Chitosan films incorporating bacterial cellulose-stabilized oregano oil emulsions: A functional approach for fresh walnut shelf-life extension.

Fresh walnuts are prone to moisture loss and spoilage after harvest, leading to reduced appearance and sensory quality. In this study, a multifunctional chitosan (CS)-based film was fabricated by incorporating a bacterial cellulose/oregano essential oil (BC/OEO) Pickering emulsion, with hydrogen bonding promoting cohesive matrix integration. The film's physicochemical properties, along with its antimicrobial and antioxidant activities, were systematically evaluated.

Dephosphorylation of astrocyte elevated gene-1 protein upregulates eIF4E expression to promote gastric cancer progression.

Protein phosphorylation modification plays an important role in regulating protein activity. Astrocyte elevated gene-1 (AEG-1), an adaptor protein, promotes the progression of various types of cancers by protein-protein interactions. We previously demonstrated that AEG-1 promoted the growth and metastasis of gastric cancer by upregulating the expression of oncogenic eukaryotic translation initiation factor 4E (eIF4E).

[Rapid screening of 111 pesticides and veterinary drugs in livestock and poultry meat by ultra performance liquid chromatography-quadrupole-time of flight mass spectrometry].

The consumption of agricultural products has increased in recent years owing to abundant production and improved living standards. Veterinary drugs are highly commercialized and widely used in animal husbandry to ensure animal health and production performance. Moreover， pesticides can become enriched during animal breeding， resulting in animal-derived food pollution through foraging， drinking， and environmental disinfection that can potentially damage human health.

Effect of LPJZ-658 on caecum microbiota and serum metabolomics of Luhua broiler.

Introduction: The purpose of this study was to investigate the effects of dietary supplementation of LPJZ-658 on body weight and serum indexes of Luhua broiler, and to explore the relevant mechanism of probiotic function of LPJZ-658 based on intestinal microbiota and serum metabolomics.

Methods: One hundred one-day-old Luhua broiler were randomly divided into the control group (CON) and LPJZ-658 treatment group (LPJZ-658). The CON group was fed a basal diet, and the LPJZ-658 group was fed the basal diet supplemented with 2 × 10 cfu/kg of LPJZ-658.

A real-world safety evaluation of new oral anticoagulants in elderly patients: evidence from the Adverse Drug Reaction Monitoring Center of Henan Province.

Background: The use of new oral anticoagulants (NOACs) is becoming increasingly widespread, but data on their adverse reactions are still incomplete. Further analysis based on data from the Drug Adverse Reaction Center is needed to guide safe clinical use.

Methods: A retrospective analysis was performed on 281 cases of rivaroxaban and 48 cases of dabigatran etexilate-related ADR reported by medical institutions collected by a provincial Food and Drug Administration from 2018 to 2023.

Analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in osteoarthritis by integrating bioinformatics and machine learning.

Objective: Exosomes as important carriers of intercellular communication have frequently appeared in recent studies related to osteoarthritis (OA), while the specific mechanism of exosome action in osteoarthritis remains unclear. The aim of this study was to identify potential exosome-related biomarkers in osteoarthritis, to explore the role and mechanism of exosome-related genes in articular cartilage.

Methods: The data on exosome related genes and normal and OA cartilage genes were obtained through online databases.

Dietary antioxidants: a challenge or an opportunity for asthma? Genetic Insights from a Two-sample Mendelian Randomization Study.

Background: Oxidative stress is crucial in the immune response and airway inflammatory process associated with asthma. While the relationship between dietary antioxidants and asthma remains debated in observational studies, this study uses two-sample Mendelian randomization (MR) to explore a potential causal link.

Methods: We acquired six distinct categories of absolute circulating antioxidants and five different types of metabolic circulating antioxidants from the most recent genome-wide association study data of the European population, including vitamin A (retinol), vitamin C (ascorbic acid), vitamin E (tocopherol), β-carotene, lycopene, and urate.

Arachidonic acid fuels inflammation by unlocking macrophage protein phosphatase 5 after myocardial infarction.

Background And Aims: An overactive inflammatory response and immune cell infiltration following myocardial infarction (MI) impair cardiac tissue repair. This study investigates the mechanistic role of the arachidonic acid (AA) metabolic cascade in mediating post-MI inflammation.

Methods: Single-cell RNA-sequencing analysis was performed to characterize cardiac macrophage heterogeneity in post-MI mice.

