Hard-Template Synthesis of Inverse Opal Macroporous NiO-SnO Heterojunction for Enhanced Acetone Detection.

Chemiresistive gas sensors have emerged as a promising technology for gas detection, due to their real-time response, low costs, high sensitivity, excellent stability, and facile fabrication. However, the full realization of their potential is currently constrained by the scarcity of sensing materials capable of delivering high selectivity and ultrafast response. In this study, we prepared a three-dimensional inverse opal macroporous SnO doped with NiO (3DIO NiO-SnO).

Multi-tracer PET and MR imaging visualize distinct metabolic and inflammatory profiles in the white matter of NMOSD and MOGAD.

This study investigates distinct neuroinflammatory patterns in neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) using multi-tracer PET and MR imaging. Eight NMOSD (5F/3M; median age 36.5) and six MOGAD patients (2F/4M; median age 34.

Protein Marker-Dependent Drug Discovery Targeting Breast Cancer Stem Cells.

Breast cancer is one of the most common cancers globally. Unfortunately, many patients with breast cancer develop resistance to chemotherapy and tumor recurrence, which is primarily driven by breast cancer stem cells (BCSCs). BCSCs behave like stem cells and can self-renew and differentiate into mature tumor cells, enabling the cancer to regrow and metastasize.

Alleviating the Kinetic Hindrance of Ni-Rich Single-Crystal Cathode Materials Driven by Local Structural Realignment.

Crack-free Ni-rich single-crystal cathodes exhibit exceptional stability; however, they encounter challenges pertaining to kinetic hindrance, low capacity, and low initial Coulombic efficiency. Herein, we present a melt infiltration-dispersion method for synthesizing a small-sized single-crystal LiNiCoMnO (N90-SC) material at lower temperatures, enabling kilogram-scale production. The inclusion of low-melting LiOH-LiSO eutectic salt enhances uniform mass and heat transfer while penetrating the grain boundaries of secondary particles, thereby inhibiting particle growth and resulting in small single crystals after washing.

Chlorocatechol-functionalized gelatin nanoparticles as a hemostatic agent with antimicrobial properties.

Hemorrhage is one of the leading preventable causes of death associated with trauma, which is often complicated by wound infection. Current hemostatic materials are not ideal and lack antimicrobial properties needed for infection prevention. Here, we tested the feasibility for 6-chlorodopamine-functionalized gelatin (GDC) nanoparticles to function as a hemostatic powder with strong tissue adhesion and antibacterial properties.

Characteristics and risk factors for medical malpractice among obstetric and gynecologic physicians in China.

Background: Limited information is available on malpractice claims against obstetricians and gynecologists in China. This study identifies risk factors associated with malpractice and explores the correlation between the hospital characteristics and medical errors in obstetrics and gynecology.

Methods: This observational study analyzed all obstetric and gynecologic malpractice claims submitted to the Chinese Medical Association (CMA) from 2016 to 2023.

Global, regional, and National burdens of cervical spinal cord injuries from 1990 to 2021, findings from global burden of disease study 2021.

Background: Spinal cord injuries (SCI) are major contributors to global disability, with high incidence rates, substantial medical costs, and profound long-term impacts. Cervical spinal cord injuries (cSCI), in particular, lead to severe outcomes, making them a critical public health challenge. While the rising global burden of SCI, including cSCI, is well-known, comprehensive and updated epidemiological studies specifically focused on cSCI, especially those that project future trends and analyze regional disparities, remain limited.

Drug resistance among students with pulmonary tuberculosis: a study based on screening in Henan, China.

Background: Tuberculosis (TB) can easily spread among students and can lead to an outbreak once there is an infection in a school. Outbreaks of drug-resistant TB (DR-TB) in schools have occasionally been reported, but the profile of DR-TB in students in a province has rarely been described. This study was conducted to determine the prevalence of DR-TB and factors associated with it in students in Henan Province, China.

Unlocking the secret of glioblastoma multiforme: the role of lactylation in tumor progression, drug resistance and immune microenvironment.

