Revealing potential interfering genes between abdominal aortic aneurysm and periodontitis through machine learning and bioinformatics analysis.

This study aimed to identify potential interacting genes between abdominal aortic aneurysm (AAA) and periodontitis. To achieve this, we obtained datasets of AAA and periodontitis from the GEO database, conducted differential analysis on the AAA dataset, and performed weighted gene co-expression network analysis (WGCNA) on the periodontitis dataset to preliminarily identify interacting genes via intersection. Subsequently, we refined key candidate genes by constructing a PPI network and applying three machine learning algorithms.

The genetic diversity and populational specificity of the human gut virome at single-nucleotide resolution.

Background: Large-scale characterization of gut viral genomes provides strain-resolved insights into host-microbe interactions. However, existing viral genomes are mainly derived from Western populations, limiting our understanding of global gut viral diversity and functional variations necessary for personalized medicine and addressing regional health disparities.

Results: Here, we introduce the Chinese Gut Viral Reference (CGVR) set, consisting of 120,568 viral genomes from 3234 deeply sequenced fecal samples collected nationwide, covering 72,751 viral operational taxonomic units (vOTUs), nearly 90% of which are likely absent from current databases.

Incidence rate and related factors of depression in older adult patients with somatization symptoms.

Background: This study aimed to determine the incidence and predictors of depressive symptoms among older adults presenting with somatization symptoms. A prospective cohort design was used to follow participants over time and evaluate the emergence of depressive symptoms.

Methods: Between July 2020 and November 2022, 162 community-dwelling adults aged ≥60 years were enrolled from three community health centers in Fujian Province.

ITLN1 exacerbates Crohn's colitis by driving ZBP1-dependent PANoptosis in intestinal epithelial cells through antagonizing TRIM8-mediated CAPN2 ubiquitination.

This study aimed to investigate the mechanisms by which PANoptosis of intestinal epithelial cells (IECs) promotes Crohn's disease (CD) progression. Single-cell RNA sequencing (scRNA-seq) was performed on inflamed and uninflamed colon tissues from patients with CD. The biological functions of intelectin-1 (ITLN1) in inflammation and PANoptosis were verified through experiments.

Phonon-limited carrier mobility modeling of two-dimensional semiconductors based on first principles.

Two-dimensional semiconductors are set to form the foundation of next-generation electronic and optoelectronic devices such as field-effect transistors, solar cells, and light-emitting devices. carrier mobility is one of the key properties that determines the device performance, such as the switching frequency, the photoelectric efficiency, and so on. The correct evaluation of carrier mobility requires accurate modeling of both the electronic and vibrational properties of a material, and thus it is an intrinsically difficult problem as one cannot focus on only one of the two sets of properties.

Neuregulin 4: A Key Regulator in Suppressing Lung Adenocarcinoma Progression.

Lung adenocarcinoma remains a significant public health concern, necessitating novel therapeutic approaches. Neuregulin 4 (NRG4), a secreted protein of the epidermal growth factor family, is recognized for its roles in metabolic regulation and anti-inflammatory processes, suggesting therapeutic potential across various diseases. However, its specific function in lung adenocarcinoma progression is not well elucidated.

Retrospective comparison of laparoscopic and open surgery for obturator hernia: a single-center experience.

Purpose: This retrospective cohort study aims to compare perioperative outcomes between laparoscopic and open surgical repair of obturator hernia, a rare but clinically significant abdominal wall hernia.

Methods: We analyzed 13 consecutive patients with CT-confirmed obturator hernia causing small bowel obstruction (2017-2023). Six underwent open repair and seven received laparoscopic transabdominal preperitoneal (TAPP) repair with mesh.

Construction and verification of a predictive model for depression risk of patients with somatization symptoms.

Background: Patients with somatization symptoms are at elevated risk of depression, yet underdiagnosis persists due to cultural tendencies (e.g., in China) to express psychological distress via physical complaints.

Non-differential gut microbes contribute to hypertension and its severity through co-abundances: A multi-regional prospective cohort study.

Microbial dysbiosis, characterized by an imbalanced microbial community structure and function, has been linked to hypertension. While prior research has primarily focused on differential abundances, our study highlights the role of non-differential microbes in hypertension. We propose that non-differential microbes contribute to hypertension through their ecological interactions, as defined by co-abundances (pairs of microbes exhibiting correlated abundance patterns).

Effect of weight loss following Roux-en-Y gastric bypass on cancer risk: A Mendelian randomization study.

Cancer incidence and development are strongly correlated with obesity, however there is insufficient data to support a causal relationship between intentional weight loss and the prevention or promotion of cancer. We investigated the causal relationship between weight loss following Roux-en-Y gastric bypass (RYGB) and the incidence of 18 cancers using Mendelian randomization (MR). A genome-wide association studies (GWAS) data related to weight loss following RYGB from the GWAS catalog database were used as exposure, and GWAS data related to 18 cancers from the Medical Research Council integrative epidemiology unit open GWAS project were used as outcomes.

Fabrication of Polyurethane-Polyacrylate Hybrid Latexes with High Organosilicon Content via Phase Inversion Emulsion Polymerization.

Waterborne polyurethane, with a mechanical strength comparable to solvent-based types, is eco-friendly and safe, using water as a dispersion medium. Polyacrylate excels in film formation and weather resistance but suffers from "hot stickiness and cold brittleness". Merging polyurethane and polyacrylate creates advanced hybrids, while organosilicon enhances properties but is restricted due to hydrolytic crosslinking.

