Phosphorylation of c-Myc at Ser62 via the protein kinase activity of acetaldehyde dehydrogenase 18A1 promotes tumor growth.

The oncoprotein c-Myc is a prominent target in cancer therapy, and modulating its stability is a promising potential treatment strategy. Phosphorylation at Ser62 is the primary mechanism by which c-Myc degradation is suppressed, which extends its half-life. Consequently, identifying kinases that regulate the phosphorylation of c-Myc at Ser62 may pave the way for novel intervention strategies.

Three new species of the genus Muir, 1925 (Hemiptera, Fulgoromorpha, Cixiidae) from China, with an updated checklist and key to species.

Three new species of the genus Muir, 1925 (Hemiptera, Fulgoromorpha, Cixiidae, Andini), Lv & Chen, , Lv & Chen, and Lv & Chen, , are described and illustrated from Southwest China (Yunnan and Guangxi) to give the genus six species in total. An updated identification key and checklist to all known species of are provided, as well as a map of their geographic distributions.

Impact of RoSCo-based preoperative risk stratification on early mobilization and short-term outcomes following robot-assisted laparoscopic partial nephrectomy for renal cell carcinoma: a single-center prospective study.

This study aimed to evaluate the effectiveness of the RoSCo preoperative risk scoring system, which incorporates the RENAL Nephrometry Score, the Charlson's Comorbidity Index, and body mass index to quantify surgical risk, in guiding individualized early mobilization protocols and to assess associated early postoperative recovery outcomes in patients undergoing robot-assisted partial nephrectomy (RAPN) for renal cell carcinoma (RCC). A prospective, randomized controlled study was conducted involving 82 patients diagnosed with RCC who underwent RAPN between October 2023 and October 2024 at the Department of Urology. Participants were randomized into an experimental group (n = 41) and a control group (n = 41).

[Traditional Chinese medicine understanding and treatment of acute myocardial infarction complicated with acute upper gastrointestinal bleeding].

Acute myocardial infarction and acute upper gastrointestinal bleeding are both critical internal medicine conditions. The incidence of acute upper gastrointestinal bleeding in patients with acute myocardial infarction ranges from 5.31% to 8.

Pde4b-regulated cAMP signaling pathway in the AUD-S1Tr circuit underlies acute-stress-induced anxiety-like behavior.

Acute-stress-induced anxiety helps animals avoid danger, but the neural and molecular mechanisms controlling this behavior remain largely elusive. Here, we find that acute physical stress activates many neurons in the primary somatosensory cortex, trunk region (S1Tr). Single-cell sequencing reveals that the S1Tr c-fos-positive neurons activated by acute stress are largely GABAergic somatostatin (Sst) neurons.

Self-assembled HO-1i-Pt(IV) nanomedicine targeting p38/MAPK and MDR pathways for cancer chemo-immunotherapy.

Platinum(II)-based antitumor drugs are widely used in clinics but limited by severe side effects and resistance. Multi-target Platinum(IV) complexes are emerging as ideal alternatives. Heme oxygenase-1 (HO-1) works as a rate-limiting step in heme degradation and is overexpressed in malignant tumors.

The microenvironment cell index is a novel indicator for the prognosis and therapeutic regimen selection of cancers.

Background: It is worthwhile to establish a prognostic prediction model based on microenvironment cells (MCs) infiltration and explore new treatment strategies for triple-negative breast cancer (TNBC).

Methods: The xCell algorithm was used to quantify the cellular components of the TNBC microenvironment based on bulk RNA sequencing (bulk RNA-seq) data. The MCs index (MCI) was constructed using the least absolute shrinkage and selection operator Cox (LASSO-Cox) regression analysis.

[Heart failure: innovative understanding from traditional Chinese medicine (TCM) and treatment with classic TCM formulas].

The prevalence of cardiovascular diseases in China has shown a rising trend. With the patient number of about 8.9 million, heart failure has brought a heavy burden to public health and wellness.

A single dominant GLOBOSA allele accounts for repeated origins of hose-in-hose flowers in Sinningia (Gesneriaceae).

Plants bearing double flowers have long been cultivated as ornamental plants. Hose-in-hose flowers, bearing two-whorled corolla tubes in whorls 1 and 2, are uncommon but recur in Sinningia (Gesnerioideae, Gesneriaceae). In this study, we selected 15 hose-in-hose cultivars as materials to explore the underlying molecular and genetic mechanisms of this floral architecture.

[Coronary heart disease: innovative understanding from traditional Chinese medicine and treatment by classic formulas].

Coronary heart disease is a common cardiovascular disease, attacking about 11.4 million patients in China. With increasing prevalence and mortality year by year, coronary heart disease has become a major factor threatening human health and public health.

[Preparation and quality evaluation of total flavonoids microemulsion of "Pueraria lobata-Hovenia dulcis"].

The effective components of flavonoids in the "Pueraria lobata-Hovenia dulcis" drug pair have low bioavailability in vivo due to their unstable characteristics. This study used microemulsions with amphoteric carrier properties to solve this problem. The study drew pseudo-ternary phase diagrams through titration compatibility experiments of the oil phase with emulsifiers and co-emulsifiers and screened the prescription composition of blank microemulsions.

[Estimation of Agricultural Greenhouse Gas Emissions and Emission Reduction Potential of Beijing During the 14th Five-Year Plan Period Under the Background of "Carbon Peak and Neutrality"].

