SYHA1813, A VEGFR and CSF1R Inhibitor, in Patients With Recurrent High-Grade Gliomas: A Multicenter, Open-Label Phase I Study.

Objective: Recurrent high-grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high-grade gliomas.

Methods: Eligible patients (aged ≥ 18) with histologically or cytologically confirmed recurrent high-grade gliomas were included.

Integrated radiomics and deep learning model for identifying medullary sponge kidney stones.

Background: Medullary sponge kidney (MSK) is a rare congenital anomaly frequently associated with nephrolithiasis. Accurate preoperative differentiation between MSK stones and non-MSK multiple kidney stones remains challenging, yet it is essential for effective clinical decision-making. This study aims to develop a novel diagnostic model that integrates radiomics and deep learning features to improve the differentiation of MSK stones using CT imaging.

Verification is All You Need: Prompting Large Language Models for Zero-Shot Clinical Coding.

Clinical coding translates medical information from Electronic Health Records (EHRs) into structured codes such as ICD-10, which are essential for healthcare applications. Advances in deep learning and natural language processing have enabled automatic ICD coding models to achieve notable accuracy metrics on in-domain datasets when adequately trained. However, the scarcity of clinical medical texts and the variability across different datasets pose significant challenges, making it difficult for current state-of-the-art models to ensure robust generalization performance across diverse data distributions.

Identification of gut microbiota causally associated with aging and longevity and mediation roles of the cerebrospinal fluid proteins: proteomic genetic evidence from Mendelian randomization.

Gut microbiota (GM) is implicated in aging biology, yet its dual regulatory role in the distinct yet interconnected processes of lifespan extension and aging remains poorly understood. This study employed genetic approaches to identify GM taxa exerting causal effects on longevity and aging and assess the mediation role of cerebrospinal fluid (CSF) proteins. We leveraged summary statistics of the GM taxa (207 taxa, 7738 participants from the Dutch Microbiome Project), the CSF proteins (7008 aptamers, 3506 participants), and the longevity and aging phenotypes (UK Biobank, Longevity Genomics, and Edinburgh DataShare) from the largest genome-wide association studies so far.

Long-term outcomes of laparoscopic distal gastrectomy for locally advanced gastric cancer: An individual patient data meta-analysis of KLASS-02 and CLASS-01 randomized controlled trials.

Objective: Laparoscopic distal gastrectomy (LDG) has potential as a surgical treatment option for locally advanced gastric cancer (LAGC). However, there is uncertainty regarding the generalizability of LDG efficacy across diverse patient populations and treatment settings. This study aimed to assess the outcomes of LDG .

Prevalence of kidney stones based on metabolic health and weight criteria: reports from the national health and nutrition examination survey 2007-2018 data analysis.

Objective: Using data from the NHANES collected between 2007-2018, this study aimed to investigate the relationship between the prevalence of kidney stones and metabolically healthy obesity (MHO) and measure the effect of physical activity as a modifying factor.

Methods: This cross-sectional analysis included 12,498 participants aged ≥20 years who were categorized into six groups based on their metabolic status (healthy or unhealthy) and BMI (normal, overweight, and obesity). Kidney stone history was self-reported.

Impact of preoperative frailty on venous thromboembolism risk following total hip and knee arthroplasty: a meta-analysis.

Background: Frailty is commonly observed in older adults and may elevate the risk of venous thromboembolism (VTE) following total hip arthroplasty (THA) or total knee arthroplasty (TKA). This meta-analysis elucidates the association between frailty and the risk of postoperative VTE, encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE), among patients undergoing THA or TKA.

Materials And Methods: A systematic search was conducted across PubMed, Embase, and Web of Science through 22 August 2024, to identify relevant observational studies with longitudinal follow-up.

Association between baseline cardio-kidney-metabolic syndrome, its transition and cognitive impairment: result from CHARLS study.

Aims: Cardiovascular-Kidney-Metabolic (CKM) syndrome is an integrated context encompassing diabetes, obesity, cardiovascular, and chronic kidney diseases. The impact of CKM syndrome on cognitive impairment remained unclear.

Methods: This longitudinal, observational study used data from the China Health and Retirement Longitudinal Study waves 1 and 4 (2011 to 2018).

