Genome-Wide Identification, Characterization, and Expression Analysis of Gene Family in .

Nitrogen (N) is crucial for plant growth and stress resistance and is primarily absorbed and transported by nitrate transporters (NRT). , known for its strong salt-alkali stress resistance, and genes have rarely been reported. This study aims to identify and analyze the gene family to understand its composition, evolutionary patterns, and roles in salt stress responses.

Causal association between gut microbiota composition and the risk of atrial fibrillation.

Background And Objectives: Considerable evidence has shown that alterations in gut microbiota composition are associated with atrial fibrillation (AF). However, the causal associations remain largely unresolved. This study aims to reveal the causality between gut microbiota and AF.

Genome-Wide Identification and Evolution of Core Cell Cycle Genes in Marchantia polymorpha: Insights Into Redundancy, Stress, and Functional Evolution.

The cell cycle is a fundamental process of plant growth, development, and reproduction, in which cyclin-dependent kinases (CDKs) and cyclins (CYCs) play central roles in regulating the progression through various stages. These proteins are coordinated with multiple interacting partners to ensure the accurate execution of essential biological events such as DNA replication, chromosome segregation, and cell division. Marchantia polymorpha, one of the earliest diverging land plant species, has emerged as a key model for exploring fundamental mechanisms in plant biology and evolution.

SPANXB1 drives brain metastasis in breast cancer via MMP1 regulation: potential therapeutic insights with metformin.

Cancer-testicular antigens (CTAs) have been considered as potential prognostic biomarkers and therapeutic targets due to their specific expression and roles in tumorigenesis and metastasis. Among these, the function and mechanism of SPANXB1 in breast cancer brain metastasis (BCBM) remain poorly understood. In this study, we investigated the role of SPANXB1 in BCBM.

Epidemiology, evolution, and biological characteristics of H3 avian influenza viruses isolated from chickens in China.

During an epidemiological investigation of avian influenza viruses (AIVs) in China, we isolated four H3 AIVs from chickens. To investigate the genetic relationships of these Chinese isolates with the globally circulating H3 viruses, we performed a detailed phylogenic analysis of the hemagglutination (HA) genes of 2613 representative H3 viruses available in the public source, and found that the HA genes of H3 viruses in China evolved from the Eurasian lineage and became established in domestic Anseriformes (primarily ducks). Bayesian phylodynamic analysis revealed that the Southern China (Guangdong and Guangxi provinces) served as a hub for the H3 virus diffusion to other parts of China, and the virus dissemination was potentially primarily driven by domestic ducks.

Mechanisms of SNP and melatonin effects on antioxidant and chlorophyll metabolism in postharvest okra.

Okra fruit rapidly undergoes chemical deterioration after harvest, necessitating effective preservation strategies. This study represents the first comprehensive investigation combining transcriptomic analysis with biochemical assessment to elucidate how SNPs and MT affect antioxidant capacity and chlorophyll metabolism in okra. MT + SNP treatment most effectively preserved fruit quality by reducing weight loss, maintaining color parameters, decreasing oxidative stress markers (HO, MDA), and enhancing antioxidant enzyme activities (SOD, CAT, POD, APX).

Displacement-Guided Anisotropic 3D-MRI Super-Resolution with Warp Mechanism.

Enhancing the resolution of Magnetic Resonance Imaging (MRI) through super-resolution (SR) reconstruction is crucial for boosting diagnostic precision. However, current SR methods primarily rely on single LR images or multi-contrast features, limiting detail restoration. Inspired by video frame interpolation, this work utilizes the spatiotemporal correlations between adjacent slices to reformulate the SR task of anisotropic 3D-MRI image into the generation of new high-resolution (HR) slices between adjacent 2D slices.

Effects of orthokeratology lenses on choroidal thickness and choriocapillaris perfusion in myopic children.

Purpose: To investigate changes in subfoveal choroidal thickness (SFChT) and choriocapillaris (CC) perfusion in children wearing orthokeratology (Ortho-K) lenses.

Methods: This retrospective study included 61 myopic children, who were divided into two groups. The Ortho-K group wore Ortho-K lenses, while the control group wore single-vision distance spectacles.

Novel Strain-Based Triple Inactivated Vaccine Confers Rapid Neutralizing Immunity to Feline Multisystemic Pathogens With Two-Dose Regimen.

The rapid global increase in companion animal populations and the rising risks of zoonotic diseases necessitate urgent advancements in veterinary vaccines. In China, over 100 million domestic cats are vulnerable to three deadly pathogens: feline calicivirus (FCV), feline herpesvirus type 1 (FHV-1), and feline panleukopenia virus (FPV). Existing trivalent vaccines face challenges, such as antigenic mismatches, supply chain inefficiencies, and delayed regional adaptability, highlighting the need for localized solutions.

