Case Report: Diagnosis of splenic marginal zone lymphoma by ultrasound and contrast- enhanced ultrasound.

Early diagnosis of splenic marginal zone lymphoma (SMZL) is difficult because of its insidious symptoms and slow progression. Combining conventional ultrasound with contrast-enhanced ultrasound can enable to differentiate between benign and malignant splenic lesions, which could guide further clinical examination and eventually improve the diagnostic rate of SMZL.

Relationship between serum ferritin and the risk of all-cause death in patients with coronary artery disease.

Objective: Ferritin is independently associated with oxidized Low-Density Lipoprotein (LDL). While high LDL levels are known independent risk factors for cardiovascular diseases, few studies have investigated the relationship between serum ferritin levels and long-term outcomes in CAD patients.

Methods: A prospective cohort study of CAD participants was performed in Xinjiang Medical University Affiliated First Hospital from December 2016 to October 2021.

The effect of resistance training for older adults with cognitive frailty: a randomized controlled trial.

Background: Cognitive decline and the progression to dementia are hastened in individuals with cognitive frailty. Exercise interventions benefit cognitive function in patients with Mild Cognitive Impairment (MCI) or frailty. While the optimal implementation of resistance training for cognitive frailty is still being explored.

Integrated Photoelectrochemical-Fluorescence Dual-Mode Aptasensor for Sensitive Detection of Fumonisin B1.

Long-term intake of fumonisin B1 (FB1) can pose a threat to human health. It is essential to develop an accurate and sensitive method to detect FB1. In this work, a photoelectrochemical-fluorescence (PEC-FL) dual-mode aptamer sensing platform was proposed for FB1 analysis.

Oxidation-Active Radical TTM-DMODPA for Catalysis-Free Hydrogen Peroxide Colorimetric Sensing.

As a crucial reactive oxygen species, hydrogen peroxide (HO) serves as both a physiological regulator and a pathological indicator in human systems. Its urinary concentration has emerged as a valuable biomarker for assessing metabolic disorders and renal function. While conventional colorimetric determination methods predominantly employ enzymatic or nanozyme catalysts, we present an innovative non-catalytic approach utilizing the redox-responsive properties of organic neutral radicals.

Cross-Cultural Adaptation and Psychometric Validation of the Body Perception Questionnaire-Short Form (BPQ-SF) Among Chinese Patients With Coronary Heart Disease.

Objective: To revise the Brief Body Perception Questionnaire (BPQ-SF) for applicability in patients with coronary heart disease (CHD), and to examine its reliability and psychometric characteristics.

Methods: In Sample 1 (n = 371), items from the two subscales of the BPQ-SF were revised using expert consultation and item analysis, followed by exploratory factor analysis (EFA). Sample 2 (n = 350) was used for confirmatory factor analysis (CFA) and for evaluating structural validity, internal consistency, test-retest reliability, and criterion-related validity.

SHR-2005, an FcγR-Dependent CD40 Agonistic Antibody with Potent Antitumor Activities and Favorable Safety Profile.

Activation of CD40, a pivotal component of immune oncology, could facilitate the infiltration of immune cells into the tumor microenvironment. In this investigation, we characterized SHR-2005, a second-generation CD40 agonistic mAb, as a potential candidate for cancer immune therapy. Our results showed that SHR-2005 possessed high affinity in binding to both human and rhesus CD40 and could effectively compete with CD40L for CD40 binding.

Association between GLP-1 receptor agonists as a class and colorectal cancer risk: a meta-analysis of retrospective cohort studies.

Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are extensively used in the management of type 2 diabetes mellitus (T2DM) and obesity. While these medications offer glycemic control and cardiovascular benefits, the risks have increased because of their potential impact on cancer risk, particularly colorectal cancer (CRC). This meta-analysis aimed to evaluate the association between GLP-1 RAs and CRC risk in patients receiving GLP-1 RAs.

Patients' knowledge, attitude, and practice toward stroke rehabilitation: a web-based cross-sectional study.