To achieve the goal of "carbon peak and neutrality," the strict requirements for greenhouse gas (GHG) emissions control in the agricultural sector were recommended in relevant plans for Beijing during the 14th Five-Year Plan period. Through collecting agricultural activity data and calculating and screening the emission factors, the amount and emission characteristics of agricultural GHG emissions in Beijing in 2020 were estimated and set as the baseline condition. On this basis, the GHG emissions in 2025 with optimized measurements implemented, which were selected in combination with the natural conditions and planting-breeding mode of Beijing, were set as the reduction condition.

[Interpretation and review of Clinical Practice Guidelines for Management of Hypertension in China (2020 edition) and exploration of traditional Chinese medicine for antihypertensive treatment].

Hypertension is the most important risk factor for cardiovascular disease-related deaths among urban and rural residents, and it has become a significant global public health issue. In October 2022, the Clinical Practice Guidelines for the Management of Hypertension in China(hereinafter referred to as the Practice Guidelines) were jointly released by the National Cardiovascular Center and other academic organizations. The Practice Guidelines sparked extensive discussions as they clearly lowered the diagnostic criteria for hypertension, raised the blood pressure targets for elderly patients, and proposed changes in the timing of early medication intervention.

Four new species of the genus Emeljanov & Hayashi (Hemiptera, Fulgoromorpha, Cixiidae) from China.

Four new species of the genus Emeljanov & Hayashi, 2007 are described and illustrated from China. These are Wang & Chen, , Wang & Chen, , Wang & Chen, and Wang & Chen, Photographs of the new species and an identification key to all species are provided.

Early life exercise training and inhibition of mRNA expression to improve age-related arrhythmias and prolong the average lifespan in .

Cardiovascular disease (CVD) places a heavy burden on older patients and the global healthcare system. A large body of evidence suggests that exercise training is essential in preventing and treating cardiovascular disease, but the underlying mechanisms are not well understood. Here, we used the melanogaster animal model to study the effects of early-life exercise training (Exercise) on the aging heart and lifespan.

[A novel phenylisoquinoline alkaloid with cardioprotective effect from Aconiti Lateralis Radix Praeparata].

Macroporous resin chromatography, silica gel column chromatography, preparative thin layer chromatography, and semi-preparative high performance liquid chromatography were performed to isolate two compounds from the acid extract of the lateral roots of Aconitum carmichaelii: a new 9-phenylisoquinoline alkaloid(1) and a known pavine alkaloid(2). Their structures were elucidated by spectroscopy. The absolute configuration of compound 1 was identified by electronic circular dichroism(ECD) and it was determined to be(aS)-7,8-dimethoxy-9-(2-carboxy-4,5-dimethoxyphenyl)-3,4-dihydroisoquinoline-1(2H)-one(1).

Two New Species of Matsumura, 1914 (Hemiptera: Fulgoromorpha: Cixiidae) from Southwestern China, with an Updated Checklist and Key to Species.

In this study, two new species of genus Matsumura, 1914 (Fulgoromorpha, Cixiidae), sp. nov. from Yunnan Province and sp.

Assessment of Drying Kinetics, Textural and Aroma Attributes of Leaves during the Hot Air Thin-Layer Drying Process.

Since leaves are rich in bioactive constitutes, particularly volatile compounds, there are higher demands for high-quality dried medicinal and aromatic peppermint products. This study aimed to assess the drying kinetics of hot air thin layer drying leaves and exploring the effects of hot air-drying temperatures on the textural properties and sensory quality. According to our results, the Midilli model is the best model representing the hot air-drying process.

Ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics.

Pulmonary fibrosis (PF) is a chronic and progressively fatal disease, but clinically available therapeutic drugs are limited due to efficacy and side effects. The possible mechanism of pulmonary fibrosis includes the damage of alveolar epithelial cells II (AEC2), and activation of immune cells such as macrophages. The ions released from bioceramics have shown the activity in stimulating soft tissue derived cells such as fibroblasts, endothelia cells and epithelia cells, and regulating macrophage polarization.

Cardioprotective effects and concentration-response relationship of aminoalcohol-diterpenoid alkaloids from Aconitum carmichaelii.

Fuzi, a well-known traditional Chinese medicine developed from the lateral roots of Aconitum carmichaelii Debx., has been widely used for the treatment of heart failure. In order to search for active compounds from Fuzi, a phytochemical study was performed, which resulted in the isolation of 14 aminoalcohol-diterpenoid alkaloids, including one new compound (1).

Testing Seven Hypotheses to Determine What Explains the Current Planthopper (Fulgoridae) Geographical and Species Richness Patterns in China.

Although many hypotheses have been proposed to understand the mechanisms underlying large-scale richness patterns, the environmental determinants are still poorly understood, particularly in insects. Here, we tested the relative contributions of seven hypotheses previously proposed to explain planthopper richness patterns in China. The richness patterns were visualized at a 1° × 1° grid size, using 14,722 distribution records for 1335 planthoppers.

Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury.

Background: Spinal cord injury (SCI) favors a persistent pro-inflammatory macrophages/microglia-mediated response with only a transient appearance of anti-inflammatory phenotype of immune cells. However, the mechanisms controlling this special sterile inflammation after SCI are still not fully elucidated. It is known that damage-associated molecular patterns (DAMPs) released from necrotic cells after injury can trigger severe inflammation.