PEDUNCLE LENGTH 1 regulates wheat peduncle elongation through brassinosteroid signaling pathway.

This study identifies TaPL1, a MADS-box transcription factor underlying the QFiriti-6B QTL, as a key regulator of peduncle elongation in wheat. TaPL1 enhances brassinosteroid signaling through direct suppression of TaBKI1, and its loss-of-function alleles exhibit reduced plant height and peduncle length, but increased grain weight, offering valuable targets for yield improvement in wheat breeding.

Boron-Modified Heterointerface Boosts Kesterite Solar Cells to 0.58 V Open-Circuit Voltage.

Achieving high open-circuit voltage (V) continues to pose a significant challenge for kesterite CuZnSn(S,Se) (CZTSSe) solar cells, predominantly due to the pronounced charge carrier recombination occurring at heterointerface (HEI). To address this issue, an innovative non-metallic boron (B)-modification strategy is developed to optimize the HEI. The key advantages of this strategy are as follows: (i) Leveraging the strong bonding characteristic of B with three valence electrons, the dangling bonds on the absorber surface can be fully saturated, effectively passivating surface states without introducing new defects; (ii) Moreover, diffusion of B into the near-surface region of HEI during selenization process can create weak n-type B donor defects, which lowers the valence band maximum (VBM) of the absorber and mitigates Fermi level pinning.

Case Report: A patient with an empty sella accompanied by rare thyrotoxicosis.

Empty sella (ES) involves herniation of the pituitary fossa, leading to pituitary flattening. While typically associated with central hypothyroidism, its co-occurrence with hyperthyroidism is rarely reported and often overlooked. We report a rare case of hyperthyroidism in a patient with ES.

Spectro-Electrochemical Insights into Electrocatalytic CO Reduction in Acidic Media through Model Catalyst Design.

Electrocatalytic CO reduction (eCOR) under acidic conditions is the game changer of resourceful CO utilization owing to the alleviated carbon loss but faces severe competition from the hydrogen evolution reaction (HER) that greatly curtails the electric current efficiency. Leveraging the eCOR side of the teeterboard calls for a fundamental understanding of the triphasic electrode process involving a complex arrangement of electric double layers (EDLs). Herein, a series of model catalysts with tailored cavernous parameters are fabricated to geometrically and spectroscopically decipher the competing HER and eCOR processes that engage different proton sources.

RING-Between-RING-Type E3 Ligase Ariadne-Like Protein 8 Negatively Regulates Plant Virus Infection by Targeting a Viral Movement Protein.

The ubiquitin-proteasome system is a highly conserved machinery that plays a crucial role in plant defense against viruses. However, the number of E3 ligases targeting viral proteins remains limited. Although RING-between-RING (RBR)-type E3 ligases are evolutionarily conserved across organisms, their functions in plant responses to biotic stress remain largely unknown.

Prognostic Role of SOCS1 Mutations in Diffuse Large B-Cell Lymphoma.

Purpose: This study investigates the prognostic impact of SOCS1 mutations in diffuse large B-cell lymphoma (DLBCL) and explores the underlying biological mechanisms, focusing on immune regulation and cellular metabolism.

Materials And Methods: We included 2,590 DLBCL patients from 7 publicly databases (integrated cohort) and 202 additional DLBCL cases from our institution (JSPH cohort). Next-generation sequencing (NGS) was used to detect SOCS1 mutations in DLBCL patients.

Comparative Genomic Analysis of Tigecycline Resistance Development in Clinical Isolates.

Objective: This study investigated the mechanisms underlying the reduced tigecycline sensitivity of strains isolated from infected patients during antimicrobial therapy. The goal is to provide clinical insights into the development of tigecycline resistance in , with a focus on multidrug-resistant strains commonly associated with hospital-acquired infections.

Methods: We conducted dynamic tracking of multidrug-resistant (MDR-AB) infections in three patients to monitor changes in tigecycline sensitivity during antimicrobial therapy.

Hydrocarbothermal flow synthesis of carbon-supported small and dense high-entropy alloy nanoparticles as electrocatalysts.

