Current knowledge on the prevalence and detection techniques of in China.

Background: is one of the most significant zoonotic food-borne parasites, particularly prevalent in China. The adult form of typically inhabits in the hepatic and biliary tracts of various mammals, including humans, and is considered a major contributor to the incidence of cholangiocarcinoma. The life cycle of is complex, understanding its prevalence among different host species is essential for developing prevention and management measures.

Efficacy and Safety of HSK31679 in Asian Patients with MASLD: A Randomized Controlled Trial.

Background And Aims: This study evaluated the efficacy and safety of the thyroid hormone receptor β agonist HSK31679 in Asian patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods: This was a phase 2a, multicenter, randomized, double-blind, placebo-controlled study at 26 centers in China. Subjects with a liver fat content (LFC) of ≥ 8% at screening, when assessed by magnetic resonance imaging-proton density fat fraction, were eligible.

Utilizing Waste Heat to Drive Selective Green Organic Conversion through a Thermoelectrocatalytic Process.

Utilizing waste heat from environmental or industrial sources is a promising strategy for eco-friendly and sustainable chemical synthesis. Here, a pioneering thermoelectrocatalytic (TECatal) system that can harness minimal heat diffusion for selective organic conversions is demonstrated. The proof-of-concept demonstrates a TECatal nanohybrid consisting of a thermoelectric (TE) BiTe nanoflake core with a Fe-doped UiO-66 metal-organic framework shell (BiTe/Fe-UiO-66).

Novel Diaryl-Substituted Pyrazolo[3,4-]pyrimidines as Tubulin/CDC5L Dual-Targeting Ligands: Discovery, Potent Antitumor Activity, and Good Metabolic Stability.

Tubulin and cell division cycle 5-like (CDC5L) protein are both implicated in various biological processes, particularly in mitosis, and represent promising targets for developing antitumor agents. Herein, a series of novel diaryl-substituted pyrazolo[3,4-]pyrimidines were designed, synthesized, and evaluated for their antiproliferative activities against multiple cancer cells, including drug-resistant ones. Among these, compounds and demonstrated potent antitumor activity with relatively low cytotoxicity toward normal cells.

Harnessing Squid Bone for Ultra-Permeable Water Purification Membranes.

As emerging contaminants like nanoplastics, organic dyes, and inorganic particles proliferate, traditional water purification faces significant challenges. Here, a novel solution grounded in sustainability and efficiency: ultra-permeable membranes crafted from carboxylated β-chitin nanofibers derived from squid bone is introduced. The 124-nm-thick membrane exhibits an exceptional pure water flux of 46 207 L·m·hbar with complete rejection (100%) of 100 nm nanoplastics.

Hydrogel delivery systems in intervertebral disc degeneration: Current status and future perspectives.

Intervertebral disc degeneration (IVDD) is a primary contributor to the development of low back pain, characterized by core pathological features which include extracellular matrix (ECM) degradation, oxidative stress, imbalanced inflammatory microenvironment, and cellular functional exhaustion. Conventional therapies (e.g.

Discovery of a Novel MNK Inhibitor (NSP-1047) with In Vivo Anti-acute Myeloid Leukemia Activity.

MAPK-interacting kinases (MNKs) phosphorylate the eukaryotic initiation factor 4E (eIF4E), critical for cap-dependent translation. The MNK/eIF4E pathway plays a role in the development and progression of various hematological and solid tumors. Here, we report the discovery of a novel polycyclic compound (NSP-1047), which inhibits MNK1 and MNK2 with high potency, leading to a reduction in the phosphorylation of eIF4E.

Hernandezine alleviates inflammatory bowel disease by enhancing gut barrier integrity via the AMPK/NRF2 pathway and regulating immune-metabolic balance.

Inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, is characterized by chronic inflammation and impaired intestinal barrier function. Current therapeutic approaches primarily aim to suppress the overly active immune response using aminosalicylates and immunosuppressive agents, which are frequently associated with significant adverse effects. In this study, we evaluated the therapeutic potential and underlying mechanisms of Hernandezine (HER), a bioactive compound extracted from Thalictrum, using a dextran sulfate sodium (DSS)-induced murine colitis model.