Objective: The objective of this research was to comprehensively assess how well patients understand stroke rehabilitation, their perceptions of it, and their inclination to participate.

Methods: This web-based cross-sectional study was conducted between February and June 2023 at the Second Hospital of Lanzhou University, using a self-administered questionnaire.

Results: A total of 497 valid questionnaires were enrolled, including 342 (68.

Efficacy and Safety of HSK31679 in Asian Patients with MASLD: A Randomized Controlled Trial.

Background And Aims: This study evaluated the efficacy and safety of the thyroid hormone receptor β agonist HSK31679 in Asian patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods: This was a phase 2a, multicenter, randomized, double-blind, placebo-controlled study at 26 centers in China. Subjects with a liver fat content (LFC) of ≥ 8% at screening, when assessed by magnetic resonance imaging-proton density fat fraction, were eligible.

An era of hyper-resolution land surface models: truth or dare?

Hyper-resolution land surface models (hLSMs) simulate land processes at kilometer and even 100-meter scales by integrating biogeophysical, biogeochemical, and human dynamics, enhancing realism. However, substantially improving their accuracy necessitates parallel progress in parameterizations, data, computational capabilities, and model evaluation.

The genetic diversity and populational specificity of the human gut virome at single-nucleotide resolution.

Background: Large-scale characterization of gut viral genomes provides strain-resolved insights into host-microbe interactions. However, existing viral genomes are mainly derived from Western populations, limiting our understanding of global gut viral diversity and functional variations necessary for personalized medicine and addressing regional health disparities.

Results: Here, we introduce the Chinese Gut Viral Reference (CGVR) set, consisting of 120,568 viral genomes from 3234 deeply sequenced fecal samples collected nationwide, covering 72,751 viral operational taxonomic units (vOTUs), nearly 90% of which are likely absent from current databases.

Predictive Accuracy of Magnetocardiography for Diagnosing Myocardial Ischemia in NSTE-ACS Patients With Residual Post-PCI Angina.

Background: Post-percutaneous coronary intervention (PCI) angina affects 20% to 40% of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) survivors but remains a clinical challenge due to its unpredictable course.

Objectives: This study aimed to validate a rapid 90-second optically pumped magnetometer magnetocardiography (OPM-MCG) test for diagnosing post-PCI angina and develop a predictive model using dynamic MCG parameters.

Methods: NSTE-ACS patients who underwent pre- and post-PCI OPM-MCG scans were included.

Butyrate enhances gut dysbiosis by activating the cAMP/PKA/CREB signaling pathway to inhibit the progression of endometrial carcinoma.

Background: Gut microbiota may contribute to the progression and prognosis of extra-intestinal tumors. The relationship and mechanism between endometrial carcinoma (EC), the gut microbiota, and short-chain fatty acids (SCFAs) remain ambiguous. This study aimed to ascertain whether alterations in gut microbiota and SCFAs are associated with EC.

Selective enhancement of fish gelatin emulsification via structural compatibility with sodium alginate: A comparative study with SPI and WPI.

This study systematically investigated the structure-dependent interactions between sodium alginate (SA) and three distinct proteins-fish gelatin (FG), soybean protein isolate (SPI), and whey protein isolate (WPI)-to elucidate their differential emulsification enhancement mechanisms. Mechanistic studies showed that FG exhibited unique structural compatibility with SA, driven by strong electrostatic interactions (ΔH = -6.59 kJ/mol, ΔS = 5.

Atrophy Masseter Recovery by Electrical Stimulation Mediated M2-Like Macrophage Polarisation via JAK/PI3K/AKT Pathway.

Background: Atrophy of the masseter muscle can result in an aged facial appearance and diminished chewing function. Electrical stimulation (ES) is known for its ability to facilitate tissue healing and functional recovery, but its precise role in the repair of atrophic masseter muscles remains incompletely understood.

Methods: We induced masseter muscle atrophy in rats through botulinum toxin (BTX) injection and subsequently treated the animals with or without ES.

ATP/P2X4 Regulates Inflammation and Oxidative Stress in Endometriosis Through NLRP3 Inflammasome-Dependent Mechanisms.

