A zwitterionic dual-network hydrogel patch with anti-inflammatory properties for efficient peritoneal adhesion prevention.

Postoperative peritoneal adhesion, driven by inflammatory response and fibrotic deposition, remains the most common complication following abdominal surgeries, with limited effective solutions. Herein, a dual-network hydrogel patch (GPSB) is developed for effective peritoneal adhesion prevention through interpenetrating a gelatin network with a zwitterionic polysulfobetaine (PSB) network. The biodegradable gelatin network is dynamically crosslinked zinc ion (Zn)-polyphenol coordination, endowing the patch with inherent antibacterial and pro-healing activities.

Virtual Observation Units: A Novel Disposition for Older Adults With Falls From the Emergency Department.

Virtual observation units (VOUs) are being implemented across the country and serve as a model for patients to receive observational-level care at home. Falls are a leading cause of emergency department (ED) visits in the geriatric population and can cause substantial morbidity or mortality. Despite ED guidelines recommending fall-risk evaluation, the ED does not typically assess future fall risk given limited resources.

Application of Predilution Plasma Exchange, a new plasmapheresis method for self-anticoagulation, in liver failure.

Introduction: For patients with severe liver failure, citrate accumulation is prone to occur, which increases the risk of death in critically ill patients. To reduce this risk, we created a self-anticoagulation protocol, predilution plasma exchange ( pre-PE ), in which exogenous plasma is replenished into the circuit before the plasma separator. This new method uses citrate in exogenous plasma as an anticoagulant to avoid the use of additional citrate, which would reduce the occurrence of citrate accumulation during PE.

Measurement Properties of Surface Topography for Scoliosis Assessment: A Systematic Review and Meta-Analysis.

Objective: To comprehensively evaluate the validity, responsiveness, and feasibility of surface topography (ST) indices and provide insights into their potential integration into clinical scoliosis assessment.

Data Sources: A systematic literature search was performed in PubMed and Web of Science for studies published between January 2010 and April 2024.

Study Selection: Studies reporting on the validity, responsiveness, and feasibility of ST indices were screened and selected by two independent researchers.

Differential Effects of Short- and Long-Term Negative Affect on Smartphone Usage: The Moderating Role of Locus of Control.

In the digital age, smartphones are often used as tools for emotion regulation. While prior research has examined affective predictors of smartphone use, few studies have considered the combined impact of short-term and long-term affective states. This study investigates how daily negative emotional states and psychological distress relate to smartphone use and whether these associations are moderated by locus of control, a core belief about perceived control.

Traceability of etomidate and its analogs in biological samples using "specific" metabolites.

With the regulation of etomidate (ETO), criminals continue to use chemical modifications to derive various ETO analogues as substitutes to enter the illegal market in order to evade punishment, and the phenomenon of substitution abuse is becoming increasingly serious. After these substitutes are ingested by the human body, the prototype drug is almost undetectable in the biological samples. It is necessary to search for "characteristic" metabolite traceability prototype drugs to effectively prevent misjudgment of cases.

Genetic engineering of Sorangium cellulosum reveals hidden enzymology in myxobacterial natural product biosynthesis.

Sorangium cellulosum is a cellulolytic myxobacterium that produces a vast array of complex natural products with diverse chemical scaffolds and biological activities. However, biosynthetic investigations of these metabolites have been hindered by the scarcity of genetic manipulation tools available for their producing microorganisms. Here, we develop an efficient electroporation method for transforming foreign DNA into various Sorangium strains, enabling effective genetic engineering via homologous recombination.

Role of CclA Loss in Parametarhizium changbaiense in Enhancing Priming Resistance of Mung Bean Against Damping Off Induced by Rhizoctonia solani.

Rhizoctonia solani is a soil-borne pathogen causing destructive diseases on various economically important crops. Beneficial plant and fungus interactions are well acknowledged to enhance plant resistance to biotic stresses. However, the underlying mechanisms are not fully understood, especially the contribution of fungal epigenetic regulation remains poorly understood.

Construction and application of a self-care behavior intervention scheme for chronic heart failure patients based on interaction model of client health behavior.

This study aimed to explore the impact and the effectiveness of interventions based on the Interaction Model of Client Health Behavior on the self-care behavior of chronic heart failure patients. Using convenience sampling, 80 chronic heart failure patients who met the inclusion and exclusion criteria were selected from the Cardiovascular Department of a tertiary hospital in Henan Province from January to June 2023. The first and second wards were randomly assigned to control and intervention groups, with the first ward serving as the control group and the second ward as the intervention group, each consisting of 40 cases.

Trajectories of Immunosuppressive Medication Adherence Among Kidney Transplant Recipients: A 2-Year Prospective Cohort Study.

Background: Immunosuppressive medication (IM) adherence, a dynamic and time-dependent behavior, is typically suboptimal among kidney transplant recipients (KTRs) and severely impacts their prognosis. Longitudinal data regarding the temporal trajectories of medication adherence are important for devising targeted intervention strategies.

Objective: To identify the trajectories of IM adherence in KTRs over the 2 years post transplantation.

Multivariate Sulfate-Pillared Metal Azolate Frameworks with Tunable Flexibility for CO Capture from C2 Hydrocarbons.

A series of sulfate-pillared metal azolate frameworks (MAFs) were synthesized via a multivariate (MTV) strategy to systematically tune framework flexibility and gas separation performance. The monotonic sulfate-pillared MAF, Zn(daTz)SO (where daTz = 3,5-diamino-1,2,4-triazolate), exhibits pronounced structural dynamics upon adaptive guest inclusions, driven by triazolate linker rotation and reversible Zn─O bonds rearrangement, enabling dynamic pore modulation for efficient CO, CH, and CH uptakes. Incorporation of an asymmetric, non-amino linker effectively suppresses framework flexibility by reducing intraframework hydrogen bonding, resulting in a locked structure with enhanced selectivity for CO over light hydrocarbons.

