Data-driven analysis of the relationship between the HbA1c/HDL-C ratio and coronary artery calcification: a cross-sectional study.

Coronary artery calcification (CAC) is a well-established cardiovascular disease (CVD) pathogenesis marker closely associated with dysregulated glucose and lipid metabolism. The present study investigated the relationship between the glycated hemoglobin A1c (HbA1c)/high-density lipoprotein cholesterol (HDL-C) ratio and CAC. A total of 1608 eligible participants were enrolled in the study.

Associations of atherogenic index of plasma and other nontraditional lipid parameters with the risk of coronary artery aneurysm.

Background: Aberrant lipid metabolism is associated with the development of coronary artery aneurysms (CAA). Research on the association between traditional and nontraditional lipid parameters, as well as CAA, in patients undergoing coronary angiography is limited. Therefore, this study aimed to investigate and compare the effects of lipid parameters on CAA development.

Understanding the CO Activation and Hydrogenation Mechanism on MXene under Electrochemical Conditions.

MXenes (MXs) are attracting growing interest as promising catalysts for CO reduction reactions. However, the specific activation and reduction mechanism of CO on MXs under realistic electrochemical conditions remain unclear. This study utilizes ab initio molecular dynamics simulations to unravel the kinetic processes of underlying CO activation and hydrogenation under aqueous conditions with MoC MX as a prototype.

A novel nomogram for predicting the risk of coronary atherosclerosis in patients with gastroesophageal reflux disease.

Background And Study Aims: This study developed a novel nomogram to predict the incidence of coronary atherosclerosis (CA) in patients with gastroesophageal reflux disease (GERD) and evaluated its predictive value.

Patients And Methods: In total, 13,658 patients with GERD from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database were analyzed. The patients were randomly divided into a training cohort (n = 9,560) and a validation cohort (n = 4,098) at a 7:3 ratio.

LONP1 facilitates pulmonary artery smooth muscle cell glycolytic reprogramming by degrading MPC1 in pulmonary hypertension.

Pulmonary hypertension (PH) is a chronic and life-threatening disease characterized by pulmonary vascular remodeling (PVR), which involves the abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs). These cells exhibit metabolic characteristics akin to cancer cells, particularly in their shift toward glycolysis. The Lon protease 1 (LONP1) has been shown to promote glycolytic reprogramming of tumor cells, conferring a malignant proliferative phenotype.

Urinary sodium-potassium ratio as a genetic predictor of myocardial infarction.

Background: The relationship between the urinary sodium-potassium ratio (USPR) and risk factors for heart disease has been observed over time. We evaluated the relationship between USPR and myocardial infarction (MI).

Methods: Causal relationships were estimated based on USPR and MI data from genome-wide association studies.

The impact of tolvaptan on the incidence of contrast-induced acute kidney injury and long-term prognosis in high-risk patients after coronary intervention.

Objective: To investigate the effect of low-dose tolvaptan combined with hydration on the incidence of contrast-induced acute kidney injury (CI-AKI) and prognosis in high-risk patients undergoing coronary angiography or intervention.

Methods: This single-center, randomized controlled clinical trial (ChiCTR2000028834) enrolled 232 patients scheduled for elective coronary angiography or intervention, randomly assigned to the experimental group (low-dose tolvaptan + standard intravenous hydration) or the control group (standard hydration alone). Multivariate logistic regression analysis was performed to explore factors associated with CI-AKI occurrence.

Stress hyperglycemia ratio as an independent predictor of acute kidney injury in critically ill patients with acute myocardial infarction: a retrospective U.S. cohort study.

Background: Acute kidney injury (AKI) is a frequent and severe complication in critically ill patients with acute myocardial infarction (AMI), significantly worsening prognosis. Identifying early risk markers for AKI in AMI patients is critical for timely intervention. The stress hyperglycemia ratio (SHR), a marker of acute glycemic response to physiological stress, has been proposed as a predictor of AKI, but its role remains unclear.

A Novel Nomogram for Predicting the Risk of Acute Heart Failure in Intensive Care Unit Patients with COPD.

Background: The objective of this study was to construct a prediction model to assess the onset of acute heart failure (AHF) in patients with chronic obstructive pulmonary disease (COPD) without a history of heart failure and to evaluate the predictive value of the nomogram.

Methods: This study involved 3730 patients with COPD and no history of heart failure. Clinical and laboratory data were collected from the Medical Information Mart for Intensive Care IV database.

