Chiral spin constrained assemblies for polarized optical mapping.

Optical-enabled identification and interaction provide an integral link between the digital and physical realms. However, nowadays optic-encodings, predominantly reliant on light's intensity and wavelength, are hindered by environmental light interference and limited information capacity. The introduction of unusual polarization states, such as circular polarization-which is absent from ordinary surroundings-holds promise for higher-dimensional interaction.

A randomized controlled trial of the short-term effect of rosuvastatin on the corrected QT interval.

Rosuvastatin can block human ether-a-go-go related gene (hERG) currents and prolong the corrected QT (QTc) interval, but this effect has not been confirmed in the population. This study compared the changes of QTc interval between populations receiving atorvastatin and rosuvastatin, explained the effect of rosuvastatin on QTc interval, and the correlation between rosuvastatin and QT prolongation. The QTc interval decreased by 0.

Engineered crRNA Drives RPA-T7-CRISPR/Cas14a Cascade for Ultrasensitive Detection of ctDNA PIK3CA H1047R.

The early detection of circulating tumor DNA (ctDNA) at mutant allele frequencies below 0.1% remains a critical challenge, significantly impeding therapeutic decision-making. To address this limitation, TIDE-Cas14a-an innovative CRISPR/Cas14a-based duplex detection system is developed that integrates recombinase polymerase amplification (RPA) with T7 exonuclease-mediated strand displacement.

The impact of ultrasound-guided erector spinae plane block combined with paravertebral block on postoperative rebound pain following thoracoscopic lobectomy.

Background: Thoracic paravertebral block (TPVB) is the mainstream analgesic regimen for post-video-assisted thoracoscopic surgery (VATS) pain management. However, rebound pain frequently emerges once the block effect subsides. Given that the erector spinae plane block (ESPB) may modulate the incidence of rebound pain through its mechanism of local anesthetic diffusion into the paravertebral space, this study sought to evaluate whether combining TPVB with ESPB could effectively reduce postoperative rebound pain in VATS patients.

Simultaneous separation on a bisphenylureido β-cyclodextrin column and determination of eight antihistamine enantiomers in human plasma by HPLC.

A bis(3,5-dichlorophenylureido)-β-cyclodextrin stationary phase (CUCDP) was prepared and characterized. It had strong chiral separation abilities for antihistamines (Rs = 1.61-2.

Tripartite evolutionary game model for recycling strategies of decommissioned wind and solar energy equipment.

The global volume of decommissioned components from wind turbines and solar photovoltaic (PV) equipment is projected to exceed 30 million tons by 2030, posing a significant challenge for their disposal and recycling. The issue of managing these components remains largely unresolved. While existing research primarily focuses on technical aspects, few studies address policies and recycling mechanisms.

Unraveling and Suppression of Multi-Directional Planar Slipping and Microcracking in Single-Crystal Co-Free, Ni-Rich Cathodes.

High-capacity Co-free Ni-rich layered oxides are promising cathode materials for lithium-based batteries, but they suffer from chemo-electro-mechanical instabilities. While single-crystal morphologies reduce these issues, slipping, and microcracking persist during extended cycling, and the degradation mechanisms remain inadequately understood. Herein, we report on multi-directional planar slipping and microcracking along the (003) and (100) planes in a single-crystal LiNiMnO (LNM) cathode.

Population prevalence and correlates of prolonged and shortened QTc intervals in a nationwide survey of adults in China: a report from Chinese arrhythmia epidemiology cross-sectional study.

Objective: QT interval irregularities correlate with severe arrhythmias and sudden cardiac death. However, epidemiological data on QT intervals in Chinese adults are lacking. This study aimed to elucidate the distribution of the QT interval (QTc) patterns in Chinese adults and the risk factors associated with a prolonged QTc interval and shortened QTc interval.

Boosting Photocatalytic CO Reduction via Oxygen Vacancy Defective S-Scheme InO@NiInS Hollow Spheres with Efficient Charge Separation.

One of the most promising approaches to carbon neutrality is photocatalytic conversion of CO into chemical fuels. Nevertheless, it continues to face significant challenges in addressing high charge-transfer resistance and sluggish charge-transfer kinetics, substantially limiting its practicality for large-scale deployment. Here, we prepared S-scheme InO@NiInS hollow spheres (HSs) utilizing an ordinal solvothermal coating of Ni-MOF and a high-temperature sulfidation process of the In(OH)-InOOH hollow sphere precursor, which facilitated close contact between the two components.

