Acoustofluidic system for targeted antibody removal in transplantation: Enabling small-volume therapeutic apheresis.

Antibody-mediated rejection is a leading cause of allograft failure and mortality in pediatric solid organ transplant recipients. Current apheresis systems require large blood volumes and are primarily designed for adults, making them unsuitable for children and small animals. These systems often indiscriminately remove both harmful and protective antibodies, increasing the risk of complications such as life-threatening infections.

Light-Driven Double-Layer Polydopamine-Coated Flexible Metal-Organic Frameworks: Balancing Antibacterial and Regenerative Functions.

Burns complicated by antibiotic-resistant bacterial infections present a formidable clinical challenge, characterized by key pathological processes, including pathogen colonization, chronic inflammatory responses, and excessive accumulation of reactive oxygen species (ROS). Photocatalytic metal-organic frameworks (MOFs) have emerged as a promising nonantibiotic strategy against antibiotic-resistant bacterial infections. However, the ROS generated by MOF-based photocatalysis is often insufficient for effective antibacterial activity, while excessive ROS may induce tissue injury.

Ciprofol Alleviates Depressive-Like Behaviors in CUMS Mice Through PPARα-Associated ERK/CREB Signaling Activation.

Background: Depression is a complex neuropsychiatric disorder involving neuroinflammation, synaptic dysfunction, and neurotransmitter dysregulation. Recent studies have highlighted the therapeutic potential of short-acting anesthetics in the treatment of depression. Ciprofol, a novel intravenous anesthetic with rapid onset and recovery, shows promise, although its antidepressant mechanisms remain underexplored.

Agreement between transurethral resection of bladder tumor and radical cystectomy pathology in patients with bladder cancer subtype histology: A retrospective cohort study.

Introduction And Objectives: Transurethral Resection of Bladder Tumor (TURBT) is a diagnostic staging procedure for bladder cancer (BC). Its pathologic interpretation may be limited by cautery artifact, lack of spatial orientation of tumor specimens, inter-pathologist variance in identifying subtypes, and sampling bias. Accurately identifying subtype histology (SH) on TURBT is critical for clinical decisions.

Adverse drug events associated with sodium zirconium cyclosilicate: A real-world pharmacovigilance study based on the FAERS database.

Background: Sodium zirconium cyclosilicate (SZC, Lokelma) is a novel hyperkalemia therapy, but comprehensive real-world safety data are lacking. This study aimed to characterize SZC-associated adverse events (AEs) using post-marketing surveillance.

Research Design And Methods: AE reports for SZC/Lokelma were extracted from the FDA Adverse Event Reporting System (FAERS) (2004-2023).

Light grazing promotes the accumulation of soil microbial necromass carbon in a desert steppe.

Background: Grazing, as one of the most important methods of utilizing natural grasslands, can significantly impact the accumulation and stabilization of soil organic carbon within grassland ecosystems. Soil microbial necromass carbon (MNC), including fungal necromass carbon (FNC) and bacterial necromass carbon (BNC), is an important source of soil organic carbon (SOC) and plays a critical role in the formation and stabilization of SOC. However, the effects of grazing intensity on soil MNC and its underlying drivers remain unclear.

Anti-inflammatory lathyrane diterpenoids from the aerial parts of Euphorbia wallichii.

An intensive phytochemical study on the aerial parts of Euphorbia wallichii afforded ten lathyrane-type diterpenoids, including six formerly unreported ones (1-4, 6 and 8). Their structures were determined via comprehensive spectroscopic analyses, and the absolute stereochemistries were assigned on the basis of electronic circular dichroism technique. Among these diterpenoids, compound 2 exhibited the best inhibitory activity on NO production and its potential anti-inflammatory mechanism was then explored by network pharmacology analysis.

Significant impacts of metal ions from ancient oceans on nucleoside phosphorylation.

Nucleotides, such as 5'-AMP and ATP, are essential biomolecules in modern organisms. The phosphorylation of nucleosides to generate nucleotides occurs in complex prebiotic environments, where metal ions played a pivotal role, particularly in the metal-rich ancient oceans. Investigating the impact of prebiotic metal ions on nucleotide formation is critical to understanding their contributions to chemical evolution.

Picroside II-Encapsulated Nanoformulations as Pyroptosis Inhibitor Alleviate Cytokine Storms and Remodel Gut Microbiota Disturbances.