Purpose: Endometriosis (EMS) is a chronic inflammatory disorder with ectopic endometrial tissues arising in extrauterine areas. We investigated the mechanism of adenosine triphosphate (ATP)/P2X4 regulating inflammation and oxidative stress in EMS.

Methods: Normal endometrial tissues and ectopic endometrial tissues were collected, and determined for P2X4 expression by immunohistochemical staining.

Deep learning-based non-invasive prediction of PD-L1 status and immunotherapy survival stratification in esophageal cancer using [F]FDG PET/CT.

Purpose: This study aimed to develop and validate deep learning models using [F]FDG PET/CT to predict PD-L1 status in esophageal cancer (EC) patients. Additionally, we assessed the potential of derived deep learning model scores (DLS) for survival stratification in immunotherapy.

Methods: In this retrospective study, we included 331 EC patients from two centers, dividing them into training, internal validation, and external validation cohorts.

Uncovering druggable hotspots on Pin1 via X-ray crystallographic fragment screening.

Pin1 is a phosphorylation-dependent peptidyl-prolyl isomerase that specifically recognizes and catalyzes the cis-trans isomerization of pSer/Thr-Pro motifs. It plays a pivotal role in cell cycle regulation, signal transduction, and tumorigenesis. Due to its overexpression in many cancer types, Pin1 has emerged as a promising target for the development of anticancer drugs.

Model-informed individualized administration of ceftazidime-avibactam in critically ill patients: population pharmacokinetics studies and a parametric time-to-event analysis.

Objectives: Ceftazidime-avibactam is effective against resistant Gram-negative bacteria but associated with a risk of acute kidney injury (AKI), with incidence rates ranging from 13.3% to 33.0%.

Cell-derived extracellular matrix-loaded gelatin electrospun nanofibrous hydrogel for trauma repair: Fabrication and biomedical application.

Severe skin damage, such as trauma and burns, is a major challenge in the field of wound healing biomaterials research. In this work, a Gel/ECM nanofibrous membrane was developed through electrospinning; structurally, it mimics the extracellular matrix (ECM) involved in skin regeneration. Its mechanical properties and biological functionality are ensured by selecting the optimal Gel/ECM ratio of 4:1.

Dietary supplement consumption is associated with lower dietary quality in Chinese university students based on a cross-sectional study.

Faced with the challenges of academic pressure and independent living, university students often experience poor dietary quality and tend to consume dietary supplements as a strategy to compensate for nutritional deficiencies. This study aimed to explore the association between dietary quality and dietary supplement consumption among Chinese university students and to provide insights for strategies that support healthier dietary behaviors. A cross-sectional online survey was conducted among 459 Chinese university students aged 18 to 26 years.

Advancing Microfluidic Photoelectrochemical Aptasensing Platform with Photogenerated Carrier Regulation for Protein Biosynthesis Inhibitors Detection.

Regulating the microscale carrier transport in semiconductor materials to enhance the macroscopic photoelectrochemical properties would drive technological advancement and industrial upgrading. In this work, we integrated the maturity of microfluidic technology control methods with current photoelectrochemical analysis sensing techniques to establish a microfluidic photoelectrochemical induction system by modulating the photon-to-current efficiency under zero bias. Traditionally, target recognition has been achieved by affecting the transport of carriers through the space resistance equivalent of the solid-liquid contact interface, which is limited in sensitivity enhancement.

Dissection of genomic drivers of spike morphology changes in wheat by high-throughput phenotyping.

Spike morphology is crucial for wheat (Triticum aestivum L.) yield and environmental adaptation. We developed a high-throughput phenotyping platform to dissect spike morphology traits based on 54 traits in 1,359 wheat accessions.

Plant Invasion Decreases the Likelihood of Community Persistence Through Asymmetric Competition.

Plant invasion is a significant driver of species loss in ecological communities. However, projecting its impact on multispecies coexistence remains a challenge. Here, we conducted pairwise experiments with five native and five non-native species, using the Ricker model to estimate interaction coefficients and population growth rates.