The good, the bad, and the successful: The Three Nightmare Traits and career success.

The Three Nightmare Traits (TNT; disagreeableness, carelessness, and dishonesty; aka the Three Nonnormative Traits) represent low levels of socially desirable self-control, i.e., unsuccessful socialization.

Acceptability and feasibility of a novel postural management night-time intervention to improve respiratory health of children and young people with complex neurodisability (Breathe-Easy): proof of concept study.

Objectives: Children and young people with complex neurodisability (CYPCN) are at high risk of respiratory illness, frequent hospital admissions and premature death. This study aimed to test the acceptability and feasibility of Breathe-Easy, a novel night-time postural intervention to improve respiratory health in CYPCN.

Design: Case series design incorporating a pre-post interventional study and qualitative study.

Efficacy of peroneal nerve functional electrical stimulation (FES) for the reduction of bradykinesia in Parkinson's disease: an assessor-blinded randomised controlled trial (STEPS II)-study protocol.

Introduction: Difficulty with walking can lead to reduced quality of life for people with Parkinson's disease (pwPD); improving walking is considered a treatment priority. Drug therapies can control PD symptoms; however, pwPD often still experience mobility problems.Functional electrical stimulation (FES) induces movement in weak muscles via external electrical stimulation.

Working across religions, cultures, settings, and development: Protocol for wave 2 data collection with children and parents by the developing belief network.

The Developing Belief Network is a global research collaborative studying religious development in diverse social-cultural settings, with a focus on the intersection of cognitive mechanisms and cultural beliefs and practices in early and middle childhood. The current manuscript describes the study protocol for the network's second wave of data collection, which aims to further explore the development and diversity of religious cognition and behavior using a multi-time point approach. This protocol is designed to investigate three key research questions-how children represent and reason about religious and supernatural agents, how children represent and reason about religion as an aspect of social identity, and how religious and supernatural beliefs are transmitted within and between generations-via a set of eight tasks for children between the ages of 5 and 13 years and a survey completed by their parents/caregivers.

(Un)timely care: findings from the Waiting Times project.

There is a historic crisis in waiting times in the UK's National Health Service. Crisis brings both a call for judgement - a response to the question 'what has gone wrong?' - and a call to action, such as better management, more resources, strategies to mitigate staff burnout, or even a shift in access commitments to reduce demand. However, not all forms of waiting are a sign of service inefficiency or failure, or a form of abandonment or lack of care.

Density-dependent network structuring within and across wild animal systems.

Theory predicts that high population density leads to more strongly connected spatial and social networks, but how local density drives individuals' positions within their networks is unclear. This gap reduces our ability to understand and predict density-dependent processes. Here we show that density drives greater network connectedness at the scale of individuals within wild animal populations.

Towards a trait-based framework for protist ecology and evolution.

Protists comprise the vast majority of eukaryotic genetic and functional diversity. While they have traditionally been difficult to study due to their small size and varied phenotypes, environmental sequencing studies have revealed the stunning diversity and abundance of protists in all ecosystems. Protists are key primary and secondary producers across many biomes, with ecological specializations that range from mutualism to parasitism, complex predation behaviors, mixotrophy, detritivory, and saprotrophy.

Perceived mental health literacy as a mediator between cognitive behavioural therapy (CBT) and depressive symptoms: a secondary data analysis of CoBalT trial data.

Cognitive behavioural therapy (CBT) is an effective treatment for depression, but little is known about mediators of treatment response. Undertaking a secondary analysis of CoBalT trial data (CBT for treatment-resistant depression), we examined: (1) whether perceived mental health literacy (PMHL) at 6-months mediates CBT effect on depressive symptoms at 12-months; and (2) whether PMHL is an independent mediator after accounting for dysfunctional attitudes (DA) and metacognitive awareness (MA). Linear regression models were fitted between treatment allocation and outcome, analysing the impact of PMHL, DA, and MA.

Local Adaptation Drives Leaf Thermoregulation in Tropical Rainforest Trees.

Tropical forests play a critical role in biodiversity, carbon sequestration, and climate regulation, but are increasingly affected by heatwaves and droughts. Vulnerability to warming may vary within and between species because of phenotypic divergence. Leaf trait variation can affect leaf operating temperatures-a phenomenon termed 'limited homeothermy' when it helps avoid heat damage in warmer conditions.

Unprecedented UK heatwave harmonised drivers of fuel moisture creating extreme temperate wildfire risk.

Climate change is resulting in more extreme fire weather during major heatwaves. Across temperate Europe, shrub landscapes dominate the area burned, with the moisture content of fuels during these events determining the threat posed. Current controls on the moisture content of temperate fuel constituents and their response to future extreme heatwaves are not known.

The genome sequence of the Brown Moss-moth, (Denis & Schiffermüller), 1775.

We present a genome assembly from a female specimen of (Brown Moss-moth; Arthropoda; Insecta; Lepidoptera; Gelechiidae). The genome sequence has a total length of 756.35 megabases.

Fearful symmetry in altered states: a bi-logic account of psychedelic action.

This conceptual study examines Matte Blanco's system of bi-logic as a novel framework for understanding psychedelic altered states of consciousness. The initial point of departure is a consideration of the complex historical relationship between psychoanalysis and psychedelics, prompting a review of contemporary psychoanalytic and neuropsychoanalytic perspectives on psychedelic action. This leads into an exposition of bi-logic, which reformulates Freud's conception of conscious and unconscious processes in terms of logico-mathematical principles, postulating binary modes of mental functioning: the , characterized by logic, differentiation, ordered relations in space and time, and cognition; and the , characterized by symmetry, generalization, unity, spacelessness, timelessness, paradox, and boundless affect.

Phage defence-system abundances vary across environments and increase with viral density.

