The Semisynthesis of 27-Deoxywithaferin A and 4--5,6-Deoxywithaferin A from Withaferin A as Potential Antitumor Agents.

We describe two concise, three-step routes for the individual synthesis of 27-deoxywithaferin A () and 4--5,6-deoxywithaferin A () from withaferin A (). The protection strategy for the double bond of enone with thiophenol and the conjugate reduction of the epoxy group are important in generating these products, with an overall yield of 40%. The absolute configuration of 4--5,6-deoxywithaferin A () has been confirmed by X-ray crystallography.

Host-Dependent Variation in Fitness and Microbiota Composition Across Strawberry Cultivars.

, commonly known as the two-spotted spider mite, is a highly adaptable and polyphagous arthropod in the family Tetranychidae, capable of feeding on over 1200 plant species, including strawberries ( Duch.). The fitness and microbiota of herbivorous arthropods can vary significantly across different plant species and cultivars.

Cysteine-Mediated Root Growth Promotion in Strawberry () Induced by -Overexpressing .

Strawberry () is a globally important economic crop valued for its nutritional and commercial significance. However, its growth is frequently challenged by various biotic and abiotic stresses. To enhance strawberry root development and resilience, we engineered a NJAU4742 strain to overexpress the gene, which encodes a plant cell-wall-loosening protein known to facilitate fungal penetration and colonization.

The high-quality telomere-to-telomere genome assembly of the earthworm (Amynthas aspergillum).

Earthworms have been extensively studied as ancient soil invertebrates, that are highly diverse. Previous studies of these invertebrates have mainly focused on their ecosystem services, medicinal value, and ecological habits. However, their genomic analysis remains inadequate.

Endophytic fungal community composition and function response to strawberry genotype and disease resistance.

Background: Utilizating the plant endophytic microbiomes to enhance pathogen resistance in crop production is an emerging alternative method to chemical pesticides. However, research on the composition and role of microbial communities related to perennial fruit plants, such as the strawberry, is still limited.

Methods: We provide a comprehensive description of the composition and diversity of fungal communities in three niches (root, stem, and leaf) of three strawberry cultivars ('White Elves', 'Tokun', and 'Akihime') using internal transcribed spacer (ITS) rRNA amplicon sequencing and isolation culture methods.

Diversity and Function of Strawberry Endophytic Bacterial Communities Associated with Host Genotype and Niche.

Strawberry (Fragaria × ananassa) is the most widely cultivated small berries in the world. They are not only delicious, juicy, and nutritious, but also have important economic value. However, current research on endophytic bacteria related to strawberry is limited.

Optimization of Shut-In Time for Hydraulic Fracturing-Assisted Oil Displacement in Offshore Low-Permeability Reservoirs.

To optimize the shut-in time for hydraulic fracturing assisted oil displacement in offshore low-permeability reservoirs, a coupled mathematical model encompassing injection, shut-in well, and production is established. The accuracy of the model is validated using production data. The law of pressure diffusion and oil-water two-phase flow during the shut-in well process is clarified, and the mechanism of hydraulic fracturing assisted oil displacement to enhance oil recovery is summarized.

Facile preparation of metal organic framework modified covalent organic framework for efficient dispersive solid-phase extraction of toxic basic dyes in food.

High performance adsorbents are crucial for improving the efficiency of sample pretreatment and ensuring the accuracy and precision of analytical results. In this study, covalent organic framework COF-SCU1 was modified with metal-organic framework ZIF-8 for efficient extraction of toxic basic dyes in food. The prepared COF-SCU1@ZIF-8 exhibited improved dispersibility and more surface negative charges compared to COF-SCU1, thereby showing enhanced adsorption performance for auramine O, rhodamine B, basic orange 21, basic orange 22 and methylene blue.

Dual Modulator of FXR and HSD17B13: Revitalizing FXR Therapies in MASH.

Dual modulation of FXR and HSD17B13 presents a promising strategy for treating metabolic dysfunction-associated fatty liver disease (MAFLD) and metabolic dysfunction-associated steatohepatitis (MASH). Compound , a groundbreaking dual modulator of FXR and HSD17B13, validates the concept of significantly enhancing liver function, reducing inflammation and fibrosis across various MAFLD models.

Rational design of dual-agonist peptides targeting GLP-1 and NPY2 receptors for regulating glucose homeostasis and body weight with minimal nausea and emesis.

There is an urgent need for effective treatments targeting comorbidities of type 2 diabetes (T2DM) and obesity. Developing dual agonists of glucagon-like peptide 1 receptor (GLP-1R) and neuropeptide Y receptor type 2 (NPY2R) with combined PYY and GLP-1 bioactivity is promising. However, designing such dual agonists that effectively control glycemia and reduce weight while minimizing gastrointestinal side effects is challenging.