Bimetallic FeNi-ZSM-5-catalyzed pyrolysis of photovoltaic waste: Selective and high-yield aromatic valorization for circular resource recovery.

Catalytic pyrolysis, an efficient thermochemical process, offers a promising pathway to valorize thermoset photovoltaic backsheets (TPV) into high-value chemicals. This study investigates the ex situ catalytic pyrolysis of TPV using two acidic catalysts, ZSM-5 and FeNi-ZSM-5, under varied operational conditions, with a focus on product distribution and process efficiency. The catalytic intervention significantly enhanced pyrolysis performance.

Identification of Immune-Related Long Non-Coding RNAs for Pulpitis Prediction Based on Competing Endogenous RNAs.

Introduction And Aims: Pulpitis is a chronic inflammatory disease affecting oral health. We aim to identify immune-related lncRNAs via bioinformatics analyses and explore their functions through ceRNA networks.

Methods: The expression profiles of 6 patients with pulpitis and 8 normal dental pulp have been obtained from Genome Sequence Archive.

Case Report: Multidimensional Analgesia via Asymmetric Dual-Target Deep Brain Stimulation of the Periaqueductal Gray and Ventral Posterior Thalamus in Central Post-stroke Pain.

Central post-stroke pain (CPSP) is an intractable neuropathic pain syndrome. Dual-target deep brain stimulation (DBS), which integrates sensory thalamic modulation and endogenous analgesic pathways, has emerged as a potential intervention; however, clinical evidence remains scarce. We report a 54-year-old woman who developed right-sided limb paresthesia progressing to persistent right hemibody pain following a left thalamic hemorrhage.

Synergistically Enhanced NiCo(OH)@NiS Heterojunction Catalyst for High-Performance Ethanol Electrooxidation.

Coupling the ethanol electrooxidation reaction (EOR) with the hydrogen evolution reaction is an effective way to obtain green energy. Although Ni-based catalysts have the characteristics of low cost and good stability, meanwhile, the activity needs to be further improved. Here, we report a Ni-based heterojunction EOR catalyst, NiCo(OH)@NiS, composed by two phases of NiS and NiCo(OH).

FAM46B inhibits CS-induced oxidative stress and ferroptosis in bronchial epithelial cells via KLHL24.

Background: Chronic obstructive pulmonary disease (COPD), mainly caused by cigarette smoke (CS), is a global health concern. Ferroptosis is recognized as a key driver of COPD progression, yet its underlying mechanisms are unclear. This study aimed to identify crucial genes involved in COPD and elucidate their functional roles in COPD via bioinformatics and experiments.

Integrating hydrological and economic assessments of soil infiltration enhancement for urban flood resilience.

Urban flooding, exacerbated by climate change and the expansion of impervious surfaces, poses growing risks to sustainable urban development. Enhancing soil infiltration through green infrastructure is a promising nature-based solution, yet its hydrological effectiveness and economic viability under diverse rainfall scenarios remain insufficiently quantified. This study develops an interdisciplinary framework integrating column experiments, physically distributed hydrological modeling, and cost-benefit analysis to assess ceramsite-amended soils for urban flood resilience.

Development of a multi-feature predictive model for risk stratification in stage IB-IIA non-small cell lung cancer: a multicenter analysis.

Objective: This study aimed to develop a comprehensive risk stratification model for stage IB-IIA non-small cell lung cancer (NSCLC) by integrating clinicopathological data with pre-treatment CT imaging.

Methods: This retrospective study included three independent cohorts of patients with stage IB-IIA NSCLC for model development and validation (Training: n = 370; Internal validation: n = 120; External validation: n = 70). Disease-free survival (DFS) was the primary endpoint.

Evaluation efficacy and accuracy of a real-time computer-aided polyp detection system during colonoscopy: a prospective, multicentric, randomized, parallel-controlled study trial.

Introduction: Colorectal cancer (CRC) ranks as the second deadliest cancer globally, impacting patients' quality of life. Colonoscopy is the primary screening method for detecting adenomas and polyps, crucial for reducing long-term CRC risk, but it misses about 30% of cases. Efforts to improve detection rates include using AI to enhance colonoscopy.

Mitochondrial protein import stress augments α-synuclein aggregation and neural damage independent of bioenergetics.

