Acupuncture modulates the microbiota-gut-brain axis: a new strategy for Parkinson's disease treatment.

Parkinson's disease is a relatively common neurodegenerative disorder in clinical practice, and its prevalence is increasing worldwide. It not only causes patients to have movement disorders such as tremors and delayed initiation but also makes them suffer from olfactory disorders, gastrointestinal disorders, insomnia and other symptoms, which imposes a heavy burden on both patients and their families. In recent years, some scholars believe that the gut-brain axis may be the key to revealing the pathogenesis of Parkinson's disease.

Multispectral imaging colorimetric measurement method with illumination-adaptive white calibration.

Accurate and standardized color measurement of non-planar surfaces in non-contact scenarios remains a challenge, primarily due to complex measurement conditions such as uncontrolled illumination and variable surface scattering properties. To address this issue, a multispectral imaging colorimetric measurement method for non-planar surfaces based on uniform illumination and illumination-adaptive white calibration was proposed. The colorimetric characterization method relies on spectral reconstruction using a multiple-channel input backpropagation neural network, which processes the imaging system's output with illumination-adaptive white calibration and spectral fusion techniques.

Advances in Techniques in Radical Prostatectomy.

Since its development in 1904, radical prostatectomy (RP) has remained a fundamental surgical option in the management of localised prostate cancer. Over time, continuous advancements in surgical techniques have improved oncological outcomes while reducing functional complications. This narrative review explores the evolution of RP, depicting its progression from the traditional open approach to minimally invasive laparoscopic and robotic-assisted techniques.

Synergically enhanced anti-tumor immunity of in vivo panCAR by circRNA vaccine boosting.

Chimeric antigen receptor (CAR) T cell therapy has shown promise in treating hematologic malignancies, but it still faces challenges, including high costs, a time-consuming manufacturing process, and the necessity of lymphodepletion. Here, we generate circular RNAs (circRNAs) encoding CAR proteins, referred to as circRNA, which mediates remarkable tumor killing in human primary T cells. We demonstrate that circRNA, delivered with immunocyte-tropic lipid nanoparticles (LNPs), can form in vivo panCAR cells (CAR-T, CAR-natural killer [NK], and CAR-macrophage), significantly inhibit tumor growth, and reshape the tumor microenvironment in mice.

A meta-analysis of Retzius-sparing and hood-technique robot-assisted radical prostatectomy.

Objectives: To compare Retzius-sparing (RS-) robot-assisted radical prostatectomy (RARP), hood-technique RARP and standard RARP, assessing functional, oncological and peri-operative outcomes.

Methods: A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The primary outcome was postoperative perfect continence rate (0 pad/day) at different time points over 12 months.

Advancements in the Research on the Preparation of Isoamyl Acetate Catalyzed by Immobilized Lipase.

This study aims to delve into the application potential of immobilized lipases in the catalytic synthesis of isoamyl acetate. Through a comparative analysis of various immobilization methods, including physical adsorption, encapsulation, covalent binding, and crosslinking, along with the utilization of nanomaterials, such as magnetic nanoparticles, mesoporous silica SBA-15, and covalent organic frameworks (COFs) as carriers, the study systematically evaluates their enhancing effects on lipase catalytic performance. Additionally, solvent engineering strategies, encompassing the introduction of organic solvents, supercritical fluids, ionic liquids, and deep eutectic solvents, are employed to intensify the enzymatic catalytic process.

Research Progress on the Application of Nanoenzyme Electrochemical Sensors for Detecting Zearalenone in Food.

Zearalenone (ZEN) is a common mycotoxin widely found in food crops such as corn. The toxicity of ZEN is manifested as multiple hazards to reproduction, genes, cells, and immune systems. Long-term exposure may have a serious impact on health, so it has received extensive attention due to its potential harm to human and animal health.

Rapid detection of multiple gas mixtures and evaluation of harmful gas removal efficiency in a deck decompression chamber using dynamic switching mass spectrometry.

The multiple gas mixtures in the deck decompression chamber (DDC) serve as a life-sustaining medium for divers to adapt to high-pressure environments and to safely decompress after saturation diving operations. However, due to the complexity of the gas composition and the wide concentration range, there is currently no technique that can rapidly detect all gases in the DDC. In this study, we developed a photoinduced chemical ionization (pCI) and electron impact (EI) dynamic switching mass spectrometry system.

Survival Outcomes for Rural Patients With Advanced Prostate Cancer: A SEER Investigation.

