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In ultrasonic inspection of internal defects within multilayer media, traditional amplitude-based imaging methods frequently suffer from low signal-to-noise ratio (SNR) and inconsistent defect characterization, particularly for identically sized flaws at varying depths, primarily due to interface reflections and material attenuation. To address these challenges, a phase-coherent far-focused pixel-based (PC-FPB) imaging algorithm is proposed in this paper. This method constructs coherent imaging signals using a vector coherence factor and introduces a novel scan-line-based coherence modulation strategy. A dynamic threshold is statistically determined from the distribution of maximum coherence factors across scan lines and applied through a multiplicative fusion mechanism to selectively enhance coherent defect signals and suppress background noise. Experimental validation on multilayer structures demonstrates that the imaging intensity and SNR for deep-seated defects are significantly enhanced by the PC-FPB imaging algorithm. Comparative results further indicate that it outperforms conventional amplitude-based methods in the detection of deep defects. For single-hole imaging, the defect amplitude was improved by 9.8 dB and the image SNR increased by 7.7 dB. In multi-hole imaging, the maximum quantification error for defects with a diameter of 1 mm was recorded at 0.245 mm2, demonstrating a high degree of consistency in the imaging of identically sized defects at varying depths. Furthermore, the average SNR of defects at various depths increased by 15 dB and the average lateral resolution improved by 53.4%. The findings confirm that PC-FPB effectively overcomes the limitations of traditional methods and enhances defect detection in multilayer structures.
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http://dx.doi.org/10.1063/5.0280144 | DOI Listing |
Cereb Cortex
August 2025
Nencki Institute of Experimental Biology, PAS, 3 Pasteur Street, 02-093 Warsaw, Poland.
In the visual cortices, receptive fields (RFs) are arranged in a gradient from small sizes in the center of the visual field to the largest sizes at the periphery. Using functional magnetic resonance imaging (fMRI) mapping of population RFs, we investigated RF adaptation in V1, V2, and V3 in patients after long-term photoreceptor degeneration affecting the central (Stargardt disease [STGD]) and peripheral (Retinitis Pigmentosa [RP]) regions of the retina. In controls, we temporarily limited the visual field to the central 10° to model peripheral loss.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202.
Retinal ganglion cells (RGCs) are highly compartmentalized neurons whose long axons serve as the sole connection between the eye and the brain. In both injury and disease, RGC degeneration occurs in a similarly compartmentalized manner, with distinct molecular and cellular responses in the axonal and somatodendritic regions. The goal of this study was to establish a microfluidic-based platform to investigate RGC compartmentalization in both health and disease states.
View Article and Find Full Text PDFJMIR Med Inform
September 2025
Department of Radiology, Air Force Medical Center, Air Force Medical University, Fucheng Road 30, Haidian District, Beijing, CN.
Background: Lateral malleolar avulsion fracture (LMAF) and subfibular ossicle (SFO) are distinct entities that both present as small bone fragments near the lateral malleolus on imaging, yet require different treatment strategies. Clinical and radiological differentiation is challenging, which can impede timely and precise management. On imaging, magnetic resonance imaging (MRI) is the diagnostic gold standard for differentiating LMAF from SFO, whereas radiological differentiation on computed tomography (CT) alone is challenging in routine practice.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
School of Medicine and Public Health, University of Wisconsin-Madison, Madison.
Importance: It is unclear whether the duration of amyloid-β (Aβ) pathology is associated with neurodegeneration and whether this depends on the presence of tau.
Objective: To examine the association of longitudinal atrophy with Aβ positron emission tomography (PET)-positivity (Aβ+) and the estimated duration of Aβ+ (Aβ+ duration), controlling for tau-positivity.
Design, Setting, And Participants: Data for this longitudinal cohort study were drawn from the Wisconsin Registry for Alzheimer Prevention and the Wisconsin Alzheimer Disease Research Center Clinical Core Study.
Appl Biochem Biotechnol
September 2025
AVT - Biochemical Engineering, RWTH Aachen University, Forckenbeckstraße 51, Aachen, 52074, Germany.
Microbial co-cultures provide significant advantages over commonly used axenic cultures in biotechnological processes, including increased productivity and access to novel natural products. However, differentiated quantification of the microorganisms in co-cultures remains challenging using conventional measurement techniques. To address this, a fluorescence-based approach was developed to enable the differentiated online monitoring of microbial growth in co-cultures.
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