Chrysin Attenuates Myocardial Cell Apoptosis in Mice.

Myocardial infarction (MI), induced by ischemia and hypoxia of the coronary arteries, presents as myocardial necrosis. Patients often experience intense, prolonged retrosternal pain that is unrelieved by rest or nitrate therapy and is frequently associated with high blood myocardial enzyme levels. Physical effort may exacerbate this anxiety, increasing the likelihood of life-threatening consequences such as arrhythmias, shock, or cardiac failure.

Impact of Short-Term Exposure to Ozone on Hospital Admissions for Multiple Cardiovascular Diseases: A Systematic Review and Meta-Analysis.

Background: The associations between short-term exposure to ambient ozone (O) pollution and the risks of hospital admissions (an indicator for morbidity) for different subtypes of cardiovascular disease (CVD) remain unclear. Therefore, this study aimed to evaluate the associations between short-term exposure to O and the risks of hospital admissions for all-cause CVD, arrhythmia, atrial fibrillation, cardiac diseases, heart failure, ischemic heart disease, myocardial infarction (MI), and stroke.

Methods: Four electronic databases, including PubMed, Web of Science, Scopus, and Embase, were searched for articles published up to December 21, 2023.

Classical-decisive quantum internet by integrated photonics.

Classical and quantum technologies have traditionally been viewed as orthogonal, with classical systems being deterministic and quantum systems inherently probabilistic. This distinction hinders the development of a scalable quantum internet even as the global internet continues expanding. We report a classical-decisive quantum internet architecture in which the integration of quantum information into advanced photonic technologies enables efficient entanglement distribution over a commercially deployed fiber network.

Multi-Metal Alloy Nanotubes with Sub-1 Nm Wall Thickness for Efficient Inorganic and Organic Nitrogen Reduction.

The multi-metal alloy (MMA) catalysts display exceptional multifunctional catalytic capabilities. However, it is still a great challenge to improve the catalytic performance by accurately synthesizing the morphology. Herein, we present a simple one-pot method for designing and synthesizing the ultrathin MMA nanotube-structured CuNiCoFeRu catalysts (CuNiCoFeRu UNT), which achieve unprecedented comprehensive performance in nitrate and nitrobenzene reduction.

Roadmap for Next-Generation Electrochemical Energy Storage Technologies: Secondary Batteries and Supercapacitors.

The transition from fossil fuels to environmentally friendly renewable energy sources is crucial for achieving global initiatives such as the carbon peak and carbon neutrality. The use of secondary batteries and supercapacitors based on electrochemical energy storage principles provides high energy density, conversion efficiency, and rapid response times, offering essential solutions for stabilizing and ensuring the reliability of energy supply from renewable sources despite their intermittency. In recent years, increased demands for higher energy density, improved rate performance, longer cycle life, enhanced safety, and cost-effectiveness have driven researchers to delve deeper into electrode materials, electrolytes, and storage mechanisms in secondary batteries.

Targeting CLK1/SRSF7 axis-dependent alternative splicing sensitizes pancreatic ductal adenocarcinoma to chemotherapy and immunotherapy.

Aim: The persistently high mortality rate of pancreatic ductal adenocarcinoma (PDAC) is largely attributed to the acquired resistance to chemotherapy, particularly gemcitabine. This study aims to elucidate the underlying molecular mechanisms of gemcitabine resistance in PDAC, uncover additional pro-tumorigenic factors contributing to drug resistance, and develop more effective and safer targeted therapeutic strategies against this phenomenon.

Methods: Circular RNA (circRNA) sequencing was employed to identify differentially expressed circRNAs between chemo-sensitive and resistant tumors.

Programmed Intermittent Bolus versus Continuous Infusion for Regional Analgesia Following Thoracoscopic Surgery: A Systematic Review and Meta-Analysis.

Background: Continuous regional analgesia techniques have emerged as a more effective alternative for postoperative analgesia, but the clinical efficacy of infusion modes in thoracoscopic surgery remains controversial. This systematic review and meta-analysis to compare the efficacy of programmed intermittent bolus infusion (PIBI) with continuous infusion (CI) for regional analgesia in patients undergoing thoracoscopic surgery.

Methods: We searched PubMed, Embase, Web of Science, and the Cochrane Library for relevant research from inception to March 2025.

The effectiveness of stem cell‑derived extracellular vesicles therapy for intrauterine adhesions: a meta-analysis of preclinical studies.

