Preliminary Functional Outcome Following Robotic Intracorporeal Orthotopic Ileal Neobladder with Integrated Pelvic Fascial Structure-Sparing in Males with Bladder Cancer.

Purpose: To describe our integrated pelvic fascial structure-sparing (IPFSS) technique for robotic-assisted radical cystectomy (RARC) with intracorporeal orthotopic neobladder (ONB) reconstruction and to evaluate its impact on urinary continence and sexual function in male patients.

Methods: This retrospective observational study was conducted at a single high-volume center. Male bladder cancer patients who underwent IPFSS RARC with ONB were included.

Astrocytic Mettl14 depletion enhances cognitive function by attenuating astrogliosis via the DUSP1/MAPK pathway in APP/PS1 mice: targeting neuroinflammation in Alzheimer's disease.

Alzheimer's disease (AD), a leading cause of dementia, represents a critical unmet global medical need. While the precise mechanisms underlying AD pathogenesis remain elusive, increasing evidence underscores the pivotal role of neuroinflammation in driving cognitive impairment. N6-methyladenosine (m6A), an epigenetic modification regulating RNA metabolism, has been found to be dysregulated in AD.

Deletion of the SHORT Syndrome Gene Prkce Results in Brain Atrophy and Cognitive and Motor Behavior Deficits in Mice.

The neurological manifestations of SHORT syndrome include intrauterine growth restriction, microcephaly, intellectual disability, hearing loss, and speech delay. SHORT syndrome is generally believed to be caused by PIK3R1 gene mutations and impaired PI3K-AKT activation. Recently, a clinical case report described a SHORT syndrome with a novel mutant in PRKCE gene encoding protein kinase Cε (PKCε).

Glucose restriction: double edged sword in cancer treatment.

Glucose restriction generally limits tumor growth. Recently, Wu et al. reported that glucose restriction inhibits primary tumors but promotes lung metastasis by forming a macrophage-dominated, natural killer (NK) cell-deficient pre-metastatic niche (PMN).

Patterns and transitions of physical, psychological, and behavioral health across adulthood: A latent transition analysis of the roles of childhood and adulthood adversities.

Despite growing recognition of health as a multidimensional construct, few studies have examined how physical, psychological, and behavioral health dimensions coalesce and evolve across the transition from young to middle adulthood, especially within the context of life-course adversities. Existing research often focuses on isolated health indicators or overlooks the dynamic, fluid nature of health over time. Additionally, the combined effects of childhood and adulthood adversities on health transitions remain underexplored.

Exploring why adolescents of disadvantaged family socio-economic status were more depressed than others: Serial mediations via personal psychological resources, loneliness, and school refusal functions.

Background: Disadvantageous family socio-economic status (DFSES) is a potential source of disparity in adolescent mental health. This study investigated the association between DFSES and probable depression and its mediation mechanisms via personal psychological resources (hope and resilience), loneliness, and school refusal functions.

Methods: A school-based anonymous survey was conducted among 8285 middle school students in China from February to March 2022; the response/eligible rate was 98.

S100A4 Facilitates Radiation-Induced Tumor Repopulation by Driving Polyploid Giant Cancer Cells Budding.

Radiotherapy, a pivotal treatment for colorectal cancer, is compromised by tumor repopulation, which is characterized by accelerated growth and increased treatment resistance. Although radiation-induced DNA breaks eliminate most cells, a subset of polyploid giant cancer cells (PGCCs) evade death through massive genomic amplification, subsequently undergoing depolyploidization via a viral budding-like process to generate proliferative progeny. Critically, these PGCCs drive tumor repopulation and underpin therapeutic failure.

Association and mechanism of Ligusticum chuanxiong alleviating itch: A combination of experimental and network pharmacology study.

Ethnopharmacological Relevance: Ligusticum chuanxiong (CX) is a traditional Chinese medicine with diverse effects, such as anti-inflammatory, antioxidant, neuroprotective, anti-nociceptive, and anticancer properties. It has been used in clinical applications with satisfying therapeutic effects. However, the underlying mechanism that contributes to the anti-pruritic effects remains to be comprehensively investigated.

Accelerating iron redox cycling via acetate modification: a ligand engineering for sustainable fenton-like oxidation.

Accelerating the rate-limiting surface Fe(III)/Fe(II) redox cycling is pivotal for efficient iron-mediated Fenton-like decontamination, yet conventional reductants (e.g., toxic hydroxylamine, thiosulfate) suffer from secondary toxicity, self-quenching, and heavy metal leaching.

Virulence-mediated colonization mechanism for TEP as a promising watershed-scale recorder and source-tracking indicator of human pathogens.

Waterborne pathogens related diseases have been a global health concern. Precise source tracking of pathogens in rivers is crucial for understanding and reducing waterborne pathogens transmission risks. Current microbial source tracking techniques are still limited by identifying pathogen indicators at low concentrations, particularly in highly dynamic confluence zones of rivers where the coalescence of microbiomes exacerbates community disturbances.

A prospective study of physical activity in full-term pregnant women and its effect on pregnancy outcomes.

Background: The effects of physical activity (PA), especially brisk walking, on labor outcomes and pregnancy health have not been clearly established. This study aimed to investigate the relationship between PA and cervical ripeness and pregnancy outcomes in term pregnant women.

Basic Procedures: A prospective cohort study was conducted with 52 pregnant women (30.

Discovery and characterization of sulfonamide derivatives as transcriptional enhanced associate domain (TEAD) inhibitors: a novel approach for targeting hepatocellular carcinoma.