CD4/CD8 ratio trajectories and their impact on prognosis: a 15-year retrospective longitudinal cohort study of people living with HIV.

Introduction: The aim of this study was to identify the heterogeneous classes of CD4/CD8 ratio trajectory and their impacts on prognosis in people living with HIV (PLHIV) during long-term antiretroviral therapy.

Methods: A retrospective cohort study of PLHIV receiving ART treatment was conducted in the Eighth Affiliated Hospital of Guangzhou Medical University, and the latent growth mixture model (LGMM) was used to identify the trajectories of longitudinal changes in the CD4/CD8 ratio between February 10, 2004, and January 31, 2019. Cox proportional hazard model and proportional subdistribution hazard model were conducted to explore the impact of CD4/CD8 ratio trajectory on prognosis.

Canagliflozin inhibits hepatic stellate cells activation and proliferation by inhibiting PP2A-mediated β-catenin dephosphorylation to attenuate hepatic fibrosis.

Hepatic fibrosis (HF) is a leading cause of death worldwide, yet there is currently no safe and effective treatment available. Canagliflozin, a novel glucose-lowering drug, has been shown to improve non-alcoholic steatohepatitis (NASH). However, its therapeutic effects on HF and the underlying molecular mechanisms remain unclear.

Fabrication of Antibacterial Poly(ethylene terephthalate)/Graphene Nanocomposite Fibers by In Situ Polymerization for Fruit Preservation.

A novel polyester/graphene nanocomposite fiber was produced using the in situ polymerization protocol with carboxylated graphene and melt spinning technology. The resulting nanocomposite fibers were characterized by X-ray diffraction (XRD), Raman spectroscopy, differential scanning calorimeter (DSC), and scanning electron microscope (SEM). The fibers containing 0.

Melanoma GPA as a novel prognostic scoring model based on initial brain metastasis velocity.

Upon initial presentation, initial brain metastasis velocity (iBMV) is a prognostic factor for patients with brain metastases (BMs). Based on this metric, this study validated the predictive value of iBMV and introduced a Graded Prognostic Assessment (GPA)-derived scale known as melanoma-GPA. We conducted a retrospective cohort study and enrolled patients diagnosed with malignant melanoma brain metastases (MBMs) between December 2010 and February 2023.

Effects of Remimazolam-Propofol with Flumazenil Reversal on the Emergence Time and Hemodynamics of Patients Undergoing Laparoscopic Partial Hepatectomy: A Prospective Randomized Controlled Trial.

Background: Laparoscopic partial hepatectomy, characterized by significant surgical trauma, profound stress responses, prolonged duration, and high anesthetic requirements, may lead to delayed recovery or emergence agitation. Whether remimazolam and propofol combined with flumazenil reversal can accelerate the recovery and enhance hemodynamic stability remains controversial.

Methods: Fifty patients aged 18-70 years with American Society of Anesthesiologists (ASA) class I-III and Child-Pugh classification A or B undergoing elective laparoscopic partial hepatectomy were enrolled.

Shikonin treats Aspergillus fumigatus keratitis by activating autophagy and reducing fungal load.

The objective of this study was to explore the therapeutic potential of Shikonin (SK) in the treatment of fungal keratitis. Various tests conducted in this study were fluorescein sodium staining, Cell Counting Kit-8 (CCK-8), RT-PCR, Western blot (WB), immunofluorescence, and enzyme-linked immunosorbent assay (ELISA) methods. And the autophagic and phagocytic functions of RAW 264.

Artesunate Treats Aspergillus fumigatus Keratitis by Inhibiting Fungal Activity and Activating Autophagy Pathway to Reduce Corneal Inflammation.

Purpose: The purpose of this study was to investigate the therapeutic effect of artesunate (ART) on fungal keratitis (FK).

Methods: The antifungal properties of ART against Aspergillus fumigatus (A. fumigatus) were confirmed by minimum inhibitory concentration (MIC), biofilm formation inhibition test, propidium iodide fluorescence, and calcium fluorescence white test.

