LC-MS-Based Serum Pharmacochemistry Combined With Network Pharmacology and Pharmacodynamics to Evaluate the Role of Macromolecular Components in TCMs' Decoction: A Case Study on Qi-Huo-Yi-Fei Decoction for COPD Therapy.

Introduction: The role of macromolecular components in traditional Chinese medicines (TCMs) decoction remains poorly understood, primarily because of their structural complexity and limited systemic bioavailability. In the modernization of TCMs' decoctions, macromolecular components are often removed as "poor bioavailable impurities" by ethanol precipitation that might attenuate the efficacy thereof.

Purpose: A novel strategy integrating LC-MS-based serum pharmacochemistry, network pharmacology, and pharmacodynamics was developed to reveal the role of macromolecular components in TCMs' decoction, using Qi-Huo-Yi-Fei decoction (QH) treating chronic obstructive pulmonary disease (COPD) as a case study.

Developing a procedure mimicking transvaginal mesh implantation in women in a modified POP rat model.

Introduction: This study aims to establish a simple and reproducible transvaginal mesh surgery rat model based on the modified pelvic organ prolapse rat model.

Methods: A total of 24 10-week-old female nulliparous Wistar rats were used in this study. The control group consisted of six rats with no interventions.

Experimental Investigation on the Strength of Fluxed Pellets Made by Medium-SiO Concentrate.

In the ironmaking process, using a high proportional pellet is a good way for energy saving. In order to maintain the basicity and MgO content of slag, CaO and MgO are necessary fluxes of pellets while the proportion of pellets in the furnace is increased. Limited by resource conditions, many iron and steel enterprises, especially in China, do not have enough low-SiO concentrate.

Chinese expert consensus on hematologic malignancy karyotyping.

Chromosomal karyotype analysis is crucial for diagnosing and managing hematologic malignancies, yet inconsistent protocols compromise reliability. To standardize practices, this consensus integrates international guidelines (WHO, ICC, ELN) with clinical expertise, providing evidence-based recommendations for specimen collection, cell culture, chromosome harvesting, banding techniques, karyotype analysis, and reporting. By establishing uniform operational standards, this initiative seeks to mitigate variability, improve detection rates, and support precision medicine in hematologic malignancies.

Meta-analysis of compression therapy for prevention of chemotherapy-induced peripheral neuropathy.

Objective: To investigate the prophylactic effect of compression therapy against chemotherapy-induced peripheral neuropathy (CIPN) through meta-analytic evaluation.

Methods: Systematically searched PubMed, Embase, Web of Science, Cochrane Library, Scopus, and Chinese databases (CBM, CNKI, Wan fang, VIP) until December 2024. Included studies were RCTs and quasi-experimental designs.

Distinct immunological signatures define three sepsis recovery trajectories: a multi-cohort machine learning study.

Importance: Understanding heterogeneous recovery patterns in sepsis is crucial for personalizing treatment strategies and improving outcomes.

Objective: To identify distinct recovery trajectories in sepsis and develop a prediction model using early clinical and immunological markers.

Design Setting And Participants: Retrospective cohort study using data from 28,745 adult patients admitted to 12 intensive care units (ICUs) with sepsis between January 2014 and December 2024.

Ethanol precipitation process affects the pharmacokinetic characteristics of major active glycosides of Qiong-Yu-Gao: evidences in normal and cisplatin-induced acute kidney injury rats.

Ethnopharmacological Relevance: Qiong-Yu-Gao (QYG) is a classical formula that shows protective effects against cisplatin-induced acute kidney injury (AKI). Recent evidence indicates that iridoid glycosides and ginsenosides are the main active substances of QYG. In the production of modern Chinese medicine preparations, ethanol precipitation is a commonly applied but not fully verified refining process.

Impact of ultralow oxygen preservation on the quality of Atractylodis Macrocephalae Rhizoma evaluated by multi-chromatographic determination of small molecules and polysaccharides.

Atractylodis Macrocephalae Rhizoma (AMR) is one of the commonly used medicinal and edible herbs in China. To prevent infestation of moths and mildew, chemical-fumigation is applied during post-harvest processing, which would produce harmful substances. Ultralow oxygen (ULO) storage, as a potential controlled atmosphere preservation method for Traditional Chinese Medicines (TCMs), has no residue of chemical hazards, but its impact on chemical composition of TCMs is unclear.

Gastrointestinal motility modulation efficacy-related chemical marker findings and QAMS-based quality control of Agastache rugosa.

Agastache rugosa (AR), a traditional edible and medicinal herb, is often used for treating gastrointestinal (GI) motility disorder. But little effort has been done on its gastrointestinal motility modulation (GMM) efficacy-related components and quality control of AR. In this study, a novel strategy was proposed to find GMM efficacy-related chemical markers for the quality control of AR.

Post-traumatic growth experience of breast cancer patients: A qualitative systematic review and meta-synthesis.

Objectives: This study aimed to systematically incorporate the post-traumatic growth experience of breast cancer patients and furnish insights for the formulation of targeted psychological care measures.

Methods: The search period we were ranged from establishing the database to February 2024. We systematically searched four Chinese databases and seven English databases.

Effect of non-pharmacological interventions on chemotherapy induced delayed nausea and vomiting for tumors: A systematic review and Bayesian network meta-analysis.

Objective: To evaluate the efficacy of non-pharmacological interventions in improving chemotherapy induced delayed nausea and vomiting symptoms using a network meta-analysis.