Relationship between stress hyperglycemia ratio and progression of non target coronary lesions: a retrospective cohort study.

Background: Stress hyperglycemia ratio is a novel indicator of acute coronary synthesis (ACS), which is closely related to the severity and complications of ACS and other cardiovascular diseases. However, its relationship with the progression of non target coronary lesions remains unclear. The purpose of this paper is to explore the relationship between stress hyperglycemia ratio and the progression of non target coronary lesions.

Association between age at diagnosis of diabetes and ocular disease: Insights from a recent article.

In this article, we discuss Ye 's recent article on the association between age at diabetes diagnosis and subsequent risk of age-related ocular diseases. The study, which utilized United Kingdom Biobank data, highlighted a strong link between early diabetes onset and major eye conditions, such as cataracts, glaucoma, age-related macular degeneration, and vision loss, independent of glycemic control and disease duration. This finding challenges the previous belief that diabetic eye disease primarily correlates with hyperglycemia.

The role of tribbles homolog 2 in cell proliferation.

Tribbles homolog 2 (TRIB2), a pseudoserine/threonine kinase, is a member of the TRIB family. TRIB2 primarily regulates cell proliferation through its scaffold or adaptor effect on promoting the degradation of target proteins by E3 ligase-dependent ubiquitination and regulating mitogen-activated protein kinase (MAPK) and protein kinase B (AKT) signaling pathways. TRIB2 is not only involved in the physiological proliferation of cells (granulosa cells, myoblasts, naive T cells, and thymocytes) during normal development but also in the pathological proliferation of vascular smooth muscle cells and a variety of cancer cells (lung cancer cells, liver cancer cells, leukemia cells, pancreatic cancer cells, gastric cancer cells, prostate cancer cells, thyroid cancer cells, cervical cancer cells, melanoma cells, colorectal cancer cells, ovarian cancer cells and osteosarcoma cells) under disease conditions.

Sex Differences in the Associations among Insulin Resistance Indexes with Metabolic Syndrome: A Large Cross-Sectional Study.

Purpose: Metabolic syndrome (MetS) is closely related to insulin resistance (IR), and the sex differences have not been fully explored. This study was aimed to investigate the sex differences in the associations among IR indexes with MetS in a large population.

Methods: A total of 60,799 participants were enrolled in the current study.

Preparation of Poly(allylamine Hydrochloride) Grafted Porous Boron Nitride Fibers for Efficient Cr(VI) Adsorption from Aqueous Solution.

Cr(VI) pollution poses great harm to the cyclic utilization of groundwater and surface water resources. Efficient adsorbent materials have great potential to change this situation and assist in the restoration of ecosystems. This work chooses porous boron nitride fibers (pBN) with stable physical and chemical properties as the matrix, 3-aminopropyltriethoxysilane (APTES) as the coupling agent, and uses a one-step crosslinking method to graft poly(allylamine hydrochloride) (PAH) onto pBN, forming pBN-AS@PAH with fascinating Cr(VI) adsorption capacity.

Controllable synthesis of porous boron nitride fibers modified by cobalt and nickel oxides for efficient ceftriaxone sodium adsorption from aqueous solution.

Antibiotics can easily enter the water environment through direct or indirect approach, causing environmental pollution and endangering the health of organisms. Therefore, development of highly efficient adsorbent materials to adsorb and remove antibiotics is necessary. Here, cobalt oxide and nickel oxide are uniformly and tightly bonded on the surface of porous boron nitride fibers (PBNFs-NiCo), increasing the number of functional groups (B-O and N-H) and hydrogen bond receptors within PBNFs.

TG2 participates in pulmonary vascular remodelling by regulating the senescence of pulmonary artery smooth muscle cells.

Pulmonary hypertension (PH) is a severe cardiovascular disease characterised by pulmonary vascular remodelling. The pivotal role of cellular senescence in vascular remodelling has been acknowledged. Transglutaminase type 2 (TG2), a calcium-dependent enzyme, is intricately linked to both cellular senescence and PH.

Electronic Structure Modification of MnO Nanosheet Arrays with Enhanced Water Oxidation Activity and Stability by Nitrogen Plasma.

The strategic design of catalysts for the oxygen evolution reaction (OER) is crucial in tackling the substantial energy demands associated with hydrogen production in electrolytic water splitting. Despite extensive research on birnessite (δ-MnO) manganese oxides to enhance catalytic activity by modulating Mn species, the ongoing challenge is to simultaneously stabilize Mn while improving overall activity. Herein, oxygen (O) vacancies and nitrogen (N) doping have been simultaneously introduced into the MnO through a simple nitrogen plasma approach, resulting in efficient OER performance.