Association between solid cooking fuels exposure and metabolic syndrome: Evidence from China.

Epidemiological evidence connecting cooking fuel use to metabolic syndrome (MetS) is lacking. Solid cooking fuel usage and MetS prevalence were prospectively investigated in this study. We included participants in 2011 and 2015 from the China Health and Retirement Longitudinal Study (CHARLS) data.

Q11, a CYP2E1 inhibitor, exerts anti-hepatocellular carcinoma effect by inhibiting M2 macrophage polarization.

Despite significant advancements in cancer immunotherapy, many patients continue to respond poorly. Novel therapeutic strategies and drugs are urgently needed. Here, we found that CYP2E1 is upregulated in M2 macrophages.

Interface phonon transport in nanomaterials: numerical methods and modulation strategies.

The thermal properties of interfaces in nanomaterials are critical for various technological applications, including thermal management in electronic and photonic devices, thermoelectric conversion and thermal insulation. Recent advancements in numerical simulation tools (the non-equilibrium Green's approach, the Boltzmann transport equation and the Monte Carlo method, molecular dynamics simulations) have significantly enhanced our understanding of phonon transport and scattering processes in nanomaterials. These advances have led to the discovery of new thermal interfacial materials and enabled precise modulation of phonon thermal conductance to achieve desired thermal performance.

Sodium Orthovanadate Mitigates Nonalcoholic Fatty Liver Disease by Enhancing Autophagy.

Sodium orthovanadate (SOV) has been investigated in recent research for its therapeutic efficacy in treating metabolic disorders. Considering the rising prevalence of non-alcoholic fatty liver disease (NAFLD), the effects of SOV on NAFLD remain to be further investigated. The aim of this study was to investigate the role and mechanism of SOV in NAFLD.

The pharmacokinetics and tissue distribution of curcumin following inhalation administration in rats-A comparative analysis with oral and intravenous routes.

A sensitive and simple method using ultra-liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed and validated to determine the concentration of curcumin in rat plasma and tissue samples. Emodin was selected as the internal standard (IS), and biological samples were pretreated with simple one-step acetonitrile precipitation. The calibration curves exhibited linearity within the range of 1-1000 ng/ml for both rat plasma and tissue samples.

Trends and risk factors analysis of aortic aneurysm mortality in China over thirty years: based on the global burden of disease 2019 data.

Objectives: This study aims to analyse the variation in mortality burden of aortic aneurysms (AAs) and explore the associated risk factors based on Global Burden of Disease (GBD) 2019 data, investigating the mortality burden of AA in China.

Methods And Results: Using GBD 2019 data, the mortality burden of AA in China from 1990 to 2019 was analysed. The age-period-cohort model was utilized to analyse time trends, period, and cohort effects of four attributable risk factors of AA by age.

Cationic Amphiphilic Comb-Shaped Polymer Emulsifier for Fabricating Avermectin Nanoemulsion with Exceptional Leaf Behaviors and Multidimensional Controlled Release.

The development of intelligent multifunctional nanopesticides featuring enhanced foliage affinity and hierarchical target release is increasingly pivotal in modern agriculture. In this study, a novel cationic amphiphilic comb-shaped polymer, termed PEI-TA, was prepared via a one-step Michael addition between low-molecular-weight biodegradable polyethylenimine (PEI) and tetradecyl acrylate (TA), followed by neutralization with acetic acid. Using the emulsifier PEI-TA, a positively charged avermectin (AVM) nanoemulsion was prepared via a phase inversion emulsification process.

XBP1 Facilitating NF-κB-p65 Nuclear Translocation Promotes Macrophage-Originated Sterile Inflammation Via Regulating MT2 Transcription in the Ischemia/Reperfusion Liver.

Background & Aims: XBP1, most conserved transcription factor of endoplasmic reticulum stress, plays important roles in physiological and pathologic settings and has profound effects on disease progression and prognosis, so it is necessary to investigate XBP1 in macrophage-originated sterile inflammation during liver ischemia/reperfusion injury (IRI). Macrophage XBP1 expression and liver injury are analyzed in patients undergoing ischemia-related hepatectomy.

Methods: A myeloid-specific male XBP1-knockout (XBP1) strain is created for function and mechanism of XBP1 on macrophage-derived sterile inflammation in murine liver IRI with in vitro parallel research.

Potential value and advances in research on bone mineral density (BMD) measurement in the auxiliary clinical assessment of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer death worldwide and its prognosis is highly heterogeneous, being related not only to underlying chronic liver disease but also to the severity of cancer cachexia. Nutritional factors play a crucial role in influencing the prognosis of HCC. Despite musculoskeletal imbalance being consistently reported as a predictor of perioperative mortality in patients with HCC, this condition is often overlooked in clinical management.

Spin Polarization Enhances the Catalytic Activity of Monolayer MoSe for Oxygen Reduction Reaction.

The key factors in achieving high energy efficiency for proton exchange membrane fuel cells are reducing overpotential and increasing the oxygen reduction rate. Based on first-principles calculations, we induce H atom adsorption on 4 × 4 × 1 monolayer MoSe to induce spin polarization, thereby improving the catalytic performance. In the calculation of supercells, the band unfolding method is used to address the band folding effect in doped systems.