Transcriptional enhanced associate domain (TEAD), overexpressed in hepatocellular carcinoma (HCC) and inversely correlated to prognosis, has emerged as a promising target for HCC therapy. To date, no small-molecule inhibitors targeting TEAD have been reported for HCC treatment. In this study, a bioinformatic analysis has been performed and has demonstrated that TEAD is a promising target for therapeutic intervention in HCC.

The professional experience of rural midwifery in China during the transition from traditional to modern birth practices (1950s-1970s): A qualitative study.

Background: Although home births have been largely discontinued in contemporary China, traditional birth attendants (TBAs) historically played a pivotal role in enhancing maternal and child health, particularly in rural areas.

Aim: This study explored the transformation of TBAs in China from the 1950s to the 1970s, focusing on their gradual shift from traditional to modern midwifery practices. By drawing on oral histories from TBAs, the research seeks to enrich the historical understanding of midwifery development in China.

Functional divergence of G protein γ subunits drives plant vigor and improvement through the CPK28-PIP1;2 pathway in tomato.

Maintaining robust plant vigor is essential for sustaining crop productivity, yet the precise roles and molecular underpinnings of G protein γ subunits in this process remain elusive. This study reveals that GGC1 is under selection during tomato domestication, and its mutants exhibit enhanced plant vigor, characterized by superior growth, increased yield, and improved fruit quality. In contrast, triple mutants gga1/ggb1/ggb2 display severely compromised vigor resembling slgb1 mutants lacking the Gβ subunit.

Thorough Physiological Assessment in Non-Culprit Vessels of Patients with Acute Myocardial Infarction: Is It a Required Action?

Backgrounds: The management of non-culprit vessels (NCV) among individuals with acute myocardial infarction (AMI) remains an unsolved problem. Angiography-derived physiological assessments developed recently may help address this issue. Our study aims to measure angiography-derived fractional flow reserve (Angio-FFR) and angiography-derived index of microcirculatory resistance (Angio-IMR) in NCVs of AMI patients and explore their prognostic values and necessity.

Global research trends in endoscopic breast surgery: a bibliometric analysis from 1994 to 2024.

Endoscopic breast surgery (EBS) is designed to reduce surgical trauma and optimize cosmetic outcomes through inconspicuous incisions. However, a comprehensive understanding of the evolution of research focus in EBS is lacking. This study aimed to analyze global publication trends, academic impacts, and evolving research directions in the field of EBS.

Dual-Functional Nanoliposome with High BPA Loading for Targeted MRI-Guided BNCT of Glioblastoma.

Glioblastoma is a highly malignant brain tumor with few available therapeutic options, for which boron neutron capture therapy (BNCT) has emerged as a promising precision radiotherapy approach. However, its efficacy remains suboptimal due to inadequate tumor targeting of boron agents and lack of in vivo visualization. Herein, a gadolinium-boron integrated lipid nanocarrier (BPA-F&DOTA-Gd@LIPO-ANG) was developed for targeted boron delivery and MRI-guided BNCT.

Intracerebral Hemorrhage: An Acute Manifestation of Small Vessel Disease?

Although intracerebral hemorrhage (ICH) and cerebral small vessel disease (cSVD) have long been considered distinct clinical entities, emerging evidence reveals significant overlap in their etiologies and imaging markers. This review aims to explore the relationship between ICH and cSVD, suggesting that ICH may represent an acute manifestation of small vessel disease. ICH is primarily caused by cerebral amyloid angiopathy and hypertension, while cSVD is mainly attributed to cerebral amyloid angiopathy and arteriolosclerosis.

Electronic Structure of Ni-Based Reconstructed Surface for Electrocatalytic Alkaline Oxygen Evolution Reaction.

The sluggish kinetics of the oxygen evolution reaction (OER) in alkaline water electrolysis lead to high overpotentials, limiting cost-effective green hydrogen production. Ni-based catalysts, recognized as promising OER electrocatalysts, require electronic structure modulation to enhance performance. However, under oxidizing conditions, Ni-based materials undergo surface reconstruction with significant electronic alterations, rendering bulk-phase studies less practical.

A multi-tissue single-cell expression atlas in cattle.

Systematic characterization of the molecular states of cells in livestock tissues is essential for understanding the cellular and genetic mechanisms underlying economically and ecologically important physiological traits. Here, as part of the Farm Animal Genotype-Tissue Expression (FarmGTEx) project, we describe a comprehensive reference map including 1,793,854 cells from 59 bovine tissues in calves and adult cattle, spanning both sexes, which reveals intra-tissue and inter-tissue cellular heterogeneity in gene expression, transcription factor regulation and intercellular communication. Integrative analysis with genetic variants that underpin bovine monogenic and complex traits uncovers cell types of relevance, such as spermatocytes, responsible for sperm motility and excitatory neurons for milk fat yield.

Estrogen receptor beta in lateral habenula mediates antidepressant effects of estrogen in postpartum-hormone-withdrawal-induced depression.

Dramatic drop in reproductive hormone, especially estrogen level, from pregnancy to postpartum period is known to contribute to postpartum depression (PPD), but the underlying mechanism and the role of the estrogen receptors (ERs) in this process were unclear. Here, we used an estrogen-withdrawal-induced PPD model following hormone simulated pregnancy (HSP) in female Sprague-Dawley rats to induce depressive-like behaviors. After estrogen withdrawal, we observe an up-regulation of astrocyte-specific potassium channel (Kir4.