Dynamic data balancing strategy-based Xception-dual-channel LSTM model for laparoscopic cholecystectomy phase recognition.

Purpose: To enhance the temporal feature learning capability of the laparoscopic cholecystectomy phase recognition model and address the class imbalance issue in the training data, this paper proposes an Xception-dual-channel LSTM fusion model based on a dynamic data balancing strategy.

Methods: The model dynamically adjusts the undersampling rate for each surgical phase, extracting short video clips from the original data as training samples to balance the data distribution and mitigate biased learning. The Xception model, utilizing depthwise separable convolutions, extracts fundamental visual features frame by frame, which are then passed to a dual-channel LSTM network.

Sesame cake fertilizer improves tobacco aroma quality by boosting root growth and leaf aroma precursor formation.

Weak flavor in flue-cured tobacco compromises quality, making aroma enhancement crucial. Sesame cake fertilizer (SF) has the potential for improving tobacco aroma, but its effects on aroma components and mechanism remain unclear. Here, a four-year field experiment was conducted in Southern tobacco region of China to compare SF with conventional fertilization (CK).

Complete response in a patient with metastatic metaplastic breast cancer treated with immune checkpoint inhibitor and chemotherapy: A case report and a review of the literature.

Metaplastic breast cancer (MpBC) is a rare subtype of breast cancer characterized by poor prognosis and lack of treatment guidance. It is notably resistant to conventional chemotherapy. Currently, immunotherapy is becoming a promising option for multiple tumor types, including triple-negative breast cancer.

A review of visual perception technology for intelligent fruit harvesting robots.

With the development of smart agriculture, fruit picking robots have attracted widespread attention as one of the key technologies to improve agricultural productivity. Visual perception technology plays a crucial role in fruit picking robots, involving precise fruit identification, localization, and grasping operations. This paper reviews the research progress in the visual perception technology for fruit picking robots, focusing on key technologies such as camera types used in picking robots, object detection techniques, picking point recognition and localization, active vision, and visual servoing.

The relationship between nursing students' psychological capital and occupational stigma in the Chinese context: A potential profiling analysis.

Aims: The aim of the present study is to analyse latent profiles of psychological capital and the demographic characteristics of undergraduate nursing students and to explore the relationship between each category and their awareness of occupational stigma.

Background: The conventional external view of nurses and a lack of a sense of professional identity may cause nursing students to leave the field. The psychological qualities of nursing students and how they relate to professional stigma must be studied to eliminate professional stigma through positive psychology.

China Expert consensus on the application of metagenomic next-generation sequencing for the etiological diagnosis of infections in hematological disorders (2024).

Infections are frequent complications in patients with hematological disorders, and pathogen diagnosis remains challenging. Metagenomic next-generation sequencing (mNGS) is an unbiased high-throughput technology that has been widely applied in the diagnosis of infectious diseases. However, to date, there are no established international guidelines or expert consensuses regarding the use of mNGS to diagnose infections in patients with hematologic disorders.

Cell Function Experiments and Bioinformatics Analysis Jointly Revealed the Antineoplastic Effect of Lumican on Hepatocellular Carcinoma.

Unlabelled: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and immune checkpoint inhibitor (ICI)-based therapies are now an integral part of systemic treatment. In this study, we identify potential biomarker for HCC and further investigate its functional significance using both bioinformatic and experimental methods. Differential analysis and weighted gene co-expression network analysis (WGCNA) were conducted, identifying () as the target gene.

Advances in adaptive laboratory evolution applications for .

Adaptive Laboratory Evolution (ALE), a well-established framework in microbial evolution research, is widely applied in synthetic biology. By simulating natural selection through controlled serial culturing, ALE promotes the accumulation of beneficial mutations, leading to the emergence of specific adaptive phenotypes and bypassing the complexities inherent in rational genetic engineering. With advancements in next-generation sequencing and molecular biology, the integration of high-throughput omics and molecular tools with ALE has significantly enhanced the mapping of genotype-phenotype relationships and the characterization of mutational landscapes.

