Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Large-scale characterization of gut viral genomes provides strain-resolved insights into host-microbe interactions. However, existing viral genomes are mainly derived from Western populations, limiting our understanding of global gut viral diversity and functional variations necessary for personalized medicine and addressing regional health disparities.
Results: Here, we introduce the Chinese Gut Viral Reference (CGVR) set, consisting of 120,568 viral genomes from 3234 deeply sequenced fecal samples collected nationwide, covering 72,751 viral operational taxonomic units (vOTUs), nearly 90% of which are likely absent from current databases. Analysis of single-nucleotide variations (SNVs) in 233 globally prevalent vOTUs revealed that 18.9% showed significant genetic stratification between Chinese and non-Chinese populations, potentially linked to bacterial infection susceptibility. The predicted bacterial hosts of population-stratified viruses exhibit distinct genetic components associated with health-related functions, including multidrug resistance. Additionally, viral strain diversity at the SNV level correlated with human phenotypic traits, such as age and gastrointestinal issues like constipation. Our analysis also indicates that the human gut bacteriome is specifically shaped by the virome, which mediates associations with human phenotypic traits. Video Abstract CONCLUSIONS: Our analysis underscores the unique genetic makeup of the gut virome across populations and emphasizes the importance of recognizing gut viral genetic heterogeneity for deeper insights into regional health implications.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369081 | PMC |
| http://dx.doi.org/10.1186/s40168-025-02185-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Viral load differences associated with infection outcomes and resistance to white spot syndrome virus (WSSV) infection in mud crab, Scylla serrata.
J Invertebr Pathol
September 2025
The Marine Science Institute, College of Science, University of the Philippines Diliman, Quezon City 1101, Philippines.
White spot syndrome virus (WSSV), the causative agent of white spot disease, remains a serious threat to crustacean aquaculture. Infecting a wide range of crustaceans, host species exhibit varying susceptibility and mortality rates. Mud crabs, Scylla serrata, a high-value aquaculture commodity across the Indo-Pacific region, are known to be relatively resistant to WSSV.
View Article and Find Full Text PDFUnlabelled: The healthy intestine maintains homeostasis in part via immune responses to microbiota, which includes basal production of interferon cytokines. Previous work showed that Type III Interferon (IFN-λ) stimulates localized pockets of interferon-stimulated genes (ISGs) in the adult mouse intestinal epithelium at homeostasis that provide preemptive protection from viral pathogens. Here, we demonstrate that a major source of homeostatic IFN-λ production in the intestine is a population of epithelium-associated plasmacytoid dendritic cells (pDC).
View Article and Find Full Text PDFLinking the edible plant microbiome and human gut microbiome.
Gut Microbes
December 2025
Institute of Environmental Biotechnology, Graz University of Technology, Graz, Austria.
The edible plant microbiome, which includes microbes in raw-eaten plants, has been recently recognized as a vehicle delivering microbes to the gut. Fruits and vegetables can carry thousands to billions of microorganisms with diverse genetic capacities on each serving. Since the 'edible plant microbiome' concept was introduced in 2014, notable progress has been made in understanding its microbial diversity, factors influencing it, functional traits and biomarkers, and its interconnection with the human gut microbiome.
View Article and Find Full Text PDFNewly discovered and conserved role of IgM against viral infection in an early vertebrate.
Elife
September 2025
State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
IgM emerged in jawed vertebrates 500 Mya and remains the most evolutionarily conserved antibody class. However, despite extensive studies on IgM as an ancient antiviral weapon in warm-blooded vertebrates, its role and mechanisms in combating viral infections in early vertebrates remain poorly understood. Here, significant virus-specific sIgM titers are generated in the serum and gut mucus of a teleost fish (largemouth bass) that survive infection, and fish lacking sIgM were more susceptible to viral infection.
View Article and Find Full Text PDFMicrobiome Diversity and Dynamics in Lotus-Fish Co-Culture Versus Intensive Pond Systems: Implications for Sustainable Aquaculture.
Biology (Basel)
August 2025
Engineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
The lotus-fish co-culture (LFC) system leverages plant-fish symbiosis to optimize aqua-culture environments, enhancing both economic and ecological yields. However, the eco-logical mechanisms of microbial communities in LFC systems remain poorly understood, particularly regarding the functional roles of fungi, archaea, and viruses. This study compared microbiota (viruses, archaea, fungi) in water, sediment, and fish (crucian carp) gut of LFC and intensive pond culture (IPC) systems using integrated metagenomic and environmental analyses.
View Article and Find Full Text PDF