Frequency modulated continuous wave LiDAR with expanded field-of-view based on polarization-splitting metasurface.

Frequency modulated continuous wave (FMCW) light detection and ranging (LiDAR) has recently become a research hotspot in the fields of autonomous driving and intelligent perception due to its high-precision ranging and velocity measurement capabilities. However, the existing LiDAR systems are usually challenged in expanding the field-of-view (FOV), which often comes at the expense of beam quality and degrades the detection accuracy and signal-to-noise ratio. On the other hand, the complexity of data processing algorithms may introduce significant measurement inaccuracies, potentially leading to substantial deviations in the final results.

An Auxiliary Hybrid Heuristic Approach for Objective Function Design Evaluation-Using Train Unit Scheduling as an Example.

Real-world combinatorial optimization problems are mostly NP-hard, and often only near-optimal solutions can be obtained practically. To differentiate as fine-grained as possible the near-optimal solutions is therefore desirable. Moreover, a real-world problem may have numerous possible structural properties of concern to the practitioners, too numerous to be all elicited and incorporated as optimization criteria in an objective function.

A Network Pharmacology-Based Investigation into the Mechanism of Quercetin Combined with Rosuvastatin in Delaying Diabetic Nephropathy via Inhibiting NRK-52E Cell Ferroptosis.

Objective: Diabetic nephropathy (DN) is a leading cause of end-stage renal disease, and current therapeutic options are limited in effectively managing DN progression. Renal tubular epithelial cell (RTEC) ferroptosis has emerged as a critical mechanism contributing to DN pathogenesis. This study aimed to investigate the potential synergistic effects of quercetin (QCT) and rosuvastatin (RSV) on inhibiting RTEC ferroptosis and ameliorating DN progression, providing a novel combinatorial therapeutic strategy.

Dissipative Topological Dynamics in Optical Waveguides: Sensitivity versus Robustness.

Topological physics has garnered attention across various fields, emphasizing topologically protected modes renowned for their robustness against disorders. Recent advancements have expanded from conservative wave systems to diffusion systems with dissipative interactions. However, the transition region between wave and diffusion dynamics remains scarce, primarily due to the complexities involved in coupling modulation.

Plastic Biodegradation by Sediment Microbial Populations under Denitrifying Conditions.

Biodegradation is critical for eliminating plastic contaminants from environments, and understanding its mechanisms under in situ conditions is crucial. The plastic biodegradation process in sediments, a major reservoir of plastic contamination with reduced redox conditions, remains elusive. This study compared the plastisphere communities and metabolic potentials of typical polyethylene (PE) contaminants collected from the Pearl River Estuary to their counterparts in the surrounding sediments.

Research Progress on the Application of Nanoenzyme Electrochemical Sensors for Detecting Zearalenone in Food.

Zearalenone (ZEN) is a common mycotoxin widely found in food crops such as corn. The toxicity of ZEN is manifested as multiple hazards to reproduction, genes, cells, and immune systems. Long-term exposure may have a serious impact on health, so it has received extensive attention due to its potential harm to human and animal health.

Recent Advances in N-Ethyl-2-Pyrrolidinone-Substituted Flavanols (EPSFs), Novel Bioactive Components in Tea: Chemical Structure, Formation Mechanism, and Potential Health Benefits.

N-Ethyl-2-pyrrolidinone-substituted flavanols (EPSFs) are a newly discovered class of flavanol derivatives in tea and have emerged as a focal point in tea studies in recent years. Over 50 EPSFs and their analogs have been identified in fresh tea leaves and various tea products. These compounds are characterized by N-ethyl-2-pyrrolidinone substitution at either the C-8 or C-6 position of flavanols, and they exist as chiral enantiomers (R- or S-configuration).

Chitosan/oxidized cellulose composite nanofiber sponges: a rapid and effective hemostasis strategy for non-compressible hemorrhage.

Non-compressible hemorrhagic wounds, prevalent in combat and mass trauma scenarios, are characterized by arterial injury-induced exsanguination and geometrically complex wound morphology that challenges conventional hemostatic interventions. This paper presents a novel nanofiber hemostatic sponge (CT@GP-HAc), made from 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO) oxidized cellulose nanofibers (TOCN) and chitosan nanofibers (CSNF), crosslinked with genipin (GP) in an acetic acid atmosphere. The sponge features excellent shape memory and rapid hemostatic capabilities, specifically designed for deep, irregular wounds.

Recent advances in glucose monitoring utilizing oxidase electrochemical biosensors integrating carbon-based nanomaterials and smart enzyme design.

