Asymmetric Triple Helical Nonbenzenoid Nanographenes with Controllable Helicene Lengths.

Helical nanographenes (NGs) play a crucial role in the development of chiral nanomaterials due to their distinctive optoelectronic and chiroptical properties. Herein, we report the efficient synthesis of two unprecedented azulene-embedded asymmetric triple helical NGs ( and ) with controllable helicene subunit lengths and π-extension. The crystallographic analysis confirms their highly twisted and asymmetric geometries.

Unraveling ozone formation sensitivity to ambient VOCs and NOx at urban and mountain sites in a typical city of eastern China.

Ozone (O) is a primary pollutant affecting air quality in China, whose formation rate was non-linearly based on volatile organic compounds (VOCs) and nitrogen oxides (NOx). A comprehensive understanding of the key drivers governing O formation and its sensitivity to precursor variations presents a persistent research challenge, stemming from the complex interplay of underlying photochemistry, meteorology, and topography. To address this knowledge gap, we conducted synchronous measurements of O and its precursors at both an urban (JPU) and a mountain (LM) site in a typical city in eastern China, enabling concurrent evaluation of O formation sensitivity and diagnostic analysis of its underlying mechanisms.

Emergence of Two Novel Species ( sp. nov. and sp. nov.) Associated with Destructive Jackfruit Gummosis in Tropical China.

Jackfruit (Artocarpus heterophyllus Lam.), a crucial economic crop in tropical regions, has recently been devastated by a novel gummosis disease in Hainan and Yunnan Provinces of China. This gummosis primarily affects the stems and branches of jackfruit, causing gum exudation, bark cracking, and plant death, which severely threatens the sustainable development of the industry.

Decoding flavor diversity in lemon varieties: a multivariate flavoromics approach coupled with statistical analysis for comprehensive flavor profiling.

Lemon is widely valued for its bioactive components and unique flavor, which are influenced by diverse volatile organic compounds (VOCs). This study implemented flavoromics, a comprehensive profiling of flavor, combining non-volatile flavor with E-nose, HS-SPME-GC--MS, HS-GC-IMS, relative odor activity value (ROAV), and multivariate statistical analysis to systematically characterize the aroma profiles of five lemon varieties (Rough lemon, Key lime, Eureka lemon, Tahiti lime, and Rosso lemon). A total of 44 and 50 VOCs were identified by HS-SPME-GC-MS and HS-GC-IMS, respectively.

Clinical utility of shear wave elastography in diagnosis and prognostic assessment of acute anterior talofibular ligament injuries.

BackgroundTo investigate the clinical utility of shear wave elastography (SWE) in the diagnosis and prognostic evaluation of acute anterior talofibular ligament (ATFL) injuries.MethodsThis prospective cohort study enrolled 46 patients with unilateral acute ATFL injuries and 32 age and gender-matched healthy volunteers. All patients underwent B-mode ultrasonography and SWE within 48 h post-injury and at 3 month post-rehabilitation.

Iron Coordination in PtFeCoNiMo High-Entropy Alloys Modulates Platinum Local Environments for pH-Universal Hydrogen Evolution Reaction.

Developing cost-effective, stable hydrogen evolution reaction (HER) electrocatalysts effective across pH-Universal remains challenging. This work reports a one-pot synthesized Pt-Fe-Ni-Mo-Co high-entropy alloy catalyst supported on Ketjen Black (HEA@KB) featuring stacked nanoparticles. By systematically tuning the iron coordination, the optimized HEA@KB demonstrates outstanding HER activity with low overpotentials of 12.

Super-resolution PET/CT radiomics nomogram for predicting spread through air spaces in stage I lung adenocarcinoma.

Background: Super-resolution (SR) reconstruction-based positron emission tomography (PET) imaging has been widely applied in the field of computer vision. However, their definitive clinical benefits have yet to be validated. Radiomics-based modeling provides an effective approach to evaluate the clinical utility of SRPET imaging.

Can Step-Based Metrics Predict Current and Future Health-Related Fitness and Patient-Reported Outcomes among Women Diagnosed with Breast Cancer?

Purpose: Wearable sensors that track physical activity in daily life may offer insights that help healthcare providers optimize care plans for individuals with cancer. Therefore, we examined the links between lower health-related fitness and worse patient-reported health and various step-based metrics.

Methods: The Alberta Moving Beyond Breast Cancer Study enrolled 1,528 women recently diagnosed with breast cancer and measured health-related fitness and patient-reported health outcomes near diagnosis, and one year later.

Hierarchical biomass-derived carbon framework with asymmetric ZnCo dual-atom pairs for synergistic polysulfide adsorption and catalysis in Lithium-sulfur batteries.

