIRT1-HIF-1α axis.

Background/objectives: Di-2-ethylhexyl phthalate (DEHP) is a universally used plasticizer and EDCs. Our previous studies verified that prolonged contact with DEHP induced detrimental impacts on reproductive physiology. Resveratrol (RES), a polyphenolic compound predominantly concentrated in Vitis vinifera epidermis, exhibits multifaceted pharmacological properties.

Omics Integration Reveals Hormonal Adjustments in Irrigated and Nonirrigated Rice Varieties Upon Mythimna separata Feeding.

Freshwater consumption is the biggest challenge in irrigated rice cultivation (Oryza sativa L.). Nonirrigated farmland rice cultivation is a strategy to mitigate the water resource shortage associated with traditional irrigated rice farming.

Interstadial diversity of East Asian summer monsoon linked to changes of the Northern Westerlies.

During the last glacial period, the iconic Greenland ice-core records provide evidence of interstadial warmings with various durations ranging from a century to millennia. However, whether differences in interstadial duration are mirrored by distinct hydroclimate responses in the tropics remains unclear. Here we present four speleothem δO records from the Indian summer monsoon (ISM) and East Asian summer monsoon (EASM) regions, spanning both short and long interstadials during the last glacial period.

Clinical efficacy and safety of bipolar water as a therapeutic approach for oral candidiasis: a randomized controlled trial.

Objectives: Oral candidiasis (OC) is a fungal infection caused primarily by Candida albicans. Treatments are associated with side-effects and toxicity. Bipolar water (BW), a novel functional water with antimicrobial, biofilm-disrupting, and wound-healing properties, offers a promising alternative therapy.

Secreted clusterin inhibits keloid formation by promoting fibroblast apoptosis.

Keloids are benign dermal proliferations resulting from excessive fibroblast activity that extends beyond the original site of injury. This study aims to investigate key biomarker genes associated with cell apoptosis and proliferation in the pathogenesis of keloids. Bioinformatic analysis of Gene Expression Omnibus datasets identified 122 differentially expressed genes (DEGs) in samples from keloid patients.