Sustained release of dual p38 inhibitors via supramolecular hydrogels to enhance cardiac repair after MI/R injury.

Activation of p38 mitogen-activated protein kinase plays an important role in the progression of ventricular muscle inflammation after myocardial ischemia-reperfusion (MI/R). The inhibition of p38 activation in ischemic myocardium can reduce ventricular muscle remodeling post-MI. However, owing to the dynamic change of p38 in ischemic myocardium after MI, the clinical therapeutic effect of p38 inhibitors is insufficient.

Network Meta-analysis of 1.5% Ruxolitinib Cream Versus Systemic Agents in the Treatment of Moderate Atopic Dermatitis.

Introduction: Atopic dermatitis (AD) is a chronic, highly pruritic, relapsing inflammatory disease associated with high quality-of-life burden. Topical 1.5% ruxolitinib cream is a selective Janus kinase (JAK)1/JAK2 inhibitor that is well tolerated and effective in improving itch and lesion clearance in patients ≥ 12 years old.

Construction and application of a mortality risk prediction model for patients with lung squamous cell carcinoma: A competing risk analysis.

Background: Lung squamous cell carcinoma (LUSC) is the dominant histological subtype of lung cancer, accounting for 30% of all cases. Most patients develop distant metastases by the time they are diagnosed with the disease, owing to a delay in the appearance of symptoms. Therefore, accurate prognostic prediction is essential for personalized treatment.

Fucoidan from alleviates MetALD via promoting HIF-1α ubiquitination to suppress peripheral monocyte infiltration.

Metabolic and alcohol-related liver disease (MetALD), characterized by excessive alcohol intake in individuals with metabolic dysfunction, is a growing health burden worldwide. Hepatic macrophages play a pivotal role in MetALD pathogenesis, with pro-inflammatory infiltrating monocytes/macrophages contributing to liver injury. Fucoidan, a sulfated polysaccharide derived from brown algae, is known for its anti-inflammatory properties, yet its intracellular targets remain poorly defined.

Evaluating the effectiveness of prenatal exercise promotion strategies on the Xiaohongshu platform: Health beliefs, information quality, and source credibility.

Although exercising during pregnancy offers numerous advantages, its prevalence in China remains relatively low. This is primarily attributed to the traditional Chinese belief that pregnancy is a period for rest and recuperation. To alter this perception, numerous individuals have promoted the benefits of prenatal exercise on Xiaohongshu, one of China's most popular social media platforms.

Updated reference intervals for serum cystatin C and creatinine based on age and sex variations.

Unlabelled: We investigated inconsistencies between results for cystatin C (Cys C) and creatinine (Crea) in patients undergoing health check-ups. Data from 36,836 individuals who underwent health checkups at Huashan Hospital over the previous 3 years were analyzed. We extracted laboratory results of 10 biomarkers and information on sex and age.

Phosphorylation of c-Myc at Ser62 via the protein kinase activity of acetaldehyde dehydrogenase 18A1 promotes tumor growth.

The oncoprotein c-Myc is a prominent target in cancer therapy, and modulating its stability is a promising potential treatment strategy. Phosphorylation at Ser62 is the primary mechanism by which c-Myc degradation is suppressed, which extends its half-life. Consequently, identifying kinases that regulate the phosphorylation of c-Myc at Ser62 may pave the way for novel intervention strategies.

Technological advances in solvents drive a significant decrease in VOC emissions and negative impacts from industrial solvent-use sources.

Industrial solvent use is a major source of volatile organic compound (VOC) emissions, posing significant environmental and health risks. However, the driving factors behind VOC reduction are rarely discussed for the specific emission source, impeding future regulatory efforts for this pollution source. This study investigates VOC emission profiles from solvent-based and water-based paints in industrial solvent use, with a focus on key drivers of emission and environmental/health risk.

Weakly Supervised Deep Learning for Monitoring Sleep Apnea Severity Using Coarse-grained Labels.

Sleep apnea, a prevalent sleep-related breathing disorder, often remains undiagnosed and untreated in a large patient population due to the need of extensive manual annotations on various physiological signals for clinical diagnosis. Despite the surge of interest in applying machine learning to automate apnea detection, the effectiveness of existing techniques highly relies on strongly supervised learning that requires massive finely labeled training data for sufficiently short time intervals - a requirement often unmet due to the prohibitively high cost of manual labeling in clinical practice. In this article, we incorporate clinical knowledge to establish a weakly supervised deep learning framework for automatically estimating the latent fine-grained apnea severity when only coarse-grained labels indicating apnea presence are available in the training data.