Background: Glioblastoma multiforme (GBM), the most prevalent and lethal type of brain cancer, is characterized by a poor prognosis despite advancements in comprehensive treatments, including surgery, chemotherapy, and radiotherapy. Lactylation, an emerging epigenetic modification, has been shown to influence the biological behavior of tumor cells; however, its role in GBM remains to be further elucidated.

Methods: In this study, we analyzed the relationship between lactylation-related genes (LRGs) and malignant biological behavior, temozolomide resistance, and the immune microenvironment of GBM using scRNA-seq data from public databases.

Wearable Ultrasound Technology in Health Monitoring and Therapy: Technological Innovations, Differentiated Applications, and Future Directions.

Ultrasound technology plays a pivotal role in health monitoring and management by virtue of its noninvasiveness, real-time imaging capability, and deep tissue penetration. As the frontier in ultrasound imaging and therapeutic applications, wearable ultrasound overcomes the limitations of conventional ultrasound devices, which are bulky and require operation by a professional. These advantages broaden its potential for use in mobile health monitoring and personalized therapy.

Efgartigimod following plasma exchange in the treatment of subjects with generalised myasthenia gravis: study protocol for a multicentre, three-arm, open-label study.

Introduction: Myasthenia gravis (MG), an IgG-mediated autoimmune disorder targeting neuromuscular junctions, shows refractory in 12-20% of generalised MG (gMG) patients despite immunotherapies. Plasma exchange (PLEX) transiently depletes pathogenic mediators, while neonatal Fc receptor antagonists (eg, efgartigimod) offer novel therapeutic potential. Both PLEX and efgartigimod require adjunctive non-steroidal immunosuppressive therapy (NSIST) for sustained remission.

Influencing factors and clinical value of anti-aquaporin-4 antibody in cerebrospinal fluid: a study of 82 patients with neuromyelitis optica spectrum disorder.

Objective: Serum AQP4 antibody (AQP4-IgG) is the causative antibody of neuromyelitis optica spectrum disorder (NMOSD) but AQP4-IgG in cerebrospinal fluid (CSF) has been seldom studied. We aimed to explore the clinical value and influencing factors of CSF AQP4-IgG in NMOSD.

Methods: In this study, we screened 137 patients with NMOSD diagnosed according to the 2015 International Consensus Diagnostic Criteria (IPND criteria).

HADHA-mediated regulation of JAK/STAT3 signaling in glioblastoma: a metabolic-epigenetic axis.

Glioblastoma multiforme (GBM) is one of the most aggressive forms of brain cancer, characterized by rapid growth and resistance to conventional therapies. This study investigates the role of HADHA, a key enzyme in fatty acid β-oxidation, in the progression of GBM. we show that the overexpression of HADHA in GBM correlates with a poor prognosis in patients and plays a role in promoting tumor growth and invasion.

Local Distortion Balancing Entropy-Enthalpy Compensation for Fast Li Migration in Garnet Solid-State Electrolytes.

Pivoting toward high-safety solid-state batteries, garnet-type solid-state electrolytes (SEs) with 3D ion transport channels are highly promising candidates. Complex cation substitutions are proved efficacious in enhancing ionic conductivity, while the role of pre-exponential factor in Arrhenius equation receives insufficient attention compared to the activation energy term. Herein, multiple lattice site substitution is employed to elucidate the contribution of increased configurational entropy to phase formation and the predominance of local distortion on ionic conductivity.

Comparing multiple assessment methods based on water quality, habitat and organism indicators: unveiling the ecological health of Ningbo's urban rivers.

The growing urgency of assessing aquatic ecosystem health has drawn increasing attention due to mounting environmental pressures. While numerous studies have assessed riverine ecological health, most rely on a single assessment method, often neglecting the integration of multiple indicators. This study advances existing research by comparing different assessment approaches to evaluate ecological health of urban rivers.

Oxidized chitosan: Combining an "Adhesion-and-Kill" antibacterial strategy with immunoregulation and angiogenesis to enhance methicillin-resistant Staphylococcus Aureus-infected wound healing.