Background: The therapeutic potential of stem cell-derived extracellular vesicles (EVs) for intrauterine adhesions (IUA) has attracted increasing preclinical investigation, yet a comprehensive and up-to-date meta-analysis is currently lacking. Before moving forward with clinical applications, it is essential to fully understand the impact of stem cell-derived EVs on IUA.

Methods: PubMed, EMBASE, Cochrane Library, Web of Science were searched up to May 19th 2025.

Multi-strategy collaborative optimization of gravitational search algorithm.

To address the shortcomings of the gravitational search algorithm, such as its tendency to fall into local optima, slow convergence, and low solution accuracy, this paper proposes a gravitational search algorithm based on multi-strategy cooperative optimization. The proposed algorithm balances global exploration and local exploitation. In the early iterations, particle positions are primarily updated using the original gravitational force, preserving the inherent characteristics of the gravitational search algorithm.

Organic Near-Infrared Afterglow Materials with Ultralong Lifetimes and Aggregation-Induced Emission Features Through Relay Phosphor Strategy.

Organic materials with afterglow properties have gained significant interest owing to their long lifetimes and potential applications. However, most of these organic materials emit light in the visible region, posing a significant challenge for developing near-infrared afterglow (NIR-AG). In this study, NIR-AG materials with ultralong lifetimes and aggregation-induced emission (AIE) features are fabricated using a relay phosphor strategy.

Nomogram to predict live birth in infertile women with adenomyosis undergoing IVF/ICSI treatment: a retrospective cohort study.

Purpose: The study aimed to develop a nomogram to predict live birth outcomes in infertile women with adenomyosis undergoing IVF/ICSI treatment.

Materials And Methods: Data were collected from the Center for Reproductive Medicine, Shandong University, between January 2016 and December 2020. This study included 222 fresh embryo transfer (ET) cycles and 266 frozen embryo transfer (FET) cycles.

Dedicated venous stent placement across the thoracic outlet: will novel venous stents transform axillosubclavian vein thrombosis treatment paradigm?

Background: Endovascular stenting is widely accepted as the standard treatment for central venous obstruction syndromes such as superior vena cava (SVC) syndrome due to its demonstrated clinical efficacy and improved patient outcomes. However, its application in axillosubclavian vein thrombosis (ASVT) has been limited due to concerns about stent compression within the thoracic outlet. This report aims to evaluate the feasibility and safety of the off-label use of dedicated venous stents-engineered with enhanced mechanical features-as an alternative endovascular approach for the treatment of ASVT.

Deep Learning-Based Point Cloud Compression: An In-Depth Survey and Benchmark.

With the maturity of 3D capture technology, the explosive growth of point cloud data has burdened the storage and transmission process. Traditional hybrid point cloud compression (PCC) tools relying on handcrafted priors have limited compression performance and are increasingly weak in addressing the burden induced by data growth. Recently, deep learning-based PCC methods have been introduced to continue to push the PCC performance boundary.

Development and application of chiral separation technology based on chiral metal-organic frameworks.

Chirality is not only a natural phenomenon but also a bridge between chemistry and life sciences. An effective way to obtain a single enantiomer is through racemates resolution. Recent literature shows that chiral metal-organic frameworks (CMOFs) have many applications in various fields because of their diverse topologies and functionalities.

Distinct Virologic Properties of African and Epidemic Zika Virus Strains: The Role of the Envelope Protein in Viral Entry, Immune Activation, and Neuropathogenesis.

The 2016 Zika virus (ZIKV) epidemic has largely subsided, but a key question remains. How did ZIKV evolve to become a virulent human pathogen compared to the virus of its original discovery? What specific virologic and pathologic changes contributed to increased pathogenicity in humans? Phylogenetic studies have identified two genetically distinct ZIKV, the African and Asian lineages, which differ in their pathogenicity. Previous studies including ours suggest that the envelope (E) protein plays a key role in viral entry, immune activation, and neuropathogenesis.

Transcriptome Sequencing-Based Analysis of Premature Fruiting in Lour.

Lour., a perennial medicinal plant in the Zingiber genus, usually requires approximately 3-4 years of vegetative growth from seed germination to first fruiting, resulting in high initial investment costs and a prolonged revenue cycle, which pose significant challenges to the industry's sustainable development. Our research team observed a distinct premature fruiting phenomenon in .

SenExo-cCCT2 Reprograms Senescence Response and Anti-Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma.

