Emotion regulation and perceptions of academic stress as key predictors of academic motivation in second language learning.

Motivation, as a driving force of human behavior, is influenced by various psychological factors. Among these, emotion regulation and perceptions of academic stress have received limited attention in the context of second language learning. This study examines the interplay between emotion regulation, perceptions of academic stress, and academic motivation among university students in China who are learning English as a second language.

Regulation of immune responses by a tumor necrosis factor in pearl oysters: insights from gene expression and function.

Tumor necrosis factor (TNF) is a multifunctional cytokine that regulates cellular processes such as inflammation, apoptosis, differentiation, and proliferation and activates various functions of the immune system. This article reports the discovery and characterization of a novel tumor necrosis factor gene in the pearl oyster , which is named . The deduced PmTNF protein sequence displays the typical structural characteristics of a TNF domain, and phylogenetic analysis of the sequences of PmTNF and its putative orthologs shows that they conform to the current taxonomy.

Role of the PomiR171n-PoUGT89B2 module in regulating the petal senescence of tree peony.

Tree peony is a traditional and popular ornamental flower. However, its short and concentrated flowering period restricts the development of the tree peony industry. In this study, the function of the PomiR171n-PoUGT89B2 combination related to senescence regulation was analyzed, using Paeonia ostii 'Fengdan' (P.

Stem cell secretome armed magneto-actuated micromotors as spatio-temporal manipulators for wound healing acceleration.

Healing complex wounds, especially deep injuries, requires therapies that can target different healing phases while penetrating physical barriers like fibrin clots and scab. Existing approaches fail to fully address these spatiotemporal challenges due to reliance on passive drug diffusion. Here, we develop magnetic microspheres loaded with therapeutic factors derived from stem cells (collectively called the "secretome") to actively guide wound repair.

nNOS-expressing neurons in the mPFC mediate depression-related behaviors in mice through pPVT-mPFC projections.

Depression is one of the most common mental disorders, but its etiology remains poorly understood. Neuronal nitric oxide synthase (nNOS) has been implicated in depression, but the role of nNOS-expressing neurons is still unknown. We used chemogenetic strategies to show that nNOS-expressing neurons in the medial prefrontal cortex (mPFC) are essential for depression-related behaviors.

A comparative study of doctor's meaning construction in diagnostic discourse with different degrees of patient satisfaction: A review.

Drawing on the theory of ideational meaning construction in Systemic Functional Linguistics, and using 22,945 words of 4 doctor's outpatient doctor-patient interaction as its data resource, the paper makes a comparative analysis of doctors' meaning construction in their diagnostic discourse via transitivity system employed by doctors with higher patient satisfaction and those with lower patient satisfaction. The results show that doctors with higher patient satisfaction choose more behavioral process, attribute and extent, in the process type, participants, and circumstantial elements respectively, indicating they pay more attention to the detailed information of the disease and patients' daily life in order to give more accurate diagnosis and relieve the pressure of the patients. By contrast, doctors with lower patient satisfaction employ fewer behavioral process, more goal, and more manner, cause and contingency, suggesting they pay less attention to patients' condition and the degree of patients' acceptance and participation, instead emphasizing their authority in medicine and the way of treatment.

Reliability of Matrix-Assisted Laser Desorption-Ionisation Time-of-Flight Mass Spectrometry as a Method for Drug-Resistant Tuberculosis Gene Identification.

Instances of drug-resistant tuberculosis (TB), particularly multidrug- and extensive drug-resistant TB, are escalating worldwide; therefore, there is an urgent need to explore suitable treatment strategies. This study assessed the precision of matrix-assisted laser desorption-ionisation time-of-flight mass spectrometry (MALDI-TOF MS) in detecting drug-resistant TB. We developed a multiplex MALDI-TOF MS detection assay that concurrently identifies 51 gene mutations for six commonly used medications: rifampicin (RFP), isoniazid (INH), levofloxacin (LVX), moxifloxacin (MOX), capreomycin (CPM) and amikacin (AMK).

A Biomimetic Sweeping Microrobot for Active Therapy of Ulcerative Colitis.

Overproduction of pathogenic cell-free DNA (cfDNA) and reactive oxygen species (ROS) plays crucial roles in the onset and perpetuation of ulcerative colitis (UC). Inspired by sweeping robots, a magnesium@polylactic acid-glycolic acid copolymer@polyethylenimine (Mg@PLGA@PEI) microswimmer capable of cleaning off deleterious disease triggers along its path of progress is designed. Mg@PLGA@PEI is successfully synthesized by adopting a core-shell structure with a small opening which allows for Mg-water reaction.

Dendritic cell-based microrobots for enhanced systemic antigen-specific immune tolerance.

Current immunotherapeutic approaches for autoimmune disorders primarily rely on the use of generalized immunosuppressive medications. However, most immune drugs and tolerogenic immunomodulators are insufficient on their own to establish antigen-specific immunological tolerance (ASIT). Therefore, steering antigen-presenting cells (APCs) towards a tolerogenic state with minimal risk of broad immune suppression may be an effective approach.

Correction: Strategies for the detection of site-specific DNA methylation and its application, opportunities and challenges in the field of electrochemical biosensors.

