Correction: Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024.

[This corrects the article DOI: 10.3389/fonc.2025.

PD-1 and LAG-3 were optimal combination of immune checkpoints for predicting poor clinical outcomes of patients with ovarian cancer.

Background: Although immune checkpoint blockade (ICB) therapy has transformed the therapeutic landscape for ovarian cancer (OC), the predictive utility of immune checkpoint (IC) expression signatures in stratifying clinical outcomes requires further systematic interrogation.

Methods: Transcriptomic profiles from 147 OC patients within The Cancer Genome Atlas (TCGA) cohort were interrogated to assess the prognostic significance of ICs. These genomic findings were subsequently validated through immunohistochemical analysis of an independent institutional cohort comprising 74 OC tissue specimens.

Nano-Biosensors for mRNA-Based Cell Sorting Using Intracellular Markers at the Early Stage of Cell Reprogramming.

Cell reprogramming and manufacturing have broad applications in tissue regeneration and disease treatment. However, many derived cell types lack unique cell surface markers for protein-based cell sorting, making it difficult to isolate these cells from mixed populations. Additionally, there is a need to identify and isolate cells of interest at the early stages of cell expansion.

Studies of speckle contrast imaging based on an improved laser speckle imaging method.

Significance: Laser speckle contrast imaging (LSCI) is widely used for intraoperative blood flow monitoring, but traditional methods have limitations in imaging low blood flow velocities and small vessels. An improved LSCI method, termed the fluent imaging technique, is proposed to enhance imaging sensitivity and accuracy, providing real-time and high-resolution blood flow assessment for neurosurgical applications.

Aim: We aim to validate the performance of the fluent imaging technique in imaging small vessels with low blood flow velocities and assess its application in cerebrovascular surgical procedures, including carotid artery clamping, reperfusion, and ferric chloride -induced thrombosis.

Metabolomics reveals key biomarkers for ischemic stroke: a systematic review of emerging evidence.

Objective: To systematically collate and evaluate metabolomics-based biomarkers of ischemic stroke (IS) to guide clinical diagnosis and treatment.

Methods: Comprehensive literature searches were conducted in PubMed, Embase, and Web of Science using "IS" and "metabolomics" as core keywords, covering publications up through February 2024. Any original metabolomic research related to IS was selected.

Therapeutic targeting of Nrf2/HO-1/NF-κB signaling axis with casticin mitigates intervertebral disc degeneration: in vitro and in vivo investigations.

As a persistent osteoarticular degenerative condition, intervertebral disc deterioration (IDD) has been established as a principal causative element in lumbar spine discomfort development. The present investigation seeks to assess the protective effects of casticin against IDD progression and elucidate associated molecular pathways. The CCK8 kit was used to assess the cytotoxicity of casticin on rat nucleus pulposus cells (NPCs).

Correction: Radiotherapy has a survival advantage over surgery in patients with choroidal melanoma: a retrospective cohort study of 6,871 patients.

[This corrects the article DOI: 10.3389/fsurg.2025.

2D Cuprous Halide Scintillator with Dual Excitation-Dependent and Thermochromic Luminescence toward Multifunctional Optoelectronic Applications.

Excitation- and temperature-dependent multicolor luminescent materials are valuable in advanced optoelectronic devices while they haven't been realized in 2D metal halides owing to the restrictions of Kasha's rule. Herein, we reported a novel 2D lead-free halide of (AMP)CuBr (AMP = N-aminomorpholine) through structural engineering, in which the [CuBr] layer is composed of corner- and edge-shared [CuBr] tetrahedron. The non-centrosymmetric structure enables (AMP)CuBr to exhibit an impressive second-harmonic generation signal of ≈0.

Prognostic value of FIB-4 and NFS for cardiovascular events in patients with and without NAFLD.

Background: The association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) is well studied. Liver fibrosis is the main histopathologic manifestations of NAFLD. However, whether concomitant NAFLD influence the association of non-invasive liver fibrosis scores with CVD remains unclear.

