Predictive Value of Early Nursing Scores on 90-Day Outcomes in Intracerebral Hemorrhage Patients.

BACKGROUND Multiple factors impact the prognosis of intracerebral hemorrhage (ICH). This study aimed to evaluate prognosis at 90 days after ICH in 561 patients using the numerical rating scale (NRS), the Braden scale, the Morse fall risk scale (MFS), and the enhanced modified early warning (MEW) scale. MATERIAL AND METHODS A retrospective study was performed among 561 patients with ICH diagnosed in our hospital.

Long-chain fatty acids promote ATP production in post-thaw boar sperm through mitochondrial β-oxidation.

Due to the current limitations of boar semen cryopreservation systems, the effective restoration of sperm quality following thawing remains a significant challenge. This study investigates whether post-thaw boar sperm can uptake exogenous long-chain fatty acids (LCFAs) and utilize them for ATP generation, thereby sustaining linear motility and enhancing sperm vitality. Boar semen was diluted in extender solutions supplemented with varying concentrations of a lipid mixture (0, 0.

A metagenome-wide association study of gut microbiota in hepatitis B virus-related cirrhosis in northwest China.

Background And Purpose: In recent years, research on the relationship between hepatitis B virus-related cirrhosis (HBV-LC) and gut microbiota has grown, but studies focusing on the Northwest Chinese population are scarce. This study characterized the gut microbiota composition and function in HBV-LC patients vs. healthy individuals in Northwest China, aiming to provide a scientific basis for region-specific precision therapies.

Comparing the Efficacy and Safety of IC-ICCRT-IO With CT-CCRT for Unresectable Locally Advanced ESCC: A Retrospective Analysis.

The present study was designed to evaluate the efficacy and safety of induction chemotherapy combined with a PD-1 inhibitor (sintilimab) followed by concurrent chemoradiotherapy (CCRT) plus sintilimab and subsequent maintenance (IC-ICCRT-IO) in patients with unresectable locally advanced esophageal squamous carcinoma (ESCC) compared with induction chemotherapy followed by CCRT without PD-1 inhibitors (CT-CCRT) using propensity score matching (PSM). Data collected from patients with histologically confirmed, inoperable ESCC treated with IC-ICCRT-IO or CT-CCRT were retrospectively analyzed-a 1:1 PSM with a caliper of 0.05 balanced potential biases.

Synergistic enhancement of chitosan-diatomite composite in microalgae flocculation: Mechanistic insights into extracellular polymeric substances-mediated harvesting.

Chitosan is a promising bioflocculant for harvesting microalgae, its practical implementation is constrained by high dosage demands (typically >1 g/L) and suboptimal settling kinetics. And the microalgae harvesting process is susceptible to the significant influence of extracellular polymeric substances (EPS), the mechanism of which is still unclear. This study synthesized amino-functionalized chitosan-diatomite composites (APTES-CTS/DTE) and revealed the action mechanism of EPS in the flocculation of microalgae.

Targeting MTPN sensitizes pancreatic cancer of wild-type BRCA1/2 to Cisplatin-based chemotherapy.

The clinical application of combination chemotherapy with cisplatin is unsatisfactory for most pancreatic cancer patients with wild-type BRCA1/2 or PALB2 due to resistance. Genes associated with cisplatin resistance in patients without BRCA1/2 or PALB2 mutations should be pursued. Through bioinformatics analysis, we found that Myotrophin (MTPN) expression was correlated with that of nuclear factor kappa B (NF-κB), a protein involved in the regulation of cisplatin sensitivity.

Dietary Omega-3 alleviates copper-induced nephrotoxicity via suppression of NLRP3-mediated pyroptosis and lipid metabolism disorder in chickens.

Excessive use of copper (Cu) in poultry farming induces nephrotoxicity closely related to inflammatory response and lipid metabolism disorder, but the mechanism remains unclear. Omega-3 (Ω-3), a natural polyunsaturated fatty acid with anti-inflammatory and antioxidative stress properties, has been demonstrated to exert protective effects on the kidneys. However, whether Ω-3 can alleviate Cu-induced renal injury and the underlying mechanisms remain unclear.