Polymer-guided grafting of single W atoms onto titanate nanotubes increases SERS activity in semiconductors.

Metal single atoms have been demonstrated to induce surface-enhanced Raman scattering (SERS) due to their effectiveness in the modification of electronic structure. However, precisely modulating the relative positions of metal single atoms on sub-nanolattices remains a formidable challenge, which makes SERS studies of metal single atoms dependent on localized environments still lacking. Herein, we rely on polyethylene glycol (PEG) as a soft template to achieve the modulation of the relative positions of W atoms on titanate nanotubes (W-TNTs) and probe the local-environment-dependent SERS induced by metal single atoms based on this technique.

Novel Insight into Metabolism Mechanism of Biogenic Amines During Fermentation of Chinese Traditional Fermented Mandarin Fish () Based on Metabolism Pathway and Correlation Network.

A complex microbial community gives the possibility to produce biogenic amines in traditional fermented foods. In this study, the metabolism mechanisms of biogenic amines during fermentation of fermented mandarin fish were revealed based on the metabolic pathways and correlation analysis. Functional genes based on KEGG orthology related to biogenic amine metabolism were selected from the metagenome and were used to construct the biogenic amine metabolic pathways in .

Lactate-Modulating Nanoreactors Facilitate Self-Amplifying Pyroptosis and the cGAS-STING Cascade for Potentiated Catalytic-Immunotherapy.

The strategic induction of pyroptosis, coupled with the targeted potentiation of cGAS-STING activation, represents a promising immunostimulatory approach. Herein, an intelligent lactate-depleting LOCoF nanoreactor system is developed that orchestrated self-amplifying pyroptosis induction and cGAS-STING signaling potentiation for enhanced catalytic immunotherapy. This nanoplatform integrated cobalt fluoride (CoF) nanoparticles with lactate oxidase (LOx), endowing it with dual enzymatic capabilities.

Branched-chain amino acids contribute to diabetic kidney disease progression via PKM2-mediated podocyte metabolic reprogramming and apoptosis.

Approximately 30-40% of patients with diabetes develop diabetic kidney disease (DKD). Identifying decisive factors for DKD initiation is crucial. Here, we observed that glomerular podocytes in male and female patients with DKD and db/db mice specifically displayed BCAA catabolic defects.

Metabolic symphony coordinates the muscle regeneration niche.

The muscle regeneration niche comprises various cell types, including muscle stem cells (MuSCs; also termed satellite cells), immune cells, and stromal cells, all of which have crucial roles in the regeneration process. Intracellular metabolic reprogramming during injury responses is closely linked to the functional activities of these cells, thus necessitating a comprehensive understanding for developing targeted metabolic interventions that promote regeneration. Recent studies have suggested the existence of a more intricate network, involving cell-cell metabolic crosstalk and even cross-organ regulation, which underpins muscle regeneration.

Reliability and validity evidence for the physical activity parenting questionnaire for children (PAP-C) in Chinese school-aged children.

Unlabelled: The physical activity parenting questionnaire for children (PAP-C) is designed to assess physical activity parenting practices from children's perspectives. While initially developed in Finland, its validity and reliability have not been evaluated in different countries. This study aimed to examine the construct validity, factorial invariance, and 4-week reliability of the PAP-C in Chinese 7- to 11-year-old children.

Predicting the therapeutic efficacy of uterine artery embolization for adenomyosis using a combined model based on MRI radiomics and clinical characteristics.

Objective: Prediction of the therapeutic efficacy of uterine artery embolization (UAE) for adenomyosis (AM) using an MRI-based radiomics model combined with clinical characteristics.

Methods: A retrospective analysis was conducted on 126 patients with AM who underwent UAE at the Interventional Radiology Department of the Second Affiliated Hospital of Soochow University. Radiomics features were extracted from uterine lesions using axial T-weighted imaging with fat suppression (TWI-FS) sequences obtained prior to treatment.

Red yeast rice extract improves lipid metabolism by modulating gut microbiota in high-fat diet mice.

