The systemic inflammatory response index as a risk factor for all-cause and cardiovascular mortality among individuals with coronary artery disease: evidence from the cohort study of NHANES 1999-2018.

Background: The association of systemic inflammatory response index (SIRI) with prognosis of coronary artery disease (CAD) patients has never been investigated in a large sample with long-term follow-up. This study aimed to explore the association of SIRI with all-cause and cause-specific mortality in a nationally representative sample of CAD patients from United States.

Methods: A total of 3386 participants with CAD from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 were included in this study.

BST-2 Promotes N Protein Degradation and Inhibits Viral Replication Through the MARCHF8/NDP52 Autophagy Pathway.

Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a recently discovered enteric coronavirus that has caused considerable economic losses in the pig industry. SADS-CoV was first reported in 2017 in Guangdong Province, China, and subsequently in Fujian, Guangxi, Henan and Jiangxi Provinces. Bone marrow stromal cell antigen 2 (BST-2), also known as tetherin, acts as an antiviral protein to limit the release of a wide range of enveloped viruses.

Crystal Phase Engineering of Carbon Nitride: Advances in Regulation Strategies and Photocatalytic Applications.

Crystal phase engineering emerges as a pivotal strategy to overcome the inherent limitations (e.g., structural defects, rapid charge recombination, and insufficient light absorption), plaguing conventional graphitic carbon nitride (g-CN) synthesized by thermal polymerization for photocatalysis.

Genetic Evidence for Causal Effects of Lipid-Lowering Drug Targets on Primary Sjögren's Syndrome Risk: A Mendelian Randomization Study.

Introduction: Primary Sjögren's Syndrome (pSS) is a chronic autoimmune condition affecting lacrimal and salivary glands. While previous studies suggest potential associations between dyslipidemia and autoimmune diseases, the causal relationship between lipid-lowering medications and pSS remains unclear.

Methods: This study employed drug-targeted Mendelian randomization (MR) analysis to assess the impact of lipid-lowering drugs on pSS risk, focusing on genetic targets including HMGCR, PCSK9, NPC1L1, APOB, CETP, and LDLR.

Metal-organic framework-mediated antioxidant enzyme delivery in disease treatment.

Excessive reactive oxygen species (ROS) induce oxidative stress (OS), resulting in biomolecular damage. ROS are closely linked to diseases such as inflammatory bowel disease (IBD), diabetes, and cancer. Antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and glucose oxidase (GOX) play crucial roles in alleviating OS by effectively reducing ROS levels through synergistic action.

Role of the PomiR171n-PoUGT89B2 module in regulating the petal senescence of tree peony.

Tree peony is a traditional and popular ornamental flower. However, its short and concentrated flowering period restricts the development of the tree peony industry. In this study, the function of the PomiR171n-PoUGT89B2 combination related to senescence regulation was analyzed, using Paeonia ostii 'Fengdan' (P.

Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.

Atrial fibrillation (AF) is a common cardiac arrhythmia with strong genetic components, yet its underlying molecular mechanisms and potential therapeutic targets remain incompletely understood. We conducted a cross-population genome-wide meta-analysis of 168,007 AF cases and identified 525 loci that met genome-wide significance. Two loci of PITX2 and ZFHX3 genes were identified as shared across populations of different ancestries.

Rational Design of Pyridinium Styryl Derivatives as PET Tracers for Cardiac Amyloidosis Imaging.

Cardiac amyloidosis (CA) is a complex restrictive cardiomyopathy, and while treatment options are advancing rapidly, specific diagnostic probes for CA have rarely been developed or reported. In this study, a series of pyridinium styryl derivatives were designed and synthesized, exhibiting specific affinity for immunoglobulin light chain protein amyloidosis (AL). Through a structure-activity relationship analysis and bioevaluations, [F] was identified as the first candidate for PET/CT imaging in rodents.

A robust single-antenna GNSS/MEMS fusion structure for reliable attitude determination in challenged environments.

