Chrysin Attenuates Myocardial Cell Apoptosis in Mice.

Myocardial infarction (MI), induced by ischemia and hypoxia of the coronary arteries, presents as myocardial necrosis. Patients often experience intense, prolonged retrosternal pain that is unrelieved by rest or nitrate therapy and is frequently associated with high blood myocardial enzyme levels. Physical effort may exacerbate this anxiety, increasing the likelihood of life-threatening consequences such as arrhythmias, shock, or cardiac failure.

Astrocytic Mettl14 depletion enhances cognitive function by attenuating astrogliosis via the DUSP1/MAPK pathway in APP/PS1 mice: targeting neuroinflammation in Alzheimer's disease.

Alzheimer's disease (AD), a leading cause of dementia, represents a critical unmet global medical need. While the precise mechanisms underlying AD pathogenesis remain elusive, increasing evidence underscores the pivotal role of neuroinflammation in driving cognitive impairment. N6-methyladenosine (m6A), an epigenetic modification regulating RNA metabolism, has been found to be dysregulated in AD.

Does unfairness evoke anger or disgust? A quantitative neurofunctional dissection based on 25 years of neuroimaging.

Over the last decades, the traditional 'Homo economicus' model has been increasingly challenged by converging evidence highlighting the critical impact of emotions on decision-making. A classic example is the perception of unfairness in the Ultimatum Game, where humans willingly sacrifice personal gains to punish fairness norm violators. While emotional mechanisms underlying such costly punishment are widely acknowledged, the distinct contributions of moral emotions, particularly anger and disgust, remain debated, partly due to methodological limitations in conventional experiments.

Optically encoded microspheres in liquid-phase suspension array technology for immunoluminescence diagnostics: A review.

Liquid-phase suspension array technology (SAT), based on optically encoded microspheres, overcomes limitations of traditional enzyme-linked immunosorbent assay (ELISA) and chemiluminescence detection techniques via meeting high-throughput and multiplexing demands in biosensing and diagnosis. It demonstrates significant advantages in terms of accuracy, speed, sensitivity, and multiplex detection capabilities, and has become an emerging research hotspot in the field of luminescent immunodiagnostics. With rapid advancement of nanotechnology and multi-functional nanomaterials, liquid-phase suspension array chips have achieved remarkable progresses in multiplex analysis capacity, encoding capacity, encoding efficiency, detection sensitivity, decoding methods, and application fields.

Synergistic stress-relieving and cognitive-enhancing effects of walnut peptide and theanine in human brain organoid and mouse stress models.

Background: Stress is a prevalent mental health concern that often emerges in late adolescence or early adulthood. Since 2007, the Food and Drug Administration (FDA) has not approved any novel anxiolytic pharmaceuticals, leading to increased interest in nutritional supplements as alternative therapies for stress management.

Purpose: Building on our previous study, this work aims to investigate the synergistic effects of Theanine (Th) and Walnut Peptide (WP) on stress mitigation and cognitive enhancement.

Overcoming resistance in RET-altered cancers through rational inhibitor design and combination therapies.

RET tyrosine kinase, a key regulator of cellular signaling, is abnormally activated due to mutations or fusions in various cancers, making it an important therapeutic target. Traditional multi-kinase inhibitors (MKIs, such as cabozantinib and vandetanib) exhibit significant side effects due to non-selective inhibition of targets like VEGFR, and also suffer from resistance associated with RET mutations (e.g.

In Situ Electrochemical Oxidation for High-Energy-Density Aqueous Batteries: Mechanisms, Materials, and Prospects.

To advance the commercial utilization of aqueous electrochemical devices for grid-scale energy storage, it is crucial to address the current limitations related to energy density and cycle stability. Indeed, the lack of high-performance cathodes is still an obstructive issue, not to mention the limited capacities related to the monotonic cation intercalation/deintercalation mechanism. Fortunately, conversion chemistries with redox reactions bring a new dimension, where materials with multiple valence states facilitate multi-electron redox reactions, offering the potential for high-energy-density storage.

Predicting tumor response to TACE plus lenvatinib and PD-1 inhibitors for unresectable HCC: A multicenter observational study.

Objectives: Preoperatively identifying patients with unresectable hepatocellular carcinoma (uHCC) who are likely to achieve an objective response to the treatment regimen of transarterial chemoembolization (TACE) plus lenvatinib and programmed death-1 inhibitors (TLP) remains challenging. We aimed to develop and validate a predictive model for tumor response to TLP treatment in patients with uHCC.