As a traditional food-medicine dual-purpose substance, red yeast rice (RYR) has gained wide attention for its lipid-lowering activity. However, existing studies mainly focus on the liver-targeted effects of statin-like components, with limited systematic insights into its lipid metabolism regulation via gut microbiota. This study combines high-fat diet (HFD)-induced hyperlipidemia mouse models, 16S rRNA gene sequencing, untargeted metabolomics, and fecal microbiota transplantation (FMT) to investigate the potential of RYR extract in improving lipid metabolism through gut microbiota modulation.

Spatiotemporal coordination between local flux and systemic homeostasis in the small intestine.

The small intestine has a pivotal role in nutrient absorption, host defense, and endocrine functions, with the maintenance of its homeostasis relying on the synergistic interplay of intrinsic and extrinsic factors. These encompass a highly organized spatiotemporal microenvironment, characterized by a regionalized histological architecture, functionally specialized cell populations, and spatially rhythmic nutrient gradient environments shaped by dietary patterns. While the link between small intestinal dysfunction and a wide range of systemic diseases has been well established, recent advances in spatial omics and dietary interventions have provided unprecedented new insights.

Structural characterization and osteogenic potential of polysaccharide purified from Sanghuangporus vaninii.

Sanghuangporus vaninii (S. vaninii) is a fungus of considerable medicinal properties. Nevertheless, the specific effects of polysaccharides derived from S.

Oat Fiber Alleviates Loperamide-Induced Constipation in Mice by Modulating Intestinal Barrier Function.

To investigate the effects of oat fiber on animal constipation and elucidate its underlying mechanisms. Male BALB/c mice were randomly allocated into five groups: control group (CON), model control group (MODEL), low dose group (LOW), middle dose group (MIDDLE), high dose group (HIGH). Constipation was induced in the mice by intragastric administration of loperamide.

Metabolic modulation-driven self-reinforcing pyroptosis-STING nanoadjuvant for potentiated metalloimmunotherapy.

Pyroptosis is a critical process that triggers inflammatory responses and mitochondrial DNA (mtDNA) release, thereby activating the cGAS-STING pathway. However, tumor metabolism, particularly glycolysis, often suppresses immune activation. To address this, we developed GOCoF, a self-amplifying pyroptosis-STING nanoadjuvant that integrates glucose oxidase (GOx) with cobalt fluoride (CoF) nanoenzymes.

Acute and chronic stress differentially regulate pain via distinct ensembles in the paraventricular nucleus of hypothalamus.

Stress impacts pain sensation and its development, but the underlying neural mechanisms are largely unclear. Using restraint stress models and complete Freund's adjuvant-induced pain model in male mice, we demonstrated that acute restraint stress (ARS) induces analgesia in both naïve and pain states. In contrast, chronic restraint stress (CRS) enhances pain hypersensitivity in naïve states, prolongs pain duration, and promotes anxiodepressive symptoms in pain states.

Liver cirrhosis may increase the incidence of delayed bleeding and mortality after endoscopic retrograde cholangiopancreatography for common bile duct stones.

Background And Purpose: Choledocholithiasis is a common disease. However, the results of studies on the complications of choledocholithiasis with cirrhosis by endoscopic retrograde cholangiopancreatography (ERCP) are inconsistent. Therefore, the purpose of this prospective study is to compare the incidence of postoperative complications of ERCP between choledocholithiasis with cirrhosis and those without cirrhosis.

Tuning of excitation wavelength to achieve dual-channel detection of Cr(VI) by cellulose-based carbonized polymer dots.

Carbonized polymer dots (CPDs), a new nanofluorescent materials inheriting the advantages of CDs, have been widely studied for their excellent physicochemical stability and tunable fluorescence properties, and have extensive application in the fields of optoelectronic devices and environmental monitoring. In this study, nitrogen-doped CPDs (CMC-M-CPDs) were synthesized via hydrothermal reaction using carboxymethyl cellulose (CMC) and melamine (M), which allowed N doping to improve the luminescence of CPDs through cross-linking and reduction of the energy gap. Due to the excitation-dependent, the luminescence wavelength of CPDs can be tuned, so these CPDs exhibit two optimal emission centers in the fluorescence spectra, which originate from the carbon core and the surface, respectively.

Willingness to pay and preference for HPV vaccine among parents in China: A study based on a multi-center cross-sectional survey.

This study assessed the willingness to pay (WTP), influencing factors, and preferences for HPV vaccine in different regions of China to support pricing and financing strategies. A cross-sectional survey was conducted across three provinces. The Vaccine Health Literacy Scale was used to measure vaccine literacy.