Correction for 'Strategies for the detection of site-specific DNA methylation and its application, opportunities and challenges in the field of electrochemical biosensors' by Chenliu Ye , , 2024, , 5496-5508, https://doi.org/10.1039/D4AY00779D.

Expression and antimicrobial characterization of rhamnose-binding lectin in Pinctada fucata martensii.

Rhamnose-binding lectins (RBLs) are key components of pattern recognition molecules involved in pathogen clearance during non-specific immune responses and play an important role in the immune response of Mollusca. Pinctada fucata martensii is an essential species for artificial seawater pearl cultivation in China. With the increasing pollution of seawater, the study of the immune function of P.

Farnesylthiosalicylic Acid Through Inhibition of Galectin-3 Improves Neuroinflammation in Alzheimer Disease via Multiple Pathways.

Aims: Many factors affect the neuroinflammatory response in patients with Alzheimer disease (AD). Galectin-3 (Gal-3) is closely related to microglial activation in the nervous system and can promote the aggregation of cancer cells in tumors. This study aimed to investigate the mechanism by which farnesylthiosalicylic acid (FTS) affects neuroinflammation in Aβ mice through Gal-3.

Biotechnology and Genomic Approaches to Mitigating Disease Impacts on Forest Health.

Outbreaks of insects and diseases are part of the natural disturbance regime of all forests. However, introduced pathogens have had outsized impacts on many dominant forest tree species over the past century. Mitigating these impacts and restoring these species are dilemmas of the modern era.

Strategies for the detection of site-specific DNA methylation and its application, opportunities and challenges in the field of electrochemical biosensors.

DNA methylation is an epigenetic modification that plays a crucial role in various biological processes. Aberrant DNA methylation is closely associated with the onset of diseases, and the specific localization of methylation sites in the genome offers further insight into the connection between methylation and diseases. Currently, there are numerous methods available for site-specific methylation detection.

Integrating histology and phytohormone/metabolite profiling to understand rooting in yellow camellia cuttings.

Vegetative propagation through cutting is a widely used clonal approach for maintaining desired genotypes. However, some woody species have difficulty forming adventitious roots (ARs) with this approach, including yellow camellia (YC) C. nitidissima.

Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders.

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system.

Phosphoproteomics changes due to allograft-induced stress responses of Pinctada fucata martensii.

Protein phosphorylation modifications are post-translational modifications (PTMs) that play important roles in signal transduction and immune regulation. Implanting a spherical nucleus into a recipient shellfish is critical in marine pearl aquaculture. Protein phosphorylation may be important in the immune responses of Pinctada fucata martensii after nucleus implantation, but their involvement in regulation remains unclear.

Defence mechanisms of Pinctada fucata martensii to Vibrio parahaemolyticus infection: Insights from proteomics and metabolomics.

Survival of pearl oysters is not only challenged by coastal pollution, but also pathogen infection that may eventually incur substantial economic losses in the pearl farming industry. Yet, whether pearl oysters can defend themselves against pathogen infection through molecular mechanisms remains largely unexplored. By using iTRAQ proteomic and metabolomic analyses, we analysed the proteins and metabolites in the serum of pearl oysters (Pinctada fucata martensii) when stimulated by pathogenic bacteria (Vibrio parahaemolyticus).

Developing Computerized Adaptive Testing for a National Health Professionals Exam: An Attempt from Psychometric Simulations.

Introduction: The accurate assessment of health professionals' competence is critical for ensuring public health safety and quality of care. Computerized Adaptive Testing (CAT) based on the Item Response Theory (IRT) has the potential to improve measurement accuracy and reduce respondent burden. In this study, we conducted psychometric simulations to develop a CAT for evaluating the candidates' competence of health professionals.

Glutamate-releasing BEST1 channel is a new target for neuroprotection against ischemic stroke with wide time window.

Many efforts have been made to understand excitotoxicity and develop neuroprotectants for the therapy of ischemic stroke. The narrow treatment time window is still to be solved. Given that the ischemic core expanded over days, treatment with an extended time window is anticipated.

A complete chloroplast genome of a traditional Chinese medicine herb, , and phylogenomics of Rubiaceae.

Unlabelled: Diels is endemic to southwestern China and belongs to the family Rubiaceae. It is used in traditional Chinese medicines. To enrich the genetic data and resolve Rubiaceae's phylogeny, we assembled a complete chloroplast (cp) genome of using Illumina HiSeq reads.

Factors affecting physicians' attitudes towards patient-centred care: a cross-sectional survey in Beijing.

Objectives: Patient-centred care has been raised as an important component in providing high-quality healthcare services. This research aims to measure physicians' attitudes towards patient-centred care in Chinese healthcare settings and to identify the sociodemographic predictors of their attitudes using an exploratory research design.

Design: A cross-sectional survey.

Adaptive particle patterning in the presence of active synthetic nanomotors.

For the maintenance of a biological system, spatial organization of material condensates within the cell through the dissipation of energy is crucial. Besides directed transport microtubules, material arrangement can be achieved motor protein facilitated adaptive active diffusiophoresis. For example, the distribution of membrane proteins during the cell division of is affected by the MinD system.