This study proposes an innovative single-antenna GNSS/MEMS integrated attitude determination system designed to address the challenges of low accuracy and poor robustness in urban complex environments, where conventional multi-antenna GNSS systems and standalone MEMS sensors often fail due to signal obstructions and drift errors. The key innovations include: (1) a hybrid TDCP/TDPR (Time Difference Carrier Phase/Pseudo-Range) technique to enhance GNSS-derived pitch and heading estimation, significantly improving data utilization; (2) a multi-strategy quality control framework incorporating Zero Velocity Detection (ZVD), Magnetic Disturbance Detection (MDD), and Fault Detection and Exclusion (FDE) to suppress outlier contamination and ensure measurement reliability; and (3) an adaptive noise parameter tuning mechanism to optimize filter performance. Experimental results demonstrate that the proposed system outperforms conventional SPP/MEMS, standalone MEMS, and baseline GNSS/MEMS fusion methods, achieving CDF95 attitude errors of 1.

Study of the Function and Expression of the Promoter in .

Background: Cultivated peanut ( L.) is a major oil and economic crop. Pod size is one of the important agronomic traits of peanut variety, with a direct impact on peanut yield.

Efficacy and safety of shensong yangxin capsules for persistent atrial fibrillation: a Systematic Review and meta-analysis of randomized controlled trials.

Background: Shensong Yangxin (SSYX), a standardized Chinese preparation, is widely utilized in arrhythmia treatment. This research sought to assess the clinical advantages of SSYX for persistent atrial fibrillation (PsAF).

Methods: We searched seven databases and two registries to identify randomized controlled trials (RCTs) assessing SSYX as an adjunctive treatment for PsAF.

Retraction Notice to: HOXA5-miR-574-5p axis promotes adipogenesis and alleviates insulin resistance.

[This retracts the article DOI: 10.1016/j.omtn.

Porcine Teschovirus 2 3C Evades Host Antiviral Innate Immunity by Inhibiting the IFN-β Signaling Pathway.

Porcine teschovirus (PTV) circulates in pig populations, causing clinical diseases such as poliomyelitis, reproductive disorders, and pneumonia. However, the molecular mechanisms underlying the pathogenesis of PTV infection have not been fully elucidated. Here, we found that PTV infection does not activate the promoters of NF-κB or IFN-β.

Population Genomics, Virulence Traits, and Antimicrobial Resistance of Isolated in China.

is a significant zoonotic pathogen of public health importance. In this study, whole-genome sequencing of 177 isolates of , isolated from diseased swine across 15 provinces in China between 2017 and 2019, was performed. A total of 23 serotypes and 28 ST types were identified, with serotypes 2 and 3 comprising 50.

Feeding Behavior and Ecological Significance of in a Freshwater Reservoir: Insights from Prey Composition and Trophic Interactions.

This study investigates the feeding behavior and ecological role of in the Danjiangkou Reservoir, a crucial freshwater source in central China. Through in situ cultivation, microscopic examination, and amplicon sequencing analysis, we identified the primary food sources of within the reservoir's aquatic food web. Our results indicate that predominantly consumes zooplankton, specifically rotifers, copepods, and cladocerans, while phytoplankton is ingested less frequently and often remains undigested.

Finely Tuned, Meticulously Screened Renal-Clearable Zwitterionic Cyanine Dyes for Targeted NIR-II Tumor Detection, Intraoperative Navigation, and Dual-Color Imaging.

Achieving clear near-infrared-II (NIR-II, 1000-1700 nm) imaging requires dyes that selectively target tissues while clearing rapidly from nontarget areas to reduce background noise. Based on zwitterionic cyanine molecules, heteroatom substitutions (O, N, S) and bridging ring modification (hexene or pentene) were employed to fine-tune emission and brightness within the NIR-II range. The optimized dye, , demonstrated a large Stokes shift (70 nm), high brightness (692 M cm), rapid renal clearance, and excellent biocompatibility.

A β-glucosidase extracted from walnut ( regia L.) green husk induces human hepatoma cell apoptosis via ROS-mediated p53 and NF-κB pathway.

Walnut green husk is the outermost green peel of walnut, which contains multiple natural ingredients with a variety of biological activities. In this study, an anti-tumor protein called regia L. husk protein (JRLHP) was isolated.

Proteomics analysis and immune profiling reveal regulators of PD-L1 in oesophageal squamous cell carcinoma.

