Constructing High-Entropy Molecular Networks on Metal Surfaces.

High-entropy materials (HEMs) have garnered intense attention due to their unique properties derived from compositional complexity, demonstrating promise in a wide range of applications, from catalysis to energy storage and beyond. Traditionally, HEMs have been primarily concerned with metal alloys. However, expanding the principle to organic systems, specifically high-entropy molecular nanostructures, remains underexplored.

Cost-utility of endoscopic screening strategies for upper gastrointestinal cancer across China: a modeling study.

Introduction: Endoscopic screening for upper gastrointestinal cancer (UGC) is effective, but it's cost-utility across comprehensive strategies remains unclear. We aimed to assess the cost-utility of various endoscopic screening strategies for UGC within the Chinese health care system.

Methods: This study assessed the cost-utility of 40 endoscopic screening strategies using a Markov model.

Rethinking softmax in incremental learning.

Mitigating catastrophic forgetting remains a fundamental challenge in incremental learning. This paper identifies a key limitation of the widely used softmax cross-entropy loss: the non-identifiability inherent in the standard softmax cross-entropy distillation loss. To address this issue, we propose two complementary strategies: (1) adopting an imbalance-invariant distillation loss to mitigate the adverse effect of imbalanced weights during distillation, and (2) regularizing the original prediction/distillation loss with shift-sensitive alternatives, which render the optimization problem identifiable and proactively prevent imbalance from arising.

A Conserved FABP5 Macrophage Subset Promotes Fibrosis and Carcinogenesis in Advanced Liver Disease.

Background And Aims: The relationship between chronic liver disease and liver cancer remains poorly understood, and treatment options for advanced liver disease remain limited. This study aims to elucidate the dynamic evolution of cellular and molecular alterations from normal liver to diseased liver.

Methods: Single-cell RNA sequencing was performed to profile the dynamic cellular variations from normal liver to diseased liver.

The phase of slow wave oscillations couples with high gamma power in human electrocorticography during performed and imagined repetitive movements.

High Gamma Band (HGB) and Slow Wave Oscillations (SWOs) have been identified as significant features in movement neurophysiology. HGB reflects local neuronal activity, while SWOs inform on the temporal characteristics of movement, especially during repetitive tasks. However, to date, they have mostly been studied separately, leaving details on their interaction largely unknown.

The emerging role of disulfidptosis in Alzheimer's disease.

Alzheimer's disease (AD) is a chronic neurodegenerative disorder primarily characterized by Aβ deposition and tau hyperphosphorylation. Clinically, AD manifests as progressive episodic-memory loss that ultimately erodes global cognition and the ability to perform activities of daily living. Despite decades of investigation, the molecular underpinnings of AD remain incompletely understood and no disease-modifying therapies are available.

Characteristics of CVA16 B1c strains isolated for the first time in the Heilongjiang Province of China.

Hand, foot, and mouth disease (HFMD) represents a globally prevalent infectious disease that is caused by enteroviruses. Enterovirus A71 (EV-A71), coxsackievirus A16 (CVA16), and coxsackievirus A6 (CVA6) are recognized as the predominant causative agents of HFMD. CVA16 is a member of the genus within the family .

Association between metabolic syndrome and prognosis in elderly gastric cancer patients.

Metabolic syndrome (MetS) is a cluster of metabolic abnormalities, including obesity, hypertension, dyslipidemia, and hyperglycemia. It has been linked to poor prognosis in various cancers, yet its effect on elderly gastric cancer patients remains underexplored. This study examined 826 elderly gastric cancer patients, with 314 (38.

Green fabrication of starch-based epoxy thermosets towards the excellent intrinsic fire safety and smoke suppression properties.

A new intrinsically flame-retardant starch-based epoxy resin (OS-DDM-EP) was successfully fabricated from a green and facile process using resource-rich and low-cost starch as raw materials. The molecule structure of OS-DDM-EP was verified by infrared spectrum and nuclear magnetic resonance. TGA results revealed a much higher than residual char rate for OS-DDM-EP/DDM (22.

CuSbSe-Alloying-Induced High Thermoelectric Performance and Mechanical Robustness in BiTe-Based Thermoelectric Materials.