Genetic and environmental factors are known to converge on mitochondria to cause Parkinson's disease (PD). However, the mechanisms by which mitochondrial dysfunction contributes to neurodegeneration remain incompletely understood. Non-bioenergetic pathways of the mitochondria are increasingly appreciated, but confounding bioenergetic defects are a major barrier to experimental validation.

Enhancing postoperative recurrence assessment in gastric and colorectal cancer patients with intraperitoneal fluorouracil implants: overcoming the diagnostic challenge of fluorouracil implant-related tumor-like lesions.

Background: Intraoperative intraperitoneal chemotherapy using sustained-release fluorouracil implants has been used to reduce the recurrence of gastrointestinal tumors. However, these implants may persist and present as tumor-like lesions in imaging studies, potentially leading to false-positive interpretations as metastatic sites, affecting patient management. Our study aimed to enhance the diagnostic accuracy of radiologists in assessing gastric and colorectal cancer patients with fluorouracil implants.

Dosimetric comparison of hybrid IMRT and different arc techniques VMAT after breast-conserving surgery for left-sided breast cancer.

Purpose: This study aimed to comprehensively compare the dosimetric characteristics of three different radiotherapy techniques-hybrid intensity-modulated radiotherapy (hy-IMRT), tangential volumetric-modulated arc therapy (t-VMAT), and continuous volumetric-modulated arc therapy (c-VMAT)-used after breast-conserving surgery for left-sided breast cancer in the target area and organs at risk (OARs) after breast-conserving surgery for left-sided breast cancer. This evaluation aims to provide a solid basis for individualized radiotherapy planning in clinical practice.

Methods: Twenty female patients who underwent breast-conserving surgery for left-sided breast cancer were retrospectively selected.

Euphebranes A-G: higher diterpenoids from the radix of Euphorbia ebracteolata.

Phytochemical investigation of roots of Euphorbia ebracteolata Hayata led to ten higher diterpenoids including seven undescribed ones (1-7) and three analogues (8-10), accompanied by four derivatives (7a and 9a-9c) obtained via chemical correlation. Notably, compound 1 represents a rare dinor-ent-isopimarane diterpenoid. Their structures were fully characterized using a combination of spectroscopic, ECD, chemical, and single-crystal X-ray diffraction means.

Rebalancing translaminar pressure difference: a novel glaucoma surgery-a pilot trial in non-human primates.

Aim: To propose a novel glaucoma surgery for rebalancing translaminar pressure difference.

Methods: Three non-human primates with normal eyes and two with laser-induced glaucoma underwent the novel surgical procedure. Cannulation of the subarachnoid space was performed after completion of routine vitrectomy steps.

Empagliflozin reduces left ventricular mass increase and improves cardiomyocyte hypertrophy after 5/6 nephrectomy.

Left ventricular hypertrophy (LVH) is a common cardiac complication in patients with cardiorenal syndrome. Empagliflozin has demonstrated cardio-renal protective effects in clinical studies, potentially linked to reductions in left ventricular mass (LVM). Using a 5/6 nephrectomy rat model to induce cardiorenal syndrome, we administered two doses of Empagliflozin (3 mg/kg/day and 15 mg/kg/day) via gavage for 95 days, with Telmisartan as a positive control.

Evaluation of Poxvirus-Specific Antibody Response in Monkey Poxvirus-Negative and -Positive Cohorts.

Objectives: Understanding the antibody response in monkeypox virus (MPXV)-infected and uninfected individuals is essential for developing next-generation MPXV vaccines. This study aimed to characterize neutralizing antibody (NAb) and antibody-dependent cellular cytotoxicity (ADCC) responses in both groups, providing insights into immune protection and vaccine design.

Methods: A recombinant vaccinia Tian Tan (VTT) virus was utilized to develop high-throughput luciferase-reporter-based neutralization and ADCC assays.

Molecular phylogenetics of Micromeles (Rosaceae: Maleae): implications for taxonomy.

Background: Micromeles Decne., belonging to the tribe Maleae of the family Rosaceae, has a complicated taxonomic history. It was either recognized as a distinct genus in the broad sense (Micromeles s.

Multifaceted Role of RIMBP2 in Promoting Hearing in Murine Cochlear Hair Cells.