Materials And Methods: Patients with uHCC who received TLP treatment were divided into training (n = 107), internal validation (n = 46), and external validation (n = 52) cohorts.

Size-Dependent Restructuring of Supported Platinum Cluster Catalysts.

Supported metal clusters have reactivities that depend on their nuclearity and structure. Herein, we present a strategy for precisely controlling the nuclearity of platinum clusters and demonstrate their size-dependent restructuring behavior and catalytic properties. The clusters are located on isolated CeO nanoislands on high-area SiO, and the isolation facilitates control of the migration of the platinum.

A zwitterionic dual-network hydrogel patch with anti-inflammatory properties for efficient peritoneal adhesion prevention.

Postoperative peritoneal adhesion, driven by inflammatory response and fibrotic deposition, remains the most common complication following abdominal surgeries, with limited effective solutions. Herein, a dual-network hydrogel patch (GPSB) is developed for effective peritoneal adhesion prevention through interpenetrating a gelatin network with a zwitterionic polysulfobetaine (PSB) network. The biodegradable gelatin network is dynamically crosslinked zinc ion (Zn)-polyphenol coordination, endowing the patch with inherent antibacterial and pro-healing activities.

Molten-Salt-Assisted Synthesis of Bismuth Catalysts with Rich Grain Boundaries for Efficient CO Conversion to High-Purity Formic Acid.

Electrochemical CO reduction to formic acid, powered by renewable electricity, enables a sustainable carbon cycle by providing a versatile chemical feedstock and energy carrier. Bismuth-based catalysts are known for their high formate selectivity but face challenges in balancing selectivity and stability at industrial current densities. In this study, we present a two-step approach that combines molten-salt synthesis with in situ reduction to fabricate polycrystalline bismuth catalysts with rich exposed grain boundaries (GB-Bi).

Pain and Its Treatment Among Outpatients with Malignant Tumors in China.

Background: Pain is common among patients with malignant tumors. It significantly impacts quality of life, yet over 80% of advanced cancer patients lack adequate pain management. Despite improvements in China's pain management program, challenges remain, especially for older adults and outpatient care.

Diagnostic utility of hematological and biochemical markers for cystic echinococcosis in Tibetan patients of Sichuan, China.

Objective: This hospital-based case-control study aims to evaluate hematological and biochemical markers for the diagnosis of cystic echinococcosis (CE) in the Tibetan population of Sichuan.

Methods: This study involved 83 patients diagnosed with CE and 45 healthy controls. Diagnosis of CE was confirmed through antibody and imaging tests, followed by an analysis of differences in blood and biochemical markers.

Effect of an emergency/planned cesarean section on the perinatal outcomes of pregnant women with placenta accreta spectrum and their neonates: a retrospective study cohort.

Background: Placenta accreta spectrum (PAS) is an obstetric condition. This study analyzes the outcomes of PAS parturients and their newborns undergoing emergency cesarean sections as opposed to planned cesarean sections.

Methods: In this research, we conduct a thorough retrospective analysis of 345 patients with placenta accreta at a single medical center.

Biomimetic membrane nanotechnology in cerebral ischemic stroke:a promising technology for therapeutic treatment and diagnosis.

Cerebral ischemic stroke (CIS) is a severe cerebrovascular disease that poses numerous challenges in diagnosis and treatment, primarily attributed to blood-brain barrier (BBB) constraints and inherent drug targeting limitations. Biomimetic membrane nanotechnology, as an emerging therapeutic approach, offers a novel therapeutic strategy by emulating biological membrane structures and functions. This review comprehensively examines biomimetic nanomedicines (BMNPs) in CIS management, encompassing preparation methodologies, material characterization, and specific diagnostic/therapeutic applications.

Positively Charged Polyurethane Scaffolds Reshape the Microenvironment to Promote Endogenous Regeneration after Brain Injury.

Traumatic brain injury (TBI) induces a prolonged inflammatory response throughout the damaged brain, which is exacerbated by the sustained accumulation of damage-associated molecular patterns (DAMPs), and consequently impairs endogenous neural regeneration significantly. To mitigate postinjury inflammation and explore the role of positively charged scaffolds in brain repair, two distinct structures of positively charged scaffolds were developed. Both scaffold types effectively reduce inflammation and promote brain tissue repair by eliminating DAMPs, markedly reducing glial scar formation, and promoting angiogenesis in peritrauma areas within 4 weeks of implantation.

A reliable UAV tracking system with online re-detection network.