BiTe-based thermoelectric materials remain the only commercially viable candidates for low-grade waste heat recovery. However, their moderate thermoelectric performance and limited mechanical robustness constrain broader industrial applications. Here, a synergistic enhancement of both the thermoelectric and mechanical properties of BiSbTe is demonstrated by alloying with CuSbSe via high‑energy ball milling followed by hot pressing.

Predicting thermal expansion in framework compounds using a charge interaction index.

The precise regulation of thermal expansion is a crucial and challenging topic with significant industrial and technological implications. We propose a charge interaction index (CII) to relate thermal expansion to chemical composition. Using AMO compounds as a case study, we show the validity of this parameter through experimental verification.

Flexible AgSe-based thin-film thermoelectrics for sustainable energy harvesting and cooling.

The high cost and complexity of fabrication limit the large-scale application of flexible inorganic thermoelectric materials. Currently, BiTe-based materials are the only commercially viable option, but the inclusion of Te significantly increases production costs. This study presents a simple and cost-effective method for fabricating flexible AgSe films, employing a combination of solvothermal synthesis, screen printing, and spark plasma sintering.

3D-Printed Geometrical-Optimized Bridge-Type Thermoelectric Generators with a High Output Power and Mechanical Robustness.

The geometric design of thermoelectric (TE) devices plays a key role in their performance, especially in terms of their energy conversion efficiency and mechanical robustness. In this study, we employed the shape-customization capabilities of three-dimensional (3D) printing to develop a novel bridge-type thermoelectric device with an enhanced device performance. To fabricate the TE devices, p-type and n-type BiTe-based TE materials were prepared through Selective Laser Melting (SLM), characterized by the pronounced anisotropy due to rapid cooling and steep temperature gradients during printing.

Construction and validation of a cell-in-cell related prognostic signature for hepatocellular carcinoma.

Cell-in-cell structures (CICs) and their biological roles contribute to disease development, particularly in cancer. However, the roles of CIC-associated genes (CICGs) in hepatocellular carcinoma (HCC) are largely unknown. This study sought to establish a a CICGs-linked HCC signature and assess its predictive significance.

Analysis of the therapeutic effect of online haemodiafiltration on delayed methotrexate excretion combined with acute kidney injury in children: a real-world study.

Background: To evaluate the efficacy and feasibility of online haemodiafiltration (HDF) in the treatment of delayed methotrexate (MTX) excretion and acute kidney injury (AKI) in children with hematological malignancies after chemotherapy.

Methods: Children diagnosed with hypermethotrexatemia combined with acute kidney injury and receiving blood purification treatment during high-dose methotrexate(HD-MTX) chemotherapy for leukemia/lymphoma in a hospital from January 2019 to August 2023 were divided into CRRT group and HDF group. The rate of decrease in MTX blood concentration, drug-related adverse reactions, renal function recovery time and hospitalization related economic costs were compared between the HDF group and CRRT group.

A Systematic Review and Quality Assessment of Pharmacoeconomic Publications for China Compared to Internationally: Is the Quality of Evidence-Base Sufficient for Health Technology Assessment?

Background: Pharmacoeconomic evaluations are becoming more important in China, and their research quality directly impacts government decisions, deserving extra attention. To summarize the quality of pharmacoeconomic publications for China compared to internationally and to identify areas for improvement both from a China-specific and international perspective.

Methods: First, we conducted a systematic review of pharmacoeconomic publications for China, with subsequent reporting quality assessment based on the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist.

Systematic screening for functional exon-skipping isoforms using the CRISPR-RfxCas13d system.

Exon skipping (ES) is the most prevalent form of alternative splicing and a hallmark of tumorigenesis, yet its functional roles remain underexplored. Here, we present a CRISPR-RfxCas13d-based platform for transcript-specific silencing of ES-derived isoforms using guide RNAs (gRNAs) targeting exon-exon junctions. We designed a transcriptome-wide gRNA library against 3,744 human ES events and conducted loss-of-function screens in colorectal cancer (CRC) cells in vitro and in vivo.

Cross-sectoral synergy governance programme for antimicrobial resistance control in China using a 'One Health' approach: study protocol for a mixed-methods study.