Sepsis still remains the leading cause of morbidity and mortality in clinical settings, characterized by pyroptosis-induced cytokine release syndrome, multiple organ dysfunction, and gut microbiota disturbances. Inhibiting the pyroptosis pathway by nanosystems represents a potential therapeutic strategy for the treatment of sepsis. However, current pharmacological interventions primarily focus on blocking reactive oxygen species (ROS)/NOD-like receptor pyrin domain-containing 3 (NLRP3)/Caspase-1-based pyroptosis rather than lipopolysaccharide (LPS)-triggered pyroptosis.

Systematic review and meta-analysis of the impact of STEM education on students learning outcomes.

Introduction: STEM education's impact on student learning outcomes is nuanced, with differentiated effects across outcome types and academic levels.

Methods: This study uses meta-analysis to systematically analyse 66 experimental and quasi-experimental studies on STEM education published in international English journals from 2000-2024.

Results: The study finds that: (1) Subgroup analysis showed that STEM education had the most significant impact on cognitive outcomes in high school ( = 0.

Functions of (L.) Gaertn Extracts: Investigating the Mechanism of Gastroparesis Amelioration from the Perspective of the Gut Microbiota and Its Metabolites.

The functional exploration of natural foods, coupled with the increasing prevalence of gastrointestinal motility disorders and the associated therapeutic challenges, has generated significant interest in this field. This study aims to investigate the ameliorative effects of the extract from (L.) Gaertn (EAEPC), a traditional edible vegetable in northwest China's desert region, on atropine-induced gastroparesis in mice, as well as to elucidate its mechanism in terms of the gut microbiota and major metabolites.

Focal Neurogenic Muscle Hypertrophy and Focal Neurogenic Myositis.

Focal neurogenic muscle hypertrophy (F-NMH) and focal myositis from neurogenic causes (F-NM) are terms used to describe the paradoxical changes in skeletal muscle following injury to peripheral motor axons. Since the first clinicopathologic description in 1978, over 100 patients with F-NMH and F-NM have been reported. We reviewed the medical records and clinicopathological data on our series of 6 patients from 2007 to 2025, and then expanded the review to include all patients reported in case studies or series with well-defined F-NMH or F-NM based electrodiagnostic studies, muscle histopathology, or both.

Study of the Reciprocal Interaction Between Tumor Cells and Macrophages Based on the Biomimic Microfluidic Device.

Tumor-macrophage interactions play a key role in various physiological and pathological processes, such as angiogenesis, immune suppression, and extracellular matrix remodeling. In this study, a biomimetic microfluidic chip was developed to simulate the immune microenvironment of glioma through the co-culture of glioma cells and macrophages in a three-dimensional (3D) matrix. Glioma cells were embedded in collagen I solution after forming spheroids in the microwell array chip and subsequently co-cultured with macrophages in different channels.

Spatial-temporal lipidomics reveals dysregulated lipid metabolism in mouse brain during Alzheimer's disease progression.

Introduction: Tracking spatial lipidomic changes during Alzheimer's disease (AD) progression is crucial for elucidating the underlying mechanisms of the disease.

Objectives: This study aims to investigate the spatial-temporal lipidomic alterations and their associated metabolic enzyme changes during AD progression.

Methods: The spatial lipidomic changes and corresponding alterations in metabolic enzymes during AD progression in amyloid precursor protein/presenilin-1 (APP/PS1) mice were thoroughly analyzed using an advanced ambient mass spectrometry imaging (MSI) technique, complemented by immunofluorescence (IF) imaging.

Mendelian randomization studies on ischemic stroke: a field synopsis and systematic review.

Background: Ischemic stroke (IS) is a major cause of disability and death worldwide. However, previous observational studies failed to establish the causality between various exposures and IS occurrence. Currently, an increasing number of Mendelian randomization (MR) studies have been performed to investigate the causal effects of exposure factors on IS risk, but the results remain inconsistent and inconclusive.

Ligustilide ameliorates cerebral ischemia-reperfusion injury by inhibiting NLRP3 inflammasome-dependent pyroptosis through enhancing Nrf2 signaling.

Pyroptosis is a type of proinflammatory programmed cell death, that closely related to the progress of cerebral ischemia/reperfusion injury (CIRI), and NLRP3 inflammasome is the most classic pathway mediating pyroptosis. Ligustilide (LIG) is a natural compound derived from the traditional Chinese herb chuanxiong hort and angelica sinensis which can penetrate the blood-brain barrier and has a good neuroprotective effect. However, it remains unclear whether LIG could alleviate CIRI by inhibiting pyroptosis.

