Bearing fault diagnosis based on Kepler algorithm and attention mechanism.

As a crucial component in rotating machinery, bearings are prone to varying degrees of damage in practical application scenarios. Therefore, studying the fault diagnosis of bearings is of great significance. This article proposes the Kepler algorithm to optimize the weights of neural networks and improve the diagnostic accuracy of the model.

Bundle recommendation methods considering rating data differences for online retailers.

Bundling has emerged as a pivotal marketing strategy for online retailers, offering mutual benefits to both merchants and consumers in the rapidly expanding e-commerce landscape. Among various types of user behavior data, user-generated product ratings serve as a critical indicator of individual preferences and satisfaction levels. This research proposes a novel bundle recommendation framework that leverages rating disparities to capture nuanced user preferences and unmet demands.

A generalizable pathology foundation model using a unified knowledge distillation pretraining framework.

The generalization ability of foundation models in the field of computational pathology (CPath) is crucial for their clinical success. However, current foundation models have only been evaluated on a limited type and number of tasks, leaving their generalization ability unclear. We establish a comprehensive benchmark to evaluate the performance of off-the-shelf foundation models across six distinct clinical task types, encompassing a total of 72 specific tasks.

Evaluating the effectiveness of prenatal exercise promotion strategies on the Xiaohongshu platform: Health beliefs, information quality, and source credibility.

Although exercising during pregnancy offers numerous advantages, its prevalence in China remains relatively low. This is primarily attributed to the traditional Chinese belief that pregnancy is a period for rest and recuperation. To alter this perception, numerous individuals have promoted the benefits of prenatal exercise on Xiaohongshu, one of China's most popular social media platforms.

De Winter sign combined with pronounced aVR lead ST segment elevation and left anterior fascicular block: a case report.

Background: The de Winter electrocardiographic (ECG) pattern, characterized by upsloping ST-segment depression and tall T waves in leads V1-V6, is typically associated with proximal left anterior descending (LAD) artery occlusion. When combined with pronounced ST-segment elevation in lead aVR, it may indicate a more severe coronary artery involvement.

Case Presentation: A 36-year-old male smoker presented with acute chest pain for 2 h.

Constructing hot-spots enriched Ag/MoS hybrid SERS platform for rapid detection of pesticide residue in juice.

Excessive pesticide residues have posed a severe risk to human health and ecological environment, making stringent testing of them a crucial step in food safety supervision. Herein, a flexible paper-based SERS platform composed of AgNPs and MoS nanoflowers was developed for the rapid and ultra-sensitive detection of thiram in juice. Among it, the hydrophobic MoS-modified paper was first fabricated, followed by co-depositing small-sized AgNPs and thiram molecules onto its surface for SERS analysis.

Perceptions of rural maternal and child health workers on using smartphone-based virtual patients to evaluate perinatal depression screening abilities: a qualitative study.

Aims: This study aims to explore the perceptions of maternal and child health (MCH) workers regarding the use of smartphone-based virtual patients (VPs) to assess perinatal depression (PND) screening abilities and to collect feedback for iterative enhancement of the VPs.

Design: A qualitative study employing inductive content analysis to identify key themes from the responses of MCH workers.

Setting: The study was conducted in six counties across Yueyang City and Yiyang City, Hunan Province, between November 2023 and January 2024.

Extracellular vesicles enriched with miR-486 from Tetramethylpyrazine-preconditioned bone marrow mesenchymal stem cells promote microglia/macrophage M2 polarization and enhance neurogenesis in rats with ischemic stroke.

Background: Bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) show therapeutic promise for ischemic stroke (IS). Preconditioning MSCs with drugs can modulate the cargo composition and function of their derived EVs. This study investigated the therapeutic effects and underlying mechanisms of EVs derived from tetramethylpyrazine (TMP)-preconditioned BMSCs (TMP-BMSC-EVs) in IS.

Application of four-section approach for prenatal diagnosis of Pierre robin sequence.

Purpose: This study aimed to evaluate the effectiveness of the four-section approach using two-dimensional sonography in diagnosing Pierre Robin sequence (PRS) during second-trimester screening.

Methods: A prospective study was conducted on low-risk pregnant women undergoing routine mid-trimester screening. Cases with suspected micrognathia prenatally were included and examined using the four-section approach.

Photo-triggered engineered microbes achieving dual epigenetic immunomodulation for gastric cancer.

DNA methylation serves as an essential epigenetic mechanism for the regulation of gene expression. One of the earliest and most common changes seen in cancer is abnormal DNA methylation at CpG sites, which may encourage tumor development by silencing tumor suppressor gene transcription. The DNMT1 inhibitor AZA can delay cancer progression by inhibiting DNA methylation and enhancing tumor immunogenicity, yet its clinical efficacy in gastric cancer is limited by poor specificity, instability, and low retention.

Circ_Slc7a11 Aggravates Intestinal Mucosa Barrier Damage by Regulating SIRT1 Acetylation Through miR-624-5p.

SIRT1 plays a crucial role in the production of reactive oxygen species (ROS) and ischemia/reperfusion (I/R), yet the upstream mechanisms that directly regulate SIRT1 expression during intestinal I/R remain unclear. Recent studies have shown that noncoding RNAs, such as circular RNAs (circRNAs), are important players in physiological and pathological processes based on their multiple regulatory roles in gene expression. This study aimed to elucidate the role of SIRT1 in intestinal mucosa barrier damage and to investigate the regulation of SIRT1 by circRNA sponges.

The mediating effect of moral distress on workplace violence and compassion fatigue in psychiatric nurses.

Aims: To examine the associations among compassion fatigue, workplace violence, and moral distress in psychiatric nurses.

