Optically encoded microspheres in liquid-phase suspension array technology for immunoluminescence diagnostics: A review.

Liquid-phase suspension array technology (SAT), based on optically encoded microspheres, overcomes limitations of traditional enzyme-linked immunosorbent assay (ELISA) and chemiluminescence detection techniques via meeting high-throughput and multiplexing demands in biosensing and diagnosis. It demonstrates significant advantages in terms of accuracy, speed, sensitivity, and multiplex detection capabilities, and has become an emerging research hotspot in the field of luminescent immunodiagnostics. With rapid advancement of nanotechnology and multi-functional nanomaterials, liquid-phase suspension array chips have achieved remarkable progresses in multiplex analysis capacity, encoding capacity, encoding efficiency, detection sensitivity, decoding methods, and application fields.

A miniaturized liver function detection system with machine learning enhancing strategy.

Serum alanine aminotransferase (ALT) is one of the most sensitive indicators of liver function and is crucial in diagnosing acute liver injury (ALI). However, its widespread clinical application is limited due to expensive equipment, detection delays, and high technical requirements, especially in resource-limited areas. This paper presents a miniaturized liver function detection system with machine learning enhancing strategy to address these challenges.