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Chirality is not only a natural phenomenon but also a bridge between chemistry and life sciences. An effective way to obtain a single enantiomer is through racemates resolution. Recent literature shows that chiral metal-organic frameworks (CMOFs) have many applications in various fields because of their diverse topologies and functionalities. This review outlines the design idea and summarizes the latest synthesis strategies and applications of CMOFs. It highlights key advances and issues in the separation domain. In conclusion, the review provides perspectives on the challenges and prospective advancements of CMOFs materials and CMOFs-based separation technologies.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305593 | PMC |
http://dx.doi.org/10.1016/j.jpha.2024.101176 | DOI Listing |
Nat Commun
August 2025
State Key Laboratory of Advanced Separation Membrane Materials, School of Chemistry, Tiangong University, Tianjin, P. R. China.
Chiral nanostructures hold transformative potential across diverse fields, yet their assembly construction remains hindered by the high entropic barrier of dissymmetric building units. Inspired by biological structural dynamics, we construct two chiral copper-based hydrogen-bonded frameworks [D(L)-Cu-crystals] via hydrogen-bonded assembly using chiral metal-organic helical as the building unit. Single-crystal X-ray diffraction elucidates hierarchical chirality evolution from asymmetric coordinations to helical chains and framework packing.
View Article and Find Full Text PDFNat Commun
August 2025
Center of Excellence for Renewable Energy and Storage Technologies (CREST), Division of Physical Science and Engineering, 4700 King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
The separation of amino acids from complex mixtures remains an essential yet multi-step, energy-intensive process. Membrane separation technology offers a more energy-efficient alternative, but its effectiveness relies on achieving highly precise molecular recognition. Here, we report a homochiral covalent organic framework (COF) membrane with ordered ultra-microporous pore structures for targeted extraction of specific enantiomer from amino acid mixtures.
View Article and Find Full Text PDFACS Appl Mater Interfaces
August 2025
School of Petrochemical Engineering, Lanzhou University of Technology, Lanzhou 730050, P. R. China.
The critical role of chirality in biological and chemical systems has driven the demand for advanced nanocatalytic platforms capable of achieving efficient chiral selective recognition and conversion. The present study details the design of chiral polyoxometalate metal-organic frameworks (POMOFs) based on polyoxometalates, which mimic enzyme-catalyzed multiphase catalysis by combining the redox activity of Keggin-type polyoxometalates with the stereoselectivity of chiral MOFs. This design strategy precludes the aggregation of catalytic sites through uniformly dispersed POM clusters.
View Article and Find Full Text PDFJ Pharm Anal
July 2025
Shanghai Engineering Research Center of Organ Repair, Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), School of Medicine, Shanghai University, Shanghai, 200444, China.
Chirality is not only a natural phenomenon but also a bridge between chemistry and life sciences. An effective way to obtain a single enantiomer is through racemates resolution. Recent literature shows that chiral metal-organic frameworks (CMOFs) have many applications in various fields because of their diverse topologies and functionalities.
View Article and Find Full Text PDFChem Bio Eng
July 2025
Center for Ordered Materials, Organometallics and Catalysis (COMOC), Department of Chemistry, Ghent University, Krijgslaan 281-S3, 9000 Ghent, Belgium.
Enzymatic catalysis is a green alternative to chemical catalysis, with high activity and selectivity toward the target products in very mild reaction conditions. However, the three-dimensional active structure of an enzyme is very fragile and highly sensitive to external variables such as temperature, pH, and chemical stressors, severely limiting the application range of natural enzymes. A viable solution is to immobilize enzymes within solid porous matrices.
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