Understory living grass mulch improves soil fertility, fruit yield and quality.

Background: Given the vulnerability of bare soils to degradation, living grass mulch is increasingly adopted to sustain soil health and improve fruit yield and quality.

Results: In this study, we conducted a meta-analysis based on 93 peer-reviewed publications to quantitatively assess the effects of living grass mulch on soil physicochemical properties, microbial communities, enzyme activities, and fruit productivity. Our results found that living grass mulch increased soil organic matter (+24.

Clinical and Safety Outcomes of Edaravone Dexborneol in Acute Ischemic Stroke: A Multicenter, Prospective, Cohort Study.

Background And Objectives: Although edaravone dexborneol, a multitarget cytoprotective drug, has demonstrated benefits in previous clinical trials, its actual clinical efficacy and safety in patients with acute ischemic stroke (AIS) remain unclear. This study aimed to test the hypothesis that edaravone dexborneol is associated with better outcomes in patients with AIS in real-world clinical practice.

Methods: We conducted a prospective, multicenter, real-world cohort study at 72 centers in China from January 14 to July 4, 2023.

Regulation of immune responses by a tumor necrosis factor in pearl oysters: insights from gene expression and function.

Tumor necrosis factor (TNF) is a multifunctional cytokine that regulates cellular processes such as inflammation, apoptosis, differentiation, and proliferation and activates various functions of the immune system. This article reports the discovery and characterization of a novel tumor necrosis factor gene in the pearl oyster , which is named . The deduced PmTNF protein sequence displays the typical structural characteristics of a TNF domain, and phylogenetic analysis of the sequences of PmTNF and its putative orthologs shows that they conform to the current taxonomy.

Influencing factors and clinical value of anti-aquaporin-4 antibody in cerebrospinal fluid: a study of 82 patients with neuromyelitis optica spectrum disorder.

Objective: Serum AQP4 antibody (AQP4-IgG) is the causative antibody of neuromyelitis optica spectrum disorder (NMOSD) but AQP4-IgG in cerebrospinal fluid (CSF) has been seldom studied. We aimed to explore the clinical value and influencing factors of CSF AQP4-IgG in NMOSD.

Methods: In this study, we screened 137 patients with NMOSD diagnosed according to the 2015 International Consensus Diagnostic Criteria (IPND criteria).

Nomogram for Predicting Postoperative Major Bleeding in Percutaneous Nephrolithotomy: A Retrospective Study.

Background And Objective: The aim of this study was to develop a nomogram for estimating the risk of postoperative major bleeding in patients who underwent surgery for percutaneous nephrolithotomy.

Methods: This retrospective study included 493 patients who had undergone unilateral percutaneous nephrolithotomy for kidney calculi at Third Xiangya Hospital from January 2022 to June 2024. Patients were temporally divided into a training set (the first 70% of treated patients) and a validation set (the last 30%).

OseR, a bacterial redox sensor, regulates ergothioneine uptake via a Cys thiol switch, enhancing oxidative stress resistance and virulence.

Ergothioneine (ET), a low-molecular-weight (LMW) thiol, serves as a potent antioxidant. While only a limited number of Actinomycetes and fungi can synthesize ET, most microorganisms acquire it from external sources. Recently, a microbial ET transporter system (EtUV) was identified in Helicobacter pylori and Streptococcus pneumoniae, but the regulatory mechanisms controlling EtUV in bacteria remain unknown.

BTG1 Mutation Correlates with Inferior Prognosis in Diffuse Large B-Cell Lymphoma.

Purpose: B celltranslocation gene 1 (BTG1) is a highly conserved gene and recurrently mutated in the MCD subtype of diffuse large B-cell lymphoma (DLBCL). The specific enrichment of BTG1 mutation (BTG1mut) raises a potential hypothesis that they may actively contribute to DLBCL. However, the biological characteristics and prognostic significance of BTG1 in DLBCL remain to be explored.

Clinical efficacy of surgically assisted transjugular intrahepatic portosystemic shunt for cavernous transformation of portal vein.

