Using Machine Learning to Predict Advanced-Stage Progression of Intermediate-Stage Hepatocellular Carcinoma after Transarterial Chemoembolization.

Purpose To develop and test a machine learning (ML)-based model that integrates preoperative variables for prediction of advanced-stage progression (ASP) after transarterial chemoembolization (TACE). Materials and Methods This multicenter retrospective study (ResearchRegistry.com identifier no.

Analysis of risk factors associated with recurrence of granulomatous lobular mastitis and establishment of a prediction model.

Objectives: To explore the risk factors that are associated to the recurrence of granulomatous lobular mastitis (GLM) after treatment and to develop a nomogram model that can predict the risk of recurrence.

Methods: Medical records and follow-up data from GLM patients treated at our facility were retrospectively analyzed. In order to identify independent risk factors for GLM recurrence, the patients were split into groups with and without recurrence using univariate and multivariate logistic regression analyses.

Broad-spectrum antitumor analysis of the telomerase activity inhibitor TPCH derived from the human constitutively expressed protein LPTS/PinX1.

Background: The human liver-related putative tumor suppressor LPTS/PinX1 is a gene encoding a telomerase inhibitory protein. Overexpression of LPTS/PinX1 protein can inhibit the growth of multiple telomerase-positive cancer cell lines. LPTS/PinX1 has therapeutic potential for cancer.

Change trajectory of dyadic coping and subjective well-being in patients with malignant bone tumors based on cross-lagged panel model and latent growth model: a longitudinal study.

Background: Malignant bone tumors can result in physical disability, which has a significant impact on the quality of patients' survival. Additionally, patients often experience high levels of psychological distress. The subjective well-being of patients with bone tumors is low, and this low level of well-being is the direct cause of the accumulation of negative emotions and misanthropy in patients.

SmbZIP5 Integrates Abscisic and Jasmonic Acid Signalling to Positively Regulate Tanshinone Biosynthesis in Salvia miltiorrhiza.

Salvia miltiorrhiza produces pharmacologically bioactive diterpenoid tanshinones which are regulated by jasmonate (JA) and abscisic acid (ABA) signalling, while their crosstalk in this process remains unclear. Here, we demonstrated that MeJA and ABA acted synergistically to enhance tanshinone biosynthesis. We reported that a novel bZIP transcription factor, SmbZIP5, was involved in ABA- and JA-induced tanshinone biosynthesis.

Development and Application of Fluorescent and Lateral Flow Dipstick Recombinase-Aided Amplification for Rapid Detection of .

() is a bacterial respiratory pathogen from pigs, which can cause high morbidity and mortality in weaned piglets in piggery. An accurate and rapid detection for is crucial for the effective control of Glässer's disease. In the present study, two distinct Recombinase-Aided Amplification (RAA) techniques, utilizing fluorescence and lateral flow dipstick, were developed for the detection of .

The Mechanism of Steroid Hormones in Non-Small Cell Lung Cancer: From Molecular Signaling to Clinical Application.

Steroid hormones play critical roles in the development and progression of NSCLC through both genomic and non-genomic pathways. This review summarizes the expression profiles and molecular functions of estrogen, progesterone, androgen, and glucocorticoid receptors in NSCLC. Estrogen and progesterone receptors exhibit gender-specific prognostic significance, while glucocorticoid receptors influence tumor growth and immune responses.

The predictive role of peripheral serum inflammatory markers NLR, PLR, and LMR in ulcerative colitis and Crohn's disease: a systematic review and meta-analysis.

Background: The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) are peripheral serum markers commonly utilized as cost-effective indicators of inflammation. However, their efficacy as predictors of clinical disease activity in inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), remains uncertain. To address this ambiguity, we conducted a meta-analysis to evaluate the clinical significance of NLR, PLR, and LMR in patients with IBD.

Correction: The predictive role of peripheral serum inflammatory markers NLR, PLR, and LMR in ulcerative colitis and Crohn's disease: a systematic review and meta-analysis.

[This corrects the article DOI: 10.3389/fimmu.2025.

