Transdiagnostic homogeneity, and diagnostic-specific biomarkers among major depressive disorder, bipolar disorder and schizophrenia during 40 Hz auditory steady-state response: a normative modeling analysis.

Background: Abnormal gamma-band auditory steady-state response (gamma-ASSR) power has been reported in major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ), but distinguishing between these disorders based solely on power remains challenging. Directed functional connectivity (DFC), which captures topological patterns of causal information flow, may provide more diagnostic-specific markers. However, conventional case-control framework often disregards the substantial individual heterogeneity, yielding unreliable biomarkers.

Molecular Insights into the Reversible Mechanisms of CO-Switchable Surfactant Solubilization and Emulsification.

Switchable surfactants exhibit broad application potential due to their reversible response to external stimuli. The reversible mechanism of the CO-switchable surfactant ('-dodecyl-, -dimethyl-acetamidines, DDA) solubilization polycyclic aromatic hydrocarbons (PAHs) and the microscopic dynamic behavior of emulsification/demulsification were systematically studied using coarse-grained molecular dynamics simulations. The dynamic transition processes of protonation (DDA to DDA) and deprotonation (DDA to DDA) were successfully simulated.

Chinese Healthy Eating Index (CHEI) and risk of hypertension: A prospective cohort study in China.

The Chinese Healthy Eating Index (CHEI) is a valuable tool for assessing dietary quality. However, the relationship between CHEI and the risk of hypertension remains unclear. Therefore, a total of 1342 adults without hypertension at baseline and provided at least two survey data from 1997 to 2018 were included.

Prediction of lymphovascular invasion in invasive breast cancer via intratumoral and peritumoral multiparametric magnetic resonance imaging machine learning-based radiomics with Shapley additive explanations interpretability analysis.

Background: The use of multiparametric magnetic resonance imaging (MRI) in predicting lymphovascular invasion (LVI) in breast cancer has been well-documented in the literature. However, the majority of the related studies have primarily focused on intratumoral characteristics, overlooking the potential contribution of peritumoral features. The aim of this study was to evaluate the effectiveness of multiparametric MRI in predicting LVI by analyzing both intratumoral and peritumoral radiomics features and to assess the added value of incorporating both regions in LVI prediction.

Development and Validation of a Machine Learning-Based Risk Prediction Model for Delirium in Older Inpatients: A Prospective Cohort Study.

Aims: To develop and validate a machine learning-based risk prediction model for delirium in older inpatients.

Design: A prospective cohort study.

Methods: A prospective cohort study was conducted.

Right Ventricular Apical Pacing in Patients With Preserved LVEF: Adverse Effects and Mechanisms.

Background: Long-term adverse cardiac effects of right ventricular (RV) pacing in patients with normal left ventricular (LV) ejection fraction (EF) are not well studied.

Objectives: The purpose of this study was to evaluate adverse effects of RV apical pacing in patients with normal LVEF.

Methods: Medical records of patients who had undergone RV apical pacemaker implantation for pacing indications and had an LVEF ≥50% were reviewed to determine the effect of RV pacing burden on LV systolic and diastolic function, mechanical dyssynchrony, heart failure hospitalization (HFH), and all-cause mortality.

Approximation-free finite-time control for uncertain active suspensions with unknown time-varying input delays.

This article investigates a new approximation-free finite-time control method for active suspension systems (ASSs) to address uncertain nonlinearities and unknown time-varying input delays (UTIDs), while enhancing suspension performance. First, to improve the transient performance of ASSs, a unique finite-time prescribed performance function (FPPF) is designed to ensure that the suspension motion converges to a predetermined range within a finite time. Then, a novel compensator is developed to resolve the impact of unknown input delays in the closed-loop system.

The predictive role of peripheral serum inflammatory markers NLR, PLR, and LMR in ulcerative colitis and Crohn's disease: a systematic review and meta-analysis.

Background: The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) are peripheral serum markers commonly utilized as cost-effective indicators of inflammation. However, their efficacy as predictors of clinical disease activity in inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), remains uncertain. To address this ambiguity, we conducted a meta-analysis to evaluate the clinical significance of NLR, PLR, and LMR in patients with IBD.