Paradoxical embolism caused by totally implantable venous access port: a case report and literature review.

Totally implantable venous access ports (TIVAPs) are commonly used for patients undergoing chemotherapy and long-term repeated infusions. The incidence of thrombosis is low and rarely leads to serious complications. We report a case of right atrial thrombosis and paradoxical embolism in a 58-year-old male with atrial fibrillation (AF) and patent foramen ovale (PFO) 28 months after TIVAP implantation.

Based on In Situ Electrode Corespun Yarn Ion Sensor and Its Arrayed Fabric for Electrical Impedance Tomography.

Flexible sensors have significant application potential in various areas, such as wearable devices, medical condition monitoring, and smart materials. However, these sensors mostly require integrated external electrodes, resulting in complex structures that limit flexibility and integration. This study integrates an in situ functional core as the electrode and a nanofiber sheath that serves dually as the sensing layer and ion transport channel, thereby simplifying the structural complexity of conventional multilayer sensors.

High-sensitivity coreless fiber surface plasmon resonance refractive index sensor based on Au/TiO2.

Fiber optic surface plasmon resonance sensor (SPR) play an important role in various fields where highly sensitive sensors are suitable. In this paper, we propose an SPR refractive index sensor composed of multi-mode fiber-coreless fiber-multimode fiber (MCM) structure modified by Au/TiO2 nanofiber material. The experimental results show that the sensitivity of the TiO2 nanofiber/Au structure sensor is 3687.

Indole-3-propionic acid enhances glycolytic myofiber formation in piglets through PI3K-mTOR activation and gut microbiota-driven tryptophan metabolic alteration.

Indole-3-propionic acid (IPA) is a metabolite of tryptophan produced by gut bacterial catabolism that has a variety of functions, including anti-inflammatory, free radical scavenging, and regulation of glucose metabolism. The present study evaluated the effects of dietary IPA supplementation on early muscle development in piglets. Twelve healthy Landrace × Rongchang piglets at 30 d of age were randomly divided into control (CON group, 10.

Effect of Intravenous Lidocaine on Postoperative Cognitive Dysfunction in Patients Undergoing Laparoscopic Colorectal Surgery: A Two-Center, Randomized, Double-Blind Controlled Trial.

Background: In patients undergoing gastrointestinal surgery, enhancing perioperative cognitive function and facilitating expedited postoperative recovery are critical components for achieving swift rehabilitation. Intravenous administration of lidocaine has been shown to mitigate the perioperative inflammatory response in surgical patients; however, its influence on postoperative cognitive performance remains unassessed. Consequently, this study was conducted to investigate the impact of intravenous lidocaine on postoperative cognitive function in participants undergoing laparoscopic surgery for colorectal cancer.

Spatial metabolomics combined with machine learning in colon cancer diagnosis research.

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circSCAP-encoded SCAP-129aa mediates platinum resistance in triple-negative breast cancer via the PI3K/AKT pathway.

Triple-negative breast cancer (TNBC) often acquires resistance to platinum-based chemotherapy, presenting significant challenges to therapeutic management and adversely affecting patient survival. In such refractory cases, even advanced treatment modalities often exhibit diminished efficacy. This study aims to elucidate the molecular mechanisms underlying platinum resistance.

Exploring the Role of Oral Microbiota in the Pathophysiology and Treatment of Bruxism.

Bruxism is an involuntary condition involving grinding and clenching of the teeth, occurring during both wakefulness and sleep. This behavior can lead to various detrimental effects on oral health, including significant tooth wear and damage, temporomandibular disorders (TMD), tooth sensitivity, gum recession, and persistent headaches along with ear pain or tinnitus. The underlying causes of bruxism have long been debated, with the consensus suggesting that psychological, genetic, and environmental factors contribute to its development.

Dual-phase Hog1 activation and transporter gene reprogramming enable extreme sugar tolerance in food osmophilic yeasts.