Background: Differences may exist in survival for patients with de novo metastatic prostate cancer according to urban-rural status.

Methods: This cohort study utilized the Surveillance, Epidemiology, and End Results database. Data on demographics, urban-rural status, histopathology, and survival were extracted for men aged ≤ 75 years, diagnosed with metastatic prostate cancer between 2009 and 2018.

Influence of Body Weight at the End of the Brooding Period on the Productive Performance in Hyline Brown Laying Hens from 6 to 72 Weeks of Age.

This research aimed to assess body weight (BW) at the end of the brooding period in affecting Hyline Brown laying hens aged 6 to 72 wks from the aspects of growth performance, egg quality, sexual maturity, and productive performance. Pullets (6 wk old, = 640) were sorted into two groups according to BW: normal (460.75 ± 10.

Recent advances in glucose monitoring utilizing oxidase electrochemical biosensors integrating carbon-based nanomaterials and smart enzyme design.

Glucose oxidase (GOx), as a molecular recognition element of glucose biosensors, has high sensitivity and selectivity advantages. As a type of biosensor, the glucose oxidase electrode exhibits advantages such as ease of operation, high sensitivity, and strong specificity, promising broad application prospects in biomedical science, the food industry, and other fields. In recent years, with the advancement of nanotechnology, research efforts to enhance the performance of GOx biosensors have primarily focused on improving the conductive properties and specific surface area of nanomaterials, while neglecting the potential to modify the structure of the core component, GOx itself, to improve biosensor performance.

Research Progress on the Application of Metal Porphyrin Electrochemical Sensors in the Detection of Phenolic Antioxidants in Food.

This paper reviews the application of metal porphyrin electrochemical sensors in the detection of phenolic antioxidants in food, focusing on the latest progress and innovative applications in this field. Phenolic antioxidants are widely used in food and can effectively prolong the shelf life of food, but their excessive use may cause potential harm to human health, so the detection of their content is very important. In recent years, electrochemical analysis technology has gradually become an emerging method for quantitative detection of phenolic antioxidants due to its advantages of sensitivity, simplicity and high selectivity.

Research Progress on Nanotechnology-Driven Enzyme Biosensors for Electrochemical Detection of Biological Pollution and Food Contaminants.

Electrochemical biosensors have attracted widespread attention from researchers due to their simple and rapid operation. Recent advancements in nanobiotechnology have further enhanced their performance, with nanomaterials like graphene, carbon nanotubes, and metal nanoparticles being widely used as carriers for immobilizing enzymes, cells, and DNA molecules. These materials improve stability, sensitivity, and selectivity, making biosensors more effective.

Research on cluster hollow fiber membrane proton transfer reaction mass spectrometry (CHFM-PTR-MS) and its application in odorous gas detection.

Odorous gas emission is one of the world's seven major public nuisances, easily causing disturbances and complaints, and posing a threat to air quality and public health. Emissions of odorous substances are characterized by their sudden and instantaneous nature, with some odorous compounds having extremely low olfactory thresholds. Therefore, it is essential to develop highly sensitive on-site rapid detection techniques.

Research Progress on the Enhancement of Immobilized Enzyme Catalytic Performance and Its Application in the Synthesis of Vitamin E Succinate.

Vitamin E succinate is a more mature vitamin E derivative, and its chemical stability and many effects have been improved compared with vitamin E, which can not only make up for the shortcomings of vitamin E application but also broaden the application field of vitamin E. At present, in developed countries such as Europe, America, and Japan, vitamin E succinate is widely used in health foods, and due to its good water solubility and stability, the vitamin E added to most nutritional supplements (tablets and hard capsules) is vitamin E succinate. At the same time, vitamin E succinate used in the food and pharmaceutical industries is mainly catalyzed by enzymatic catalysis.

Effects and health risk assessments of different spray disinfectants on microbial aerosols in chicken houses.

This study aims to explore the effects of spray processes with four different disinfectants on airborne culturable and pathogenic microbial concentrations, microbial community compositions and health risk assessments in chicken houses. Results indicate that compared to the microbial concentrations before spraying, hypochlorous acid, glutaraldehyde-decamethonium bromide and sodium dichloroisocyanate increase culturable bacteria, culturable fungi, airborne Staphylococcus and Candida albicans, respectively. Beyond that, the spray processes with different disinfectants have no significant effects on the microbial concentrations.