The burden and etiologies of diarrhea in Asia and its countries from 1990 to 2021 and the forecast to 2040: analyses informed by the global burden of disease study 2021.

Background: This study aimed to analyze the burden, temporal trends and etiologies of diarrhea from 1990 to 2021, and to forecast the burden from 2022 to 2040 in Asia and Asian countries.

Methods: Data were sourced from the Global Burden of Diseases (GBD) 2021 study. Temporal trends from 1990 to 2021 were analyzed using estimated annual percentage change (EAPC) values.

An updated systematic review and meta-analysis: correlation between circulating plasminogen activator inhibitor-1 levels and metabolic dysfunction-associated steatotic liver disease.

Background Metabolic dysfunction-associated steatotic liver disease (MASLD)-formerly known as non-alcoholic fatty liver disease-is the leading cause of chronic liver disease globally. However, early diagnosis and specific treatment have not yet been achieved. Plasminogen activator inhibitor-1 (PAI-1) is closely related to MASLD and may be an important indicator for its diagnosis and treatment.

Release kinetics and bioaccessibility of heavy metal from antifouling paint particles in simulated digestive fluids: An emerging threat to marine biota.

Antifouling paints can effectively prevent marine organisms from biofouling. However, the release of antifouling paint particles (APPs) and their toxic additives has emerged as a significant source of marine contamination, posing potential threats to marine biota. Hence, this study investigated the release kinetics and bioaccessibility of heavy metals from APPs in simulated digestive fluids, mimicking the gastrointestinal conditions of marine polychaete, fish, and seabird.

Prevalence, incidence, and risk factors for herpes zoster in systemic lupus erythematosus: a systematic review and meta-analysis.

Background: Patients with systemic lupus erythematosus (SLE) are particularly vulnerable to infections, with herpes zoster (HZ) being the most common opportunistic infection. This meta-analysis aimed to systematically review the available literature on the prevalence, incidence, and risk factors of HZ in SLE patients.

Methods: A comprehensive search through Embase, PubMed, Web of Science, and Cochrane Library was conducted for studies published up to November 1, 2024.

Performance of heavy metals in the intertidal zone surface sediments of the Yellow River Estuary under water-sediment regulation scheme.

This study investigates the distribution, sources, and ecological risks of heavy metals (Cr, Cu, Zn, Cd, Pb, and Hg) and metalloid (As) in surface sediments of the Yellow River Estuary intertidal zone during the 2023 water-sediment regulation scheme (WSRS) period (summer) and the non-WSRS period (autumn). The results revealed that metal accumulation in both periods was primarily controlled by the co-adsorption of organic matter and fine particles. Hydrodynamic enhancement during the WSRS period reduced metal accumulation through sediment flushing and dilution, whereas weakened flows in the non-WSRS period promoted metal buildup.

Rainfall, seasonal variation, and stream type governing the multi-media fate and ecological risks of tire additives and their transformation products in mega-urban streams.

Tire additives and their transformation products (TATPs) are increasingly recognized for their toxicity and widespread environmental presence. However, the interplay of rainfall, seasonal variation, and stream type in governing their multi-media partitioning and risks remains largely unexplored. This study investigated the spatiotemporal distribution, environmental drivers, and ecological risks of 21 TATPs in three distinct urban streams (general road, expressway, and rural road-adjacent).

SOX4-ZIP14-zinc metabolism mediates oncogenesis and suppresses T cell immunity in nasopharyngeal carcinoma.

Subtle variations of micronutrients in the tumor microenvironment often coincide with tumor progression and immune disorders. Nevertheless, the underlying mechanisms of how micronutrients, such as metal ions, influence tumor-intrinsic properties and tumor-immune crosstalk remain inadequately characterized. Here, our integrative analysis of multi-center single-cell, spatial transcriptome sequencing, and bulk RNA sequencing (RNA-seq) cohorts reveals that nasopharyngeal carcinoma (NPC)-specific SRY-box transcription factor 4 (SOX4) governs microenvironmental and cellular zinc metabolism through its downstream target, SLC39A14 (ZIP14), a membrane zinc uptake transporter.

Cytochrome P450-mediated biotransformation of octocrylene in Tetradesmus obliquus: Integrative insights from transcriptomics, proteomics, molecular docking, and density functional theory calculation.

Octocrylene (OC), a sunscreen active ingredient, has received considerable attention due to its widespread occurrence and toxicity. However, little is known about its removal efficiency, elimination routes and the associated mechanisms by microalgae. Here, we investigated the removal efficiency, biotransformation products, pathways, and the cytochrome P450 (CYP450) catalytic reaction mechanism of OC by Tetradesmus obliquus.

Drug substitutes - Insights on benefits, risks, detection methods, and management strategies: a systematic review.

The abuse of new psychoactive substances and narcotic drugs as drug substitutes poses a serious threat to public health and safety. This study outlines the effective use and negative abuse of drug substitutes and outlines associated criminal behaviors to help readers understand the potential risks of such substances. By summarizing the technical bottlenecks in the analysis and detection of criminal cases, this study highlights their impact on case discrimination, which in turn can limit or even render policy implementation ineffective.

Deep Learning-Based Point Cloud Compression: An In-Depth Survey and Benchmark.

With the maturity of 3D capture technology, the explosive growth of point cloud data has burdened the storage and transmission process. Traditional hybrid point cloud compression (PCC) tools relying on handcrafted priors have limited compression performance and are increasingly weak in addressing the burden induced by data growth. Recently, deep learning-based PCC methods have been introduced to continue to push the PCC performance boundary.