Lithium‑sulfur (LiS) batteries have recently attracted ever-increasing attention owing to their ultrahigh specific energy and substantial cost benefits of sulfur. However, the sluggish redox kinetics from the critical conversion of soluble long-chain lithium polysulfide to solid-state LiS remains a fundamental challenge. Herein, hierarchical porous nitrogen-doped carbon frameworks with asymmetric ZnCo dual-atom pairs (Zn-Co/NC) were successfully constructed using biomass-derived porous carbon as structural matrix through in situ growth and assisted pyrolysis strategy.

Comparative analysis of complete chloroplast genomes of and , two commonly used medicinal plants in southern China.

and , belonging to the genus , are ethnomedicinal plants that contain valuable medicinal and nutritional compounds. However, their medicinal materials are frequently confused in the Chinese medicinal materials market. Moreover, molecular genomic resources for this genus remain limited, which hinders phylogenetic studies.

An electrochemical immunosensor based on HFABP for the early detection of drug-induced cardiac toxicity from traditional Chinese medicines.

An electrochemical immunosensor was successfully developed for evaluating traditional Chinese medicine (TCM)-induced cardiac toxicity by immobilizing heart-type fatty acid-binding protein (HFABP)-specific antibodies on an electrode surface modified with chitosan (CS)-functionalized metal-organic framework ZIF-8 and gold nanoparticles (AuNPs). Leveraging the excellent biocompatibility of AuNPs, the excellent stability and high surface area of ZIF-8, along with the strong specific recognition capability of HFABP antibodies, the sensor demonstrated superior performance. Under optimized experimental conditions, it achieved an ultra-low detection limit of 7.

A novel high-pressure low-temperature interface shear apparatus: Mechanical behavior of interface between hydrate-bearing sediment and foundation structure.

Metastable hydrates are widely distributed in shallow deep-sea sediments, posing significant risks to the long-term stability of offshore foundation structures. Unveiling the weakening mechanisms at the hydrate-bearing sediment-structure interface is crucial for establishing a theoretical framework for the safe design of deep-sea structures. A high-pressure (up to 12.

Deep learning-based histomorphological subtyping and risk stratification of small cell lung cancer from hematoxylin and eosin-stained whole slide images.

Background: Accurate subtyping and risk stratification are imperative for prognostication and clinical decision-making in small cell lung cancer (SCLC). However, traditional molecular subtyping is resource-intensive and challenging to translate into clinical practice.

Methods: A total of 517 SCLC patients and their corresponding hematoxylin and eosin (H&E)-stained whole slide images (WSIs) from three independent medical institutions were analyzed.

Brain levels of the neurotransmitter γ-aminobutyric acid are reduced in people with HIV-related neuropathic pain.

Previous studies suggest a dysregulation of the inhibitory γ-aminobutyric acid (GABA) and the excitatory glutamate/glutamine (Glx) neurotransmitter systems in people living with chronic pain. Here, we test this hypothesis in people with HIV (PWH) on stable antiretroviral therapy, either with or without neuropathic pain (PWHpain and PWHnopain, respectively), and people without HIV and pain (Ctrl). Fourteen PWHpain (age, mean ± SD: 59 ± 6.

High-sensitivity and fast-response solar-blind photodetectors via band offset engineering for motion tracking.

Single-pixel imaging is emerging as a promising alternative to traditional focal plane array technologies, offering advantages in compactness and cost-effectiveness. However, the lack of solar-blind photodetectors combining fast-response and high-sensitivity has constrained their application in the deep ultraviolet spectrum. This work introduces a self-powered solar-blind photodetector based on a heterostructure comprising a GaO photosensitive layer, an AlN barrier layer, and an N-polar AlGaN:Si contact layer.

Epidemiological characteristics and environmental contamination of monkeypox in Beijing's Chaoyang district: Field evidence from 2023 to 2024.

Objectives: The mpox outbreak in Beijing's Chaoyang District after late May 2023, this study aims to evaluate the epidemiological characteristics and environmental contamination of this outbreak.

Methods: A field investigation was conducted to evaluate the epidemiological characteristics of mpox cases and their living environments in Chaoyang District, Beijing, between May 2023 and May 2024. Laboratory testing, epidemiological description, and statistical analysis were conducted subsequently.

Immune checkpoint inhibitors combined with anti-angiogenic therapy as second- or further-line treatment for small cell lung cancer: Efficacy, safety, and prognostic biomarkers.