Patient and Physician Preferences for Maintenance Treatment in Advanced Non-Small Cell Lung Cancer: Insights into Treatment Selection.

Introduction: Advanced/metastatic non-small cell lung cancer (a/mNSCLC) is associated with a poor prognosis. Although maintenance therapy after first-line (1L) induction treatment can extend survival, it may also present with drawbacks like risk of certain adverse events (AEs), underscoring the need for shared decision-making between patients and their treating physicians. This study aimed to quantify the extent to which maintenance treatment attributes impact the preferences of patients and physicians after 1L induction therapy for a/mNSCLC.

Multisignal Conversion Electrochemiluminescence Strategy Based on Nanozyme-Enhanced Nitrogen-Vacancy/Oxygen-Doped g-CN for the Detection of Cholesterol.

The high and stable signal intensity of electrochemiluminescence (ECL) is crucial for establishing highly sensitive ECL biosensors. Here, nitrogen-vacancy/oxygen-doped carbon nitride (OCNNV-650) was first used as an ECL emitter, significantly improving the low ECL activity and poor dispersion of graphitic carbon nitride (g-CN) through a molecular engineering strategy. It is particularly noteworthy that FeO@MoS peroxidases, as coreaction accelerators, are the key to achieving the first and last "signals on", promoting the production of more SO and even promoting the production of •OH radicals when cholesterol is electrocatalyzed to produce HO.

Clinical characteristics and immunotherapy efficacy in advanced lung cancer patients with immune checkpoint inhibitor-related adrenal insufficiency.

To investigate the clinical characteristics and treatment efficacy in advanced lung cancer patients with adrenal insufficiency (AI) induced by immune checkpoint inhibitors (ICIs). A retrospective study was conducted on advanced lung cancer patients who developed AI following ICI treatment at Lishui Central Hospital between January 2019 and November 2024. Patients from both the Oncology and Respiratory & Critical Care Departments were included.

Evaluation of cell-free DNA from papanicolaou smears and peripheral blood to detect endometrial cancer.

Objective: This study aimed to identify tumor-derived DNA in Papanicolaou (Pap) smears and plasma specimens from patients with endometrial cancer or endometrial intraepithelial neoplasia (EC/EIN).

Methods: Tumor tissue, peripheral blood, and Pap smear samples were collected from 84 patients with EC and EIN. Somatic mutations in tumor specimens were analyzed using targeted exome sequencing with a 363-cancer-related gene panel.

Effect of preload on lumbar muscle contraction during co-activation of trunk muscles in young males simulating anti-G straining maneuver.

ObjectPreload is known to improve spinal stability; however, its effect on the voluntary contraction of lumbar muscles needs investigation. This study aimed to investigate the role of preload in enhancing the voluntary contraction of lumbar muscles in a group of young men.MethodsTwenty healthy participants successively participated in experiments with the following preload conditions arranged in random order: no preload, forward preload, backward preload, or right-hand-pull preload.

Effectively Determining Dopamine Based on Dopamine Self-polymerization through Fluorescent Method Using Silicon Quantum Dots as Probe.

Dopamine, a catecholamine neurotransmitter found in both neural tissue and body fluids, plays a critical role in brain function. Its distribution in specific brain regions affects the coordination of pituitary endocrine functions and is directly involved in neural activities, making dopamine concentration detection vital. In this study, highly fluorescent silicon quantum dots (silicon nanoparticles: SiNPs) were synthesized and employed as a fluorescent probe for convenient dopamine detection in Tris buffer.

Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy.

Despite the success of autologous chimeric antigen receptor (CAR)-T cell therapy, achieving persistence and avoiding rejection in allogeneic settings remains challenging. We showed that signal peptide peptidase-like 3 (SPPL3) deletion enabled glycan-mediated immune evasion in primary T cells. SPPL3 deletion modified glycan profiles on T cells, restricted ligand accessibility, and reduced allogeneic immunity without compromising the functionality of anti-CD19 CAR molecules.

Red-light-triggered microenvironment-responsive sustained carbon monoxide release for enhanced tumor therapy.