Boron carbon nitride as efficient oxygen reduction reaction support.

The electrocatalytic oxygen reduction reaction (ORR) is crucial for energy conversion systems such as fuel cells and metal-air batteries. Boron carbon nitrogen (BCN) is a novel functional material with a high specific surface area, excellent corrosion resistance, and outstanding electrochemical stability. These properties make BCN an effective ORR catalyst and a promising support for metal catalysts.

Assessing the Role of Bioelectrical Impedance Vector Analysis in Prognosis and Prevention of Contrast-Associated Acute Kidney Injury After Percutaneous Coronary Intervention.

This study evaluated the impact of Bioelectrical Impedance Vector Analysis (BIVA)-guided hydration therapy on contrast-associated acute kidney injury (CA-AKI) in patients undergoing percutaneous coronary intervention (PCI). From April 2022 to January 2023, this prospective study at the Eastern General Hospital of the Chinese People's Liberation Army involved 902 adults with stable coronary artery disease (CAD) scheduled for PCI. BIVA measurements were performed pre-contrast, followed by a standard hydration regimen.

Bidirectional two-sample Mendelian randomization study of association between smoking initiation and atrial fibrillation.

Introduction: The relationship between smoking and heart disease has been frequently reported. Therefore, we aimed to explore the association between smoking initiation and atrial fibrillation.

Methods: Genetic association data pertaining to smoking initiation and atrial fibrillation were obtained from genome-wide association studies (GWAS).

Red Blood Cell Distribution Width to Albumin Ratio for Predicting Type I Cardiorenal Syndrome in Patients with Acute Myocardial Infarction: A Retrospective Cohort Study.

Purpose: Red blood cell distribution width to albumin ratio (RAR) is a novel inflammatory biomarker that independently predicts adverse cardiovascular events and acute kidney injury. This study aimed to assess the predictive value of RAR for cardio-renal syndrome type I (CRS-I) risk in acute myocardial infarction (AMI) patients.

Patients And Methods: This study retrospectively enrolled 551 patients who were definitively diagnosed as AMI between October 2021 and October 2022 at the Affiliated Zhongda Hospital of Southeast University.

Boron nitride microfiber reinforced polyacrylic acid hydrogels with excellent self-adhesion, fast pH response, and strain sensitivity.

Hydrogels are widely utilized in the sensor field, but their inadequate adhesion presents a significant obstacle. Herein, a new multifunctional BNMFs/PAA composite hydrogel was prepared the incorporation of one-dimensional porous boron nitride microfibers (BNMFs) and polyacrylic acid (PAA) hydrogels. BNMFs, as a reinforcing filler, play a very important role in enhancing the properties of the composite hydrogels.

MiR-411-5p Promotes Vascular Smooth Muscle Cell Phenotype Switch by Inhibiting Expression of Calmodulin Regulated Spectrin-Associated Protein-1.

When stimulated, vascular smooth muscle cells (VSMCs) change from a differentiated to a dedifferentiated phenotype. Dedifferentiated VSMCs have a key activity in cardiovascular diseases such as in-stent restenosis. MicroRNAs (miRNAs) have crucial functions in conversion of differentiated VSMCs to a dedifferentiated phenotype.

Rational design of bimetallic MBene for efficient electrocatalytic nitrogen reduction.

Electrocatalytic nitrogen reduction reaction (NRR) is one of the most promising approaches to achieving green and efficient NH production. However, the designs of efficient NRR catalysts with high activity and selectivity still are severely hampered by inherent linear scaling relations among the adsorption energies of NRR intermediates. Herein, the properties of ten MB type MBenes have been initially investigated for efficient N activation and reduction to NHvia first-principles calculations.

Pressureless Welding of Temperature-Invariant Multifunctionality Body Based on Hydroxyl-Functionalized Boron Nitride Nanosheets and Bifunctional Monoethanolamine Cross-linker.

Bulk hexagonal boron nitride (h-BN) ceramics with structural integrity, high-temperature resistance and low expansion rate are expected for multifunctional applications in extreme conditions. However, due to its sluggish self-diffusion and intrinsic inertness, it remains a great challenge to overcome high-energy barrier for h-BN powder sintering. Herein, a cross-linking and pressureless-welding strategy is reported to produce bulk boron nitride nanosheets (BNNSs) ceramics with well-crystalized and dense B-N covalent-welding frameworks.