Small cell lung cancer (SCLC) is an aggressive malignancy with limited treatment options, especially after failure of initial therapy. Immune checkpoint inhibitors (ICIs) and anti-angiogenic agents have emerged as promising options for relapsed SCLC. This observational study aimed to evaluate the effectiveness and safety of ICIs plus anti-angiogenic therapy for relapsed SCLC patients, and to identify potential prognostic indicators.

Pulse wave-driven machine learning for the non-invasive assessment of coronary artery calcification in patients with end-stage renal disease undergoing hemodialysis.

Background: Coronary artery calcification (CAC) represents a major cardiovascular risk in patients with end-stage renal disease (ESRD) undergoing hemodialysis. Given that radial artery pulse waveforms can reflect vascular status, this study aimed to evaluate their utility in the non-invasive assessment of CAC severity.

Methods: 58 patients with ESRD undergoing hemodialysis were enrolled.

Overexpression of Ent-Kaurene Synthase Genes Enhances Gibberellic Acid Biosynthesis and Improves Salt Tolerance in (Wall.) Lindl.

: (Wall.) Lindl. () was widely used in traditional Chinese medicine and also as a health food in China.

Enhancement of Foaming Performance of Oat Globulin by Limited Enzymatic Hydrolysis: A Study from the Viewpoint of the Structural and Functional Properties.

This study identified the optimal enzymatic treatment for improving the foaming characteristics of oat globulin, and alkaline protease was found to be the most effective enzyme. The impact of alkaline protease on the foaming properties and structural changes in oat globulin was explored. The results show that the foaming capacity of oat globulin hydrolysates is negatively correlated with surface hydrophobicity and positively correlated with the degree of hydrolysis.

ECR-MobileNet: An Imbalanced Largemouth Bass Parameter Prediction Model with Adaptive Contrastive Regression and Dependency-Graph Pruning.

The precise, non-destructive monitoring of fish length and weight is a core technology for advancing intelligent aquaculture. However, this field faces dual challenges: traditional contact-based measurements induce stress and yield loss. In addition, existing computer vision methods are hindered by prediction biases from imbalanced data and the deployment bottleneck of balancing high accuracy with model lightweighting.

YOLO-TPS: A Multi-Module Synergistic High-Precision Fish-Disease Detection Model for Complex Aquaculture Environments.

Fish are a vital aquatic resource worldwide, and the sustainable development of aquaculture is essential for global food security and economic growth. However, the high incidence of fish diseases in complex aquaculture environments significantly hampers sustainability, and traditional manual diagnosis methods are inefficient and often inaccurate. To address the challenges of small-lesion detection, lesion area size and morphological variation, and background complexity, we propose YOLO-TPS, a high-precision fish-disease detection model based on an improved YOLOv11n architecture.

Photoinduced EDA Complexes Enabled C3 (Hetero)arylation of Indoles Using Amine as a Transient Occupying Group.

Herein, an EDA complex enabled selective C3 (hetero)arylation of indole was established, utilizing morpholine as the transient occupying group. This protocol is efficient, sustainable, and exhibits excellent substrate compatibility and functional group tolerance. Mechanistic studies revealed the binding of morpholine to the C2 position of the indole cation radical plays a key role in forming the transient radical at the C3 position.

Adjuvant icotinib for resected EGFR-mutated stage II-IIIA non-small-cell lung cancer (ICTAN, GASTO1002): a randomized comparison study.

The efficacy, safety and ideal treatment duration of an adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for patients with resected EGFR-mutated non-small-cell lung cancer (NSCLC) were not known until 2014, when this study was initiated. In this phase 3 ICTAN trial (GASTO1002, NCT01996098), patients with completely resected, EGFR-mutated, stage II-IIIA NSCLC after adjuvant chemotherapy were assigned in a 1:1:1 ratio to receive icotinib (125 mg, three times daily) for 12 months, to receive icotinib for 6 months, or to undergo observation. The primary endpoint was disease-free survival (DFS).

Comparative Analysis of Hydrodynamic Performance for Flapping Hydrofoils Driven by Three Typical Transmission Mechanisms.

This study aims to optimize bionic hydrofoil propulsion performance and establish design guidelines for efficient transmission mechanisms by comparing three mechanisms (crank-slider, cylindrical cam, and synchronous belt drive). Through 3D modeling, virtual assembly, and ADAMS simulations, dynamic responses of slider displacement and driving force/torque were obtained, revealing that the crank-slider consumes the least energy, followed by the cylindrical cam, with the synchronous belt being the most energy-intensive. Further CFD analysis demonstrated that while the crank-slider generates drag intermittently, the cylindrical cam and synchronous belt sustain continuous thrust.