Subjective socioeconomic status moderates depression's impact on fairness perception in the ultimatum game: A moderated mediation model.

Individuals with depression often exhibit cognitive distortions in socioeconomic decision-making, particularly in interpreting fairness. However, the role of subjective socioeconomic status in shaping these distortions remains underexplored. This study investigates how depression influences fairness perception and rejection behavior in the Ultimatum Game.

CLDN4 promotes ferroptosis and inflammation involving JAK2/STAT3 pathway in acute pancreatitis.

Acute pancreatitis (AP) is a severe inflammatory disease characterized by pancreatic acinar cell injury and oxidative stress. Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, has been implicated in AP pathogenesis. However, the molecular mechanisms linking ferroptosis to AP remain unclear.

Current landscape of the immunoproteasome: implications for disease and therapy.

The immunoproteasome, an inflammation-induced proteasome variant, coordinates proteostasis and adaptive immunity by replacing constitutive subunits (β1, β2, β5) with inducible counterparts (β1i, β2i, β5i). This specialization enhances antigen processing for MHC class I presentation and oxidative protein clearance. Beyond immune regulation, it critically contributes to cardiovascular, respiratory, neurodegenerative, autoimmune, retinal, and oncological pathologies through mechanisms involving NF-κB activation, mitochondrial dysfunction, and inflammatory polarization.

Electroclinical features and surgical outcome of cingulate epilepsy.

Background: Cingulate epilepsy is rare and can manifest with variable semiology features. The symptomatic diversity elucidates ictal involvement of certain subregions of the cingulate gyrus and early spread patterns. Knowledge of the features of cingulate epilepsy is important for better localization and surgical strategy.

A Staged Event Source Location Identification Scheme in Power Distribution Networks Under Extremely Low Observability.

Recent advancements in synchrophasor measurement technologies have introduced an unprecedented level of visibility in power distribution networks (PDNs), providing a high-quality data foundation for the accurate perception of event source locations. However, the high cost and deployment expense pose a significant challenge in balancing system observability and event source location identification (ESLI) accuracy. In this paper, we propose a staged ESLI scheme based on voltage measurement deviation (VMD), which can achieve high-precision ESLI and event current calculations under extremely low-observability conditions, where the measurement devices are deployed only at the head substation and terminal buses.

Preparation and characterization of a iRGD-modified recombinant spider silk particles for antitumor polypeptide drug delivery into cancer cells.

Spider silk is highly attractive material because of its superior mechanical properties and excellent biocompatibility, enabling it to self-assemble into a wide range of morphological structures for drug delivery system. However, most spider silk particles developed as drug carriers are based on complex repetitive domains of spider silk proteins and exhibit relatively large particle sizes (> 300 nm), which limits their biomedical applications. In this study, we engineered a novel recombinant spider silk protein (NC-iRGD) by integrating terminal domains derived from major ampullate silk and the tumor-penetrating peptide iRGD.

Genetically predicted optimal mediator models for oxidative stress, immunity and intracerebral hemorrhage.

Background: The influence of oxidative stress (OS) and cellular traits on ICH onset remains uncertain. We aimed to investigate the mediating role of cellular traits between OS biomarkers and ICH using multiple Mendelian randomization (MR) methods.

Methods: We included summarized data from seven sources to select 19 OS biomarkers, including trace elements, metabolites, proteins, functional composite structures, and 24-hour dietary quantification.

LAMP-Based 4-Channel Microfluidic Chip for POCT Detection of Influenza A H1N1, H3N2, and Influenza B Victoria Viruses.

: Influenza viruses are major pathogens responsible for respiratory infections and pose significant risks to densely populated urban areas. RT-qPCR has made substantial contributions in controlling virus transmission during previous COVID-19 epidemics, but it faces challenges in terms of detection time for large sample sizes and susceptibility to nucleic acid contamination. : Our study designed loop-mediated isothermal amplification primers for three common influenza viruses: A/H3N2, A/H1N1, and B/Victoria, and utilized a 4-channel microfluidic chip to achieve simultaneous detection.