BCKDK accelerates the progression of diabetic kidney disease by regulating leucine-mediated metabolic remodelling in renal tubular cells.

Aims/hypothesis: Kidney tubular cell injury is largely responsible for the pathophysiological features of diabetic kidney disease (DKD). Increased leucine levels in individuals with DKD have been associated with the progression of diabetes to end-stage renal failure, yet a comprehensive understanding of leucine metabolism in kidney tubules during the progression of DKD is lacking.

Methods: Human kidney biopsies and mouse models were used to assess leucine metabolism during DKD progression.

Developing a procedure mimicking transvaginal mesh implantation in women in a modified POP rat model.

Introduction: This study aims to establish a simple and reproducible transvaginal mesh surgery rat model based on the modified pelvic organ prolapse rat model.

Methods: A total of 24 10-week-old female nulliparous Wistar rats were used in this study. The control group consisted of six rats with no interventions.

Peritransplant lysine methyltransferase 2a-rearranged measurable residual disease dynamics as a prognostic marker in adult acute myeloid leukemia.

Background: This study examined the impact of measurable residual disease (MRD) dynamics in adults with lysine methyltransferase 2a rearrangement (KMT2Ar) in acute myeloid leukemia (AML) during the peritransplant period (before and early after allogeneic hematopoietic stem cell transplantation [HSCT]).

Methods: This study involved 144 adult patients with AML with KMT2Ar who underwent HSCT between 2015 and 2024. Patients were enrolled if they survived without relapse for at least 3 months post-HSCT.

Impact of first-line chemoimmunotherapy with or without radiotherapy on the prognosis of patients with locally advanced or metastatic esophageal squamous cell carcinoma: a multicenter, real-world, retrospective cohort study from China (NCT06478355).

Background: Chemotherapy combined with immunotherapy has already become the standard first-line treatment for advanced or metastatic esophageal squamous cell carcinoma (ESCC), whereas there are no satisfying overall survival (OS) and progression-free survival (PFS). This research aims to evaluate whether first-line chemoimmunotherapy combined with radiotherapy (RT) improves outcomes and safety in patients who suffer from locally advanced and metastatic ESCC.

Methods: A total of 664 patients who suffer from locally advanced or metastatic ESCC going through first-line chemoimmunotherapy with or without radiotherapy at China's 11 large cancer centers from Jan.

A facile photonics reconfigurable memristor with dynamically allocated neurons and synapses functions.

The dynamic neural network function realized by reconfigurable memristors to implement artificial neurons and synapses is an effective method to complete the next generation of neuromorphic computing. However, due to the limitation of reconfiguration conditions, there are inconsistencies in the turn-on voltage and operating current before and after the reconfiguration of neuromorphic devices, which leads to huge difficulties in hardware application development and is an urgent problem to be solved. In this work, we introduced light as a regulatory means in the memristor and achieved the reconfiguration of volatile (endurance ~10 cycles) and non-volatile (retention ~10 s) characteristics with a unified working parameter through the photoelectric coupling mode.

Development and validation of a nomogram for predicting immune-related thyroid dysfunction during immunotherapy in non-small cell lung cancer: a prospective cohort study in China.

Background: Immune checkpoint inhibitors (ICIs) have improved survival for non-small cell lung cancer (NSCLC) patients, but immune-related adverse events (irAEs), like immune-mediated thyroid dysfunction (IMTD), have been reported. IMTD causes irreversible thyroid damage, affecting NSCLC patients' quality of life. This study aims to explore IMTD risk factors and develop a Nomogram to predict IMTD risk at 6, 12, and 24 months.

Neonatal sevoflurane anesthesia induces persistent cognitive deficits in mice through CypD-dependent mitochondrial impairment in parvalbumin interneurons.

Repeated neonatal sevoflurane anesthesia induces cognitive impairment in adulthood, but its neuropathological mechanisms remain unclear. Parvalbumin (PV) interneurons, which rely heavily on mitochondrial stability, are susceptible to anesthesia. Mitochondrial matrix protein Cyclophilin D (CypD) is involved in cognition by regulating the mitochondrial function.

All-cause and cause-specific mortality in psoriasis patients: a systematic review and meta-analysis.

Objective: The objective of this meta-analysis is to assess the all-cause and cause-specific mortality in patients with psoriasis.

Method: In accordance with PRISMA guidelines, a systematic search of PubMed, EMBASE, and the Cochrane Library (from inception to March 2025) was conducted. Eligible studies comprised English-language cohort studies comparing mortality risk (HR/OR/RR) in adults with psoriasis versus healthy/non-psoriasis controls.

