Dermal Fibroblasts-derived Exosomes Alleviated Bronchopulmonary Dysplasia in Neonatal Rats Partially by Regulating Autophagy.

Objective: Bronchopulmonary dysplasia (BPD), a prevalent chronic pulmonary disorder predominantly affecting preterm infants, is characterized by impaired lung development and persistent inflammatory-mediated lung injury. Dermal fibroblast-derived exosomes (DF-Exos) have been demonstrated to alleviate inflammation and promote epithelial tissue repair; however, their role in lung injury remains to be elucidated. This study aimed to evaluate the effects of DF-Exos on BPD and explore their relationship with autophagy.

Extremely Compact 3D Printed Glass Ternary Diffractive Optical Element for Holographic Images.

The design and fabrication of compact and versatile holographic structures are critical for advancing next-generation technologies, ranging from augmented and virtual reality (AR/VR) devices to optical holographic data storage. While significant progress has been made in holographic design and fabrication, existing methods often involve trade-offs between size, holographic image quality, and manufacturing complexity. Binary or few-level holographic structures, though simple to design and fabricate, are prone to twin-image artifacts, limiting their performance.

High-quality marriage mitigates psychological distress in caregivers of older inpatients with severe COPD: A moderated mediation model.

Family caregivers play a crucial role in reinforcing health and social care systems. This study aims to explore the psychological distress of older spouse caregivers of inpatients with severe Chronic Obstructive Pulmonary Disease (COPD), and to reveal the underlying mechanisms by which high quality marital quality alleviates psychological distress. We included 148 older spouse caregivers in this study and found that over half reported experiencing varying degrees of psychological distress.

Intelligent Visualization of Single Microbead Bubbling Enables Attomolar Protein Quantification.

Quantification of low-abundance proteins in biofluids using affordable and portable biosensors stands as the top priority for point-of-care testing and in-field disease screening/monitoring. Herein, we propose a cellphone-based portable immunoassay platform coupled with an intelligent single microbead (SMB) bubbling visualization mechanism, which allows for facile, low-cost, and highly sensitive protein analysis. The use of solely an SMB as the immunocarrier can remarkably boost the sensitivity by superenriching the target-mediated, platinum nanoparticle (PtNP)-involved immunocomplexes on its surface.

The effectiveness of stem cell‑derived extracellular vesicles therapy for intrauterine adhesions: a meta-analysis of preclinical studies.

Background: The therapeutic potential of stem cell-derived extracellular vesicles (EVs) for intrauterine adhesions (IUA) has attracted increasing preclinical investigation, yet a comprehensive and up-to-date meta-analysis is currently lacking. Before moving forward with clinical applications, it is essential to fully understand the impact of stem cell-derived EVs on IUA.

Methods: PubMed, EMBASE, Cochrane Library, Web of Science were searched up to May 19th 2025.

Asiaticoside alleviates atherosclerosis progression by suppressing RhoF-NF-κB/MAPK signaling and inflammation in macrophages.

Background: Asiaticoside (AT), a triterpenoid derived from Centella asiatica, has long been recognized for its anti-inflammatory properties. Its potential to ameliorate atherosclerosis (AS), a chronic inflammatory disease, positions it as a promising therapeutic agent, although its underlying mechanisms remain to be fully elucidated.

Purpose: This study aimed to evaluate the anti-atherosclerotic effects of AT and elucidate the molecular mechanisms underlying its therapeutic actions in AS.

ApoBDs: a paradigm shift from cellular debris to therapeutic vehicles.

Apoptosis, a genetically programmed cell death process, is essential for maintaining tissue homeostasis. Apoptotic vesicles (ApoVs), membrane-bound vesicles generated during apoptosis and once considered mere cellular debris, can be classified into apoptotic bodies (ApoBDs), microvesicles, and apoptotic extracellular vesicles (ApoEVs) based on their grain size. These vesicles, packed with bioactive molecules, not only drive tumor growth and metastasis, but also contribute to tissue and organ repair.

Interfacial Engineering-Free Microfluidics: Toward a Mild and Cost-Effective Strategy for Surfactant- and Demulsifier-Free Hydrogel Microsphere Fabrication.