LRRC75A-AS1 facilitates breast cancer cell proliferation and invasion via functioning as a CeRNA to modulate miR489-3p/ARD1.

This study aimed to elucidate the molecular mechanism through which ARD1 regulates breast cancer (BC) progression via the LRRC75A-AS1/miR-489-3p axis. The expression levels of ARD1, miR-489-3p, and LRRC75A-AS1 in BC cells were quantified using reverse transcription-polymerase chain reaction (RT-PCR). The interaction between miR-489-3p and ARD1 was validated through dual-luciferase reporter assays and RNA-binding protein immunoprecipitation (RIP).

Yatein-induced DNA damage of breast cancer cells by interfering with DNA topoisomerase IIα.

DNA topoisomerase IIα (TOP2A) plays a key role in resolving DNA topological stress during replication, transcription, and chromosome segregation. Yatein, a biogenic precursor of deoxypodophyllotoxin possesses antitumor effects. Herein, we explored its antitumor effect in breast cancer.

Integrative speckle-tracking echocardiography for the early detection and prediction of cancer therapy-related cardiac dysfunction.

Background: The cancer therapy–related cardiac dysfunction (CTRCD) induced by anthracycline could involve the whole heart. However, the overall changes of strain parameters, including the atrial and right heart strains, myocardial work, along with the established left ventricular global longitudinal strain (GLS), during cancer therapy, remain unclear.

Methods: In this prospective cohort study, 83 women undergoing anthracycline treatment for breast cancer, underwent serial echocardiographic examinations at baseline (pre-chemotherapy, T0), after 1 to 4 cycles (T1-T4) and 3 months after treatment completion (T5).

Targeting TXN1 Induces G2M Phase Arrest and Apoptosis of Glioma Cells Through P38 MAPK Pathway.

Glioma is the most common and aggressive primary adult brain tumor. Furthermore, the prognosis for glioma patients following chemoradiotherapy is unfavourable due to the inherent anti-apoptotic characteristics of glioma cells. Thus, the treatment of gliomas remains a challenge.

Correction: Effect of subsp. YLGB-1496 on common diseases in pediatrics: a randomized, blinded, placebo-controlled trial.

[This corrects the article DOI: 10.3389/fnut.2025.

Butein Alleviates Non-Alcoholic Steatohepatitis in Leptin-Deficient Mice by Modulating the PDE4/cAMP/p-CREB Pathway.

Purpose: Non-alcoholic steatohepatitis (NASH) is a prevalent liver disease characterized by steatosis, inflammation, and liver injury. Despite its increasing incidence, effective treatments are limited. Butein, a flavonoid with anti-cancer, anti-inflammatory, and antioxidant properties, has not been thoroughly studied for its potential therapeutic effects in NASH.

Swinging the SWI/SNF complexes for cancer therapy.

SWI/SNF chromatin remodeling complexes are essential epigenetic regulators that control chromatin accessibility and transcriptional programs. Alterations in SWI/SNF components are common across a wide spectrum of human cancers, driving tumorigenesis through diverse mechanisms. Increasing insights into the oncogenic roles of aberrant SWI/SNF complexes have spurred the development of novel therapeutic strategies.

Innovative emulsification and freeze-drying techniques for developing heat-resistant chocolates with tunable textures and sensory attributes.

The development of heat-resistant chocolate that meets customer preferences has been a longstanding challenge for both industry and academia. This study presented an innovative method for producing freeze-dried (FD) chocolate with enhanced heat resistance by integrating emulsification and freeze-drying technologies without altering the chocolate composition. Cryo-electron microscopy and X-ray microscopy revealed a unique microstructure in the product, where water-soluble components, such as sugar, formed a matrix that encapsulated fat-soluble components such as cocoa butter, providing heat resistance up to 70 °C.