Outcomes of arthroscopic one-stage repair and reconstruction of Schenck II-IV knee dislocations with multiple ligament injuries: a single-center study.

Objective: To evaluate the outcomes of arthroscopic one-stage repair and reconstruction of Schenck II-IV knee dislocations with multiple ligament injuries.

Methods: We retrospectively reviewed the data of patients with Schenck II-IV knee dislocations and multiple ligament injuries treated in our hospital during 2019-2022. Patients underwent single-bundle reconstruction of the cruciate ligaments via an arthroscopic all-inside technique, along with repair/reconstruction of the collateral ligaments if necessary, and management of concomitant injuries.

Optimizing aspiration efficiency in RIRS: the impact of ratio of endoscope-sheath diameter, irrigation flow, and negative pressure in an vitro study.

To examine the impact of ratio of endoscope-sheath diameter (RESD), irrigation rate, and negative pressure on the efficiency of stone fragment aspiration during retrograde intrarenal surgery (RIRS) in an in vitro setting. Five grams of stone fragment were precisely measured and placed in renal calyx. A flexible ureteroscope with a Flexible Adjustable Navigation Suction Ureteral Access Sheath (FANS) was introduced into the renal calyx, connected to an irrigation pump and suction pump.

Comparison of medical history documentation efficiency and quality based on GPT-4o: a study on the comparison between residents and artificial intelligence.

Background: As medical technology advances, physicians' responsibilities in clinical practice continue to increase, with medical history documentation becoming an essential component. Artificial Intelligence (AI) technologies, particularly advances in Natural Language Processing (NLP), have introduced new possibilities for medical documentation. This study aims to evaluate the efficiency and quality of medical history documentation by ChatGPT-4o compared to resident physicians and explore the potential applications of AI in clinical documentation.

B.T.C.H. nephrolithometry score: a novel scoring system to predict stone-free rate and complexity for ultrasound-guided percutaneous nephrolithotomy.

Background: The existing scoring systems for percutaneous nephrolithotomy fail to adequately consider the influence of renal anatomy, leading to limited predictive accuracy. This study introduces and validates a novel B.T.

Bionic Triboelectric Nanogenerator Activates the "mechano-electro-biochemical" Cascade Effect In Situ to Accelerate Critical-Sized Bone Defect Repair.

The loss of the intrinsic "mechano-electro-biochemical" cascade effect in critical-sized bone defects (CSBDs) impedes the bone self-healing process. Traditional strategies cannot provide bionic electrical output, thereby failing to sufficiently activate the "mechano-electro-biochemical" cascade effect in situ and limiting the repair efficiency of CSBDs. Here, a bionic, self-adhesive, and biodegradable triboelectric nanogenerator (TENG) called PPCs-TENG using silk-fibroin-derived peptide (Cs)-grafted polydopamine-polyacrylamide (PPCs) as the electrode layer is fabricated.

Gut commensal bacteria influence colorectal cancer development by modulating immune response in AOM/DSS-treated mice.

The gut microbiota has been closely associated with the pathogenesis of colorectal cancer (CRC). However, precise identification of particular microorganisms promoting CRC carcinogenesis, and more importantly those blocking tumor development, has been challenging based on human gut microbiota profiling studies. With a well-established azoxymethane/dextran sodium sulfate induction murine CRC model, we found a subset of mice consistently failed to develop CRC.

A N, S-Containing Graphene Oxide Composite for the Adsorptive Removal of p-Nitrophenol from Aqueous Solutions.

A novel 3-amino-5-mercapto-1,2,4-triazole functionalized graphene oxide composite (GO-ATT) was successfully prepared via a covalent coupling method, then employed for the removal of p-nitrophenol (PNP) from wastewater. The morphology as well as the composition of GO-ATT composite were investigated using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), X-ray diffraction spectroscopy (XRD), and X-ray photoelectron spectroscopy (XPS). The surface charge of GO-ATT composite was evaluated by Zeta potential analyses.

The Cytokinin Oxidase/Dehydrogenase TaCKX11-D Positively Regulates Grain Size in Wheat.

Grain size is one of the essential determinants of yield in wheat (Triticum aestivum L.). Cytokinin signaling affects grain size, and cytokinin oxidase/dehydrogenase (CKX) regulates cytokinin homeostasis by catalyzing cytokinin degradation.