Transumbilical single-site double-port laparoscopic appendectomy in children. Report of a single center experience with comparison with three-port laparoscopic appendectomy.

Objective: Transumbilical single-site double-port laparoscopic appendectomy (TSSDPLA) represents an innovative and minimally invasive approach for managing acute appendicitis. This study aims to compare the clinical outcomes of TSSDPLA vs. three-port laparoscopic appendectomy (TPLA) in a pediatric series.

Cascade Catalytic Nanozymes: Design, Classification, and Biomedical Applications.

Enzyme catalysis plays a fundamental role in biological systems, particularly in multienzyme cascade reactions that achieve efficient and precise transformation of complex substrates through synergistic cooperation. These cascades exemplify the high-level division of labor and ordered regulation intrinsic to natural catalytic networks. Inspired by such biological systems, nanozymes, which are artificial catalytic materials that combine the physicochemical properties of nanomaterials with enzyme-like activities, have emerged as a promising platform for constructing multistep catalytic processes.

Lithium Lactate Modified Polyolefin Separators for High-Performance Lithium Metal Batteries.

As the fast-paced evolution of high energy density rechargeable batteries continues, the lower lithium ion (Li) mobility of polyolefin separators has become a major bottleneck in the adoption of lithium metal electrodes. With undesired Li-anion solvated structures in the electrolyte, previous separator modification strategies are generally confronted with the dilemma of concurrently enhancing the Li transference number and reducing the anion transference number, as well as overall conductivity. Here, a strategy are reported to prepare high-performance separators with polyolefin separators coated by lactic acid lithium with the assistance of dopamine hydrochloride and triethanolamine, which can achieve a stable LMB operation at 1 C for 600 cycles with a capacity retention of 92%, substantially outperforming pristine PP separator.

Integrated metabolomics and serum pharmacochemistry reveal Q-markers of Zhigancao decoction for antiarrhythmic efficacy.

Ethnopharmacological Relevance: Zhigancao decoction (ZGCD) is a classic plant-derived compound traditional Chinese medicine, which is widely used in the treatment of arrhythmia, palpitation, weakness of spleen and stomach, and deficiency of qi and blood. However, there are still some deficiencies in the current quality assessment system, especially the lack of systematic selection of quality control indicators. It is urgent to establish a robust quality control paradigm based on multi-dimensional analysis.

Virus-like Particle Vaccine for Feline Panleukopenia: Immunogenicity and Protective Efficacy in Cats.

Background/objectives: Feline panleukopenia, caused by FPV, is a highly contagious disease in cats. Current vaccines face challenges including complex production, high cost, and safety risks. Developing safer, more efficient alternatives is crucial.

Self-Catalysis-Graphitization Strategy Toward Coal-Derived Graphitic Hierarchical Porous Carbon with Advanced Zn-Ion Storage Capability and Ultrastability.

Based on dual carbon targets, it is a clean and efficient utilization to convert coal into high value-added carbon materials for Zn-ion hybrid supercapacitor (ZIHSC), coupling high energy density of batteries and high power output of supercapacitors. Herein, a one-step self-catalysis-graphitization approach is developed to fabricate N/O/S co-doped graphitic hierarchical porous carbon from bituminous coal by taking advantages of the intrinsic heteroatoms for self-doping, the associated minerals for graphization and KOH activation for hierarchical porosity, contributing to abundant entrapments for Zn capture, express transfer pathway for fast kinetics and sturdy skeleton for long-term duration and thereby endowing the coin-type ZIHSC device an ultrahigh capacity of 229.8 mAh g at 0.

Efficacy and safety of cross-linked acellular porcine corneal stroma for infectious corneal disease in China: a multicenter prospective clinical trial.

Background: Acellular porcine corneal stroma (APCS) is a promising alternative to allografts, however its potential requires verification. To evaluate the efficacy and safety of novel cross-linked APCS transplantation for the treatment of infectious corneal disease.

Methods: This prospective, multicenter, single-arm clinical trial was conducted from 2015-2019.

Dexmedetomidine alleviates renal ischemia reperfusion injury via suppressing SLC2A1-mediated glycolysis.

Renal ischemia reperfusion injury (IRI) represents a significant factor in perioperative acute kidney injury (AKI), which in turn predisposes to acute renal failure. Dexmedetomidine (Dex) is an anesthetic drug with sedative and analgesic effects, and clinical evidence supports its renoprotective properties. However, the exact molecular mechanism of Dex's renoprotection remains unclear.