The emergence of antibiotic-resistant bacteria, particularly methicillin-resistant Staphylococcus aureus (MRSA), presents a significant challenge in clinical wound management due to their resistance to conventional antibiotics and ability to form persistent biofilms. This study explores the antibacterial properties and wound-healing potential of oxidized chitosan (OCTS), fabricated by oxidizing chitosan with hydrogen peroxide (H₂O₂), which introduces carboxyl groups to enhance its solubility, adhesion, and antibacterial activity. In vitro experiments demonstrate that OCTS exhibits lower MIC concentration (20 mg/mL vs.

Enhancing biolistic plant transformation and genome editing with a flow guiding barrel.

The biolistic delivery system is an essential tool in plant genetic engineering, capable of delivering DNAs, RNAs, and proteins independent of tissue type, genotype, or species. However, its efficiency and consistency remain longstanding challenges despite decades of widespread use. Here, through advanced simulations, we identify gas and particle flow barriers as the root cause of these limitations.

BaNbMoO: A Proton or Oxide Ion Conductor?

BaNbMoO is a recently emerging fast oxide ion conductor, attracting increasing attention. It was reported to also show proton conduction in a humid atmosphere, which is, however, opposite to the results in this work. Theoretical calculations indicate that protons can hardly move, being stabilized in the perovskite blocks or trapped in the palmierite layers, which is in line with the experimental evidence of almost no HO/DO isotope effect and a negligibly small transport number of protons by EMF measurements up to 800 °C.

Mdivi-1 promotes steroidogenesis in granulosa cells by inhibiting mitochondrial fission.

Targeted metabolomics and ELISAs shown that Mdivi-1 treatment increased the levels of steroid hormones (progesterone and estradiol) in the supernatants of KGN cell culture medium. The purpose of this study was to explore the mechanism of Mdivi-1 promoting steroid hormone synthesis in granulosa cells (GCs). In vitro experiments revealed that Mdivi-1 did not affect the total protein expression of Drp1 in KGN cells or human luteinized GCs but increased Drp1 Ser637 phosphorylation, reduced Drp1 Ser616 phosphorylation, inhibited Drp1 mitochondrial translocation, and upregulated mitochondrial fusion proteins, promoting mitochondrial fusion.

Cognitive decline before and after incident chronic respiratory disease.

Few studies have comprehensively measured the changes in cognition occurring in the years before and after the onset of specific respiratory disease type, which could help tailor the timing and design of future intervention strategies. Here we aimed to explore the temporal pattern of cognitive change before and after incident COPD and asthma. Data from wave 1 to wave 9 (2002-2018) of the English Longitudinal Study of Ageing were used.

Identification of neuronal synapse-related signatures and potential therapeutic drugs in colorectal cancer based on machine learning algorithms and molecular docking.

Background: Nervous system-cancer interactions can regulate tumorigenesis, invasion, and metastasis. However, specific biomarkers for targeting neuron synapse in colorectal cancer (CRC) remain unexplored. This study aims to develop a neuronal synapse-related signature (NSRS) to predict survival in CRC patients, identify potential therapeutic drugs, and explore its clinical applications.

Single-cell and spatial transcriptome analyses reveal MAZ(+) NPC-like clusters as key role contributing to glioma recurrence and drug resistance.

Background: Temozolomide (TMZ) is an important chemotherapeutic agent for glioma treatment. However, the emergence of drug resistance impedes its application. Traditional population-level studies are limited in elucidating resistance mechanisms.

Association between baseline cardio-kidney-metabolic syndrome, its transition and cognitive impairment: result from CHARLS study.

Aims: Cardiovascular-Kidney-Metabolic (CKM) syndrome is an integrated context encompassing diabetes, obesity, cardiovascular, and chronic kidney diseases. The impact of CKM syndrome on cognitive impairment remained unclear.

Methods: This longitudinal, observational study used data from the China Health and Retirement Longitudinal Study waves 1 and 4 (2011 to 2018).

Isolation, Sphalerite Bioleaching, and Whole Genome Sequencing of QBS3 from Zinc-Rich Sulfide Mine Drainage.

The genus has been widely used in bioleaching, and novel strains in this genus, such as , have also been confirmed to possess bioleaching capabilities. In this study, an strain, QBS3, was isolated from zinc-rich sulfide mine drainage using the gradient dilution method. QBS3 is a Gram-negative, 1.