Combination chemotherapy and immunotherapy have failed to achieve breakthroughs in pancreatic ductal adenocarcinoma (PDAC). Chemotherapy-induced senescence is a potential solution for this problem. This study integrates clinical samples with single-cell transcriptomic sequencing, proteomics, and RNA sequencing and reveals that FOLFIRINOX (a combination regimen of 5-fluorouracil, oxaliplatin, irinotecan, and leucovorin) treatment induces a higher proportion of senescent tumor cells (senTCs).

MicroRNA signatures of VO2peak in older adult participants of the Study of Muscle, Mobility and Aging.

Background: Peak oxygen consumption during exercise (VO2peak), is a direct measure of cardiorespiratory fitness (CF), a key indicator of physical function and overall health. However, the molecular changes that underpin VO2peak variation are not clear. Our objective is to understand the miRNA signatures that relate to VO2peak variation, which could provide insights to novel mechanisms that contribute to low VO2peak.

Health inequality and the global burden of mesothelioma: insights from the global burden of disease study 2021.

Background: This study aims to systematically analyze the disease burden and epidemiological trends of mesothelioma at the global, regional, and national levels from 1990 to 2021, based on the Global Burden of Disease (GBD) 2021 database, and to explore its relationship with health inequality.

Method: DALYs were calculated by integrating Years of Life Lost due to premature mortality (YLL) and Years Lost due to disability (YLD) to comprehensively assess the disease burden. Additionally, the study analyzes cross-country health inequalities using the Slope Index of Inequality (SII) and the Concentration Index (CI).

Triazole-amine metal-organic framework chiral stationary phases: A novel chiral separation approach for amino acids in capillary electrochromatography.

Background: Efficient enantiomer separation is crucial in drug analysis and biomedical research. The strategy of combining capillary electrochromatography (CEC) with metal-organic frameworks (MOFs) has attracted much attention due to its high specific surface area and tunable chiral recognition sites. However, conventional MOF-based CEC systems suffer from poor stability and limited enantioselectivity.

GH-UNet: group-wise hybrid convolution-VIT for robust medical image segmentation.

Medical image segmentation is vital for accurate diagnosis. While U-Net-based models are effective, they struggle to capture long-range dependencies in complex anatomy. We propose GH-UNet, a Group-wise Hybrid Convolution-ViT model within the U-Net framework, to address this limitation.

Revisiting the Impact of Anion Selection on Sulfur Redox Reaction Kinetics for High Sulfur Loading Lithium-Sulfur Batteries.

Lithium bis(trifluoromethane)sulfonimide (LiTFSI) is widely used in lithium-sulfur (Li-S) battery electrolytes due to its stability with lithium polysulfides (LiPSs) and moderate compatibility with lithium metal anodes. However, LiTFSI presents environmental concerns due to its association with per- and polyfluoroalkyl substances (PFAS), which are environmentally persistent and potentially toxic, raises sustainability concerns. This research also reveals that LiTFSI limits sulfur redox reactions (SRRs), making it less effective than other lithium salts.

Transcranial Optogenetic Stimulation Promotes Corticospinal Tract Axon Regeneration to Repair Spinal Cord Injury by Activating the JAK2/STAT3 Pathway.

Objective: Regeneration of corticospinal tract (CST) axons after spinal cord injury (SCI) is a key element in rebuilding neuronal connections to restore voluntary motor function. However, it remains challenging owing to limited effective interventions. This study adopted a modified transcranial optogenetic technique to stimulate CST axon regeneration into the injury site of completely transected SCI and explore the underlying molecular mechanisms.

Construction of a chiral metal-organic framework material with triazole amino acid ligands and its application in capillary electrochromatography for enantioseparation.

Chiral separation is vital in medicine because the two versions of a chiral drug can act differently, and one might cause toxicity. Therefore, efficient enantioseparation is essential in pharmaceutical quality control. In this study, we modified the amino site of l-lysine (L-Lys) with a triazole ring.

TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis.

Unlabelled: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies. PDAC is characterized by prominent necrotic foci within the tumor and a high propensity for distant liver metastasis, leading to a poor prognosis. In this study, using patient-derived organoid models, single-cell RNA sequencing, and multiplex immunofluorescence staining of samples from patients with PDAC, in vivo TGFβ1 conditional knockout mouse models, and 3D in vitro models, we discovered that the formation of intratumoral necrotic foci in pancreatic cancer is closely associated with liver metastatic events.