A glycogen synthase kinase-3 gene enhances grain yield heterosis in semi-dwarf rapeseed.

Optimizing plant height is a key breeding objective in Brassica napus to enhance lodging resistance and increase yield potential. In the present study, we identified a semi-dwarf gene in rapeseed, BnDWARF5 (BnDF5), which encodes a glycogen synthase kinase 3, BRASSINOSTEROID-INSENSITIVE 2 (BnaC03.BIN2), primarily controlling the elongation of basal internodes by inhibiting the elongation of internode cells.

Urodynamic Changes Following a Staged Trial of Sacral Neuromodulation in Patients With Detrusor Underactivity.

Objective: Sacral neuromodulation (SNM) is an established treatment for detrusor underactivity (DU) and nonobstructive urinary retention. The mechanism of action for SNM in DU, however, remains poorly understood. The objective of this study was to investigate the urodynamic study (UDS) changes in DU patients during the trial period following first stage tined-lead placement (FSTLP).

Dynamic metabolic profiling of sea cucumbers (Apostichopus japonicus) under predation stress.

The present study utilized non-targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) to investigate the metabolomic responses of sea cucumber (Apostichopus japonicus) juveniles under predation stress induced by sea stars (Asterina pectinifera) at various time points (3 h, 12 h, 72 h, and 96 h). The findings revealed significant temporal changes in the metabolic profiles of the sea cucumber juveniles under predation stress, with 25, 72, 55, and 53 metabolic products exhibiting significantly different expression levels at each time point (positive ion mode, P < 0.05), respectively.

Google infodemiology and temporal trends in benign prostatic hyperplasia surgery in Australia.

Objective: To contextualise the national population-based temporal surgical trends in the management of benign prostatic hyperplasia (BPH) in Australia.

Methods: Google Trends (GT) was used to analyse the level of patients' online interest in various surgical options for the treatment of BPH. Analysis of variance was performed and the average rates of change in GT popularity score was calculated for the period from 1 January 2010 to 31 October 2022.

Increased Sensitivity in VOC Detection by Using a Novel Photoinduced Multiple Ionization Mass Spectrometry.

Proton transfer reaction mass spectrometry (PTR-MS) is an important online monitoring technique for volatile organic compounds (VOCs). VOCs have the characteristics of many types, rapid change, and low concentration. Enhancing the detection sensitivity and expanding the detection range of VOCs have been key challenges in PTR-MS research.

Endoscopic management of hernia repair fixing tacks embedded in the bladder wall: A case report.

Background: Migration of fixing tacks into the bladder wall is a rare complication following laparoscopic hernia repairs.

Case Presentation: This report detailed an 80-year-old male who presented to the clinic with hematuria. Cystoscopy revealed a bladder calculus adherent to the bladder wall, with an underlying metallic tack.

Utility of PSA free-to-total ratio for clinically significant prostate cancer in men with a PSA level of <4 ng/mL.

Objective: To investigate the relationship between the prostate-specific antigen (PSA) free-to-total ratio (FTR) and International Society of Urological Pathology Grade Group ≥2, clinically significant prostate cancer (csPCa) in men with a low PSA level (≤4 ng/mL). Patients and Methods Data were obtained from the Prostate Cancer Prevention Trial. Patients with a PSA level of ≤4 ng/mL and who received a biopsy within a year of this PSA measurement were included.

Effects of 1-Deoxynojirimycin Extracts of Mulberry Leaves on Oxidative Stress and the Function of the Intestinal Tract in Broilers Induced by HO.

The poultry industry struggles with oxidative stress affecting gut health and productivity. This study examined using 1-Deoxynojirimycin (DNJ) extracts from mulberry leaves as an antioxidant in broilers feed to combat this issue. We divided 240 broilers, aged 16 days, into six groups, including a control and groups exposed to oxidative stress through HO injections, with different supplement levels of DNJ-E (40, 80, 120, and 160 mg/kg of the basal diet) lasting until the broilers reached 42 days old.

Age-dependent genetic architectures of chicken body weight explored by multidimensional GWAS and molQTL analyses.

Chicken body weight (BW) is a critical trait in breeding. Although genetic variants associated with BW have been investigated by genome-wide association studies (GWAS), the contributions of causal variants and their molecular mechanisms remain largely unclear in chickens. In this study, we construct a comprehensive genetic atlas of chicken BW by integrative analysis of 30 age points and 5 quantitative trait loci (QTL) across 27 tissues.