The effect of high-intensity interval training on health-related outcomes in obese adolescents: a systematic review and meta-analysis.

Objective: The present research was to evaluate the impacts of high-intensity interval training (HIIT) intervention on health-related outcomes in obese adolescents, adopting a systematic review and meta-analysis.

Methodology: The study was performed by searching four databases (PubMed, Web of Science, Embase, and Cochrane Library) to determine randomized controlled trials (RCTs) exploring the impacts of HIIT to physiological parameters among obese adolescents. The sequential execution of a meta-analyses, subgroup analyses, and publication bias analyses was accomplished utilizing the software package RevMan version 5.

Phytochemical profiling and toxicity assessment of Yinaoxin granules.

Ethnopharmacological Relevance: Yinaoxin granules (YNX) is a widely used Chinese herbal preparation composed of six medicinal herbs. YNX has been shown to effectively mitigate both headaches and dizziness. However, systematic investigations into its chemical basis and safety profile remain limited.

Involvement of the E2-like enzyme Atg3 in fungal development and virulence of .

Autophagy is a fundamental cellular degradation and recycling system that is crucial for maintaining cellular homeostasis, responding to stress, and ensuring the proper functioning of cells. To date, the biological functions of autophagy in the plant-pathogenic fungus remains largely unknown. In this study, we identified and characterized the E2-like enzyme Atg3 in .

Analyses of the formation and characteristics of flavor and taste in a sesame meal-based soy sauce.

Background: Sesame meal, characterized by high moisture, viscosity and oxidative instability, presents utilization challenges and is frequently relegated to farmland fertilizer - a practice that underutilizes its rich protein content.

Methods: This study developed three types of soy sauce using sesame meal supplemented with soybeans. For the first time, a dual-strain co-fermentation system employing Aspergillus oryzae 3.

Pixel-level transformer GAN for enhanced parametric mapping of DCE MRI analysis.

Background: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) plays a crucial role in the diagnosis and monitoring of cancers, as it reveals physiological and vascular characteristics of tumors. Traditional pharmacokinetic modeling necessitates high temporal resolution, resulting in relatively low signal-to-noise ratio (SNR) and spatial resolution with limited allocated time for each phase.

Purpose: To explore the feasibility of using deep learning with sparse DCE MRI phases to generate dense temporal resolution DCE-MRI-derived parametric map.

Resistance of three acetyl-CoA carboxylase (ACCase) inhibitors and the target gene mutations in spp. from rice fields of Jiangsu Province, China.

To determine the acetyl-CoA carboxylase (ACCase) inhibitors resistance and diversity of the target gene mutations in spp., we assessed the metamifop, cyhalofop-butyl, and fenoxaprop--ethyl resistance of 59 populations collected from rice fields in Jiangsu Province that were highly infested by spp. by the discriminating dose assays, and analyzed the gene mutations.

Kurarinone protects against renal injury and fibrosis after unilateral ureteral obstruction through enhancement of the Nrf-2 signaling pathway.

Background: Chronic kidney disease (CKD) is an epidemic with higher cardiovascular risk, and this pathology involves renal injury and fibrosis. Kurarinone (KAR) has anti-inflammatory and anticancer effects, which can regulate immune responses and macrophage polarization. This study aimed to investigate the effect of KAR on model-induced unilateral ureteral obstruction (UUO) renal injury and fibrosis.

Higher serum vitamin D concentration and supplementation were associated with improved survival outcomes and treatment response in cancer patients receiving immunotherapy: A systematic review and meta-analysis.

Biological evidence has demonstrated the anti-tumor effects of vitamin D, but whether it could predict the effect of cancer immunotherapy remains inconclusive. We hypothesized that higher serum vitamin D concentration and supplementation might be correlated with better prognosis and treatment response among cancer patients receiving immunotherapy. We systematically searched the Medline, Embase, Cochrane Library, PubMed, and Web of Science databases to identify relevant articles from inception to June 19, 2025.

Progress in spatiotemporal regulation of fear memory: neural circuit mechanisms and implications for PTSD.