The mammalian cochlea relies on outer and inner hair cells (OHCs/IHCs) for sound amplification and signal transmission. Rab3-interacting molecular binding protein 2 (RIMBP2), expressed in receptor cells and neurons at synaptic active zones, remains poorly characterized in hearing. We therefore generated a Rimbp2 knockout (KO) mouse model (Rimbp2), which exhibited severe hearing loss with elevated thresholds, prolonged latencies, and reduced amplitudes in auditory brainstem response Wave I.

Discovery of Pyrazolo[1, 5-a]pyrimidine-Based Selective HDAC6 Inhibitors with Broad-Spectrum Antiproliferative Activity.

Selective histone deacetylase 6 inhibitors show distinctive advantages for cancer treatment. In this paper, phenylhydroxamic acid group, a key pharmacophore of histone deacetylase 6 inhibitor, is introduced on common active pyrazolo[1,5-a]pyrimidine scaffold. Among all thirteen analogs, N-hydroxy-4-(((7-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl)benzamide (8e) emerged as the most potent compound.

Honeysuckle-derived carbon dots as fluorescent nanoprobes for determination of sunset yellow and cell imaging.

Sunset yellow (SY) is a widely used food and pharmaceutical colorant, but concerns over its safety highlight the need for sensitive and accurate detection methods. In this work, carbon dots were synthesized from the herbal medicine Honeysuckle (H-CDs). H-CDs exhibited excellent luminescent properties, structural stability, and remarkable selectivity and sensitivity toward SY.

Homocysitaconate controls inflammation through reshaping methionine metabolism and N-homocysteinylation.

Inflammation and its metabolic-network interactions generate novel regulatory molecules with translational implications. Here, we identify the immunometabolic crosstalk that generates homocysitaconate, a metabolite formed by homocysteine and itaconate adduction catalyzed by S-adenosyl-L-homocysteine hydrolase (AHCY). Homocysitaconate increases 152-fold during inflammation and exhibits anti-inflammatory effects.

Barthel Index Score at Admission to Predict 1-Month and 1-Year Prognosis in Inpatients Aged ≥ 75 Years With Multimorbidity.

Objective: To investigate the Barthel Index (BI) score in predicting the 1-month and 1-year prognosis after discharge.

Methods: This was a retrospective observational single-center study. We retrospectively enrolled consecutive inpatients aged ≥ 75 years from a large public hospital.

Dual T/NK cell engagement via B7-H6-targeted bispecific antibodies and IL-15 eradicates chemo-resistant solid tumors.

Introduction: B7-H6, a tumor-specific immune checkpoint molecule within the B7 family, represents a promising therapeutic target due to its selective overexpression in malignancies and negligible expression in normal tissues.

Method: Here, we developed bispecific antibodies (BsAbs) targeting B7-H6 to redirect T and NK cells against solid tumors. Through phage display, 15 high-affinity B7-H6 monoclonal antibodies were generated.

Iron-Only Metasurface Broadband Absorber for Solar Energy Harvesting.

We investigated a metasurface broadband absorber composed entirely of iron and featuring a simple bilayer structure: a metallic iron substrate topped with an iron nanodisk-patterned layer. This absorber structure achieved over 90% absorption across the visible spectrum, with an average absorption of 97%. The designed metasurface structure had an aspect ratio of less than 1, which facilitated high-quality sample fabrication.

LAMP-Based 4-Channel Microfluidic Chip for POCT Detection of Influenza A H1N1, H3N2, and Influenza B Victoria Viruses.

: Influenza viruses are major pathogens responsible for respiratory infections and pose significant risks to densely populated urban areas. RT-qPCR has made substantial contributions in controlling virus transmission during previous COVID-19 epidemics, but it faces challenges in terms of detection time for large sample sizes and susceptibility to nucleic acid contamination. : Our study designed loop-mediated isothermal amplification primers for three common influenza viruses: A/H3N2, A/H1N1, and B/Victoria, and utilized a 4-channel microfluidic chip to achieve simultaneous detection.

Neutrophils-astrocyte interactions in central nervous system inflammation.

The concept of central nervous system (CNS) "immune privilege" has undergone substantial revision. We now understand that the CNS exhibits sophisticated inflammatory responses that serve dual functions: potentially detrimental in acute phases while facilitating repair and recovery during chronic stages of various neurological conditions. Recent advances in genomic technologies, particularly high-throughput single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics, have revolutionized our understanding of cellular dynamics and interactions within the CNS inflammatory microenvironment.