Efficacy and safety of efgartigimod versus intravenous immunoglobulin in early intervention of acetylcholine receptor antibody-positive impending myasthenic crisis: A retrospective cohort study.

Early intervention in impending myasthenic crisis (IMC) is critical to avert life-threatening progression. This study compared the clinical effectiveness and safety of the novel FcRn antagonist efgartigimod versus intravenous immunoglobulin (IVIg) in IMC management. In this retrospective cohort study, we analyzed 51 acetylcholine receptor antibody-positive (AChR-Ab+) IMC patients who received either efgartigimod (n ​= ​30) or IVIg (n ​= ​21) from June 2023 to November 2024.

Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity.

The brain is a metabolically demanding organ as it orchestrates and stabilizes neuronal network activity through plasticity. This mechanism imposes enormous and prolonged energetic demands at synapses, yet it is unclear how these needs are met in a sustained manner. Mitochondria serve as a local energy supply for dendritic spines, providing instant and sustained energy during synaptic plasticity.

Predictive performance of distinct skeletal muscle index cut-offs-defined sarcopenia for long-term mortality in decompensated cirrhosis: A prospective observational study.

Purpose: Although the clinical implication of sarcopenia has been verified in the context of cirrhosis, there is limited data concerning cut-offs of CT-measured skeletal muscle index (SMI) across different ethnicities. We aimed to compare the predictive performance of distinct SMI values-defined sarcopenia for prognosis in cirrhosis.

Methods: Totally, 478 inpatients due to cirrhosis-associated acute insults were prospectively enrolled.

Barriers to implementing clinical practice guidelines for managing patients with pressure injuries in China: a qualitative study using the theoretical domains framework.

Background: Pressure injuries (PIs) are a common challenge faced by healthcare institutions worldwide. Evidence-based practice is crucial for improving the quality of patient care, but its implementation often faces many difficulties. This study aims to explore the barriers to implementing clinical practice guidelines (CPGs) to manage patients with PIs in Chinese tertiary hospitals.

Surgical robot-guided unilateral percutaneous kyphoplasty: anatomical features and clinical efficacy of a modified transverse process-pedicle approach.

The purpose of the current study was to evaluate the anatomical feasibility and the clinical efficacy of robot-assisted unilateral percutaneous kyphoplasty (PKP) via the extreme lateral transverse process-pedicle approach (ETPA) in treating osteoporotic vertebral compression fractures (OVCF). Researchers analyzed 1000 lumbar vertebrae (L1-L5) from 200 patients and simulated PKP via the ETPA using 3D-CT imaging. The distance between the entry point and the midline of the vertebral body (DEM), the puncture inclination angle (PIA), the safe range of the puncture inclination angles (SRP), the success rate (SR) of puncture, sagittal inclination angle (SIA), and the safe range of the sagittal inclination angle (SRS) were measured and compared.

High-flux and anti-fouling membrane distillation membrane with VOC capture ability enabled by ZIF-8.

Seawater desalination and wastewater purification from brackish water, shale gas extraction, and industrial processes remain vital but challenging. Membrane distillation offers a promising solution yet struggles with low flux, membrane fouling, and the permeation of volatile organic compounds alongside water vapor. Here, we introduce an omniphobic ZIF-8 composite membrane that traps volatile organic compounds under vacuum through crystal phase transitions and enhances water evaporation via linkage swing within hydrophobic micropores.

A Miniaturized FSS Using the Parallel LC Resonant with Angular Stability.

This paper proposes a highly symmetrical miniaturized, frequency-selective surface (FSS) based on LC parallel resonance to optimize high-frequency passband characteristics, enhancing transmission efficiency under large-angle conditions. Through meandered design optimization, the device size is further reduced. Utilizing cell bending techniques and LC resonators, a single-layer FSS unit with parallel LC resonance is designed, achieving reflection and transmission peaks at approximately 1.

Biological functions and clinical implications of the CMPK2 across multisystemic diseases.