Association between sleep patterns, circadian rhythms, and hair loss in young adults.

The increasing prevalence of delayed bedtimes and androgenetic alopecia (AGA) among younger individuals raises the question of whether late bedtimes could be a potential risk factor for AGA. This study aimed to investigate the relationship between sleep patterns and AGA in young individuals and explore whether circadian rhythms contribute to the underlying mechanisms. A cross-sectional survey among college students assessed AGA prevalence and chronotype.

Value of the spot sign combined with the blend sign for predicting the outcome of patients with intracerebral hemorrhage who have undergone stereotactic minimally invasive surgery.

Objective: This study aimed to explore the effect of combining the computed tomographic angiography (CTA) spot sign with the computed tomography (CT) blend sign for predicting the outcome of patients with intracerebral hemorrhage (ICH) who have undergone stereotactic minimally invasive surgery (sMIS).

Methods: Patients with ICH treated with sMIS between January 2018 and April 2023 at the affiliated hospital of Guizhou Medical University were retrospectively included. A modified Rankin scale (mRS) score of ≥3 at 3 months was defined as a poor outcome.

Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review.

With the acceleration of global population aging, effective strategies for the prevention and management of aging-related diseases have become increasingly urgent. The receptor for advanced glycation end products (RAGE), a pattern recognition receptor of the immunoglobulin superfamily, plays a central regulatory role in the pathogenesis of chronic conditions such as diabetes and Alzheimer's disease. By binding to a wide range of ligands (e.

Regulation of aging-related chronic diseases by dietary polyphenols: An updated overview.

With the aging of the population, diseases of aging such as Alzheimer's disease, diabetes and coronary heart disease are gradually becoming a key concern in global health. Dietary polyphenols, as a natural antioxidant with biological activities such as anti-inflammatory, anti-glycation, and anticancer, can effectively prevent and treat these diseases through a variety of mechanisms. However, the current means of prevention and control for these age-related diseases are still insufficient, especially the lack of reviews and studies on systematic regulation from a dietary perspective.

The genomic history of East Asian Middle Neolithic millet- and rice-agricultural populations.

The Yellow and Yangtze river basins in China are among the world's oldest independent agricultural centers, known for the domestication of millet and rice, respectively, yet their genetic history is poorly understood. Here, we present genome-wide data from 74 Middle Neolithic genetic samples from these regions, showing marked genetic differentiation but bidirectional gene flow, supporting a demic diffusion model of mixed farming. Yellow River populations exhibit distinct genetic substructures resulting from interactions with surrounding groups during the mid-Neolithic expansion of millet agriculture.

Association between prognostic nutritional index and risk of moderate-to-severe basic activities of daily living dependence two years after hip fracture surgery in older adults.

Background: Hip fractures are a common and serious health concern in older adults. The ability to perform basic activities of daily living (BADL) is a key indicator of long-term functional status. This study aimed to evaluate the prognostic value of the Prognostic Nutritional Index (PNI) in identifying older patients at risk of moderate-to-severe BADL dependence two years after hip fracture surgery.

Transcriptomic, phenotypic and physiological analyses identify candidate regulators of Dendrobium stigma maturation and pollen-stigma interaction.

Background: species are prized for their ornamental and economic value, yet their low hybrid compatibility remains a critical challenge, potentially linked to stigma recognition mechanisms. The stigma, as the primary site for pollen interaction, undergoes dynamic developmental changes that lay the foundation for successful pollination. However, the molecular mechanisms governing stigma maturation and subsequent pollen recognition are poorly characterised.

Cooperative spin alignment enhances dimerization in the electrochemical ammonia oxidation reaction.

Ammonia has recently attracted growing attention as a promising hydrogen carrier because it can be liquefied and stored in bulk under mild conditions. To fully harness its potential, more efforts are needed to elucidate and control the mechanisms of its decomposition. Here we show that intermediate dimerization processes proceed through a cooperative spin alignment effect between intermediates and can be promoted by the magnetic ordering rearrangement of magnetic substrates.

Melanoma GPA as a novel prognostic scoring model based on initial brain metastasis velocity.

Upon initial presentation, initial brain metastasis velocity (iBMV) is a prognostic factor for patients with brain metastases (BMs). Based on this metric, this study validated the predictive value of iBMV and introduced a Graded Prognostic Assessment (GPA)-derived scale known as melanoma-GPA. We conducted a retrospective cohort study and enrolled patients diagnosed with malignant melanoma brain metastases (MBMs) between December 2010 and February 2023.