Based on In Situ Electrode Corespun Yarn Ion Sensor and Its Arrayed Fabric for Electrical Impedance Tomography.

Flexible sensors have significant application potential in various areas, such as wearable devices, medical condition monitoring, and smart materials. However, these sensors mostly require integrated external electrodes, resulting in complex structures that limit flexibility and integration. This study integrates an in situ functional core as the electrode and a nanofiber sheath that serves dually as the sensing layer and ion transport channel, thereby simplifying the structural complexity of conventional multilayer sensors.

Amygdala and cortical substrates of subjective well-being: pathways to reduced aggression in emotional processing contexts.

Subjective well-being has been implicated in the regulation of aggressive behavior, potentially through its influence on mood and neural processing. However, the underlying neuropsychological mechanisms remain insufficiently understood. This study aimed to elucidate the neural correlates of subjective well-being and examine its potential association with aggression using a two-part investigation.

Optimized Tangential Flow Filtration for Efficient Isolation of Highly Pure and Bioactive sEVs.

Small extracellular vesicles (sEVs) have demonstrated significant therapeutic potential. However, the lack of efficient and scalable methods for sEV separation remains a critical barrier to their large-scale production as therapeutic agents. Tangential flow filtration (TFF) has emerged as a promising technique for large-scale sEV separation, but the absence of comprehensive and systematic studies makes it challenging to determine optimal TFF parameters for sEV isolation.

Microbial diversity characteristics and differential analysis in green turtle nests in the Xisha Islands, South China Sea.

Sea turtles are renowned "living fossils" and ideal flagship marine conservation species. Sea turtles display high fidelity to their nesting grounds, and the quality of nesting grounds is related to the survival of sea turtles, in which microbial diversity, abundance, and potential pathogens are important indicators for assessing the quality of nesting grounds. The Xisha Islands are the largest nesting grounds for green turtles () in China.

A pH-responsive PEG coating strategy for enhancing the enrichment of small extracellular vesicles towards disease regions with acidic microenvironment.

The clinical translation of small extracellular vesicles (sEVs) as nanocarriers and therapeutic agents is severely hindered by their rapid clearance, leading to significant off-target effects. Polyethylene glycol (PEG) coating of sEVs provides a straightforward approach to address this challenge, yet it compromises their cellular internalization. To overcome this issue, we developed an acid-responsive PEG coating strategy for sEVs using 2,5-dihydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid (CDM)-modified methoxy PEG (mPEG-CDM).

Mechanism of Ammonia-Induced Brain Damage in Chinese Striped-Necked Turtle (Mauremys sinensis).

Social advancement and heightened waste discharge have resulted in escalating ammonia pollution in aquatic ecosystems, presenting toxicity hazards to aquatic fauna, especially turtles, by impairing their neurological function. To assess the ammonia effect on turtle brains, we subjected Chinese striped-necked turtles (Mauremys sinensis) to varying ammonia concentrations (CK, control; A1, 0.790 mg/L NH3; A2, 1.

Corrigendum to 'JD-312 - A novel small molecule that facilitates cartilage repair and alleviates osteoarthritis progression'[Journal of Orthopaedic Translation 44 (2024) 60-71].

[This corrects the article DOI: 10.1016/j.jot.

Impact of environmental salinity on the MAPK-NFAT5 pathway in Trachemys scripta elegans and its role in osmoregulaton.

Globally, sea level rise (SLR) leads to salinization of coastal freshwater, in where organisms might be affected and in turn promote osmoregulation and adaptation in response to freshwater salinization. Trachemys scripta elegans a freshwater turtle species, exhibits remarkable tolerance to varying salinity environments, yet the underlying regulatory mechanisms remain poorly understood. This study aimed to elucidate the molecular mechanisms of osmoregulation in this species based on previous RNA-seq data.

Highly Corrosion-Resistant Ultrafine Silver Fiber Biopotential Sensor for Long-Term Monitoring.

Fabric electrodes are an important part of long-term medical-health-monitoring garments, but sweat corrosion can greatly affect their longevity and stability. In this study, the metal fabric biopotential sensor was chemically modified with 3-mercaptopropyltrimethoxysilane (MPTS). Ag/AgCl was formed on the electrode surface by constant voltage deposition.

Smart Health Monitoring: Review of Electrochemical Biosensors for Cortisol Monitoring.

Cortisol, also known as the stress hormone, is a crucial corticosteroid hormone that significantly increases secretion in the human body when facing notable stress. Monitoring cortisol levels is crucial for personal stress management and the diagnosis and treatment of certain diseases. Electrochemical biosensors combine the efficient sensitivity of electrochemical technology with the high specificity of biological recognition processes, making them widely applicable in the analysis of human body fluid components.

Glycosylated and rhodamine-conjugated tetraphenylethylene: a type I and II reactive oxygen species generator for photodynamic therapy.

A lactosylated and AIE-active multifunctional photosensitizer (Lac-TR) was synthesized. Lac-TR can self-assemble into fluorescent nanoparticles (Lac-TRs) to achieve fluorescence self-reporting during photodynamic therapy and induce pyroptosis under both normoxia and hypoxia to kill HepG2 cells.

