Neurological impairments in Duchenne muscular dystrophy: A comprehensive review.

Duchenne muscular dystrophy, the most prevalent form of muscular dystrophy, is characterized by neurological complications including cognitive impairment, neuropsychiatric disorders, and epilepsy. Neuroimaging investigations have demonstrated structural brain alterations, hemodynamic disturbances, and metabolic dysregulation in individuals with Duchenne muscular dystrophy. These neurological impairments are primarily attributed to cerebral dystrophin deficiency and subsequent downstream molecular/cellular abnormalities, including altered excitation-inhibition balance, blood-brain barrier disruption, calcium dysregulation, and neuroinflammation.

Integrative speckle-tracking echocardiography for the early detection and prediction of cancer therapy-related cardiac dysfunction.

Background: The cancer therapy–related cardiac dysfunction (CTRCD) induced by anthracycline could involve the whole heart. However, the overall changes of strain parameters, including the atrial and right heart strains, myocardial work, along with the established left ventricular global longitudinal strain (GLS), during cancer therapy, remain unclear.

Methods: In this prospective cohort study, 83 women undergoing anthracycline treatment for breast cancer, underwent serial echocardiographic examinations at baseline (pre-chemotherapy, T0), after 1 to 4 cycles (T1-T4) and 3 months after treatment completion (T5).

Facile surface modification of cellulose nanofiber with "cross-linkable" internal alkene by syringaldehyde in aqueous medium towards mechanically robust nanocomposite hydrogels.

Incorporating "cross-linkable" double bonds into cellulose nanofibers (CNFs) is crucial for fabricating high-performance composite hydrogels. Herein, TEMPO-oxidized CNFs syringaldehyde propiolate ether (TS), functionalized with "cross-linkable" internal alkenes (-C=C-), was synthesized via hydroxyl-yne click chemistry under mild aqueous conditions. This rapid modification yielded 0.

Diagnostic value of serum TSI levels in Graves' disease and direct comparison of diagnostic performance with TRAb: A systematic review and meta-analysis.

This study aimed to systematically assess the diagnostic value of thyroid-stimulating immunoglobulin on the Siemens Immulite platform (the TSI assay) and to conduct a direct comparison with thyrotropin receptor antibodies on the Roche cobas platform (the TRAb assay) for the diagnosis of Graves' disease (GD). We performed systematic literature searches across multiple databases. Following strict screening, we identified 20 eligible clinical studies that evaluated the diagnostic value of the TSI assay, either alone or in comparison with the TRAb assay.

Clinical Characteristics and Diagnosis of Chronic Myelogenous Leukemia with Rare Karyotype.

Background: The aim was to investigate the clinical features and diagnostic methods of chronic myelogenous leukemia with rare karyotype.

Methods: The clinical features and diagnostic methods of a case of chronic myelogenous leukemia with rare karyotype were retrospectively analyzed, including a comprehensive review of the literature.

Results: The patient is a young male, 36 years old.

Electric Field-Induced Underwater-Oil Diode on a Janus-Porous Ion-Doped Polypyrrole Membrane.

Directional liquid transport on the surface is of great significance in liquid collection, transfer, and separation. Despite extensive research on surface wetting control, achieving unidirectional liquid permeation on material surfaces under water remains a challenge. Here, we demonstrate that electric field-induced unidirectional oil permeation can be achieved on a Janus-porous ion-doped polypyrrole membrane (Janus-PIPM).

The nucleocytoplasmic translocation of HINT1 regulates the maturation of cell density.

In normal epithelial cells on tissue culture dishes, contact inhibition typically progresses with a reduction in cell size after cell-cell contact. This transition involves actin cytoskeleton reorganization from stress fibers (SFs) to a cortical network, stabilizing cell shape and strengthening connections. However, the regulatory signaling pathways remain unclear.

The impact of stratified management of Ki-67 on the prognosis of small-cell lung cancer.

Objective: The Ki-67 protein is frequently employed in pathological immunohistochemistry to indicate cell proliferation activity. The principal aim of this study was to examine the impact of stratified management of Ki-67 on the clinicopathological characteristics and prognosis of patients with small-cell lung cancer (SCLC).