Introduction: Antimicrobial resistance (AMR) is a critical global public health concern, particularly acute in rural China. Counties, which cover extensive rural regions, face major challenges in AMR governance and thus require priority attention. Yet, AMR governance efforts across sectors are fragmented, with notable gaps in translating policy objectives into sustainable, practical governance measures.

Exploring Multifactorial Conflicts and Resolution Strategies in the Field of Peri-Implant Osseointegration: A Study Based on the WOE-NLP-Delphi Framework and Bibliometrics.

Titanium implants remain the gold standard for dental and orthopedic rehabilitation, yet challenges in osseointegration and postoperative infection persist. This study integrated bibliometric analysis with an AI-driven framework (DeepSeek-R1) to map global research trends, quantify technical conflicts, and predict future translational trajectories. Analyzing 3078 publications (2015-2025) from Web of Science, the authors identified China as the most productive country (251 articles), while Switzerland led in citation impact (25 citations/article).

SNX11 Deletion Inhibits Dabie bandavirus Infection by Interfering with the Assembly of V-ATPase.

SNX11, a sorting nexin protein localized on the endosomal membrane, is an important protein closely related to protein sorting and endosomal trafficking. Previously, through a genome-wide CRISPR screening, we identified SNX11 as a critical protein for the entry of Dabie bandavirus. SNX11 deletion significantly inhibits the replication of Dabie bandavirus.

Development and validation of a novel prognostic model to predict 1-year post-transplant mortality for acute-on-chronic hepatitis B liver failure: a nationwide, multicentre, cohort study.

Background: Liver transplantation (LT) provides a potential cure for hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). We aimed to develop and externally validate a prognostic model to predict 1-year post-LT mortality in patients with HBV-ACLF.

Methods: This retrospective, nationwide, observational cohort study was conducted at ten high-volume LT centres in China.

Parallel-Shaped poly(L-lactic acid) electrospun membrane promotes facial nerve injury regeneration by upregulating miR-451a expression.

Facial nerve injury (FNI) causes devastating sequelae, including impaired eyelid closure, dysphagia, and permanent facial asymmetry, leading to long-term functional deficits and profound psychosocial impacts that pose significant rehabilitation challenges. To address this, neural regenerative scaffolds represent a promising therapeutic alternative. This study engineered poly(L-lactic acid) (PLLA) electrospun membranes with parallel topographical cues (Align) and functionalized miR-451a-incorporated scaffolds (miR-451a mimics@PLLA) electrostatic spinning, aiming to decipher how topographical cues steer neurogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and their crosstalk with microRNA regulation.

Barriers and challenges: a descriptive qualitative study of job satisfaction among direct care workers who provide long-term care services in Shandong Province, China.

Background: The special nature of the functional ability of older individuals with disabilities places higher demands on the quantity and quality of long-term care (LTC) services. However, LTC services lag significantly behind, with LTC facilities facing challenges in recruiting and retaining direct care workers (DCWs). Job satisfaction significantly affects turnover rates.

TNF-α Promotes Synovial Inflammation and Cartilage Bone Destruction in Rheumatoid Arthritis via NF-κB/YY1/miR-103a-3p Axis.

Tumor necrosis factor alpha (TNF-α) plays important roles in inflammation and bone destruction in rheumatoid arthritis (RA), but the detailed mechanism is still not fully elucidated. Here, we found that the levels of microRNA (miR)-103a-3p were decreased markedly in the inflamed synovial tissues of patients with RA compared with osteoarthritis (OA) or healthy control subjects. Further studies uncovered that miR-103a-3p was significantly downregulated by TNF-α/IL-1β in RA fibroblast-like synoviocytes (FLSs) through an NF-κB-dependent manner via the de novo produced transcription factor Yin Yang 1 (YY1).

Dual nanozymes-loaded core-shell microneedle patches with antibacterial and NETs-degradation bifunctional properties for periodontitis treatment.

Periodontitis, a chronic inflammatory disease affecting over one billion people worldwide, is characterized by bacterial infections and hyperactive immune responses. Recent studies have revealed that the formation of neutrophil extracellular traps (NETs) contributes significantly to periodontal tissue destruction, and NETs degradation plays a critical role in periodontitis treatment. Current treatments, including mechanical debridement and systemic antibiotics, face limitations such as antibiotic resistance and insufficient local efficacy.