Background: Transjugular intrahepatic portosystemic shunt (TIPS) is contraindicated for patients with cavernous transformation of the portal vein (CTPV) due to high surgery-related mortality risk. However, surgically assisted TIPS (SATIPS) can significantly reduce the risk.

Aim: To evaluate the clinical efficacy of SATIPS, this study was conducted.

Metformin activates autophagy and inhibits apoptosis and fetal heart abnormalities via the Dnmt3l/Usp18/STAT1 pathway.

Gestational diabetes mellitus (GDM) is an important risk factor for developing congenital heart disease (CHD). It is urgent to find therapeutic drugs that reduce blood glucose and protect patients from CHD. In this study, rat models of type 1 (intraperitoneal injection with 50 mg/kg streptozocin) and type 2 (high fat/high sugar diet for 5 weeks plus 28 mg/kg streptozocin) gestational diabetes were established.

PTPN2 Inhibition Disrupts Mitochondrial Renewal and Blocks TFRC-Mediated Mitophagy to Exert Anti-Tumor Activities in ALK-Positive Anaplastic Large Cell Lymphoma.

Anaplastic large cell lymphoma (ALCL) is a heterogeneous subtype of T-cell lymphoma usually driven by genetic alterations affecting the anaplastic lymphoma kinase (ALK) gene. Despite the relatively favorable prognosis of ALK-positive (ALK) ALCL, approximately 30-40% of patients experience relapses or disease progression. This work identifies protein tyrosine phosphatase PTPN2 as a critical gene essential for the growth and survival of ALK ALCL by CRISPR/Cas9 editing.

Novel quantitative analysis of relative peripheral refraction changes in orthokeratology and their relationship with one-year axial elongation.

Purpose: To investigate changes in relative peripheral refraction (RPR) and their associations with axial length (AL) growth after one year of orthokeratology (ortho-k) therapy.

Methods: This prospective cohort study included 60 myopic children aged 8-15 years. RPR and AL were measured at baseline and 12 months after ortho-k therapy.

How to Implement Advance Care Planning for People With Dementia: A Scoping Review.

Background: Advance care planning for people with dementia is an important process to ensure that patient preferences are respected throughout disease progression. However, the complexity of advance care planning and the challenges in effective communication hinder its implementation. The lack of clear procedural guidance for health care teams and the limited research on practical issues such as building trust and resolving conflicts further complicate this process.

Effects of regular exercise on blood rheology.

Regular physical activity (RPA) promotes cardiovascular health but its effects on blood flow and rheology characteristics remain unclear. This study compared hemorheological parameters between healthy adults who regularly jogged (n = 35) and sedentary controls (n = 35). Participants in the RPA group showed significantly lower fibrinogen levels, C-reactive protein concentrations, blood viscosity, plasma viscosity, and red blood cell aggregation (all p < 0.

Spatial-temporal evolution and associated factors of older adult care institutions in Shanghai.

Background: Shanghai is one of the first Chinese cities to tackle the challenges presented by an aging population. In response, the city has been actively seeking solutions for older adult care within a metropolitan context. This study is based on data from 1,272 older adult care institutions in Shanghai.

Three-dimensional surface deformation field monitoring and influencing factors analysis in mountainous areas based on SBAS-INSAR technology (Tianjin, China).

Synthetic aperture radar interferometry (InSAR) technology has emerged as a critical methodology for disaster reduction and prevention, offering unprecedented all-weather operational capabilities and extensive spatial coverage that effectively address the limitations of traditional detection methods. Despite the inherent challenges of temporal and spatial coherence in conventional time-series InSAR approaches, the small baseline subset InSAR (SBAS-InSAR) technique presents a sophisticated solution by significantly mitigating coherence-related uncertainties and enhancing measurement precision. While existing research predominantly focuses on urban environments, this study uniquely addresses the research gap in mountainous terrain deformation monitoring by utilizing Sentinel-1A and 1B single-look complex (SLC) data from ascending and descending orbits between January 2018 and May 2022.