Failures in long-term tracking have been frequently reported, posing significant challenges for the practical implementation of UAV tracking systems. Previous research has often employed a metric based on the current tracking state to assess reliability, coupled with a time-consuming re-detection network designed to recover the lost target. However, this approach lacks sufficient robustness and flexibility when dealing with unknown factors present in complex tracking scenarios.

Target volume delineation of the neck for radiotherapy in nasopharyngeal carcinoma: CSTRO, CACA, CSCO, HNCIG, ESTRO, and ASTRO guidelines and contouring atlas.

The Chinese Society for Therapeutic Radiology Oncology, the Chinese Anti-Cancer Association, the Chinese Society of Clinical Oncology, the Head and Neck Cancer International Group, the European Society for Radiotherapy and Oncology, and the American Society for Radiation Oncology collaboratively developed evidence-based guidelines and a comprehensive contouring atlas for neck target volume delineation in nasopharyngeal carcinoma. These guidelines address five key challenges in modern radiotherapy practice: margin design of clinical target volume; nodal target volume delineation after induction chemotherapy; delineation of equivocal nodes evident on imaging; low-risk clinical target volume delineation based on regional stepwise extension patterns; and modifications for anatomical boundaries of lymphatic areas. Developed through a rigorous systematic review and expert appraisal process by a panel of 50 international, multidisciplinary members from 17 countries and regions, these guidelines incorporate the latest advances in nasopharyngeal carcinoma diagnosis and treatment.

Primary target volume delineation for radiotherapy in nasopharyngeal carcinoma: CSTRO, CACA, CSCO, HNCIG, ESTRO, and ASTRO guidelines and contouring atlas.

The Chinese Society for Therapeutic Radiology Oncology, the Chinese Anti-Cancer Association, the Chinese Society of Clinical Oncology, Head and Neck Cancer International Group, the European Society for Radiotherapy and Oncology, and the American Society for Radiation Oncology jointly developed evidence-based guidelines and a contouring atlas for primary target volume delineation for radiotherapy in nasopharyngeal carcinoma. The guidelines systematically address three crucial challenges: margin design of clinical target volumes; target volume delineation after induction chemotherapy; and low-risk clinical target volume delineation based on local stepwise extension patterns. Based on a comprehensive systematic review and critical appraisal by an international multidisciplinary panel of 50 nasopharyngeal carcinoma specialists from 17 countries and regions, these guidelines are in keeping with advances in nasopharyngeal carcinoma diagnosis and treatment, embodying contemporary treatment concepts, and elaborating on the differences in practice.

Activated Dendritic Cell Membrane-Engineered Nanoformulation of Metallo-Immunomodulators as Lysosome-Targeted Adjuvants for Synergistic Cancer Immunotherapy.

Combination of chemotherapy and cancer immunotherapy has shown substantial clinical promise. However, the immunosuppressive tumor microenvironment (TME) poses a critical barrier to this combination therapy. Here, a tumor lysosome-targeted immunomodulatory strategy based on a biomimetic nanoadjuvant is presented, which effectively overcomes the immunosuppressive TME and demonstrates enhanced therapeutic efficacy when combined with chemotherapy.

Chromatin Accessibility Dynamics Reveal Conserved Transcriptional Regulatory Networks During Insect Metamorphosis in and .

Insect metamorphosis is a complex developmental process regulated by hormonal signaling and gene transcription. To elucidate its transcriptional regulatory mechanisms, we examined chromatin accessibility dynamics during metamorphosis in two holometabolous insects, and , using ATAC-seq. Our analysis revealed distinct stage-specific chromatin accessibility patterns, with peak accessibility during the prepupal stage in and the wandering larval to prepupal transition in .

Effect of radical radiotherapy dose on the prognosis of limited-stage thoracic small cell carcinoma of the esophagus: A multicenter retrospective trial from China (CHiSCEC).

Background: The optimal radiation dose for the treatment of small cell carcinoma of the esophagus (SCEC) has not been established. This study aimed to investigate the treatment outcomes and toxicities in patients with limited-stage SCEC (LS-SCEC) treated by radiotherapy.

Methods: Patients with LS-SCEC from 14 institutions were retrospectively identified between December 2000 and October 2021.

InSe Dynamic Memristor-Based Reservoir Computing for Temporal and Spatial Signal Recognition.

Multimodal recognition techniques are pivotal for advancing contemporary artificial intelligence, particularly in enhancing visual perception. However, research on electronic devices capable of robust multimodal recognition remains limited. In this study, we employ an InSe/AlO/ Pb(Zr·Ti·)O (PZT) heterostructure as a dynamic memristor.