Carbon monoxide (CO), a gasotransmitter, has gained attention as a potential therapeutic agent in cancer treatment. The precise and sustained release of CO is crucial for minimizing its toxicity and enhancing its therapeutic efficacy. We have developed a light-gated, microenvironment-responsive CO release platform for precise and sustained CO delivery.

A 2B Protein-Derived Peptide Effectively Inhibits Coxsackievirus B3 Infection.

The nonstructural 2B protein of coxsackievirus B (CVB) is a transmembrane protein that forms a hydrophilic tetramer viroporin on the cellular membrane structures. 2B plays a key role in the replication of CVB. We hypothesized that blocking the polymerization of 2B may interfere with CVB replication.

c-MET Inhibition Reverses the Osimertinib Resistance in Lung Circulating Tumor Cell Clusters and Suppresses Metastasis.

Background: Circulating tumor cells (CTCs) serve as the “seeds” of tumor metastasis, and the clustering of CTCs is critically associated with tumor metastasis and the mortality of lung cancer patients. Inhibiting the survival of CTC clusters represents a pivotal strategy for anti-lung cancer metastasis therapy. This study is designed to explore the impact and underlying mechanism of lung cancer CTC clusters in mediating resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), thereby offering novel insights into anti-lung cancer metastasis treatment.

Histone H3 lysine 18 lactylation attenuates neuroinflammation and neurological damage by regulating microglial plxnb2 after ischemic stroke.

Microglia are major resident immune cells in the central nervous system and are actively involved in the pathogenesis of ischemic stroke. Histone lactylation confers macrophage homeostatic gene expressions and regulates physiological and immune-related pathological conditions. However, the spatiotemporal expression and functional role of histone lactylation in microglial reprogramming and neurological injuries after ischemic stroke remain elusive.

Arabidopsis MACP2 contributes to autophagy induction by modulating starvation-induced reactive oxygen species homeostasis.

In plants, autophagy is a conserved recycling system essential for development and stress responses by targeting cellular components for massive degradation in the vacuole. Our previous work suggested that autophagy contributes to Arabidopsis (Arabidopsis thaliana) stress responses by modulating NADPH-oxidase-mediated reactive oxygen species (ROS) homeostasis; however, the molecular link between extracellular ROS and autophagy remains unknown. We performed a yeast two-hybrid screen to identify components involved in autophagy, using the central autophagy component ATG8e as a bait.

Chiral intercalation in layered cyano-bridged metal frameworks.

In this work, a series of chiral nanomaterials have been successfully constructed by intercalating chiral molecules of α-methylbenzylamine into diverse layered cyano-bridged metal frameworks through host-guest interaction. These unique layered chiral nanomaterials show enhanced CO photoreduction activity with the CO production rate up to 40.4 mmol h g.

Circulating Tumor DNA Genotyping of Intrinsic and Acquired Gene Alterations in Patients With Advanced Breast Cancer Receiving Palbociclib: Biomarker Results From POLARIS Study.

Purpose: To identify gene alterations in circulating tumor DNA (ctDNA) from palbociclib-treated patients with advanced or metastatic breast cancer (ABC) in POLARIS to identify potential mutagenic drivers of resistance.

Methods: POLARIS was a prospective, real-world study of palbociclib in patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) ABC in the United States and Canada. Patients who received ≥1 palbociclib dose and had ≥1 ctDNA measurement were included in the biomarker analysis.

Seasonally disparate responses of surface thermal environment to land use/land cover patterns: a case study of central urban area of Jinan city, China.

Land use/land cover (LULC) changes exacerbate urban heat island (UHI) effect, leading to ecological and environmental problems. LULC patterns exhibit different driving mechanisms on land surface thermal environments across different seasons. However, so far, quantitative research distinguishing seasonal differences in LULC patterns at the landscape and class levels in relation to land surface temperature (LST) has remained limited.

WITHDRAWN: Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function.

Due to a miscommunication, after publishing the correction notice announcing the new Figure 5D for this article, the production team inadvertently created a copy of the correction notice containing the same information as the first correction notice. The production team regrets this error and apologizes for any confusion. The full Elsevier Policy on Article Withdrawal can be found at https://www.