Supported small and dense high-entropy-alloy nanoparticles (HEA-NPs) are promising functional materials for many applications. However, their synthesis remains a grand challenge because the extreme heating typically required to raise the entropic contribution to the formation of a solid solution unavoidably causes the sintering of HEA-NPs. Herein, we present a one-step continuous-flow spray pyrolysis strategy to synthesize multicomponent (from quinary to denary) HEA-NPs with an average size of <2 nanometers and metal loadings of ~30 wt% uniformly dispersed on various carbon substrates, including graphene and carbon black.

African swine fever virus pMGF505-9R enhances RIG-I-like Receptor signaling by promoting RING finger protein 125 auto-ubiquitination.

African swine fever (ASF) is a highly infectious disease that poses a significant threat to the global pig industry. Recent studies have demonstrated that the African swine fever virus (ASFV) infection can cause severe inflammatory responses and promote the production of cytokines, but it is still unclear whether the viral proteins play a role in this process. Therefore, we conducted a genome-wide screening by dual luciferase activity assay.

Radiation-sensitive circRNA promotes intestinal regeneration.

Background: The intestine is one of the most sensitive organs to ionizing radiation (IR), and radiation-induced intestinal injury (RIII) impacts the quality of life of patients undergoing radiotherapy. There are limited early diagnostic biomarkers and specific medicines clinically approved for RIII. Therefore, we sought to identify new theranostic targets to prevent RIII and to facilitate the reestablishment of the intestinal epithelium.

Molecular characterization and prognostic modeling associated with M2-like tumor-associated macrophages in breast cancer: revealing the immunosuppressive role of DLG3.

Background: M2-like tumor-associated macrophages (TAMs) promote an immunosuppressive microenvironment and contribute to tumor progression and metastasis. However, their molecular characterization and prognostic value have not been fully explored in the field of breast cancer.

Methods: Weighted gene co-expression network analysis (WGCNA) was used to identify modules significantly associated with M2-like TAMs.

Pulse wave-driven machine learning for the non-invasive assessment of coronary artery calcification in patients with end-stage renal disease undergoing hemodialysis.

Background: Coronary artery calcification (CAC) represents a major cardiovascular risk in patients with end-stage renal disease (ESRD) undergoing hemodialysis. Given that radial artery pulse waveforms can reflect vascular status, this study aimed to evaluate their utility in the non-invasive assessment of CAC severity.

Methods: 58 patients with ESRD undergoing hemodialysis were enrolled.

BST-2 Promotes N Protein Degradation and Inhibits Viral Replication Through the MARCHF8/NDP52 Autophagy Pathway.

Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a recently discovered enteric coronavirus that has caused considerable economic losses in the pig industry. SADS-CoV was first reported in 2017 in Guangdong Province, China, and subsequently in Fujian, Guangxi, Henan and Jiangxi Provinces. Bone marrow stromal cell antigen 2 (BST-2), also known as tetherin, acts as an antiviral protein to limit the release of a wide range of enveloped viruses.

Comparative Analysis of Structural Characterisation and Gel Properties of Blended/Co-Precipitated Soy-Pea Dual-Protein.

This study proposed a pH-driven co-precipitation strategy to overcome the limitations of traditional physical blending in functional improvement of a dual-protein system. The results demonstrated that, in comparison with the soy-pea blended protein (SPBP), the soy-pea co-precipitated protein (SPCP) showed a decrease in α-helix and β-sheet content, accompanied by in an increase in random coil structure. SPCP exhibited decreased fluorescence intensity, smaller particle size (from 392.

CD4 T Cell Subsets and as Novel Biomarkers of Immune Dysregulation in Dilated Cardiomyopathy.

Recent multiomics advancements have improved our understanding of immune dysregulation in dilated cardiomyopathy (DCM). However, specific immune cell subsets and their regulatory genes are still ambiguous. This study aimed to explore immune cell imbalances and regulatory genes in DCM, discover diagnostic biomarkers, and identify potential therapeutic targets.

The lncRNA Jpx participates in testosterone-induced H9c2 cell hypertrophy by targeting the miR-145-5p/Nfatc3 axis.

Cardiac hypertrophy is an adaptive cardiac response to overload. The ensuing decompensation eventually leads to heart failure or sudden death. Testosterone can induce cardiomyocyte hypertrophy, although the underlying mechanism has not been completely elucidated.