Multiply doses of FDC of rosuvastatin and ezetimibe versus rosuvastatin monotherapy in Chinese patients with hypercholesterolemia (ROSE-CH): multicenter, randomized-controlled trial.

Objective: Rosuvastatin plus ezetimibe improves the lipid-lowering effect through different mechanisms of action. This study intended to compare the efficacy and safety of the fixed-dose combination (FDC) of rosuvastatin/ezetimibe vs. rosuvastatin alone in hypercholesterolemia patients.

Molecular mechanisms of unique therapeutic potential of CUDC-907 for MEF2D fusion-driven BCP-ALL.

MEF2D fusions are found in a special subtype of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with poor prognosis. In this study, we conducted high-throughput drug screenings using cell line and ex vivo cell model harboring, respectively, MEF2D::HNRNPUL1(MH) and MEF2D::BCL9(MB), the two major MEF2D fusions. We identified CUDC-907 as a highly potent dual-target inhibitor of PI3K/HDAC, demonstrating remarkable efficacy in inducing robust lethality while maintaining selectivity for MEF2D fusion-expressing cells.

Identification of Mycobacterium Species by DNA Microarray Chip Method.

This study presents a DNA microarray chip method designed for the accurate identification of Mycobacterium species. By leveraging asymmetric PCR amplification and hybridization principles, this method targets 17 common mycobacteria, including those in the Mycobacterium tuberculosis complex and various non-tuberculous mycobacteria. It is applicable to a wide range of clinical specimens like sputum, pus, bronchoalveolar lavage fluid, cerebrospinal fluid, and puncture fluid from patients suspected of mycobacterial diseases.

Visual information processing characteristics of tactical decisions of soccer players in 3V3 offense scenarios.

Objective: To quantitatively access the visual search of soccer players in the 3V3 offensive tactical situation and explore the eye movement characteristics and information processing mechanisms of high-level athletes under multi-target tracking.

Methods: Using the expert-novice research paradigm, eight second-level soccer players were selected as the expert group, and eight university students majoring in soccer were selected as the novice group. Real match 3V3 offensive tactical scenarios were used as stimulus materials.

Identification of hemocyte types and characterization of their immune function in the house fly based on morphological observation and single-cell RNA sequencing.

Hemocytes represent a pivotal element of insect defense against pathogens through the mechanisms of cellular and humoral immunity. However, hemocyte types and functions exhibit variation across different insect taxa, leading to the lack of a standardized classification system for insect hemocytes. To gain insight into the immune mechanisms of the house fly Musca domestica, we used a combination of morphological observations and single-cell RNA sequencing techniques (scRNA-seq) to taxonomically characterize house fly larval hemocytes and analyze their immune function.

Construction of a Prognostic Model Using RNA Processing Factor Genes and the Key Role of NSUN6 in Glioma Outcomes.

Glioma is the most common malignant brain tumor and remains associated with a poor prognosis and limited predictive tools. The dysregulation of RNA processing factor genes has been implicated in glioma development, yet their prognostic relevance remains unclear. This study aimed to construct a robust prognostic model based on RNA processing factor genes and explore their functional roles and therapeutic potential.

MGNet: RGBT tracking via cross-modality cross-region mutual guidance.

Compared to single modal object tracking, the main challenge in RGBT tracking lies in effectively fusing features from both modalities. However, many existing methods neglect the dependence of distinct regions from different modalities, instead only considering that of identical regions, which fails to capture the cross-modal cross-regional relationships. In other words, they do not leverage the mutual guidance between different regions of different modalities.

[Correlation between dietary patterns of pregnant women and weight changes in early pregnancy in Shenzhen from 2018 to 2021].

Objective: To understand the dietary pattern characteristics of pregnant women in early pregnancy and analyze the association between these dietary patterns and weight changes in early pregnancy.

Methods: Using the birth cohort of the China Birth Cohort Study(CBCS), we analyzed the early pregnancy information and food frequency questionnaire data of 3, 540 subjects who met the inclusion and exclusion criteria at the Shenzhen sub-center from July 2018 to January 2021. Dietary patterns were extracted using factor analysis.