The defence systems bacteria use to protect themselves from their viruses are mechanistically and genetically diverse. Yet the ecological conditions that predict when defences are selected for remain unclear, as substantial variation in defence prevalence has been reported. Experimental work in simple communities suggests ecological factors can determine when specific defence systems are most beneficial, but applying these findings to complex communities has been challenging.

Phage susceptibility to a minimal, modular synthetic CRISPR-Cas system in is nutrient dependent.

CRISPR-Cas systems can provide adaptive, heritable immunity to their prokaryotic hosts against invading genetic material such as phages. It is clear that the importance of acquiring CRISPR-Cas immunity to anti-phage defence varies across environments, but it is less clear if and how this varies across different phages. To explore this, we created a synthetic, modular version of the type I-F CRISPR-Cas system of .

Phage provoke growth delays and SOS response induction despite CRISPR-Cas protection.

Bacteria evolve resistance against their phage foes with a wide range of resistance strategies whose costs and benefits depend on the level of protection they confer and on the costs for maintainance. can evolve resistance against its phage DMS either by surface mutations that prevent phage binding or through CRISPR-Cas immunity. CRISPR immunity carries an inducible cost whose exact origin is still unknown, and previous work suggested it stems from the inability of the CRISPR-Cas system to completely prevent phage DNA injection and subsequent gene expression before clearing the phage infection.

A new screening tool for early recognition of ATTRv polyneuropathy in clinical practice: AmyloScan.

Hereditary transthyretin (ATTRv) amyloidosis is a progressive multisystem disorder, mainly characterized by cardiac dysfunction and polyneuropathy. Due to its rarity and heterogeneous presentation, diagnosis is often delayed, which has a direct impact on the initiation of treatment and, therefore, span and quality of life. To facilitate early disease recognition, we aimed to develop and validate a new screening tool for early identification of ATTRv amyloidosis with polyneuropathy (AmyloScan).

Improving the reporting on health equity in observational research (STROBE-Equity): extension checklist and elaboration.

Data on health equity to inform societally relevant evidence based decisions and policy making are lacking in the research literature. Observational studies have the potential to provide data on health equity. Yet, guidance on how to report health equity data and considerations in observational research is inadequate.

Transparent reporting of observational studies emulating a target trial: the TARGET Statement.

Importance: When randomized trials are unavailable or not feasible, observational studies can be used to answer causal questions about the comparative effects of interventions by attempting to emulate a hypothetical pragmatic randomized trial (target trial). Published guidance to aid reporting of these studies is not available.

Objective: To develop consensus based guidance for reporting observational studies performed to estimate causal effects by explicitly emulating a target trial.

Response to biologics along a gradient of T2 involvement in patients with severe asthma: a data-driven biomarker clustering approach.

Background: Asthma with low levels of T2-biomarkers is poorly understood.

Objective: To characterize severe asthma phenotypes and compare pre- to post-biologic change in asthma outcomes along a gradient of T2-involvement.

Methods: This was a registry-based, cohort study including data from 24 countries.

Mammographic density assessed using deep learning in women at high risk of developing breast cancer: the effect of weight change on density.

High mammographic density (MD) and excess weight are both associated with increased risk of breast cancer. Classically defined percentage density measures tend to increase with reduced weight due to disproportionate loss of breast fat, however the effect of weight loss on artificial intelligence-based density scores is unknown. We investigated an artificial intelligence-based density method, reporting density changes in 46 women enrolled in a weight-loss study in a family history breast cancer clinic, using a volumetric density method as a comparison.

Longitudinal association between dysmenorrhoea in adolescence and chronic pain in adulthood: a UK population-based study.

Background: Dysmenorrhoea affects many adolescents and often goes untreated for various sociocultural reasons. Dysmenorrhoea frequently co-occurs with other chronic pain conditions, and adult women with dysmenorrhoea have greater sensory sensitivity compared with controls. We aimed to test the hypothesis that adolescent dysmenorrhoea leads to the development of general chronic pain, including pain outside the pelvis, by estimating the risk of chronic pain in adulthood following the experience of dysmenorrhoea at age 15 years.

Risk factors to predict mortality in people with seizures reattending emergency departments: a dual-centre study.

Background: Recurrent seizure-related emergency department (ED) attendances are common and associated with poor outcomes. We aimed to identify factors associated with repeated seizure-related ED use and to develop a mortality risk score among individuals re-attending with seizures.

Methods: We conducted a retrospective cohort study across two district general hospitals in South-West England, Royal Cornwall Hospitals NHS Trust (RCH; 2015-2018) and Royal United Hospitals Bath NHS Trust (RUH; 2018-2022).

How loneliness relates to health, wellbeing, quality of life, and healthcare resource utilisation and costs across multiple age groups in the UK.

Increasing evidence of its detrimental impact has brought loneliness to the forefront of public health in recent years. Loneliness has been recognised as a cross-cutting theme for Healthy Ageing by the World Health Organisation and there is increasing need to better understand its wide-ranging health, wellbeing, and economic impacts across the wider population. This study utilises data from wave 13(2021-2023) of the Understanding Society UK Household Longitudinal Study to evaluate health and economic outcomes associated to loneliness (UCLA 3-item scale).

Behaviour Change for Parkinson's Disease: A Randomised Controlled Feasibility Study to Promote Physical Activity and Exercise Adherence Among People with Parkinson's Disease.

Objective: Exercise reduces fall risk, sarcopenia and frailty in Parkinson's disease, but motor and non-motor symptoms hinder adherence. This study aimed to feasibility test an exercise intervention with behaviour change techniques, examining recruitment, procedures, and measure responsiveness.

Methods: A mixed-methods parallel-arm, single-blinded, randomized feasibility study.