Methods: A total of 175 patients with SCLC who underwent surgical treatment were included in the study, with available data on the results of postoperative immunohistochemistry of the Ki-67 protein.

mTORC2 Regulates Non-homologous End Joining Through Modulating the Temporal Dynamics of 53BP1.

DNA damage repair is a critical biological process that maintains genomic integrity, and its dysregulation is closely related to tumorigenesis. To reveal the roles of mammalian target of rapamycin complex 2 (mTORC2) in DNA damage response (DDR), we investigated the temporal changes of cellular protein phosphorylation in mTORC2 deficient renal cancer cells in response to DNA double-strand break (DSB) induced by ionizing radiation (IR) using quantitative phosphoproteomics. The results showed that knockdown of Rictor, a specific component of mTORC2, induced profound changes in the dynamics of protein phosphorylation in response to IR.

Metabolic syndrome is associated with prognosis in patients with acute ischemic stroke after intravenous thrombolysis: a prospective cohort study.

Objective: Metabolic syndrome (MetS) is a known risk factor for stroke, but its impact on prognosis after intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) remains unclear. This study aimed to evaluate the association between MetS and prognosis in AIS patients treated with IVT.

Methods: We conducted a prospective cohort study including AIS patients who received IVT at Shanxi Bethune Hospital between January 2022 and December 2023.

Flexible cement fibers with high toughness and water-activated setting behavior for construction.

Brittle fracture and facile crack initiation present significant challenges for the toughening and processing of cementitious composites. In this work, the continuous and large-scale fabrication of cement-based fiber is enabled by cellulose-assisted wet spinning strategy, during which cement grains are in-situ implanted into porous cellulose matrix. The subsequent hydration process induces the in-situ formation of a hard continuous network which interconnects with the flexible porous cellulose skeleton, leading an interpenetrating dual-network architecture formed within the resulting cellulose-supported cement-based (CSC) fibers.

Exploring the Anti-Inflammatory and Anti-NET Properties of Zidian Zhenxiao Granule in IgA Vasculitis: A Network Pharmacology and Proteomic Study.

Background And Purpose: Immunoglobulin A vasculitis (IgAV) is the most common systemic vasculitis of childhood. Zidian Zhenxiao granule (ZDZX), a 9-herb formula optimized through decades of clinical practice, uniquely integrates anti-inflammatory and immunomodulatory properties. However, its mechanisms targeting neutrophil extracellular traps (NETs) and thromboinflammatory pathways in combating IgAV remain unclear.

The anti-inflammatory effects of oridonin in resisting esophageal cancer.

Objectives: Explore whether Oridonin (Ori) improves esophageal cancer by interfering in the TLR4/NF-κB/NLRP3 inflammasome.

Materials And Methods: An esophageal mouse model was induced by 4-nitroquinoline N-oxide (4-NQO) for 16 weeks. Starting from the 17th week of modeling, the mice were randomly divided into three groups: the model group (M), the high dose group of Ori (Ori -H) and the low dose group of Ori (Ori -L).

Co-phase errors simultaneous detection for optical sparse aperture systems via deep learning.

Since the sparse structure of the optical sparse aperture systems, co-phasing is crucial for achieving high resolution. In practice, tip-tilt errors affect the piston error, necessitating step-by-step detection, reducing efficiency, and most existing methods focus on detecting single-type co-phase error. In this Letter, we propose a novel, to the best of our knowledge, piston and tip-tilt errors simultaneous detection method using both the object-independent feature map (FM) related to optical transfer function (OTF) and deep learning.

Comparative efficacy and safety of rhTPO, romiplostim, and eltrombopag in the treatment of pediatric primary immune thrombocytopenia: a systematic review and network meta-analysis.

Background: Pediatric primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia and an increased risk of bleeding. Conventional therapies, while effective in some cases, are often limited by suboptimal response rates and significant adverse effects with prolonged use. Thrombopoietin receptor agonists (TPO-RAs), including recombinant human thrombopoietin (rhTPO), romiplostim, and eltrombopag, have emerged as promising therapeutic alternatives for pediatric ITP.

Operational parameters regulate in-situ emissions of volatile organic compounds (VOCs) and greenhouse gases (GHGs) during kitchen waste composting: Linking functional microbial dynamics to emission mitigation.

Emission of volatile organic compounds (VOCs) and greenhouse gases (GHGs) from kitchen waste composting plants causes significant environmental issues. This paper characterized the emission profiles of VOCs and GHGs from KW composting with different operating parameters. Quantitative results showed that emission intensities spanned 7.