The intrathecal morphine analgesia for full endoscopic lumbar discectomy: a prospective dose-finding study.

Background Context: Anesthesia for full endoscopic lumbar discectomy (FELD), typically administered locally or regionally, often fails to provide adequate analgesia, necessitating additional analgesics or even sedation. Our previous work has shown that intrathecal morphine (ITM) administration is considered an effective adjuvant approach for managing peri-operative pain for FELD, but the adverse events (AEs) for ITM remain concerns.

Purpose: This study aimed to determine the effective dose of intrathecal morphine required to eliminate intraoperative pain in 90% of patients (ED) undergoing FELD under spinal anesthesia and to evaluate the safety profile of ITM within 100 µg.

Electrode Fouling by Gas Bubbles Enables Catalyst-Free Hydrogen Peroxide Synthesis.

Hydrogen peroxide (HO) is an essential chemical for environmental remediation, chemical synthesis, and energy storage, yet conventional synthetic methods are energy-intensive and environmentally taxing. Herein, we report a catalyst-free strategy for HO synthesis by exploiting the gas-liquid-solid triple phase boundary formed at bubble-pinned porous carbon electrodes. The process involves three key mechanisms: (i) hydroxide anions enrichment in the electric double layer reduces the energy barrier for their oxidation to hydroxyl radicals, (ii) the hydrophobic bubble interface suppresses overoxidation, favoring the two-electron water oxidation pathway, and (iii) oxygen molecules capture electrons from previous steps to form HO.

Discovery of an ALK degrader for lorlatinib-resistant compound mutations.

Three generations of ALK tyrosine kinase inhibitor (ALK TKI) have achieved significant clinical success in the treatment of ALK rearranged non-small cell lung cancer (NSCLC). However, the emergence of acquired mutations after sequential ALK TKI therapies poses significant challenges for cancer treatment. Here we identified WZH-15-125 as a potent ALK inhibitor that can effectively override drug resistance, especially compound ALK mutations, including the highly refractory G1202R/L1196M mutation that is resistant to lorlatinib.

MoS/CoS heterostructures as a thermoelectric-catalyst for HO generation under a small temperature gradient.

We demonstrate a MoS/CoS nano-heterostructure as a thermoelectric (TE) catalyst for HO generation from pure water under a mild temperature gradient. The strong interfacial interaction enhances charge separation and reactivity, significantly improving catalytic efficiency. This synergistic effect greatly boosts TE catalytic performance, demonstrating a sustainable and efficient strategy for green synthesis.

The effect of exercise intervention on amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Objective: Quantitative evaluation of the effect of exercise intervention in amyotrophic lateral sclerosis (ALS).

Methods: The CNKI, WOS, PubMed, and Scopus databases were searched by computer, and randomized controlled trials (RCTs) of exercise intervention in ALS were screened out according to the inclusion and exclusion criteria of the PICOS principle. Stata 12.

Poly(acrylic acid)-grafted cellulose nanocrystal reinforced supramolecular adhesives: Ultrahigh strength, humidity resistance, and pH-controlled recyclability.

Bio-based adhesives have drawn growing attention due to the environmental and ecological issues posed by petroleum-based adhesives. However, their practical applications remain constrained by the limited adhesion strength and insufficient humidity intolerance. Herein, we have developed a bio-based adhesive using poly(acrylic acid)-grafted cellulose nanocrystals (CNC-PAA) and poly(vinyl alcohol) (PVA) through the construction of highly dense non-covalent supramolecular networks.

Cellulose gels with controllable oriented porous structure by regulating regeneration process.

The processing of raw cellulose materials to biomimetic regenerated cellulose materials with oriented porous structures is crucial for mimicking multiscale oriented porous structures of natural organisms. However, it remains challenging to understand how the cellulose/ionic liquid (IL) solution interacts with non-solvent water to regenerate and form oriented porous channels. Additionally, broadening the range of controllable pore sizes presents significant difficulties.