Dietary Taurine Regulation of the Intestinal Microbiome in Chinese Stripe-Necked Turtle ().

Taurine is essential for sustaining the body's physiological equilibrium and is extensively utilized as a dietary supplement and immune system enhancer for aquatic creatures. The gut microbiota serves as a vital health indicator in animals. In this study, our goal was to evaluate the effects of dietary taurine on the gut microbiome of Chinese stripe-necked turtles ().

Neuroanatomical and functional substrates of the short video addiction and its association with brain transcriptomic and cellular architecture.

Short video addiction (SVA) has emerged as a growing behavioral and social issue, driven by the widespread use of digital platforms that provide highly engaging, personalized, and brief video content. We investigated the neuroanatomical and functional substrates of SVA symptoms, alongside brain transcriptomic and cellular characteristics, using Inter-Subject Representational Similarity Analysis (IS-RSA) and transcriptomic approaches. Behaviorally, we found that dispositional envy was associated with SVA.

The effect of different immobilization approaches on red-eared sliders.

The ethical issues surrounding sacrifice methods in animal experimentation have garnered increasing attention, making immobilization and sedation an integral part of the sacrifice process for experimental animals. Currently, internationally recognized general sacrifice methods for commonly used laboratory animals have been established, but there remains significant controversy over the sacrifice methods for turtles. To explore the effectiveness of various immobilization methods and their impact on stress-related indicators in turtles, this study used red-eared sliders (Trachemys scripta elegans) as subjects.

MYB30-INTERACTING E3 LIGASE 1 regulates LONELY GUY 5-mediated cytokinin metabolism to promote drought tolerance in cotton.

Ubiquitination plays important roles in modulating the abiotic stress tolerance of plants. Drought seriously restricts agricultural production, but how ubiquitination participates in regulating drought tolerance remains largely unknown. Here, we identified a drought-inducible gene, MYB30-INTERACTING E3 LIGASE 1 (GhMIEL1), which encodes a RING E3 ubiquitin ligase in cotton (Gossypium hirsutum).

Research on antibiotic resistance genes in wild and artificially bred green turtles (Chelonia mydas).

Sea turtles, vital to marine ecosystems, face population decline. Artificial breeding is a recovery strategy, yet it risks introducing antibiotic resistance genes (ARGs) to wild populations and ecosystems. This study employed metagenomic techniques to compare the distribution characteristics of ARGs in the guts of wild and artificially bred green turtles (Chelonia mydas).

Adherence and HIV Protection Thresholds for Emtricitabine and Tenofovir Disoproxil Fumarate Preexposure Prophylaxis among Cisgender Women: A Systematic Review.

Purpose Of Review: Adherence-concentration-efficacy benchmarks have not been fully characterized for cisgender women using emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) oral daily pre-exposure prophylaxis (PrEP) for HIV prevention.

Recent Findings: We conducted a systematic review to investigate current evidence on the adherence-concentration-efficacy relationship of tenofovir-diphosphate (TFV-DP) derived from FTC/TDF PrEP in dried blood spots (DBS) and peripheral mononuclear cells (PBMC) in cisgender women without HIV, including during pregnancy. We searched for completed and ongoing studies published before May 2024 in PubMed, Embase, Cochrane Library, CINAHL, and clinicaltrial.

Effects of Freshwater Acidification on the Gut Microbial Community of .

Freshwater acidification (FA) has become a global environmental problem, posing a potential threat to freshwater ecosystems. The gut microbiota plays a crucial role in the host's response and adaptation to new environments. In this study, we investigated the changes in microbial communities in Red-eared slider () under acidic conditions to reveal the ecological impacts of acidification on freshwater turtles.

Simulations on coal water slurry gasification by molecular dynamics method with ReaxFF.

Context: Coal water slurry (CWS) is a new type of liquid coal product with low pollution, which is mainly used in the chemical industry to produce syngas (CO + H). It is of great significance to study the microscopic mechanism of CWS gasification reaction for improving the efficiency of coal gasification. In this paper, the method of molecular dynamics based on reaction force fields (ReaxFF-MD) is used to study the gasification process of CWS/O system at different temperatures.

Comparison of the intestinal flora of wild and artificial breeding green turtles ().

Gut microbes are pivotal reference indicators for assessing the health status of animals. Before introducing artificially bred species into the wild, examining their gut microbe composition is crucial to help mitigate potential threats posed to wild populations. However, gut microbiological trait similarities between wild and artificially bred green turtles remain unexplored.

Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.

Pluripotent stem cell-derived small extracellular vesicles (PSC-sEVs) have demonstrated great clinical translational potential in multiple aging-related degenerative diseases. Characterizing the PSC-sEVs is crucial for their clinical applications. However, the specific marker pattern of PSC-sEVs remains unknown.

JD-312 - A novel small molecule that facilitates cartilage repair and alleviates osteoarthritis progression.

Background: The chondrogenic differentiation of mesenchymal stem cells (MSCs) to enhance cartilage repair and regeneration is a promising strategy to alleviate osteoarthritis (OA) progression.

Method: The potency of JD-312 in inducing chondrogenic differentiation of MSCs was assessed and verified. The efficacy of JD-312-treated MSCs was evaluated using a Sprague-Dawley rat DMM model.