Correction: The predictive role of peripheral serum inflammatory markers NLR, PLR, and LMR in ulcerative colitis and Crohn's disease: a systematic review and meta-analysis.

[This corrects the article DOI: 10.3389/fimmu.2025.

Zuogui and Yougui pills extend lifespan and improve ageing biomarkers via kaempferol-mediated mitophagy in Caenorhabditis elegans.

Zuogui pill (ZGP) and Yougui pill (YGP) are classical kidney-tonifying formulas in Traditional Chinese Medicine, widely used clinically but with their potential to delay ageing and improve ageing biomarkers remaining unclear. This study combined network pharmacology and Caenorhabditis elegans models to investigate the anti-ageing effects and mechanisms of ZGP and YGP. Both formulas significantly extended lifespan (ZGP dose-dependently at 5-20 mg/mL; YGP at 20 mg/mL) and improved ageing biomarkers, as evidenced by enhanced motility, reduced lipofuscin accumulation and endogenous ROS levels, and increased resistance to heat and oxidative stress.

Understanding face processing in autism spectrum disorder: insights from cognitive neuroscience.

Faces convey critical information for social communication, such as identity, expression, and eye gaze. Unfortunately, individuals with autism spectrum disorder (ASD) often experience difficulties in processing this information, and these deficits lead to their suffering from social interactions. Importantly, since face processing is a social skill developed during early childhood, its deficits may be an early symptom of ASD.

S-glutathionylation in cancer: from fundamental mechanisms to clinical applications.

Glutathione (GSH) is a thiol-containing antioxidant composed of glutamic acid, cysteine and glycine. GSH can form a disulfide bond with the cysteine sulfhydryl group of a protein, resulting in S-glutathionylation (-SSG). S-glutathionylation is a reversible posttranslational modification that plays important roles in redox regulation, detoxification, cell signaling pathway regulation, cell death, infection and inflammation.

Single-dose infusion of engineered viral receptor binding domain confers rapid and durable protection against viral infection.

Developing both rapid- and long-acting antiviral drugs for single-dose administration can improve medication adherence and protect people at risk of infection. To provide proof of this concept, here, we designed multimerized form of viral receptor-binding domains (RBDs) to immediately occupy viral receptors to block infection and subsequently induce virus-specific protective immunity. We engineered SARS-CoV-2 RBD, enhancing its affinity to ACE2 and immunogenicity through multimerization and Fc modification.

Research on internal defect detection of multilayer media based on phase coherence far-focused pixel-based imaging method.

In ultrasonic inspection of internal defects within multilayer media, traditional amplitude-based imaging methods frequently suffer from low signal-to-noise ratio (SNR) and inconsistent defect characterization, particularly for identically sized flaws at varying depths, primarily due to interface reflections and material attenuation. To address these challenges, a phase-coherent far-focused pixel-based (PC-FPB) imaging algorithm is proposed in this paper. This method constructs coherent imaging signals using a vector coherence factor and introduces a novel scan-line-based coherence modulation strategy.

Oxygen-Tailored MoS as a High-Performance Substrate for Pressure-Induced Surface-Enhanced Raman Spectroscopy.

Pressure-induced SERS (PI-SERS) has garnered increasing attention due to its applications in enhancing Raman signals under extreme conditions. However, the effective implementation of PI-SERS enhancement and the elucidation of its underlying mechanisms remain open questions. In this study, we introduce an innovative approach utilizing oxygen-tailored MoS as SERS substrates, significantly improving PI-SERS performance.

LiPO-enriched solid electrolyte interphase on Si-based anode for enhanced Li transport and interfacial stability in lithium batteries.

The structure and composition of the solid electrolyte interphase (SEI) exerts a significant influence on the fast-charging capability and stability of lithium-ion batteries (LIBs). However, elucidating the design principles governing anode interfacial structures and revealing the kinetics and mechanisms of Li transport remain challenging. SEI layer.

Zincophilic MOF Protective Layer for Stable Zinc Anodes in Zinc-Ion Batteries.