High-Safety Design of Organic Electrolytes for Sodium-Ion Batteries.

The pursuit of intrinsically safe sodium-ion batteries (SIBs) with high energy density has spurred significant research into developing nonflammable organic liquid electrolytes, given their wide electrochemical stability window and excellent compatibility with electrodes. As safety requirements grow increasingly stringent, electrolyte design must comprehensively address both internal risks such as dendrite growth, parasitic reactions, and high flammability, and external abuses including overcharging and short circuits. In this review, the critical role of electrolytes in suppressing thermal runaway in SIBs is systematically elucidated, and contemporary methodologies for electrolyte safety assessment are summarized.

Inhibition of PRC1 elicits immunogenic cell death by triggering ROS-dependent ER stress in colorectal cancer via the Wnt/β-catenin signaling pathway.

Due to the low response rate and severe side effects, the clinical efficacy of current immunotherapy for patients with colorectal cancer (CRC) remains unsatisfactory. Induction of immunogenic cell death (ICD) has been evidenced to be conducive to enhancing the survival benefit of immune checkpoint blockade (ICB) therapy. Protein regulator of cytokinesis 1 (PRC1) has been proven to be a tumor promoter in CRC and an immune marker.

High scattering sensitivity entropy imaging for breast tumor characterization and classification.

Background: Diagnosing and characterizing breast lesions and tumors remains a common challenge in clinical practice. Ultrasound imaging stands out for its safety, real-time capability, and affordability. However, the image quality of conventional ultrasound examination is limited, and the diagnosis of ultrasonographic images depends heavily on the experience of the sonographer.

CT derived myocardial extracellular volume predict major adverse cardiovascular events in patients with prostate cancer.

Background: Prostate cancer (PCa) patients with androgen deprivation therapy (ADT) are at high risk for cardiotoxicity and major adverse cardiovascular events (MACE). It is unclear whether the myocardial extracellular volume (ECV) derived from chest contrast-enhanced CT (CECT) can detect cardiotoxicity and predict MACE in these patients. This work aimed to assess the value of chest CECT derived myocardial ECV for detecting cardiotoxicity and the association of ECV with MACE in PCa patients receiving ADT.

The WRKY transcription factor RsWRKY28 mediates cadmium extrusion via activating RsPDR8 expression in radish (Raphanus sativus L.).

Cadmium (Cd) is a widespread dangerous pollutant for its toxic effects on plants and human beings. The uptake and accumulation of Cd from soil impedes taproot enlargement, thereby reducing yield, quality and safety of radish taproot. However, the molecular mechanisms and regulatory networks underlying Cd accumulation in radish remain unclear.

The influence of physical activity on emotional management ability in college students: a chain mediating role of psychological resilience and health literacy.

Objective: This study aimed to investigate the impact of physical activity (PA) on emotional management ability (EMA) in college students and to analyze the chain mediating roles of psychological resilience (PR) and health literacy (HL) in the relationship between PA and EMA.

Methods: Demographic information was collected using a stratified, cluster, and multi-stage sampling method. Data on PA, PR, HL, and EMA among college students were collected using an online questionnaire.

Long-range cholinergic input promotes glioblastoma progression.

Glioblastoma (GBM), the most aggressive primary brain tumor, is shaped by its integration into neural networks. While glutamatergic input is linked to tumor progression, the broader architecture and function of neuron-glioma connectomes remain unclear. Using monosynaptic rabies tracing, we map brain-wide neural input to patient-derived xenografts and reveal a consistent organizational logic: local inputs are primarily glutamatergic, while long-range connections exhibit diverse neurotransmitter profiles, with basal forebrain cholinergic projections emerging as a conserved input across sites.

Effects of water migration and grain structural evolution on substance dissolution and consistency variation during cooking of different foxtail millet varieties porridge.

Different millet varieties exhibit distinct porridge consistency, influencing consumer preferences. This study investigated water migration and grain structural evolution influencing solids leaching and consistency in five commercial foxtail millet varieties during cooking. Using texture analysis, low-field NMR, stereomicroscopy, and leaching assays, we quantified dynamic changes over a 40-min cooking period.