Cytidine/Uridine monophosphate kinase 2 (CMPK2) is a crucial enzyme responsible for the phosphorylation of nucleotides, specifically converting cytidine monophosphate (CMP) and uridine monophosphate (UMP) into their respective diphosphates, known as cytidine diphosphate (CDP) and uridine diphosphate (UDP). Recent studies have demonstrated that CMPK2 plays a pivotal role in multiple pathophysiological processes, such as cellular nucleotide metabolism, energy homeostasis, and inflammatory response. Dysregulation of CMPK2 has been implicated in a variety of pathologies, including viral infections, neurodegenerative diseases, and autoimmune disorders.

Role and potential of artificial intelligence, robotics, and navigation-assisted technologies in the diagnosis, treatment, and prognosis of osteoporotic vertebral compression fractures.

In recent years, there has been a rise in fractures caused by osteoporosis. Such fractures significantly contribute to bone morbidity and place an increasing strain on global healthcare systems. Among them, osteoporotic vertebral compression fractures (OVCFs) have shown a steady upward trend.

Engineering stem cell exosomes promotes the survival of multi-territory perforator flap in diabetes via regulating anti-inflammatory and angiogenesis.

The versatile multi-territory perforator flap remains a cornerstone of reconstructive surgery for diabetic ulcerations, yet its clinical efficacy faces significant challenges in hyperglycemic conditions. The diabetic milieu significantly exacerbates tissue ischemia through augmented chronic inflammation and impaired angiogenesis, which collectively harm flap perfusion and compromise its overall viability. A major postoperative complication is distal flap necrosis, which is closely associated with the critical "Choke zone," a hypoperfused transitional area that exhibits delayed vascular recruitment and suboptimal angiogenesis.

Environmental determinants of depression risk in China: insights from a longitudinal and cross-sectional analysis.

Objectives: Depression is a global health issue, with environmental factors emerging as potential contributors. This study explores the impact of living environment factors on depression in China to inform prevention and intervention strategies.

Methods: This study used data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018.

The FLATCAN Model: A Novel Score for Predicting Mortality Risk in Anti-Melanoma Differentiation-Associated Gene 5-Positive Dermatomyositis.

Background And Objective: Anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5 + DM) exhibits the worst prognosis among all subtypes of idiopathic inflammatory myopathies, with substantial heterogeneity in patient outcomes. This study aimed to investigate prognostic factors for MDA5 + DM and develop a scoring system to determine mortality risk.

Methods: This retrospective study included 621 patients with MDA5 + DM.

A practical photocatalytic strategy for radical (deuterio)difluoromethylation using imidazolium reagents.

The difluoromethyl group (CFH) has garnered significant interest in medicinal chemistry owing to its unique biochemical and physicochemical properties. Its deuterated counterpart (CFD), building on the established utility of CFH, exhibits multifaceted potential for advancing biomedical research and therapeutic development. While the incorporation of the difluoromethyl group (CFH) into drug molecules has matured, efficient installation of its deuterated counterpart (CFD) remains a formidable challenge in medicinal chemistry.

End-to-end deep learning for the diagnosis of pelvic and sacral tumors using non-enhanced MRI: a multi-center study.

This study developed an end-to-end deep learning (DL) model using non-enhanced MRI to diagnose benign and malignant pelvic and sacral tumors (PSTs). Retrospective data from 835 patients across four hospitals were employed to train, validate, and test the models. Six diagnostic models with varied input sources were compared.

Mulberry Leaf Protein: Extraction Technologies, Functional Attributes and Food Applications.

In the context of a rapidly expanding global population, mulberry leaf protein emerges as an emerging source of plant protein, with most applications currently at Technology Readiness Level (TRL), presenting substantial potential for application in functional foods and nutraceuticals. This paper analyzes three key advantages of mulberry leaf protein. Firstly, the abundant and inexpensive production of mulberry leaves establishes a solid foundation for large-scale protein extraction.

Risk Factors for Acute Exacerbation in Patients with COPD Group E in Ningbo: Risk Analysis of Irregular Review, Cardiovascular Complications, and Lung Function Decline.