Aqueous zinc-ion batteries (AZIBs) are under the spotlight due to their substantial potential, abundant natural resources, inherent safety, and high specific capacity. However, uncontrollable zinc dendrite growth and side reactions on the zinc surface hinder the application of ZIBs. In this article, a uniform copper-based metal-organic frameworks (MOFs) coating layer was fabricated on a zinc metal surface (CuZIF@Zn) to serve as a protective interface.

Blind Source Separation-Embedded Electroencephalogram Microstate Trajectory Modeling for Generalized Anxiety Disorder Identification.

Generalized anxiety disorder (GAD) diagnosis remains challenging due to lacking reliable biomarkers. Electroencephalography(EEG) microstate analysis shows promise in detecting GAD-related neural dynamics, but its clinical application is limited by insufficient spatial resolution and sensitivity. To address this challenge, we propose a novel framework integrating fast independent component analysis (FastICA) with microstate analysis to enhance spatial specificity in EEG signal decomposition,consequently, GAD can be more accurately identified.

The growth-promoting effect and mechanism of microalgae on plants in PAHs contaminated soil.

Microalgae can effectively degrade polycyclic aromatic hydrocarbons (PAHs) in water. However, the remediation mechanism of microalgae in PAH-contaminated soil remains unclear. In this study, the growth-promoting effects of wheat by Chlorella vulgaris in PAH-contaminated soil were studied.

Cinobufagin overcomes bortezomib resistance in multiple myeloma strains by targeting SEC62/TRPM4-mediated NECSO.

Background: Necrosis by sodium overload (NECSO) is a poorly understood, novel form of cell death implicated in cancer. TRPM4 is the only protein currently linked to NECSO and is downregulated in bortezomib-resistant multiple myeloma (MM) patients and cell lines.

Purpose: To investigate the potential of cinobufagin to overcome bortezomib resistance in MM and elucidate its underlying mechanism of action, particularly regarding TRPM4 and NECSO induction.

Treatment Outcomes and Prognostic Factors for Patients With Medulloblastoma Having Defined Molecular Subtypes.

Purpose: This study aims to evaluate treatment outcomes and prognostic factors in pediatric patients with medulloblastoma (MB) with defined molecular subtypes to inform subsequent individualized treatment.

Methods And Materials: A retrospective analysis was conducted on 145 patients with MB with defined molecular subtypes who underwent radiation therapy (RT) at our institution from January 2017 to 2021. Patients were subjected to traditional clinical risk stratification, molecular risk stratification, and National Comprehensive Cancer Network (NCCN) risk stratification, respectively.

WTAP Dysregulation Mediates HLF-m6A Modification to Inhibit Trophoblast Ferroptosis in Preeclampsia.

Preeclampsia (PE) is a severe pregnancy-specific disorder that poses significant risks to maternal and perinatal health. The pathophysiological mechanisms underlying PE are complex and not yet fully elucidated. This study focuses on the role of ferroptosis in PE and identifies a significant downregulation of the transcription factor hepatic leukemia factor (HLF) in PE placental tissues.

Sociopsychological determinants of functional foods consumption in China: based on the theory of the planned behavior expansion model.

This study investigates the determinants of Chinese consumers' purchase intentions and behavior toward functional foods, incorporating health consciousness and trust into the theory of planned behavior (TPB) as a conceptual framework. An online quota-sample survey was conducted on 1,011 Chinese consumers. Structural equation modeling was used to test the proposed hypotheses.

Gut-lung axis in allergic asthma: microbiota-driven immune dysregulation and therapeutic strategies.

Background: Allergic asthma, a chronic respiratory disorder, is intricately linked to gut microbiota dysbiosis and metabolite perturbations through the gut-lung axis.

Objective: This review the relationship between microbial immune crosstalk and the onset of asthma, with the aim of determining the mechanism by which gut microbiota drives the onset of asthma and providing evidence for therapeutic interventions.

Methods: Literature search was conducted on PubMed using keywords ("gut microbiota" or "gut microbiota" or "gut microbiota metabolites" or "lung gut axis"), ("allergic asthma" or "asthma"), and ("immune regulation"), without date restrictions.