Platelet-rich plasma inhibits ferroptosis and inflammation to alleviate frozen shoulder via activating the CST1/GPX4 signaling pathway.

Platelet-rich plasma (PRP) has been shown to be beneficial to frozen shoulder (FS), but the mechanism of PRP's intervention in FS is still incomplete. Ferroptosis and inflammation are important pathological factors of cartilage injury, but their role in FS has not been explored. In vivo, we found that PRP treatment significantly enhanced the joint range of motion and mitigated joint histopathological damage in FS rats.

Body-Integrated Ultrasensitive All-Textile Pressure Sensors for Skin-Inspired Artificial Sensory Systems.

Tactile sensing plays a vital role in human somatosensory perception as it provides essential touch information necessary for interacting with the environment and accomplishing daily tasks. The progress in textile electronics has opened up opportunities for developing intelligent wearable devices that enable somatosensory perception and interaction. Herein, a skin-inspired all-textile pressure sensor (ATP) is presented that emulates the sensing and interaction functions of human skin, offering wearability, comfort, and breathability.

Identifying PDAP1 as a Biological Target on Human Longevity: Integration of Mendelian Randomization, Cohort, and Cell Experiments Validation Study.

Identifying factors affecting lifespan, including genes or proteins, enables effective interventions. We prioritized potential drug targets and provided insights into biological pathways for healthy longevity by integrating Mendelian randomization, cohort, and experimental studies. We identified causal effects of tissue-specific genetic transcripts and serum protein levels on three longevity outcomes: the parental lifespan, the top 1% and 10% extreme longevity, utilizing Mendelian randomization and multi-traits colocalization, combining the latest genetics data of gene expression (eQTLGen and GTEx) and proteomics (4746 proteins from five studies).

Combined Anterolateral and Anterior Cruciate Ligament Reconstruction Improves Pivot Shift and Anterior Tibial Translation With Similar Outcomes Compared With Isolated Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Purpose: To compare the subjective measurement indicators between isolated anterior cruciate ligament reconstruction (ACLR) and combined ACLR with anterolateral ligament reconstruction (ALLR) in patients with anterior cruciate ligament injuries.

Methods: The Ovid MEDLINE and the Cochrane Central Registry of Controlled Trials were searched for randomized controlled trials with a level of evidence I-II published until September 2024 that evaluated subjective and safety outcomes between ACLR+ALLR and isolated ACLR. The Cochrane Risk of Bias 2.

A spatially resolved transcriptome landscape during thyroid cancer progression.

Tumor microenvironment (TME) remodeling plays a pivotal role in thyroid cancer progression, yet its spatial dynamics remain unclear. In this study, we integrate spatial transcriptomics and single-cell RNA sequencing to map the TME architecture across para-tumor thyroid (PT) tissue, papillary thyroid cancer (PTC), locally advanced PTC (LPTC), and anaplastic thyroid carcinoma (ATC). Our integrative analysis reveals extensive molecular and cellular heterogeneity during thyroid cancer progression, enabling the identification of three distinct thyrocyte meta-clusters, including TGIYG subpopulation in PT, HLA-DRB1HLA-DRA subpopulation in early cancerous stages, and APOEAPOC1 subpopulation in late-stage progression.

Identification of c-Jun phosphorylation as a crucial mediator of complement activation in renal ischemia-reperfusion injury revealed by phosphoproteomics and functional validation.

Background: Ischemia reperfusion injury (IRI) is an unavoidable condition that primarily affects graft function in renal transplantation. Blockage of complement activation by complement receptor immunoglobulin/ factor H (CRIg/FH), a novel complement inhibitor, shows great potency to ameliorate renal IRI. Sublytic membrane attack complex (MAC) disrupts cellular functions via the activation of different protein kinases and phosphorylation of critical signal transduction factors.

Two homoeoallelic gene expression of TaCHLIs ensures normal chlorophyll biosynthesis in Hexaploid wheat.

Being polyploid has a fitness advantage but is physically complex. During polyploid plant evolution, some duplicate genes retain their ancestral function, which affected the plant phenotype in allelic dosage or functional redundancy. However, how duplicated genes whose products needed to form functional complexes coped with deleterious mutations remained unclear.