Clinical and genetic analysis of X-linked nephrogenic diabetes insipidus caused by a novel mutation (NM_000054.6:exon3:c.245G>A (p.Cys82Tyr)) in a Chinese boy.

X-linked nephrogenic diabetes insipidus (X-NDI) is a rare congenital disease caused by inactivating mutations of the vasopressin type-2 receptor (), characterized by impaired renal concentrating ability, dramatic polyuria, polydipsia and risk of dehydration. This study aims to elucidate the pathogenic mechanisms associated with a novel variant in the gene, which has been implicated in X-NDI. Whole exome sequencing (WES) was employed to identify genetic variants, complemented by bioinformatic analyses to predict the functional impact of these mutations.

Osmotic Energy Directly Driving Flexible All-Solid-State 2D Nanofluidic Pressure Sensors.

Current utilization of osmotic energy often involves multiple complex processes, including collection, storage, and conversion, which limits its applicability in portable electronic devices. Inspired by the biosensing system of human skin, a novel iontronic pressure sensor is developed, directly driven by osmotic energy. By leveraging the tunable nanofluidic effects of 2D materials, ion selective migration driven by osmotic energy is controlled through mechanical modulating of interlayer spacing, thereby converting external pressure into encodable electrical signals.

Engineering Dual Active Sites of Au Nanoparticles and Nitrogen Vacancies for Enhanced Photocatalytic Toluene Selective Oxidation.

The efficient and selective activation of C(sp)-H bonds in toluene plays a pivotal role in the synthesis of value-added chemicals, yet achieving this transformation under mild conditions remains a challenge. Herein, the Au nanoparticles supported on rich-nitrogen vacancies on CN (AuNPs/CN-N) are synthesized via Ar atmosphere calcination and photoinduced deposition. The electronic state and coordination environment of Au species, as well as nitrogen vacancies, are systematically elucidated using X-ray absorption fine structure (XAFS), X-ray photoelectron spectroscopy (XPS), electron spin resonance (ESR), and in situ Fourier-transform infrared (in situ FT-IR).

[Retracted] Inhibition of EMMPRIN by microRNA-124 suppresses the growth, invasion and tumorigenicity of gliomas.

[This retracts the article DOI: 10.3892/etm.2021.

Relapsing polychondritis following PD-1 blockade diagnosed via 18F-FDG PET/CT and improved by steroid administration: a case report and literature review.

Background: Up to 22% of cancer patients treated with immune checkpoint inhibitors (ICIs) can experience immune-related adverse events (irAEs) that mimic rheumatic disease, such as relapsing polychondritis (RP), which is a rare autoimmune disease that mainly manifests as inflammation of airway cartilage.

Methods: We report a case of RP induced by humanized recombinant anti-PD-1 monoclonal antibody therapy (tislelizumab). 18F-Fluorodeoxyglucose positron emission tomography/ computed tomography (18F-FDG PET/CT) contributed to the diagnosis of RP, and methylprednisolone was used to effectively control its progression.

Identification of biomarkers based on ubiquitin-correlated genes for predicting immune profile and drug sensitivity in lung adenocarcinoma.

Background: Lung adenocarcinoma (LUAD) shows high recurrence rate and poor prognosis. Genes associated with ubiquitin play a role in the onset and advancement of cancers; however, they have yet to be employed for the diagnosis and prognosis of LUAD.

Methods: First, gene modules correlated with ubiquitin were identified by WGCNA.

Development and validation of a deep learning-based assessment tool for teacher leadership: A case study from Xinjiang, China.

Teacher leadership is widely regarded as a critical driver of school reform and educational quality improvement. Although the field has been extensively studied, empirical research remains limited in Xinjiang, China-a region characterized by its multiethnic and multilingual context. To address this gap, the present study developed and validated a culturally sensitive assessment tool based on a sample of 371 primary and secondary school teachers from Xinjiang.

Regiodivergent Ligand-Controlled Cobalt-Catalyzed Reductive Hydroxymethylation of Alkynes with Aqueous Formaldehyde.

Allylic alcohols are versatile and essential building blocks in synthetic chemistry, widely used for the preparation of complex molecules, pharmaceuticals, and materials. We report here a regiodivergent reductive hydroxymethylation of terminal alkynes with aqueous formaldehyde to prepare allylic alcohols enabled by visible light photoredox and cobalt dual catalysis. Using readily available, bulk, and cheap aqueous formaldehyde as a simple C1 source, this method allows for the selective production of both linear and branched allylic alcohols in one-step manner.