Background: Proteomics studies have advanced our comprehension of cancer biology, accelerated targeted therapy, and improved patient outcomes.

Methods: High-resolution mass spectrometry and immune profiling based on immunohistochemistry and multiple immunohistochemistry were employed to investigate proteomic and immune landscapes in oesophageal squamous cell carcinoma (ESCC) and explore the regulators of PD-L1 in ESCC. Molecular validation was performed using qRT-PCR, western blotting, and in vitro functional assays.

A Unique Amino Acid, Se-Met, Regulates Autophagy and Inflammation in Infection in Mice through the PAK1/Akt1/mTOR and NF-κB Signaling Pathway.

is a prevalent opportunistic pathogen that poses significant clinical challenges due to its diverse virulence factors and complex resistance mechanisms. Thus, exploring novel drugs against bacterial infections is critical. Here, we report that a unique selenium-containing amino acid (Selenomethionine) has potential for inhibiting infections through in vitro experiments.

Rutin ameliorates LPS-induced acute lung injury in mice by inhibiting the cGAS-STING-NLRP3 signaling pathway.

Introduction: Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), represent critical respiratory failures with high mortality rates and limited treatment options. While the flavonoid rutin exhibits documented anti-inflammatory and antioxidant properties, its therapeutic mechanisms in ALI/ARDS remain unclear. This study investigated rutin's efficacy against lipopolysaccharide (LPS)-induced ALI in mice, with a mechanistic focus on the cGAS-STING pathway and NLRP3 inflammasome activation.

Research Progress on Traditional Chinese Medicines Reversing Multidrug Resistance and Mechanisms in Lung Cancer.

Lung cancer continues to be a primary contributor to cancer-related deaths globally, and multidrug resistance (MDR) poses a significant obstacle in its management. Traditional Chinese medicines (TCMs), recognized for their comprehensive therapeutic strategies and low incidence of adverse effects, have garnered attention due to their capacity to mitigate MDR in cancer cells. Nevertheless, deciphering the precise mechanisms through which TCMs reverse MDR in lung cancer presents a substantial scientific challenge.

A Raf-Like MAPKKK Gene TaHT1 Controls Drought Tolerance and Primary Root Length in Wheat.

Wheat (Triticum aestivum L.) is one of the world's staple food crops, but it often suffers from water shortages during the growing season. Mitogen-activated protein kinase kinase kinases (MAPKKKs) are the critical signaling modules in plant drought response signaling pathways.

Precision Nanoconfined Self-Assembly of ACQ Carbon Dots for Enhanced Solid-State Fluorescence.

Carbon dots (CDs) are promising fluorescent nanomaterials, however, they are often hindered by aggregation caused quenching (ACQ) in solid-state application because of close π-π stacking interactions. Furthermore, the challenges still exist in the development of CDs-based solid-state fluorescent materials with stable structure and high fluorescence intensity. To address this challenge, a general and robust polymer directed nanoconfined self-assembly strategy is developed, enabling the fabrication of regular morphology, structurally ultra-stable and solid-state fluorescent CDs assemblies using hydrophilic star-liked di-block copolymer unimolecular micelles as templates.

A spontaneous nonhuman primate model of inherited retinal degeneration.

Inherited retinal degenerations (IRDs) are important causes of progressive, irreversible blindness. Hereditary macular diseases, in particular, are significant in their effect on the specialized, central cone photoreceptor-rich macula responsible for high resolution vision. Autosomal dominant Best vitelliform macular dystrophy (BVMD), caused by variants in the BEST1 gene, is one of the most common inherited macular dystrophies.

Enhancing the efficiency of coagulation method for sewage treatment by adding sludge.

The high performance sedimentation tank (HPST) is an efficient water treatment technology, which accelerates the settling rate of flocculates by adding sludge, so as to increase the water treatment load of coagulation sedimentation tank. Its sewage treatment effect is affected by many factors such as sludge dosage, wastewater pH, flocculant dosage, stirring time, settling time, etc. This paper was to study the optimal conditions of HPST, first, some single-factor tests were conducted to preliminarily explore the optimal range of influencing factors, and then response surface methodology (RSM) tests were performed to accurately determine the optimums of significant factors.