Cellulose gels with controllable oriented porous structure by regulating regeneration process.

The processing of raw cellulose materials to biomimetic regenerated cellulose materials with oriented porous structures is crucial for mimicking multiscale oriented porous structures of natural organisms. However, it remains challenging to understand how the cellulose/ionic liquid (IL) solution interacts with non-solvent water to regenerate and form oriented porous channels. Additionally, broadening the range of controllable pore sizes presents significant difficulties.

USP35 promotes hepatocellular carcinoma proliferation through GASC1-mediated ROCK2 upregulation.

Ubiquitin-specific protease 35 (USP35) regulates the oncogenic process of various cancers by stabilizing target proteins through deubiquitination. However, the function of USP35 in hepatocellular carcinoma (HCC) remains unclear. Our results demonstrated that USP35 was significantly over-expressed in HCC.

Three antenna-specific odorant binding proteins in Protaetia brevitarsis (Coleoptera: Scarabaeoidea) involve in recognition of floral volatiles.

Odorant binding proteins (OBPs) play a vital role in the insect olfactory recognition system, as they bind and transport specific semiochemicals to chemosensory receptors for further processing. The agricultural and horticultural pest, white-spotted flower chafer (WSFC), Protaetia brevitarsis (Coleoptera, Scarabaeoidea), has significantly harmed numerous crops and fruits in China. It is hypothesized that WSFCs rely on specific OBPs and chemosensory receptors to identify palatable food sources and optimal oviposition sites.

RNA-Seq uncovers endogenous NO-induced hormone signal transduction and carbon metabolism in response to PEG stress in alfalfa.

Background: Alfalfa (Medicago sativa L.) has the benefits of high yield and nutritional value as a sustainable forage. However, the water deficit significantly limits its growth and yield performance.

Designing ultrasensitive mechanochromic pure cellulose nanofiber hydrogels via simple and feasible gas phase coagulation.

Nanoellulose-based mechanochromic materials represent a frontier in sustainable optics, offering a renewable platform for advanced functional materials. However, the precise manipulation of cellulose nanofibers (CNFs) into intelligent optical systems remains challenging due to their inherent variability in size and the difficulty of achieving controlled orientation. Herein, we developed a straightforward and scalable strategy to construct mechanochromic CNF hydrogels (MCNFHs) with engineerable interference colors (ranging from yellow, red, blue, green) under compressive stress by exploiting their response to acidic vapor, that is, via simple and feasible gas phase coagulation.

Psychiatric disorders with antiseizure medications in children: an analysis of the FDA adverse event reporting system database.

Background: Epilepsy is a chronic neurological disorder marked by a persistent tendency to generate seizures, leading to substantial cognitive, behavioral, and psychosocial consequences. This study investigated psychiatric disorder-related adverse events (AEs) associated with antiseizure medications (ASMs) in children using the Food and Drug Administration Adverse Event Reporting System (FAERS) database.

Methods: This study conducted a comprehensive analysis of FAERS data from 2004 to 2024, focusing on psychiatric AEs in children with epilepsy or seizures treated with ASMs.

Engineering Light-Element Modified LaFeSi Compounds Enables Tunable Giant Magnetocaloric Effect.

Magnetocaloric refrigeration is one of the most promising next-generation solid-state caloric techniques to revolutionize the traditional air-compression technique. The La(Fe,Si)-based materials are recognized as candidates with potential for practical applications. However, flexible strategies to improve the Curie temperature (T) and further achieve the tunable giant magnetocaloric effect (GMCE) still need to be developed.

[Review of chemical constituents, pharmacological effects, and quality control status of Eucommiae Cortex and prediction of its Q-markers].

Eucommiae Cortex, the dried bark of Eucommia ulmoides( Eucommiaceae), has both medicinal and edible values.Modern research has shown that Eucommiae Cortex contains various components such as flavonoids, lignans, iridoids, phenolic acids,terpenoids, and steroids, which have anti-osteoporosis, antioxidant, anti-inflammatory, blood glucose-lowering, and gastrointestinal tract-protecting effects. Eucommiae Cortex has applications in multiple fields such as healthcare, industry, and animal husbandry,demonstrating broad development prospects.