This study proposes a simple yet versatile microfluidic strategy for fabricating monodisperse alginate hydrogel microspheres using a symmetric flow-focusing device. The system integrates three key innovations: (1) Cost-effective mold fabrication: A paper-based positive master replaces conventional SU-8 photoresist, significantly simplifying device prototyping. (2) Surfactant-free droplet generation: Alginate hydrogel droplets are formed at the first flow-focusing junction without requiring interfacial stabilizers.

Preparation and Properties of Flexible Multilayered Transparent Conductive Films on Substrate with High Surface Roughness.

The flexible transparent conductive films (TCFs) of a ZnS/Cu/Ag/TiO multilayered structure were deposited on a flexible PET substrate with high surface roughness using magnetic sputtering, and the effects of structural characteristics on the performance of the films were analyzed. The TCFs with TiO/Cu/Ag/TiO and ZnS/Cu/Ag/ZnS symmetric structures were also prepared for comparison. The TCF samples were deposited using ZnS, TiO, Cu and Ag targets, and they were analyzed using scanning electronic microscopy, atomic force microscopy, grazing incidence X-ray diffraction, spectrophotometry and a four-probe tester.

Exploring Susceptibility of Dementia in Spouses of Diagnosed Patients: A Cross-Sectional Study.

The number of patients with dementia is rising. Although there is abundant information on the prevalence of dementia, we specifically focused our sample in the Jimo region in China which has a higher than typical prevalence. Additionally, there is insufficient evidence concerning the effects of having a diagnosis of dementia on the spouse of the diagnosed patient.

Effects of Biochar Amendment on Potassium Supply Capacity and Potassium Accumulation in Soybean Across Diverse Soils.

Biochar enhances soil available potassium and plant uptake, yet its effects on soil potassium supply capacity and crop potassium accumulation require clarification. This study used a pot experiment with three soil types (albic, brown, and sandy soils) and four biochar application rates (0, 10, 20, and 30 g·kg) to investigate potassium supply capacity and soybean potassium accumulation using the potassium site coordination theory and Q/I curve analysis. The results showed that biochar significantly increased the available potassium content in soil.

Doublesex and GATAβ4 synergistically regulate the sex-dimorphic expression of storage protein 1 in Bombyx mori.

Sexually dimorphic traits are widespread in organisms and are crucial for reproduction and behavior. These traits are typically controlled by sex-specific genes. However, their regulatory mechanisms are complex and incompletely understood.

The effect of monotherapy versus combination antiviral therapy on all-cause mortality risk in COVID-19 patients.

This study aimed to determine the effect of Azvudine and Paxlovid on COVID-19 prognosis. A retrospective investigation was conducted on 2,103 hospitalized patients from December 2022 to February 2023 at Shanxi Medical University's First Hospital. Patients were categorized into three groups based on their antiviral treatment: monotherapy, combination therapy, and no treatment.

Embryonic stem cell-derived small extracellular vesicles alleviate lead-induced cochlear spiral ganglion neurons injury by activating PI3 K/AKT signaling pathway.

ObjectiveEmbryonic stem cell (ESC)-derived small extracellular vesicles (sEVs) exhibit considerable potential as an innovative therapeutic approach in the fields of regenerative medicine and disease management. This in vitro study aimed to evaluate the protective efficacy of ESC-sEVs against lead acetate (PbAc)-induced damage in cochlear spiral ganglion neurons (SGNs).MethodsCochlear SGNs of neonatal rats were primarily cultured and administrated with (i) serum-free medium (control); (ii) 25 μM PbAc; (iii) 0.

UBE2T-mediated HP1α ubiquitination enhances nucleolar function and promotes the progression of IDH1/TP53-mutant glioma.

Background: High-grade glioma is the most aggressive form of primary brain tumor, characterized by rapid progression and a grim prognosis. The presence of mutations in the IDH1 and TP53 is associated with a specific molecular phenotype in glioma, and their interaction is a potential target for therapy.

Methods: Our study utilized a combination of bioinformatics analysis, in vitro experiments, and in vivo tumor xenograft models to investigate the role of the ubiquitin-conjugating enzyme UBE2T in the malignant progression of IDH1/TP53 mutant glioma.