Correlation analysis of serum miRNA expression levels with the degree of macular edema in patients with retinal vein occlusion and its clinical implications.

Objective: To investigate the correlation between serum microRNA (miRNA) levels and the degree of macular edema in retinal vein occlusion (RVO) patients.

Methods: 180 RVO patients were divided into three groups based on macular edema severity: mild, moderate, and severe. Their serum miR-155-5p, miR-17-5p, and miR-375 levels were compared with 60 healthy controls.

Exploration of the Therapeutic Time Window for Thrombectomy in Rat Models of Middle Cerebral Artery Ischemia-Reperfusion.

Objective: To investigate the therapeutic time window of middle cerebral artery occlusion (MCAO) reperfusion in rats and the potential mechanism of injury beyond the time window.

Methods: Male Sprague Dawley (SD) rats were randomly divided into eight groups: a sham operation group, six ischemia-reperfusion groups (reperfusion initiated 1, 2, 3, 4, 5, and 6 h after infarction, respectively), and a 24-h infarction group without reperfusion therapy. Neurological function scores were assessed 24 h after reperfusion, and then brain samples were collected to explore the mechanisms.

Case Report: Surgery for proximal gastric cancer with splenic artery aneurysm: approach and complication mangement.

Introduction: Gastric cancer surgery is gradually shifting from extensive, standardized operations to individual, precise procedures. The two surgical options for proximal gastric cancer are total gastrectomy and proximal gastrectomy. In recent years, proximal gastrectomy has gained wider acceptance in clinical practice, with increasingly relaxed indications.

A novel device for studying temperature and touch interactions.

Background: Existing methods to study the effects of skin temperature on mechanical touch perception range from large hot plates, water baths, or bulky, water-controlled thermal contactors which have limited range and resolution. The limited capabilities of these methods prevent the study of thermo-tactile interactions at the finger level in a flexible and precisely controlled manner.

New Method: Here, we combine small Proportional-Integral-Derivative (PID)-controlled Peltier elements with a calibrated shaker motor for a novel thermo-tactile stimulus delivery system capable of precisely controlling temperature and vibrotactile stimulation to the fingertip.

Association of admission blood glucose and postoperation fast blood glucose with futile recanalization in patients with endovascular therapy.

Background: Futile recanalization (FR), defined as patients with long-term functional dependence despite successful recanalization, is common in patients with large-vessel stroke undergoing endovascular treatment (EVT). The present study aimed to identify the relationship between blood glucose and FR.

Methods: Patients admitted to our stroke center in China between November 2019 and September 2022 were recruited according to the inclusion criteria and exclusion criteria.

Preparation of a phenylcarbamoylethylenediureido-β-cyclodextrin-bonded phase for enantioseparation and determination of cyproconazole, metconazole and other triazole fungicides in fruits and vegetables by high-performance liquid chromatography.

we reported a new phenylcarbamoylethylenediureido-β-cyclodextrin CSP (PUCDP) for HPLC, which was conveniently prepared by immobilizing the addition product of diethylenetriamino-β-CD with 3,5-dichlorophenyl isocyanate onto silica gel. After structural characterization, the chromatographic performance of PUCDP was preliminarily evaluated by using common 11 triazole pesticides as probes. The results showed that PUCDP had strong chiral separation abilities for all triazoles (Rs=1.

A retrospective observational study on the prognostic role of inflammatory markers in futile recanalization after endovascular treatment for large-vessel stroke.

ObjectiveEndovascular treatment has proven to be effective in improving the outcome of patients with large-vessel stroke. However, more than half of the patients experience poor outcomes despite successful recanalization, which was defined as futile recanalization. The present study aimed to identify the relationship between multiple inflammatory markers (before and after endovascular treatment) and futile recanalization.

Biomaterial-driven regenerative drug delivery: a vicennial bibliometric landscape.

Introduction: Biomaterials are increasingly central to innovations in drug delivery and regenerative medicine, driving new therapeutic strategies for chronic diseases and tissue repair. Despite rapid growth, a comprehensive, data-driven overview of this evolving interdisciplinary landscape has been lacking.

Methods: Here, we present a bibliometric analysis of articles and reviews published in the Science Citation Index Expanded (Web of Science Core Collection) from January 2005 to December 2024.