Methods: Four Chinese databases (CNKI, Wanfang Data Knowledge Service Platform, VIP, Sinomed) and five English databases (PubMed, Cochrane Library, Embase, Web of Science, CINAHL) were searched from the establishment of the database to April 2024. A Bayesian network meta-analysis was performed on the response rate to the improvement of chemotherapy induced delayed nausea and vomiting, as well as improvement in KPS score, under different non-pharmacological interventions by using R 4.

Interfacial and electronic dual regulation of metal organic frameworks for enhanced catalytic oxidation of peroxymonosulfate into dyes.

In heterogeneous advanced oxidation processes, it is important to improve the catalytic performance, which can be achieved by increasing the mass transfer of catalysts and utilization efficiency of reactive oxygen species (ROSs). Herein, the functional groups, amino group (NH) and hydroxyl group (OH), were introduced onto the surface of metal organic frameworks (MOFs), FeBDC (Iron terephthalate) by ligand exchange. The synthesized MOFs were used as catalysts to activate peroxymonosulfate (PMS) for the efficient removal of dye from wastewater.

Dose-response relationship between the age at diagnosis of cardiovascular metabolic multimorbidity and cognitive impairment among middle-aged and older adults in China.

Aims: The purpose of this study was to explore the dose-response relationship between the age at diagnosis of cardiovascular metabolic multimorbidity and cognitive impairment among middle-aged and older adults in China.

Methods: This is a secondary study using the China Health Retirement Longitudinal Study 2018(CHARLS 2018). The study included 1338 middle-aged and older adults.

Integrated anti-fatigue effects of polysaccharides and small molecules coexisting in water extracts of ginseng: Gut microbiota-mediated mechanisms.

Ethnopharmacological Relevance: Both clinical and animal studies have demonstrated that ginseng has curative effects on fatigue. Our previous study found that water extracts of ginseng (WEG) could significantly mitigate exercise-induced fatigue (EF). Notably, polysaccharides (GP) and small molecules (GS, mainly ginsenosides) coexist in WEG.

Enhancement of high-efficiency potassium ion hybrid supercapacitors utilizing oxygen-deficient CoNiO@nitrogen-doped carbon nanoflower.

Transition metal oxides represent a promising category of pseudocapacitive materials for potassium-ion hybrid supercapacitors (PIHCs) characterized by high energy density. Nevertheless, their utility is hindered by intrinsic low conductivity, restricted electrochemical sites, and notable volume expansion, all of which directly contribute to the degradation of their electrochemical performance, thereby limiting their practical applicability in supercapacitor systems. In this study, we present a facile synthesis approach to fabricate nitrogen-doped carbon-supported oxygen vacancy-rich CoNiO nanoflowers (Ov-CoNiO/NC NFs) featuring tunable surface layering and electron distribution.

Fe-Catalyzed Fluorosulfonylation of Alkenes via Sulfur Dioxide Insertion: Synthesis of Lactam-Functionalized Alkyl Sulfonyl Fluorides.

A novel Fe-catalyzed fluorosulfonylation of alkenes with NaSO and -fluorobenzenesulfonimide (NFSI) for assembling various lactam-functionalized alkyl sulfonyl fluorides is disclosed. In this reaction, NaSO acts as both an SO source and a reductant. Furthermore, the resulting products can be efficiently transformed into valuable chemicals, including sulfonyl esters and sulfonamides, via the sulfur(VI) fluoride exchange (SuFEx) click reaction.

Transforming Commercial Polymers into Tough yet Switchable Adhesives by Trident Photoswitch Molecule Doping: Break Adhesion-Switchability Paradox.

Here, a trident molecule doping strategy is introduced to overcome both cohesion-adhesion trade-off and adhesion-switchability conflict, transforming commercial polymers into tough yet photo-switchable adhesives. The strategy involves initial rational design of new trident photoswitch molecules namely TAzo-3 featuring azobenzene and hydroxy-terminated alkyl chains involved rigid-soft tri-branch structure, and subsequent doping into commercial polycaprolactone (PCL) via simple blending. Unique design enables TAzo-3 as a versatile dopant, not only regulating the internal and external supramolecular interaction to balance cohesion and interface adhesion for tough bonding, but also affording marked photothermal effect to facilitate rapid adhesive melting for great photo-switchability.

Rigid-Flexible Coupled Dendritic Molecule Doping: General Approach to Activate Commercial Polymers into Harsh Condition-Tolerant Multi-Reusable Strong Supramolecular Adhesives.

Developing functional adhesives combining strong adhesion, good recyclability and diverse harsh-condition adaptability is a grand challenge. Here, we introduce a general dendritic molecule doping strategy to activate commercial polymers into a new family of supramolecular adhesives integrating high adhesion strength, ultralow temperature, water resistant and multi-reusable properties. Our method involves rational design of a new rigid-flexible coupled dendritic molecule-MCOH as a versatile dopant, while simple MCOH doping into commercial polymers can modulate internal and external non-covalent interaction to enable H-bonding enhanced interchain cross-linking for tough cohesion along with enhanced interphase interaction.

Efficiency of endoscopic artificial intelligence in the diagnosis of early esophageal cancer.

Background: The accuracy of artificial intelligence (AI) and experts in diagnosing early esophageal cancer (EC) and its infiltration depth was summarized and analyzed, thus identifying the advantages of AI over traditional manual diagnosis, with a view to more accurately assisting doctors in evaluating the patients' conditions and improving their cure and survival rates.

Methods: The PubMed, EMBASE, Cochrane, Google, and CNKI databases were searched for relevant literature related to AI diagnosis of early EC and its invasion depth published before August 2023. Summary analysis of pooled sensitivity, specificity, summary receiver operating characteristics (SROC) and area under the curve (AUC) of AI in diagnosing early EC were performed, and Review Manager and Stata were adopted for data analysis.