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Introduction: STEM education's impact on student learning outcomes is nuanced, with differentiated effects across outcome types and academic levels.
Methods: This study uses meta-analysis to systematically analyse 66 experimental and quasi-experimental studies on STEM education published in international English journals from 2000-2024.
Results: The study finds that: (1) Subgroup analysis showed that STEM education had the most significant impact on cognitive outcomes in high school ( = 0.58) and reduced heterogeneity ( = 62.1%), while the overall effect size was exploratory due to construct diversity. (2) Overall, STEM education has a moderate effect on students' learning outcomes, but the overall moderate effect size masks these key differences. (3) The effect of STEM education on students' learning outcomes is influenced by the moderating variables of sample size, academic level, subjects, experimental period and teaching method.
Discussion: These findings highlight the need to tailor STEM interventions to outcome type and academic level, strengthening the integration of theory and practice in STEM education.
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http://dx.doi.org/10.3389/fpsyg.2025.1579474 | DOI Listing |
J Clin Invest
September 2025
Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.
Understanding the genetic causes of diseases affecting pancreatic β cells and neurons can give insights into pathways essential for both cell types. Microcephaly, epilepsy and diabetes syndrome (MEDS) is a congenital disorder with two known aetiological genes, IER3IP1 and YIPF5. Both genes encode proteins involved in endoplasmic reticulum (ER) to Golgi trafficking.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
School of Medicine, Chongqing University, Chongqing 400044, China.
Engineering functional exosomes represents a cutting-edge approach in biomedicine, holding the promise to transform targeted therapy. However, challenges such as achieving consistent modification and scalability have limited their wider adoption. Herein, we introduce a universal and effective strategy for engineering multifunctional exosomes through cell fusion.
View Article and Find Full Text PDFNucleic Acids Res
September 2025
Key Laboratory of Clinical Laboratory Diagnostics (Chinese Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P. R. China.
Local pH variations play a pivotal role in numerous critical biological processes. However, achieving the tunability and selectivity of pH detection remains a challenge. Here, we present a DNA-based strategy that enables programmable and selective pH responses, which is termed shadow-strand hybridization-actuated displacement engineering (SHADE).
View Article and Find Full Text PDFFASEB J
September 2025
National Heart Center Singapore, Singapore, Singapore.
Cardiovascular diseases are increasingly recognized as chronic disorders driven by a complex interplay between inflammation and fibrosis. In this review, we elucidate emerging mechanisms that govern the transition from acute inflammation to pathological fibrosis, with particular focus on cellular crosstalk between neutrophils, macrophages, fibroblasts, and myofibroblasts. We explore how dysregulated immune responses and extracellular matrix (ECM) remodeling sustain a pathogenic feedback loop, promoting myocardial stiffening and adverse cardiac remodeling.
View Article and Find Full Text PDFCureus
August 2025
Stem Cell and Regenerative Biology Laboratory, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Introduction: The presence of stem cells in the ovary has been a topic of discussion due to their questionable existence. Isolation of stem cells has been possible by enzymatic digestion; however, the percentage of cells harvested and expanded has not been satisfactory. This could be due to the lack of optimal adhesion provided by the standard commercial culture dishes, which affects the initial attachment and further growth of cells.
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