Glucose oxidase (GOx), as a molecular recognition element of glucose biosensors, has high sensitivity and selectivity advantages. As a type of biosensor, the glucose oxidase electrode exhibits advantages such as ease of operation, high sensitivity, and strong specificity, promising broad application prospects in biomedical science, the food industry, and other fields. In recent years, with the advancement of nanotechnology, research efforts to enhance the performance of GOx biosensors have primarily focused on improving the conductive properties and specific surface area of nanomaterials, while neglecting the potential to modify the structure of the core component, GOx itself, to improve biosensor performance.

Dual-regulation biomimetic composite nerve scaffold with oriented structure and conductive function for skin peripheral nerve injury repair.

Skin peripheral nerve injury repair still faces significant clinical challenges. Although nerve tissue engineering scaffolds show potential, issues such as limited functionality and low repair efficiency persist. This study developed a dual-regulation biomimetic composite nerve scaffold with oriented structure and conductive function to promote nerve injury repair.

Research Progress on the Application of Metal Porphyrin Electrochemical Sensors in the Detection of Phenolic Antioxidants in Food.

This paper reviews the application of metal porphyrin electrochemical sensors in the detection of phenolic antioxidants in food, focusing on the latest progress and innovative applications in this field. Phenolic antioxidants are widely used in food and can effectively prolong the shelf life of food, but their excessive use may cause potential harm to human health, so the detection of their content is very important. In recent years, electrochemical analysis technology has gradually become an emerging method for quantitative detection of phenolic antioxidants due to its advantages of sensitivity, simplicity and high selectivity.

Research Progress on Nanotechnology-Driven Enzyme Biosensors for Electrochemical Detection of Biological Pollution and Food Contaminants.

Electrochemical biosensors have attracted widespread attention from researchers due to their simple and rapid operation. Recent advancements in nanobiotechnology have further enhanced their performance, with nanomaterials like graphene, carbon nanotubes, and metal nanoparticles being widely used as carriers for immobilizing enzymes, cells, and DNA molecules. These materials improve stability, sensitivity, and selectivity, making biosensors more effective.

Cu-doped ZiF-8 and calcined UIO-66-based biomimetic enzyme electrochemical sensor for rapid and sensitive detection of Zearalenone in vegetable oil.

In order to ensure the safety of the raw material vegetable oil deodorizer distillate (VODD) using in vitamin E and phytosterols production process, it is necessary to rapidly and sensitively detect the content of Zearalenone (ZEN) mycotoxins. In this study, the catalytic activity of ZIF-8 was enhanced by adding copper, and the synergistic effect of calcined UIO-66 and Cu-ZIF-8 was used to improve the electrical response of the sensor to ZEN, improve the conductivity and promote electron transfer, so as to enhance the recognition ability of ZEN. Cu-ZiF-8@CN-UIO-66 biomimetic enzyme was prepared and characterized using SEM, EDS, XPS, XRD and FT-IR.

Applied machine learning in intelligent systems: knowledge graph-enhanced ophthalmic contrastive learning with "clinical profile" prompts.

Introduction: The integration of artificial intelligence (AI) into ophthalmic diagnostics has the potential to significantly enhance diagnostic accuracy and interpretability, thereby supporting clinical decision-making. However, a major challenge in AI-driven medical applications is the lack of transparency, which limits clinicians' trust in automated recommendations. This study investigates the application of machine learning techniques by integrating knowledge graphs with contrastive learning and utilizing "clinical profile" prompts to refine the performance of the ophthalmology-specific large language model, MeEYE, which is built on the CHATGLM3-6B architecture.

Research Progress on the Enhancement of Immobilized Enzyme Catalytic Performance and Its Application in the Synthesis of Vitamin E Succinate.

Vitamin E succinate is a more mature vitamin E derivative, and its chemical stability and many effects have been improved compared with vitamin E, which can not only make up for the shortcomings of vitamin E application but also broaden the application field of vitamin E. At present, in developed countries such as Europe, America, and Japan, vitamin E succinate is widely used in health foods, and due to its good water solubility and stability, the vitamin E added to most nutritional supplements (tablets and hard capsules) is vitamin E succinate. At the same time, vitamin E succinate used in the food and pharmaceutical industries is mainly catalyzed by enzymatic catalysis.

Effects of suggestion therapy on mood and sleep quality in middle-aged women with depression.

Background: Depression is one of the most common mental disorders, with high rates of disability, particularly among women.

Aim: To explore the effects of suggestion therapy on anxiety, mood, and sleep-quality in middle-aged women with depression treated with escitalopram.

Methods: Overall, 102 female patients with depression aged 35-49 years were divided into control and experimental groups.