Objective: To understand the high-risk factors for disease progression in patients in the chronic obstructive pulmonary disease (COPD) group E in Ningbo, and to explore the impact of and treatment on the prognosis of these patients.

Methods: We retrospectively analyzed the clinical data of 101 COPD patients in terms of general demographics, physical baseline data, lung function, disease treatment, and prognosis and used crosstab analysis and logistic regression analysis to understand the characteristics of the population of patients at high risk of acute exacerbation of COPD (AECOPD) and the associated risk factors.

Results: Univariate analysis demonstrated that frequent acute exacerbation (AE) in the COPD group E population was significantly associated with more severe airflow limitation, a lower FEF75%, higher mMRC scores, and irregular disease management (P<0.

How Healthy and Unhealthy Lifestyle Behaviors Affect Cognitive Function-Evidence From Older Adults in Chinese Communities: Cross-Sectional Study.

Background: Many lifestyle behaviors-including smoking, alcohol consumption, and engagement in physical activity and social activity-have been identified as potential determinants of the risk of cognitive impairment. Understanding how those lifestyle behavior patterns in older adults affect cognitive function is crucial for developing targeted interventions.

Objective: This study examined the lifestyle behavior patterns of Chinese community-dwelling older adults and their associations with cognitive impairment.

Correction: Evaluation of a novel IgG lateral flow assay for the diagnosis of non-neutropenic patients with acute and subacute invasive aspergillosis.

[This corrects the article DOI: 10.3389/fcimb.2025.

Social isolation in older adults with type 2 diabetes mellitus-a pathway analysis.

Background: Due to aging, the use of antidiabetic drugs, and dietary restrictions following a diagnosis of type 2 diabetes mellitus (T2DM), the social interactions of older adults with T2DM are often limited. As a result, this population experiences a higher incidence of social isolation than the general older adult population. This study aims to analyze the prevalence and influencing factors of social isolation among older adults with T2DM using a structural equation model.

LncRNA-driven programmed cell death networks: new therapeutic targets for neurological disorders.

Neural cell death is a critical pathological mechanism underlying the development and progression of central nervous system (CNS) diseases, where programmed cell death (PCD) pathways serve as critical regulatory hubs. In addition to classical apoptosis and autophagy, emerging PCD modalities including necroptosis, pyroptosis, ferroptosis, and cuproptosis exhibit distinct activation patterns in different neurological diseases. Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of these PCD processes through multiple molecular strategies by modulating chromatin accessibility, assembling signaling complexes, and regulating post-transcriptional processes.

Iterative recombinase technologies for efficient and precise genome engineering across kilobase to megabase scales.

Genome editing technologies face challenges in achieving precise, large-scale DNA manipulations in higher organisms, including inefficiency, limited editing scales and types, and the retention of undesired sequences such as recombination sites ("scars"). Here, we present programmable chromosome engineering (PCE) and RePCE, two programmable chromosome editing systems enabling scarless kilobase-to-megabase DNA manipulations in plants and human cells. Through high-throughput engineering, we obtained Lox sites with a 10-fold reduced reversibility and applied an AI-assisted recombinase engineering method (AiCE) to generate Cre variants with 3.

Quantitative ultrasound-derived fat fraction for identifying pediatric patients with metabolic dysfunction-associated steatotic liver disease: a prospective study.

Background: Metabolic dysfunction-associated steatotic liver disease is increasingly affecting younger populations. Ultrasound-derived fat fraction is a technique used in ultrasound to quantify liver fat content. The diagnostic performance of ultrasound-derived fat fraction in pediatric patients with metabolic dysfunction-associated steatotic liver disease is yet to be evaluated.

Characterization of the mulberry field antibiotic resistome and mobilome across China.

Antibiotic resistance genes (ARGs) are emerging environmental contaminants that pose increasing risks to ecosystems and human health. However, the distribution and drivers of ARGs associated with woody plants remain underexplored. In this study, we leverage large-scale sampling and metagenomics to provide a comprehensive survey of ARGs in both mulberry (Morus) field soil and rhizosphere across China.