Background: The demanding environment of psychiatric departments, characterized by frequent exposure to workplace violence, may contribute to both moral distress and compassion fatigue among nurses. This reciprocal relationship underscores the necessity of interventions targeting both issues concurrently, with the goal of enhancing psychiatric nurses' well-being and retention.

Mouse trophectoderm stem cells generated with morula signalling inducers capture an early trophectoderm state.

The first embryonic cell differentiation in mice segregates the trophectoderm and the inner cell mass. Successful derivation of mouse trophoblast stem cells (TSCs) and trophectoderm stem cells (TESCs) has greatly facilitated the understanding of trophoblast differentiation. However, our understanding of early trophectoderm differentiation remains incomplete.

The DCD domain-containing protein HaB2 enhances sunflower resistance to Orobanche cumana via the ABA signaling pathway.

Broomrape (Orobanche cumana) is a major threat to sunflower (Helianthus annuus) production. Although B2 proteins, a class of DCD (development and cell death) domain-containing proteins, are reported to play a role in responses to a variety of abiotic stresses in plants, their function in biotic stress remains unclear. This study explored the role of HaB2 in sunflower resistance to O.

Intrathecal Pemetrexed Administration and Myelosuppression in Patients with Leptomeningeal Metastases from Lung Adenocarcinoma: A Retrospective Study.

Background: Non-small cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM) have a very poor prognosis. Intrathecal pemetrexed (IP) has shown moderate efficacy in treating patients with NSCLC-LM. Myelosuppression is the most common adverse effect following IP administration.

Alternative splicing of OsNPR3 promoted by the bacterial TAL effectors-targeted splicing regulator OsRBP11 antagonizes OsNPR1 function and enhances disease susceptibility in rice.

Plant proteins that belong to the nonexpressor of pathogenesis-related (NPR) gene family are paralogous receptors of the plant defense hormone salicylic acid and essential regulators of hormone-dependent plant immunity against diseases caused by various pathogens. Previous studies have established NPR1 and NPR3 as a transcriptional activator and a transcriptional repressor, respectively, of defense-gene expression to promote and inhibit broad-spectrum resistance against different strains of pathogens. However, the regulatory mechanism that underlies the opposing roles of NPR1 and NPR3 in defense-gene activation remains unclear.

Isolation and Molecular Characterization of Swine Parainfluenza Virus 5 from Piglets Co-Infected with PEDV.

Parainfluenza virus 5 (PIV5), now reclassified as , is a negative-sense, single-stranded RNA virus belonging to the genus of the family [...

The Role of Traditional Chinese Medicine in Targeting NF-[Formula: see text]B Ubiquitination Against Ischemic Stroke.

Ischemic Stroke (IS) is a severe neurological disease with high mortality rates worldwide, involving a complex cascade reaction in which the ubiquitination process of nuclear factor kappa B (NF-[Formula: see text]B) pathway has been proposed as a therapeutic target for IS on account of the fact that NF-[Formula: see text]B can be suppressed by the Ubiquitin-Proteasome System (UPS). This review systematically discusses the epidemiology of IS, the NF-[Formula: see text]B signaling pathway, and the anti-inflammatory and anti-apoptotic effects that TCM monomers and formulations exert by regulating the ubiquitination process of the NF-[Formula: see text]B signaling pathway. We initially offer an overview of the incidence and treatment of IS, following which the canonical pathway and non-canonical pathway of NF-[Formula: see text]B are introduced.

Association between serum GFAP, BDNF and NfL levels and clinical symptoms in restless legs syndrome: a case-control study.

Background: Restless legs syndrome (RLS) is a prevalent neurological condition marked by an uncontrollable urge to move the legs, which often disrupts sleep and impairs quality of life. Although neuroinflammatory and neurodegenerative processes have been implicated, the roles of serum glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF), and neurofilament light chain (NfL) in treatment-naïve RLS remain unclear.

Methods: In this case-control study, 108 treatment-naïve RLS patients and 90 age- and sex-matched healthy controls were enrolled.

Oppositely charged polysaccharide nanofibers coated gauze with hemostatic potential.

Cotton gauze remains a clinically prevalent hemostatic material, yet its effectiveness remains compromised by bleeding. We have deposited cationic quaternized chitosan (QCS) and anionic catechol-functionalized hyaluronic acid (HADA) nanofibers onto cotton gauze to prepare QCS/HADA@gauze. Upon blood contact, oppositely charged nanofibers electrostatically adhere through complementary charge interactions.

Association of stress hyperglycemia ratio with hospital mortality and acute kidney injury in patients with transfusion.

Background: Patients in intensive care units (ICUs) commonly experience stress hyperglycemia, which is linked with poor cardiovascular outcomes and high hospital mortality. The stress hyperglycemia ratio (SHR) may serve as a critical risk factor for acute kidney injury (AKI) in specific individuals. Nevertheless, the link between SHR and hospital mortality and AKI in transfused patients is unclarified.

circRNA_Atp8a1 Promotes Glycolytic Reprogramming in Damage of Intestinal Mucosal Barrier by Upregulating IGF2 through miR-200b-3p.

Background: This study investigated a circRNA (Circ_Atp8a1) in regulating intestinal epithelial repair in intestinal mucosal barrier damage.

Methods: A mouse model of intestinal mucosal barrier damage caused by burn injury was constructed. Skin and intestinal histopathologic changes in injured and control mice were compared.

Multi-omics Analysis Reveals miR-7220-5p Alleviates NO Addictive Behaviors via NR2B/ERK/CREB Signaling.

Nitrous oxide use disorder (NUD) has recently received increasing social concern for its sharp rise among young people. However, the underlying mechanisms of NUD remain largely unexplored, which obstructs treatment strategy development and may exacerbate the epidemic of NO abuse. Thus, specifying the essential mechanisms and targets in NUD are desperately needed.