Analysis of the Influence of Boron Distribution on Compound Biological Effectiveness Values in Boron Neutron Capture Therapy.

Purpose: Boron neutron capture therapy (BNCT) is an innovative cancer treatment that uses the B(n,α)Li reaction to selectively destroy cancer cells at the cellular level. In BNCT, the biological effectiveness of boron doses is typically assessed using the compound biological effectiveness (CBE) factor. This study analyzes the impact of boron distribution on CBE values based on the microdosimetric kinetic model and Monte Carlo simulations.

Application Progress of Immobilized Enzymes in the Catalytic Synthesis of 1,3-Dioleoyl-2-palmitoyltriglyceride Structured Lipids.

In recent years, the preparation of OPO (1,3-dioleoyl-2-palmitoyltriglyceride)-structured lipids through immobilized lipase catalysis has emerged as a research hotspot in the fields of food and biomedical sciences. OPO structured lipids, renowned for their unique molecular structure and biological functions, find wide applications in infant formula milk powder, functional foods, and nutritional supplements. Lipase-catalyzed reactions, known for their efficiency, high selectivity, and mild conditions, are ideal for the synthesis of OPO structured lipids.

Neutron Activation Dose Assessment Based on a Human Head Phantom Post-BNCT.

This study aims to assess the residual radioactivity produced in the human head phantom following irradiation from a boron neutron capture therapy neutron source based on a 2.8 MeV proton accelerator. Using Monte Carlo software to simulate irradiation on a head phantom based on ICRP Publication 110, it was found that, in addition to the nuclides 24Na, 38Cl, and 42K reported in other literature, 32P is the nuclide that contributes the most to the internal exposure dose in patients post-BNCT.

Flower-like biomimetic enzyme for rapid and sensitive detection of zearalenone in vegetable oil deodorizer distillate.

In order to achieve high quality production of vitamin E and plant sterols, it is necessary to conduct rapid and accurate detection of fungal toxins in their production raw material (vegetable oil deodorizer distillate, VODD). In this study, the flower-like biomimetic enzyme of silver-doped ZnO was synthesized through wet chemical method and in-situ reduction method. Based on above work, a flower-like biomimetic enzyme modified glass carbon electrode was fabricated, and its excellent detection capability against fungal toxins zearalenone was confirmed through electrochemical analysis.

Gut Microbiota-Derived Hyocholic Acid Enhances Type 3 Immunity and Protects Against Salmonella enterica Serovar Typhimurium in Neonatal Rats.

This study investigates how microbiome colonization influences the development of intestinal type 3 immunity in neonates. The results showed that reduced oxygen levels in the small intestine of neonatal rats induced by Saccharomyces boulardii accelerated microbiome colonization and type 3 immunity development, which protected against Salmonella enterica serovar Typhimurium infection. Microbiome maturation increased the abundance of microbiome-encoded bile salt hydrolase (BSH) genes and hyocholic acid (HCA) levels.

Pralatrexate represses the resistance of HCC cells to molecular targeted agents via the miRNA-34a/Notch pathway.

Metabolism-related pathways are important targets for intervention in the treatment of hepatocellular carcinoma (HCC), but few studies have reported on the combination of inhibitors of folate metabolism-related enzymes and molecularly targeted drugs for HCC. The results of the present work are the first to reveal the effects of an inhibitor of dihydrofolate reductase (DHFR), pralatrexate, on the sensitivity of HCC cells to molecularly targeted agents examined using multiple assays. In HCC cells, knockdown of DHFR or treatment with pralatrexate enhanced the sensitivity of HCC cells to molecularly targeted agents, such as sorafenib, regorafenib, lenvatinib, cabozantinib, or anlotinib.

EGCG-enabled Deep Tumor Penetration of Phosphatase and Acidity Dual-responsive Nanotherapeutics for Combinatory Therapy of Breast Cancer.

The presence of dense collagen fibers is a typical characteristic of triple-negative breast cancer (TNBC). Although these fibers hinder drug penetration and reduce treatment efficacy, the depletion of the collagen matrix is associated with tumor metastasis. To address this issue, epigallocatechin-3-gallate (EGCG) is first exploited for disrupting the dense collagenous stroma and alleviate fibrosis by specifically blocking the TGF-β/Smad pathway in fibroblasts and tumor cells when intraperitoneally administrated in TNBC tumor-bearing mice.

Approaching the adiabatic infimum of topological pumps on thin-film lithium niobate waveguides.

Topological pumps reveal topological insights of adiabatic mode evolution, in which adiabaticity plays a crucial role. However, the adiabatic infimum, i.e.