Post-traumatic stress disorder (PTSD) is a severe neuropsychiatric disorder characterised by re-experiencing, avoidance and hyperarousal. Memory abnormalities manifested as intrusive thoughts and prolonged distressful emotions are postulated as key roles in PTSD development and persistence. Over the past decades, convergent results from human and animal studies have systematically investigated contributions of the amygdala, hippocampus and medial prefrontal cortex (mPFC) in fear memory processes, including fear acquisition, storage, reconsolidation and extinction.

Calreticulin in the nasal mucus promotes neutrophil migration and pathogen clearance.

The nasal cavity harbors diverse microbiota, and the nasal mucosal innate defense against microbial infiltration is crucial for respiratory infections. Both the nasal mucus covering the surface of the nasal cavity and the neutrophils beneath the nasal epithelia are the first line of innate defense against pathogens. Studying nasal mucus is challenging because of difficulties in collecting stable, high-quality samples from humans.

ACSS2-TFEB axis acts as a critical regulator of the autophagic machinery in head and neck squamous cell carcinoma.

Head and neck squamous cell carcinoma (HNSCC) has a high rate of metastasis and recurrence, and poses a considerable threat to patient survival. Autophagy, an intracellular degradation pathway, plays a crucial role in tumor progression; however, the underlying mechanisms of action remain unclear. This study aimed to explore the role of the ACSS2-TFEB axis in the regulation of autophagy and its impact on HNSCC cell proliferation, migration, invasion, and lysosomal function.

Ultrasound-actuated platelet mimetic nanomotors enable targeted piezocatalytic ROS storm for precision thrombolysis.

Thrombotic diseases pose life-threatening risks, yet current thrombolytic therapies face limitations including poor targeting and bleeding risks. To address this, ultrasound-activatable nanomotors (hBT-Pt@Pm) were developed through the integration of hollow BaTiO₃/Pt Schottky heterojunctions with platelet membrane (Pm) coatings. The hollow structure enhances piezocatalytic efficiency by shortening charge migration distances, while Pt deposition improves carrier separation, collectively boosting reactive oxygen species (ROS) generation under ultrasound.

Association Between Gastroesophageal Reflux Disease, Barrett's Esophagus and Ear Disorders: A Mendelian Randomization Study.

Objective: This study aims to examine the correlation between gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), and ear disorders using Mendelian randomization (MR).

Methods: For GERD, BE, and ear disorders, GWAS genetic data from individuals of European ancestry in the IEU GWAS database (https://gwas.mrcieu.

Towards expert-level autonomous carotid ultrasonography with large-scale learning-based robotic system.

Carotid ultrasound requires skilled operators due to small vessel dimensions and high anatomical variability, exacerbating sonographer shortages and diagnostic inconsistencies. Prior automation attempts, including rule-based approaches with manual heuristics and reinforcement learning trained in simulated environments, demonstrate limited generalizability and fail to complete real-world clinical workflows. Here, we present UltraBot, a fully learning-based autonomous carotid ultrasound robot, achieving human-expert-level performance through four innovations: (1) A unified imitation learning framework for acquiring anatomical knowledge and scanning operational skills; (2) A large-scale expert demonstration dataset (247,000 samples, 100 × scale-up), enabling embodied foundation models with strong generalization; (3) A comprehensive scanning protocol ensuring full anatomical coverage for biometric measurement and plaque screening; (4) The clinical-oriented validation showing over 90% success rates, expert-level accuracy, up to 5.

Characteristics of CVA16 B1c strains isolated for the first time in the Heilongjiang Province of China.

Hand, foot, and mouth disease (HFMD) represents a globally prevalent infectious disease that is caused by enteroviruses. Enterovirus A71 (EV-A71), coxsackievirus A16 (CVA16), and coxsackievirus A6 (CVA6) are recognized as the predominant causative agents of HFMD. CVA16 is a member of the genus within the family .

Static magnetic field treatment regulates reactive oxygen species metabolism and cell wall metabolism to delay postharvest softening of blueberries.

Fruit softening and cell wall pectin decomposition are prevalent phenomena in postharvest blueberry fruits. To mitigate blueberry softening and preserve the firmness and nutrient content of blueberries, a 6 mT static magnetic field (SMF) treatment was implemented. The treatment inhibited the content of peroxide (HO) and superoxide anion production rate (O), while enhancing the activity of peroxidase (APX), catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) antioxidant enzymes and the relative expression of associated genes.