The protein kinase Hog1 plays a central role in cellular responses, including cell volume and gene expression regulation during osmoregulation in the model yeast Saccharomyces cerevisiae. Despite sharing the conserved kinase Hog1 for osmotic response, Zygosaccharomyces rouxii and S. cerevisiae exhibit markedly different sugar resistance.

Recent Progress on CoP as Anodes for Metal-Ion Batteries.

With the rapid development of portable electronic devices and electric vehicles, metal-ion batteries, especially lithium/sodium/potassium-ion batteries (LIBs/SIBs/PIBs), have become a research hotspot because of their high energy density and cycle stability. The battery system primarily comprises three key components: negative electrode material, positive electrode material, electrolyte, and diaphragm. The selection of the negative electrode material will directly impact the battery's energy density.

Efflux pumps positively contribute to rifampin resistance in rpoB mutant Mycobacterium tuberculosis.

Background: While several recent studies have documented the importance of efflux pumps as mediators of rifampin (RIF) resistance, it remains uncertain which efflux pumps play major roles in rifampin-resistant Mycobacterium tuberculosis strains harboring rpoB gene mutations.

Methods: In this study, minimum inhibitory concentration (MIC) values for RIF were calculated and the expression of 13 efflux pump genes was evaluated across 35 clinical rifampicin-resistant M. tuberculosis isolates carrying the rpoB mutation before and after efflux pump inhibitor treatment.

Instance-Adaptive Spatial-Temporal Enhancement for Efficient Video Compression.

Efficiently compressing HD/UHD content has long been challenging due to high bitrate costs. Instance-adaptive enhancement methods try to tackle this issue by compressing a video at reduced resolution and enhancing it using a neural model specifically overfitted for this video. However, existing methods focus solely on spatial super-resolution (SR) and under-utilize the videos' temporal redundancy.

Nanoconfinement assists the selective generation of singlet oxygen to efficiently remove emerging organic contaminants in soil with a low consumption of oxidant.

The application of advanced oxidation processes (AOPs) to remove emerging organic contaminants (EOCs) in soil is a powerful and rapid soil remediation technology, but the diversity of soil components makes the contact between reactive oxygen species (ROS) and pollutants limited, while the large consumption of oxidant still seriously restricts the decontamination performance in soil. Herein, a nanoconfinement strategy has been applied to encapsulate metal oxide FeO to the channels of carbon nanotube, thereby synthesizing a FeO@CNT catalyst to activate peroxydisulfate (PDS) for the selective removal of carbamazepine (CBZ) in soil. FeO@CNT can efficiently activate PDS to oxidize CBZ in soil through a nonradical pathway dominated by singlet oxygen (O).

Succinylation regulates boar sperm linear motility via reprogramming glucose metabolism.

Succinylation is a recently identified post-translational modification (PTM) that modulates enzyme activity and metabolism. However, how it regulates metabolic reprogramming in sperm remains unclear. In this study, we show that succinylation of pyruvate kinase M2 (PKM2) promotes oxidative phosphorylation (OXPHOS) and linear motility in boar sperm.

SPANXB1 drives brain metastasis in breast cancer via MMP1 regulation: potential therapeutic insights with metformin.

Cancer-testicular antigens (CTAs) have been considered as potential prognostic biomarkers and therapeutic targets due to their specific expression and roles in tumorigenesis and metastasis. Among these, the function and mechanism of SPANXB1 in breast cancer brain metastasis (BCBM) remain poorly understood. In this study, we investigated the role of SPANXB1 in BCBM.

Bidirectional modulation of somatostatin-expressing interneurons in the basolateral amygdala reduces neuropathic pain perception in mice.

Introduction: Neuropathic pain is characterized by mechanical allodynia and thermal (heat and cold) hypersensitivity, yet the underlying neural mechanisms remain poorly understood.

Methods: Using chemogenetic excitation and inhibition, we examined the role of inhibitory interneurons in the basolateral amygdala (BLA) in modulating pain perception following nerve injury.

Results: Chemogenetic excitation of parvalbumin-positive (PV) interneurons significantly alleviated mechanical allodynia but had minimal effects on thermal hypersensitivity.