A one-year study of biochar in immobilizing PFOA in soil-plant rainfall leaching systems: Residue fraction and metabolomics perspectives.

The strong vertical transport capacity and facile plant uptake of perfluorooctanoic acid (PFOA) make its control in soil-plant rainfall leaching systems both urgent and challenging. This study investigated the effectiveness of biochar amendment (2 % and 4 %, w/w) in regulating the PFOA fate in a soil-lettuce system over 360 days, covering two seasons across two different soil types. Soil sequential chemical extraction and plant metabolomics analysis were employed to clarify the underlying immobilization mechanism and related metabolic outcomes.

Cloche/Npas4l is a pro-regenerative platelet factor during zebrafish heart regeneration.

Zebrafish has full capacity of heart regeneration, but little is known about how blood cells, especially platelets, are involved in this regenerative process. Here, we report that cloche/npas4l is a pro-regenerative platelet factor for heart regeneration. We found that haploinsufficiency of npas4l disrupted cardiomyocyte (CM) and endothelial cell (EC) proliferation and heart regeneration after injury.

employs C3 derivative to mediate internalization and infection via the teleost-specific receptor.

is a prominent fish pathogen, and spreads the infection to humans and mammals. It can resist serum killing and invade the host phagocytic cells. However, the precise mechanisms underlying infection remain unclear.

Reducing chalkiness and enhancing quality and yield in hybrid indica rice at the middle panicle position through optimal water and nitrogen management.

Chalkiness considerably impacts rice quality and is influenced by water and fertilizer management. This study investigates the regulatory mechanisms of water and nitrogen management on yield and chalkiness across different panicle positions. Compared to the upper and lower panicle positions, grain yield from the middle panicle position was significantly increased by 8.

Semi-Crystalline Ruthenium Catalyst for Zero-Drag Hydrogen Production from Hybrid Alkaline Seawater Electrolysis.

Hydrazine-assisted hybrid alkaline seawater electrolysis offers a dual-functional platform for environmentally benign remediation of toxic hydrazine and energy-autonomous hydrogen generation. Addressing the critical need for simplified system integration, a single-metal bifunctional catalyst is developed by modulating electronic metal-support interactions (EMSI) to construct semi-crystalline Ru domains with metastable crystalline-amorphous interfaces. The optimized catalyst achieves ultralow overpotentials of 21.

Differential effects of biochar and straw incorporation on soil organic carbon: A case study on paddy cultivation in Northeast China.

The accumulation of soil organic carbon (SOC) is critical for maintaining soil fertility and mitigating climate change. The incorporation of organic amendments is a common practice for improving SOC, but the SOC dynamics affected by biochar and straw in rice cultivation still remain unclear. This study focused on paddy ecosystems in cold regions of Northeast China.

Modulator-Induced Secondary Building Unit Control in Lanthanide-Porphyrin Metal-Organic Frameworks for Enhanced Photooxidation.

Controlling secondary building units (SBUs) in metal-organic frameworks (MOFs) provides a powerful strategy for tuning their photophysical properties and enhancing photocatalytic performances, particularly in singlet oxygen-mediated reactions. Herein, we report the synthesis of a series of lanthanide-porphyrin frameworks (QPF-3, QPF-4, and QPF-5) via a modulator-induced approach, yielding diverse SBUs that range from dinuclear cluster to a one-dimensional rod SBU. Among these, QPF-5(Yb) with rod SBU exhibits the highest O generation efficiency and remarkably improved photocatalytic activity in oxidizing 1,5-dihydroxynaphthalene to juglone, achieving up to a 6.

Ecological risk assessment of oilfield soil through the use of machine learning combining with spatial interaction effects.

With the intensification of oil extraction activities, total petroleum hydrocarbons (TPHs) and toxic elements contamination in soil around oil wells have become severe environmental problems. This paper proposed a novel method based on machine learning (ML) and remote sensing (RS) to predict concentrations of TPHs and toxic elements in the soil around 1252 oil wells for pollution investigation and monitoring in the Huabei Oilfield in China. RS can obtain variables that are closely related to soil pollution, such as the fractional vegetation cover (FVC), soil type and topographic factors.