The tryptophan catabolite pathway in major and simple neurocognitive psychosis: a double-edged sword with two sharpened edges.

Objectives: There are differences in IgA responses to tryptophan catabolites (TRYCATs) in major neurocognitive psychosis (MNP) versus simple neurocognitive psychosis (SNP) and normal controls. MNP and SNP are distinct schizophrenia classes which are differentiated by neurocognitive deficits, phenome features, and biomarker pathways. Nevertheless, there is no data on serum concentrations of those TRYCATs in MNP and SNP.

Multi-omics analysis reveals synergistic effects of terpenoids and phenylpropanoid compounds on flavour formation in skin and pulp of 'Shine Muscat' grape.

Flavour is a key trait that determines table grape quality and marketability. However, specific volatile compounds remain inadequately characterised. In this study, we have performed a comprehensive analysis of the volatile compounds in Muscat 'Shine Muscat' and no-flavour 'Thompson Seedless' during three different stages using widely targeted metabolomics and transcriptomics.

Danhong Injection targets CaMKII through Dihydrotanshinone I to alleviate cardiomyocyte death and inflammation in viral myocarditis.

Viral myocarditis, an inflammatory heart disorder caused by viral infections, often leads to poor outcomes due to the lack of effective prevention and treatment strategies. Despite the characteristic feature of cardiomyocyte death in this condition, the underlying mechanisms and potential therapeutic approaches remain poorly understood. Traditional Chinese medicine (TCM), despite its extensive history in treating various diseases, has not yet been approved for the treatment of viral myocarditis.

An Interpretable Radiomics Model Integrating Ultrasound and Clinical Features for Multiclass Classification of Axillary Lymph Nodes.

Objective: Accurate identification of common lesions (benign, metastatic carcinoma, lymphoma) of axillary lymph nodes (ALNs) is of vital importance for clinical decision-making, directly affecting tumor staging, treatment strategy formulation and prognosis of patients. However, current diagnostic methods by radiologists have limited accuracy in differentiating between benign lesions, metastatic carcinoma, and lymphoma.This study aimed to develop and validate the Axillary Lymph Node Interpretable Prediction (ALNIP) model for classifying axillary lymph nodes into benign, metastatic carcinoma, or lymphoma based on ultrasound imaging.

Microbial lipases in cheese production: an in-depth review of their role in quality, texture, and flavor.

Cheese, a widely consumed dairy product globally, derives its commercial value primarily from its flavor and textural characteristics that crucially determine consumer acceptance. The quality of cheese including flavor and texture is intricately related to the enzymatic activities of microorganisms during the fermentation process. Among these enzymes, lipases play a pivotal role by hydrolyzing milk fat to generate free fatty acids, which serve as precursors for the formation of key flavor compounds, thereby significantly enhancing the sensory attributes of cheese.

Data-driven analysis of the relationship between the HbA1c/HDL-C ratio and coronary artery calcification: a cross-sectional study.

Coronary artery calcification (CAC) is a well-established cardiovascular disease (CVD) pathogenesis marker closely associated with dysregulated glucose and lipid metabolism. The present study investigated the relationship between the glycated hemoglobin A1c (HbA1c)/high-density lipoprotein cholesterol (HDL-C) ratio and CAC. A total of 1608 eligible participants were enrolled in the study.

Nature-Inspired MXene Electrode with the Highly Interconnected Gradient Nanoconfined Architecture.

Achieving efficient ion transport in thick electrodes remains a fundamental challenge in electrochemical systems with high energy density, primarily due to prolonged diffusion pathways and poorly integrated architectures. Leveraging the nanoconfinement effect, (sub)nanoscale channels can significantly accelerate ion transport kinetics to maximize electrochemical performance. Inspired by the hierarchical network structure of bamboo membrane, a gradient nanoconfined MXene electrode (GNC-MX) is designed, where multiscale interlayer spacing is coupled with in-plane mesopores that bridge adjacent nanoconfined channels, enabling synergistic vertical and horizontal ion migration.

Impact of cycling exercise in patients with chronic kidney disease: protocol for a systematic review and trial sequential meta-analysis.

Background: Chronic kidney disease is a global public health problem affecting approximately 10% of the adult population. Conventional management combines pharmacotherapy and dialysis, yet long-term complications persist. Cycling, a low joint load exercise, may improve cardiopulmonary function and renal outcomes, but conflicting evidence exists regarding its efficacy in advanced CKD.