A nomogram and risk stratification for predicting subsyndromal delirium in elderly patients in a post-anaesthesia care unit: A prospective cohort study.

Background: Subsyndromal delirium, as a transitional state of postoperative delirium, does not meet the diagnostic threshold for delirium but independently contributes to adverse outcomes in elderly patients. Early identification and intervention can effectively prevent disease progression.

Objective: This study focuses on the post-anesthesia care unit, a critical window period for postoperative recovery, aiming to develop a reliable risk prediction model.

ICAM-1 identifies preadipocytes and restricts white adipogenesis by adhering immune cells.

Adipose stem cell hierarchy was delineated by scRNA-seq analysis, revealing that ICAM-1, a glycoprotein that mediates cell-cell interaction, is a preadipocyte marker. However, the cellular and molecular mechanisms of how ICAM-1 preadipocytes contribute to adipose tissue homeostasis in vivo remain unclear. To address this, Icam1 mice were generated, and it was demonstrated that ICAM-1-expressing progenitors actively participated in developing and remodeling white adipose tissue.

The value of dual-energy spectral CT in differentiating the pathological grades of T1-size lung adenocarcinoma.

Background: Accurate preoperative diagnosis of pathological grades in T1-sized lung adenocarcinoma (LUAD) is crucial for clinical decision-making. The study aimed to investigate the value of dual-energy computed tomography (DECT) in distinguishing pathological grades in newly diagnosed LUAD lesions ≤3 cm in size.

Methods: From October 2018 to January 2022, 137 patients with 161 pathologically confirmed LUAD lesions (≤3 cm) having received DECT were retrospectively enrolled with clinical information collected (low-grade: high-grade =41:120).

Mirror therapy in the neuroadaptive training paradigm in rehabilitation and potential mechanisms of neural remodeling: a 20-year bibliometrics analysis.

Objective: Mirror Therapy activates mirror neurons, promotes neural connection regeneration, promotes brain reorganization and motor recovery, and alleviates limb pain. This study uses bibliometric methods to analyze the research trends of Mirror Therapy, aiming to fill the current research gap and provide valuable insights and suggestions for future research.

Methods: Publications related to mirror therapy from 2004 to 2024 were retrieved from the Web of Science Core Collection database.

Risk Factors for Acute Exacerbation in Patients with COPD Group E in Ningbo: Risk Analysis of Irregular Review, Cardiovascular Complications, and Lung Function Decline.

Objective: To understand the high-risk factors for disease progression in patients in the chronic obstructive pulmonary disease (COPD) group E in Ningbo, and to explore the impact of and treatment on the prognosis of these patients.

Methods: We retrospectively analyzed the clinical data of 101 COPD patients in terms of general demographics, physical baseline data, lung function, disease treatment, and prognosis and used crosstab analysis and logistic regression analysis to understand the characteristics of the population of patients at high risk of acute exacerbation of COPD (AECOPD) and the associated risk factors.

Results: Univariate analysis demonstrated that frequent acute exacerbation (AE) in the COPD group E population was significantly associated with more severe airflow limitation, a lower FEF75%, higher mMRC scores, and irregular disease management (P<0.

Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes.

Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity, learning and memory, but their evolutionary changes across species and specialized features in humans remain poorly understood. Here we performed machine-learning-augmented analysis of published single-nucleus RNA-sequencing datasets and identified macaque imGCs with transcriptome-wide immature neuronal characteristics. Our cross-species comparisons among humans, monkeys, pigs and mice showed few shared (such as DPYSL5), but mostly species-specific gene expression in imGCs that converged onto common biological processes regulating neuronal development.

Discovery of Streptomyces marinisediminis sp. nov., a new thiolutin producing actinomycete isolated from Thai marine sediment.

Thiolutin and 2,2-dioxidothiolutin are sulfur-containing antibiotics discovered through a targeted high-throughput screening strategy designed to identify compounds with antimicrobial activity. The producing strain, JHD1, is an actinomycete isolated from marine sediment collected in Chonburi Province, Thailand. Chemotaxonomic characteristics and 16S rRNA gene sequence analysis indicated that strain JHD1 belongs to the genus Streptomyces.